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Chapter 51 : In Pursuit of New Antibiotics

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Abstract:

Antibacterial agents were required to eradicate , , and microorganisms, and the objective has been achieved satisfactorily in the case of some bacterial species but not others, or intensive research has not yet resulted in one or more medications that fulfill the requirements, as for . From 1980s to the 1990s, about two families of antibiotics resulting from the fermentation products of microorganisms were developed, such as mupirocin and monocyclic β-lactams from sulfazecin, giving rise to two medications, aztreonam and carumonam. More complex research has shown that the mechanisms of expulsion may differ in the same family of antibiotics. Bacteria need the iron which is found in the external environment for their physiology, and they use siderophores to obtain it. Some antibiotics, such as cephalosporins of the catechol type, use this route as a second mechanism of action. The adherence of bacteria can occur through pili for gram-negative bacilli or sortases for gram-positive bacilli. To enlarge the potential of virulence factor inhibitors, the central regulatory pathway was focused to avoid the narrow spectrum obtained with antipili, antitoxins. Anti-infective agents are not limited to antibacterial agents, and intensive research has been conducted on antifungal agents. There is an urgent need to find agents against Plasmodium falciparum, but also to increase the number of agents active against Leishmania donovani and Trypanosoma gambiense, to find drugs active against Chagas’ disease, and to produce new molecules against Giardia lamblia.

Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51

Key Concept Ranking

Bacterial Proteins
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Antibacterial Agents
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Elongation Factor Inhibitors
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Chemicals
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
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Tables

Generic image for table
Table 1

Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
Generic image for table
Table 2

Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
Generic image for table
Table 3

Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51
Generic image for table
Table 4

Citation: Bryskier A. 2005. In Pursuit of New Antibiotics, p 1242-1259. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch51

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