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Chapter 18 : Enteroviruses and Parechoviruses

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Abstract:

Human enteroviruses (EV) are members of the Enterovirus genus of the family Picornaviridae and are among the most common human viral infections. These investigations had implications for all of virology because they indicated, first, that poliovirus (PV) grew in various tissue culture cells that did not correspond to the tissues infected during the human disease and, second, that PV destroyed cells with a specific cytopathic effect (CPE). The infectious virus is relatively resistant to many common laboratory disinfectants, including 70% ethanol, isopropanol, dilute Lysol, and quaternary ammonium compounds. Poliomyelitis should be considered in all cases of pure motor paralysis and is usually associated with a normal or slightly elevated value for protein, normal sugar value, and moderate mononuclear pleocytosis in cerebrospinal fluid (CSF). The innate immune system is especially important because it is the earliest response and, in addition, it regulates the adaptive immune response. All important information about a virus could potentially be obtained directly by PCR in conjunction with nucleic acid sequencing if all the molecular correlates of viral phenotypic determinants were understood. The most common molecular typing system is based on reverse transcription (RT)-PCR and nucleotide sequencing of a portion of the genomic region encoding VP1. The major advantage of the pan-EV PCR is that rapid detection of an EV is possible, even with very small amounts of clinical specimens such as CSF. Like the EV, human parechoviruses were traditionally detected and identified by virus isolation and antigenic typing.

Citation: Pallansch M, Oberste M. 2009. Enteroviruses and Parechoviruses, p 249-282. In Specter S, Hodinka R, Young S, Wiedbrauk D (ed), Clinical Virology Manual, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815974.ch18
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Figures

Image of FIGURE 1
FIGURE 1

Morphology of PV. (A) Transmission electron micrograph of PV type 1 particles, negatively stained with 0.5% uranyl acetate. Bar, 100 nm. (B) Schematic representation of the three-dimensional structure of a PV particle and the four neutralizing antigenic (N-Ag) sites. X-ray crystallographic structure analysis of PV type 1 (Hogle et al., 1985) has revealed an icosahedral capsid structure typical of EV. The capsid surface is composed of 60 protomers, each consisting of the capsid proteins VP1, VP2, and VP3 (black areas). Each of the 12 fivefold symmetry axes is surrounded by five protomers, forming a pentamer (surrounded by a bold black line). The attachment site for the virus-specific receptor is a depression around the fivefold symmetry axis, also called the canyon (dark gray circles). Each of the three surface-exposed capsid proteins contains immunodominant antigenic sites at which neutralizing antibodies bind, resulting in neutralization of virus infectivity. Four N-Ag sites (white ellipses) have been mapped to surface loop extensions (for a review, see Hogle and Filman, 1989). N-Ag I is a continuous sequence in VP1 mapping to amino acids 95 to 105. N-Ag II is a discontinuous site mapping to amino acids 221 to 226 of VP1 and amino acids 164 to 172 and 270 in VP2. N-Ag III consists of two independent discontinuous sites. N-Ag IIIA is composed of amino acids 58 to 60 and 71 to 73 of VP3, and N-Ag IIIB consists of amino acid 72 of VP2 and amino acids 76 to 79 of VP3. The smallest capsid protein, VP4, lies buried in the capsid shell in close association with the single molecule of viral RNA.

Citation: Pallansch M, Oberste M. 2009. Enteroviruses and Parechoviruses, p 249-282. In Specter S, Hodinka R, Young S, Wiedbrauk D (ed), Clinical Virology Manual, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815974.ch18
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Image of FIGURE 2
FIGURE 2

Genome organization of PV type 1. The PV genome is a single-stranded positive-sense RNA of approximately 7,500 nucleotides. Nucleotides 743 to 7370 encode in a single open reading frame the capsid proteins (white boxes in coding regions P1) and functional proteins (gray boxes in coding regions P2 and P3). The 5′ and 3′ NTRs are shown as lines. The IRES is shown schematically with the two-dimensional structure. The virus protein VPg is covalently linked to the terminal uracil of the 5′ NTR. For further details, see “Structure” and “Replication in Cell Culture” in the text.

Citation: Pallansch M, Oberste M. 2009. Enteroviruses and Parechoviruses, p 249-282. In Specter S, Hodinka R, Young S, Wiedbrauk D (ed), Clinical Virology Manual, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815974.ch18
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Image of FIGURE 3
FIGURE 3

Replication cycle of PV. Parental PV enters its host cell by receptor-mediated endocytosis and releases its viral RNA from the virus capsid (uncoating) in acidic organelles (endosomes). After release of VPg from the parental viral RNA, protein synthesis of PV starts at the rough endoplasmic reticulum. The viral precursor polyprotein is autocatalytically cleaved by viral proteases, releasing in the viral RNA polymerase, and via several precursor proteins, the virus capsid proteins. At the smooth endoplasmic reticulum, the viral RNA polymerase synthesizes new viral RNA. Positive-sense RNA serves as a template for negative-sense RNA molecules, which themselves are templates for new positive-sense RNA. This positive-sense RNA is released from multistranded replicative intermediates (RI) and used for either further viral transcription and translation or encapsidation into assembling provirus particles. After the capsid protein precursor VP0 has finally been cleaved into VP2 and VP4, the maturation of progeny virus is completed. One cycle of PV reproduction takes about 6 h.

Citation: Pallansch M, Oberste M. 2009. Enteroviruses and Parechoviruses, p 249-282. In Specter S, Hodinka R, Young S, Wiedbrauk D (ed), Clinical Virology Manual, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815974.ch18
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Image of FIGURE 4
FIGURE 4

Scanning electron micrograph of HEp-2 cells infected with PV type 1. (A) Infected cells show a severe CPE, characterized by rounded-up cells that are attached to the substratum only by long filopodia. (B) Mock-infected HEp-2 cells are characterized as a monolayer of confluent cells with evenly distributed microvilli at the plasma membrane. Bars, 10 μm.

Citation: Pallansch M, Oberste M. 2009. Enteroviruses and Parechoviruses, p 249-282. In Specter S, Hodinka R, Young S, Wiedbrauk D (ed), Clinical Virology Manual, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815974.ch18
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Image of FIGURE 5
FIGURE 5

Course of PV infection.

Citation: Pallansch M, Oberste M. 2009. Enteroviruses and Parechoviruses, p 249-282. In Specter S, Hodinka R, Young S, Wiedbrauk D (ed), Clinical Virology Manual, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815974.ch18
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Image of FIGURE 6
FIGURE 6

Temporal prevalence of E9, E30, and CVB3 in the United States from 1970 to 2005. The graph shows the number of isolates (bar graph) and the fraction of all nonpolio EV (line graph) that each of the serotypes represents in each year.

Citation: Pallansch M, Oberste M. 2009. Enteroviruses and Parechoviruses, p 249-282. In Specter S, Hodinka R, Young S, Wiedbrauk D (ed), Clinical Virology Manual, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815974.ch18
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Image of FIGURE 7
FIGURE 7

Lim and Benyesh-Melnick antiserum pools for typing of EV. Filled boxes represent neutralization of EV by antiserum pools A to H. The typing of a virus is based on combined neutralization of different antiserum pools. (Adapted from Melnick et al., 1979.)

Citation: Pallansch M, Oberste M. 2009. Enteroviruses and Parechoviruses, p 249-282. In Specter S, Hodinka R, Young S, Wiedbrauk D (ed), Clinical Virology Manual, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815974.ch18
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Image of FIGURE 8
FIGURE 8

Global distribution of wild PV and progress in eradication. The maps indicate (shading) which countries had endemic wild PV circulation in 1988 (top) and 2007 (bottom). In 2007, several countries (light shading) that were polio free for at least 3 years had virus circulation following importations of wild PV and circulation was reestablished for a period of at least 12 months.

Citation: Pallansch M, Oberste M. 2009. Enteroviruses and Parechoviruses, p 249-282. In Specter S, Hodinka R, Young S, Wiedbrauk D (ed), Clinical Virology Manual, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815974.ch18
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References

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1. Abad, F. X.,, R. M. Pinto, and, A. Bosch. 1994. Survival of enteric viruses on environmental fomites. Appl. Environ. Microbiol. 60:37043710.
2. Abad, F. X.,, R. M. Pinto, and, A. Bosch. 1997. Disinfection of human enteric viruses on fomites. FEMS Microbiol. Lett. 156:107111.
3. Abraham, A. 1967. Isolation of two enteroviruses, possible “prime” strains of coxsackie A type 17 virus. Proc. Soc. Exp. Biol. Med. 125:195200.
4. Abraham, A. A.,, and K. Inverso. 1977. Isolation and characterization of an echovirus, intratypic variant of echovirus 33. Arch. Virol. 53:3944.
5. AbuBakar, S.,, N. Shafee, and, H. Y. Chee. 1998. Outbreak of fatal childhood viral infection in Sarawak, Malaysia in 1997: inocula of patients’ clinical specimens induce apoptosis in vitro. Malays. J. Pathol. 20:7181.
6. AbuBakar, S.,, H. Y. Chee,, M. F. Al-Kobaisi,, J. Xiaoshan,, K. B. Chua, and, S. K. Lam. 1999. Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia. Virus Res. 61:19.
7. Abzug, M. J.,, H. L. Keyserling,, M. L. Lee,, M. J. Levin, and, H. A. Rotbart. 1995. Neonatal enterovirus infection: virology, serology, and effects of intravenous immune globulin. Clin. Infect. Dis. 20:12011206.
8. Ackermann, W. W.,, R. S. Fujioka, and, H. B. Kurtz. 1970. Cationic modulation of the inactivation of poliovirus by heat. Arch. Environ. Health 21:377381.
9. Alexander, J. P., Jr.,, L. E. Chapman,, M. A. Pallansch,, W. T. Stephenson,, T. J. Torok, and, L. J. Anderson. 1993. Coxsackievirus B2 infection and aseptic meningitis: a focal outbreak among members of a high school football team. J. Infect. Dis. 167:12011205.
10. Alexander, J. P., Jr.,, L. Baden,, M. A. Pallansch, and, L. J. Anderson. 1994. Enterovirus 71 infections and neurologic disease—United States, 1977–1991. J. Infect. Dis. 169:905908.
11. Alexander, L. N.,, J. F. Seward,, T. A. Santibanez,, M. A. Pallansch,, O. M. Kew,, D. R. Prevots,, P. M. Strebel,, J. Cono,, M. Wharton,, W. A. Orenstein, and, R. W. Sutter. 2004. Vaccine policy changes and epidemiology of poliomyelitis in the United States. JAMA 292:16961701.
12. Al-Sunaidi, M.,, C. H. Williams,, P. J. Hughes,, D. P. Schnurr, and, G. Stanway. 2007. Analysis of a new human parechovirus allows the definition of parechovirus types and the identification of RNA structural domains. J. Virol. 81:10131021.
13. Andersson, P.,, K. Edman, and, A. M. Lindberg. 2002. Molecular analysis of the echovirus 18 prototype. Evidence of interserotypic recombination with echovirus 9. Virus Res. 85:7183.
14. Andrus, J. K.,, P. M. Strebel,, C. A. de Quadros, and, J. M. Olive. 1995. Risk of vaccine-associated paralytic poliomyelitis in Latin America, 1989–91. Bull. W. H. O. 73:3340.
15. Anonymous. 1993. Poliomyelitis: dangers of incomplete immunization [news]. World Health Forum 14:330331.
16. Arya, S. C. 1997. Poliovirus genomic sequences in the central nervous systems of patients with postpolio syndrome. J. Clin. Microbiol. 35:334335. (Letter.)
17. Avellon, A.,, I. Casas,, G. Trallero,, C. Perez,, A. Tenorio, and, G. Palacios. 2003. Molecular analysis of echovirus 13 isolates and aseptic meningitis, Spain. Emerg. Infect. Dis. 9:934941.
18. Aycock, W. L. 1928. The significance of the age distribution of poliomyelitis: evidence of transmission through contact. Am. J. Hyg. 8:3554.
19. Baboonian, C.,, and T. Treasure. 1997. Meta-analysis of the association of enteroviruses with human heart disease. Heart 78:539543.
20. Bailly, J. L.,, A. Béguet,, M. Chambon,, C. Henquell, and, H. Peigue-Lafeuille. 2000. Nosocomial transmission of echovirus 30: molecular evidence by phylogenetic analysis of the VP1 encoding sequence. J. Clin. Microbiol. 38:28892892.
21. Bailly, J. L.,, D. Brosson,, C. Archimbaud,, M. Chambon,, C. Henquell, and, H. Peigue-Lafeuille. 2002. Genetic diversity of echovirus 30 during a meningitis outbreak, demonstrated by direct molecular typing from cerebrospinal fluid. J. Med. Virol. 68:558567.
22. Barton, D. J.,, B. J. O’Donnell, and, J. B. Flanegan. 2001. 5′cloverleaf in poliovirus RNA is a cis-acting replication element required for negative-strand synthesis. EMBO J. 20:14391448.
23. Baum, S. G.,, and B. Koll. 2003. Acute viral meningitis and encephalitis, p. 1288–1293. In S. L. Gorbach,, J. G. Bartlett, and, N. R. Blacklow (ed.), Infectious Diseases, 3rd ed. Lippincott Williams & Wilkins, Philadelphia, PA.
24. Baumgarte, S.,, L. K. de Souza Luna,, K. Grywna,, M. Panning,, J. F. Drexler,, C. Karsten,, H. I. Huppertz, and, C. Drosten. 2008. Prevalence, types, and RNA concentrations of human parechoviruses, including a sixth parechovirus type, in stool samples from patients with acute enteritis. J. Clin. Microbiol. 46:242248.
25. Beeman, E. A.,, R. J. Huebner, and, R. M. Cole. 1952. Studies of coxsackie viruses: laboratory aspects of group A viruses. Am. J. Hyg. 55:83107.
26. Bell, E. J.,, R. A. McCartney,, D. Basquill, and, A. K. Chaudhuri. 1986. Mu-antibody capture ELISA for the rapid diagnosis of enterovirus infections in patients with aseptic meningitis. J. Med. Virol. 19:213217.
27. Benschop, K.,, R. Molenkamp,, A. van der Ham,, K. Wolthers, and, M. Beld. 2008. Rapid detection of human parechoviruses in clinical samples by real-time PCR. J. Clin. Virol. 41:6974.
28. Benschop, K. S. M.,, J. Schinkel,, M. E. Luken,, P. J. M. van den Broek,, M. F. C. Beersma,, N. Menelik,, H. W. M. van Eijk,, H. L. Zaaijer,, C. M. J. E. VandenBrouke-Grauls,, M. G. H. M. Beld, and, K. C. Wolthers. 2006a. Fourth human parechovirus serotype. Emerg. Infect. Dis. 12:15721575.
29. Benschop, K. S. M.,, J. Schinkel,, R. P. Minnaar,, D. Pajkrt,, L. Spanjerberg,, H. C. Kraakman,, B. Berkhout,, H. L. Zaaijer,, M. G. Beld, and, K. C. Wolthers. 2006b. Human parechovirus infections in Dutch children and the association between serotype and disease severity. Clin. Infect. Dis. 42:204210.
30. Benyesh, M.,, E. C. Pollard,, E. M. Opton,, F. L. Black,, W. D. Bellamy, and, J. L. Melnick. 1958. Size and structure of echo, poliomyelitis, and measles virus determined by ionizing radiation and ultrafiltration. Virology 5:256274.
31. Blackburn, R. V.,, V. R. Racaniello, and, V. F. Righthand. 1992. Construction of an infectious cDNA clone of echovirus 6. Virus Res. 22:7178.
32. Bodian, D.,, I. M. Morgan, and, H. A. Howe. 1949. Differentiation of types of poliomyelitis viruses. III. The grouping of fourteen strains into three basic immunological types. Am. J. Hyg. 49:234245.
33. Boman, J.,, B. Nilsson, and, P. Juto. 1992. Serum IgA, IgG, and IgM responses to different enteroviruses as measured by a coxsackie B5-based indirect ELISA. J. Med. Virol. 38:3235.
34. Brandful, J. A.,, N. Takeda,, T. Yoshii,, K. Miyamura,, J. A. Mingle,, E. T. Addy, and, S. Yamazaki. 1991. A study of the evolution of coxsackievirus A24 variant in Ghana by viral RNA fingerprinting analysis. Res. Virol. 142:5765.
35. Brown, B.,, M. S. Oberste,, K. Maher, and, M. A. Pallansch. 2003. Complete genomic sequencing shows that polioviruses and members of human enterovirus species C are closely related in the noncapsid coding region. J. Virol. 77:89738984.
36. Brown, B. A.,, and M. A. Pallansch. 1995. Complete nucleotide sequence of enterovirus 71 is distinct from poliovirus. Virus Res. 39:195205.
37. Brown, B. A.,, M. S. Oberste,, J. P. Alexander, Jr.,, M. L. Kennett, and, M. A. Pallansch. 1999. Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998. J. Virol. 73:99699975.
38. Buck, G. E.,, M. Wiesemann, and, L. Stewart. 2002. Comparison of mixed cell culture containing genetically engineered BGMK and CaCo-2 cells (Super E-Mix) with RT-PCR and conventional cell culture for the diagnosis of enterovirus meningitis. J. Clin. Virol. 25(Suppl. 1):S13S18.
39. Cardosa, M. J.,, D. Perera,, B. A. Brown,, D. Cheon,, H. M. Chan,, K. P. Chan,, H. Cho, and, P. McMinn. 2003. Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: comparative analysis of the VP1 and VP4 genes. Emerg. Infect. Dis. 9:461468.
40. Caro, V.,, S. Guillot,, F. Delpeyroux, and, R. Crainic. 2001. Molecular strategy for ‘serotyping’ of human enteroviruses. J. Gen. Virol. 82:7991.
41. Casas, I.,, G. F. Palacios,, G. Trallero,, D. Cisterna,, M. C. Freire, and, A. Tenorio. 2001. Molecular characterization of human enteroviruses in clinical samples: comparison between VP2, VP1, and RNA polymerase regions using RT nested PCR assays and direct sequencing of products. J. Med. Virol. 65:138148.
42. Centers for Disease Control and Prevention. 2000. Poliomyelitis prevention in the United States. Updated recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recommed. Rep. 49(RR-5): 122.
43. Centers for Disease Control and Prevention. 2001. Apparent global interruption of wild poliovirus type 2 transmission. MMWR Morb. Mortal. Wkly. Rep. 50:222224.
44. Centers for Disease Control and Prevention. 2002. Certification of poliomyelitis eradication—European Region, June 2002. MMWR Morb. Mortal. Wkly. Rep. 51:572574.
45. Centers for Disease Control and Prevention. 2006. Resurgence of wild poliovirus type 1 transmission and consequences of importation—21 countries, 2002–2005. MMWR Morb. Mortal. Wkly. Rep. 55:145150.
46. Centers for Disease Control and Prevention. 2007a. Progress toward interruption of wild poliovirus transmission—worldwide, January 2006–May 2007. MMWR Morb. Mortal. Wkly. Rep. 56:682685.
47. Centers for Disease Control and Prevention. 2007b. Progress toward poliomyelitis eradication—Nigeria, 2005–2006. MMWR Morb. Mortal. Wkly. Rep. 56:278281.
48. Chan, L. G.,, U. D. Parashar,, M. S. Lye,, F. G. L. Ong,, S. R. Zaki,, J. P. Alexander,, K. K. Ho,, L. L. Han,, M. A. Pallansch,, S. Abu Bakar,, M. Jegathesan, and, L. J. Anderson. 2000. Deaths of children during an outbreak of hand, foot, and mouth disease in Sarawak, Malaysia: clinical and pathoilogical characteristics of the disease. Clin. Infect. Dis. 31:678683.
49. Chang, K. H.,, P. Auvinen,, T. Hyypia, and, G. Stanway. 1989. The nucleotide sequence of coxsackievirus A9; implications for receptor binding and enterovirus classification. J. Gen. Virol. 70:32693280.
50. Chen, J. H.,, N. C. Chiu,, J. H. Chang,, F. Y. Huang,, K. B. Wu, and, T. L. Lin. 2005. A neonatal echovirus 11 outbreak in an obstetric clinic. J. Microbiol. Immunol. Infect. 38:332337.
51. Cherry, J. D. 1993. Contemporary infectious exanthems. Clin. Infect. Dis. 16:199205.
52. Cherry, J. D. 2004. Enteroviruses and parechoviruses, p. 1984–2041. In R. D. Feigin,, J. D. Cherry,, G. Demmler, and, S. L. Kaplan (ed.), Textbook of Pediatric Infectious Diseases, 5th ed, vol. 2. Saunders, Philadelphia, PA.
53. Chevaliez, S.,, A. Szendroi,, V. Caro,, J. Balanant,, S. Guillot,, G. Berencsi, and, F. Delpeyroux. 2004. Molecular comparison of echovirus 11 strains circulating in Europe during an epidemic of multisystem hemorrhagic disease of infants indicates that evolution generally occurs by recombination. Virology 325:5670.
54. Chumakov, M.,, M. Voroshilova,, L. Shindarov,, I. Lavrova,, L. Gracheva,, G. Koroleva,, S. Vasilenko,, I. Brodvarova,, M. Noikolova,, S. Gyurova,, M. Gacheva,, G. Mitov,, N. Ninov,, E. Tsylka,, I. Robinson,, M. Frolova,, V. Bashkirtsev,, L. Martiyanova, and, V. Rodin. 1979. Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria. Arch. Virol. 60:329340.
55. Chung, J. Y.,, T. H. Han,, S. W. Kim, and, E. S. Hwang. 2007. Respiratory picornavirus infections in Korean children with lower respiratory tract infections. Scand. J. Infect. Dis. 39:250254.
56. Clark, C. S.,, A. B. Bjornson,, G. M. Schiff,, J. P. Phair,, G. L. Van Meer, and, P. S. Gartside. 1977. Sewage worker’s syndrome. Lancet i:1009. (Letter.)
57. Coller, B. A.,, N. M. Chapman,, M. A. Beck,, M. A. Pallansch,, C. J. Gauntt, and, S. M. Tracy. 1990. Echovirus 22 is an atypical enterovirus. J. Virol. 64:26922701.
58. Committee on Enteroviruses. 1962. Classification of human enteroviruses. Virology 16:501504.
59. Committee on the ECHO viruses. 1955. Enteric cytopathogenic human orphan (ECHO) viruses. Science 122:11871188.
60. Committee on the Enteroviruses. 1957. The enteroviruses. Am. J. Public Health 47:15561566.
61. Contreras, G.,, V. H. Barnett, and, J. L. Melnick. 1952. Identification of coxsackie viruses by immunological methods and their classification into 16 antigenically distinct types. J. Immunol. 69:395414.
62. Conyn-van Spaendonck, M. A.,, P. M. Oostvogel,, A. M. van Loon,, J. K. van Wijngaarden, and, D. Kromhout. 1996. Circulation of poliovirus during the poliomyelitis outbreak in The Netherlands in 1992–1993. Am. J. Epidemiol. 143:929935.
63. Corless, C. E.,, M. Guiver,, R. Borrow,, V. Edwards-Jones,, A. J. Fox,, E. B. Kaczmarshi, and, K. J. Mutton. 2002. Development and evaluation of a ‘real-time’ RT-PCR for the detection of enterovirus and parechovirus in CSF and throat swab samples. J. Med. Virol. 67:555562.
64. Dahllund, L.,, L. Nissinen,, T. Pulli,, V. P. Hyttinen,, G. Stanway, and, T. Hyypia. 1995. The genome of echovirus 11. Virus Res. 35:215222.
65. Dalakas, M. C. 1987. New neuromuscular symptoms after old polio (“the post-polio syndrome”): clinical studies and pathogenetic mechanisms. Birth Defects Orig. Artic. Ser. 23:241264.
66. Dalldorf, G.,, and G. M. Sickles. 1948. An unidentified, filtrible agent isolated from the feces of children with paralysis. Science 108:6162.
67. Dalldorf, G. 1950. The coxsackie viruses. Bull. N. Y. Acad. Med. 26:329335.
68. Dalldorf, G.,, and G. M. Sickles. 1956. The coxsackie viruses, p. 153–168. In E. H. Lennette and, N. J. Schmidt (ed.), Diagnostic Procedures for Virus and Rickettsial Diseases, 2nd ed. American Public Health Association, New York City, NY.
69. Day, C.,, H. Cumming, and, J. Walker. 1989. Enterovirus-specific IgM in the diagnosis of meningitis. J. Infect. 19:219228.
70. Dayan, G.,, M. Thorley,, Y. Yamamura,, N. Rodriguez,, L. Torres,, S. McLaughlin,, A. Seda,, M. Carbia,, V. Caceres, and, M. Pallansch. 2007. Serologic response to inactivated polio vaccine: a randomized clinical trial comparing two vaccination schedules in Puerto Rico. J. Infect. Dis. 195:1220.
71. Dec, G. W. 2003. Introduction to clinical myocarditis, p. 257–281. In L. T. J. Cooper (ed.), Myocarditis: from Bench to Bedside. Humana Press, Totowa, NJ.
72. De Sena, J.,, and D. L. Jarvis. 1981. Modification of the poliovirus capsid by ultraviolet light. Can. J. Microbiol. 27:11851193.
73. Deshpande, J.,, M. Ram,, S. Durrani, and, J. Wenger. 2005. Detecting polio through surveillance for acute flaccid paralysis (AFP). J. Indian Med. Assoc. 103:671675.
74. de Vries, M.,, K. Pyrc,, R. Berkhout,, W. Vermeulen-Oost,, R. Dijkman,, M. F. Jebbink,, S. Bruisten,, B. Berkhout, and, L. van der Hoek. 2008. Human parechovirus type 1, 3, 4, 5, and 6 detection in picornavirus cultures. J. Clin. Microbiol. 46:759762.
75. Diamond, C.,, and J. Tilles. 2004. Pericarditis and myocarditis, p. 589–597. In S. L. Gorbach,, J. G. Bartlett, and, N. R. Blacklow (ed.), Infectious Diseases, 3rd ed. Lippincott Williams & Wilkins, Philadelphia, PA.
76. Diedrich, S.,, and E. Schreier. 2001. Aseptic meningitis in Germany associated with echovirus type 13. BMC Infect. Dis. 1:14.
77. Dorval, B. L.,, M. Chow, and, A. M. Klibanov. 1989. Stabilization of poliovirus against heat inactivation. Biochem. Biophys. Res. Commun. 159:11771183.
78. Dotta, F.,, S. Censini,, A. G. van Halteren,, L. Marselli,, M. Masini,, S. Dionisi,, F. Mosca,, U. Boggi,, A. O. Muda,, S. D. Prato,, J. F. Elliott,, A. Covacci,, R. Rappuoli,, B. O. Roep, and, P. Marchetti. 2007. Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc. Natl. Acad. Sci. USA 104:51155120.
79. Drescher, K. M.,, and S. M. Tracy. 2008. The CVB and etiology of type I diabetes, p. 259–274. In S. Tracy,, M. S. Oberste, and, K. M. Drescher (ed.), Group B Coxsackieviruses. Springer-Verlag, Berlin, Germany.
80. Dussart, P.,, G. Cartet,, P. Huguet,, N. Leveque,, C. Hajjar,, J. Morvan,, J. Vanderkerckhove,, K. Ferret,, B. Lina,, J. J. Chomel, and, H. Norder. 2005. Outbreak of acute hemorrhagic conjunctivitis in French Guiana and West Indies caused by coxsackie-virus A24 variant: phylogenetic analysis reveals Asian import. J. Med. Virol. 75:559565.
81. Earle, J. A.,, R. A. Skuce,, C. S. Fleming,, E. M. Hoey, and, S. J. Martin. 1988. The complete nucleotide sequence of a bovine enterovirus. J. Gen. Virol. 69:253263.
82. Eggers, H. J. 1990. Experiments on antiviral activity of hand disinfectants. Some theoretical and practical considerations. Zentralbl. Bakteriol. 273:3651.
83. Enders, J. F.,, T. H. Weller, and, F. C. Robbins. 1949. Cultivation of the Lansing strain of poliomyelitis virus in cultures of various human embryonic tissues. Science 109:8587.
84. Esfandiarei, M.,, and B. M. McManus. 2008. Molecular biology and pathogenesis of viral myocarditis. Ann. Rev. Pathol. 3:127155.
85. Feldman, R. A.,, S. Christopher,, S. George,, K. R. Kamath, and, T. J. John. 1970. Infection and disease in a group of South Indian families. 3. Virological methods and a report of the frequency of enteroviral infection in preschool children. Am. J. Epidemiol. 92:357366.
86. Figueroa, J. P.,, D. Ashley,, D. King, and, B. Hull. 1989. An outbreak of acute flaccid paralysis in Jamaica associated with echovirus type 22. J. Med. Virol. 29:315319.
87. Filman, D. J.,, R. Syed,, M. Chow,, A. J. Macadam,, P. D. Minor, and, J. M. Hogle. 1989. Structural factors that control conformational transitions and serotype specificity in type 3 poliovirus. EMBO J. 8:15671579.
88. Flodstrom-Tullberg, M.,, M. Hultcrantz,, A. Stotland,, A. Maday,, D. Tsai,, C. Fine,, B. Williams,, R. Silverman, and, N. Sarvetnick. 2005. RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus infection. J. Immunol. 174:11711177.
89. Frisk, G.,, E. Nilsson,, A. Ehrnst, and, H. Diderholm. 1989. Enterovirus IgM detection: specificity of mu-antibody-capture radioimmunoassays using virions and procapsids of coxsackie B virus. J. Virol. Methods 24:191202.
90. Fujinami, R. S.,, M. G. Von Herrath,, U. Christen, and, J. L. Whitton. 2006. Molecular mimicry, bystander activation, or viral persistence: infectious and autoimmune disease. Clin. Microbiol. Rev. 19:8094.
91. Gauntt, C. J.,, E. K. Godeny,, C. W. Lutton, and, G. Fernandes. 1989. Role of natural killer cells in experimental murine myocarditis. Springer Semin. Immunopathol. 11:5159.
92. Gear, J. H. S. 1984. Nonpolio causes of polio-like paralytic syndromes. Rev. Infect. Dis. 6:S379S384.
93. Gelfand, H. M.,, W. W. Henigst,, J. P. Fox, and, D. R. LeBlanc. 1958. Longitudinal studies of enteric viral infections. Proc. Sixth Int. Congr. Trop. Med. Malar. 5:265283.
94. Gifford, R.,, and G. Dalldorf. 1951. The morbid anatomy of experimental coxsackie virus infection. Am. J. Pathol. 27:10471063.
95. Gjoen, K.,, A. L. Bruu, and, I. Orstavik. 1996. Intratypic genome variability of echovirus type 30 in part of the VP4/VP2 coding region. Arch. Virol. 141:901908.
96. Glimaker, M.,, A. Samuelson,, L. Magnius,, A. Ehrnst,, P. Olcen, and, M. Forsgren. 1992. Early diagnosis of enteroviral meningitis by detection of specific IgM antibodies with a solid-phase reverse immunosorbent test (SPRIST) and mu-capture EIA. J. Med. Virol. 36:193201.
97. Godeny, E. K.,, and C. J. Gauntt. 1986. Involvement of natural killer cells in coxsackievirus B3-induced murine myocarditis. J. Immunol. 137:16951702.
98. Godeny, E. K.,, and C. J. Gauntt. 1987. Murine natural killer cells limit coxsackievirus B3 replication. J. Immunol. 139:913918.
99. Goldwater, P. N. 1995. Immunoglobulin M capture immuno-assay in investigation of coxsackievirus B5 and B6 outbreaks in South Australia. J. Clin. Microbiol. 33:16281631.
100. Goyal, S. M.,, C. P. Gerba, and, J. L. Melnick. 1979. Human enteroviruses in oysters and their overlying waters. Appl. Environ. Microbiol. 37:572581.
101. Graham, A. K.,, and D. R. Murdoch. 2005. Association between cerebrospinal fluid pleocytosis and enteroviral meningitis. J. Clin. Microbiol. 43:1491.
102. Grant, R. A.,, C. N. Hiremath,, D. J. Filman,, R. Syed,, K. Andries, and, J. M. Hogle. 1994. Structures of poliovirus complexes with antiviral drugs: implications for viral stability and drug design. Curr. Biol. 4:784797.
103. Grist, N. R.,, and E. J. Bell. 1970. Enteroviral etiology of the paralytic poliomyelitis syndrome. Arch. Environ. Health 21:382387.
104. Hall, C. E.,, M. K. Cooney, and, J. P. Fox. 1970. The Seattle virus watch program. I. Infection and illness experience of virus watch families during a communitywide epidemic of echovirus type 30 aseptic meningitis. Am. J. Public Health Nations Health 60:14561465.
105. Hammon, W. M.,, D. S. Yohn,, E. H. Ludwig,, R. A. Pavia, and, G. E. Sather. 1958. A study of certain nonpoliomyelitis and poliomyelitis enterovirus infections. JAMA 167:727735.
106. Hampil, B.,, and J. L. Melnick. 1968. WHO collaborative studies on enterovirus reference antisera: second report. Bull. W. H. O. 38:577593.
107. Handscher, R.,, L. M. Shulman,, B. Abramovitz,, I. Silberstein,, M. Neuman,, M. Tepperberg-Oikawa,, T. Fisher, and, E. Mendelsohn. 1999. A new variant of echovirus 4 associated with a large outbreak of aseptic meningitis. J. Clin. Virol. 13:2936.
108. Harper, G. J. 1961. Airborne micro-organisms: survival tests with four viruses. J. Hyg. (London). 59:479486.
109. Helfand, R. F.,, A. S. Khan,, M. A. Pallansch,, J. P. Alexander,, H. B. Meyers,, R. A. DeSantis,, L. B. Schonberger, and, L. J. Anderson. 1994. Echovirus 30 infection and aseptic meningitis in parents of children attending a child care center. J. Infect. Dis. 169:11331137.
110. Herold, J.,, and R. Andino. 2001. Poliovirus RNA replication requires genome circularization through a protein-protein bridge. Mol. Cell 7:581591.
111. Heymann, D. L.,, R. W. Sutter, and, R. B. Aylward. 2006. A vision of a world without polio: the OPV cessation strategy. Biologicals 34:7579.
112. Ho, M.,, E. R. Chen,, K. H. Hsu,, S. J. Twu,, K. T. Chen,, S. F. Tsai,, J. R. Wang,, S. R. Shih, et al. 1999. An epidemic of enterovirus 71 infection in Taiwan. N. Engl. J. Med. 341:929935.
113. Hodgson, J.,, J. Bendig,, P. Keeling, and, J. C. Booth. 1995. Comparison of two immunoassay procedures for detecting enterovirus IgM. J. Med. Virol. 47:2934.
114. Hogle, J. M. 1982. Preliminary studies of crystals of poliovirus type I. J. Mol. Biol. 160:663668.
115. Hogle, J. M.,, M. Chow, and, D. J. Filman. 1985. Three-dimensional structure of poliovirus at 2.9 Å resolution. Science 229:13581365.
116. Hogle, J. M.,, and D. J. Filman. 1989. The antigenic structure of poliovirus. Philos. Trans. R. Soc. Lond. B 323:467478.
117. Horie, H.,, S. Koike,, T. Kurata,, Y. Sato-Yoshida,, I. Ise,, Y. Ota,, S. Abe,, K. Hioki,, H. Kato, and, C. Taya. 1994. Transgenic mice carrying the human poliovirus receptor: new animal models for study of poliovirus neurovirulence. J. Virol. 68:681688.
118. Horstmann, D. M. 1967. Enterovirus infections of the central nervous system. The present and future of poliomyelitis. Med. Clin. N. Am. 51:681692.
119. Horwitz, M. S.,, L. M. Bradley,, J. Harbertson,, T. Krahl,, J. Lee, and, N. Sarvetnick. 1998. Diabetes induced by coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat. Med. 4:781785.
120. Horwitz, M. S.,, A. La Cava,, C. Fine,, E. Rodriguez,, A. Ilic, and, N. Sarvetnick. 2000. Pancreatic expression of interferon-gamma protects mice from lethal coxsackievirus B3 infection and subsequent myocarditis. Nat. Med. 6:693697.
121. Hosoya, M.,, Y. Kawasaki,, M. Sato,, K. Honzumi,, A. Kato,, T. Hiroshima,, H. Ishiko, and, H. Suzuki. 2006. Genetic diversity of enterovirus 71 associated with hand, foot and mouth disease epidemics in Japan from 1983 to 2003. Pediatr. Infect. Dis. J. 25:691694.
122. Hosoya, M.,, Y. Kawasaki,, M. Sato,, K. Honzumi,, A. Hayashi,, T. Hiroshima,, H. Ishiko,, K. Kato, and, H. Suzuki. 2007. Genetic diversity of coxsackievirus A16 associated with hand, foot, and mouth disease epidemics in Japan from 1983 to 2003. J. Clin. Microbiol. 45:112120.
123. Hovi, T.,, and M. Stenvik. 1994. Selective isolation of poliovirus in recombinant murine cell line expressing the human poliovirus receptor gene. J. Clin. Microbiol. 32:13661368.
124. Huang, Q. S.,, J. M. Carr,, W. A. Nix,, M. S. Oberste,, D. R. Kilpatrick,, M. A. Pallansch,, M. C. Croxson,, J. A. Lindeman,, M. G. Baker, and, K. Grimwood. 2003. An echovirus type 33 winter outbreak in New Zealand. Clin. Infect. Dis. 37:650657.
125. Huang, Y. T.,, P. Yam,, H. Yan, and, Y. Sun. 2002. Engineered BGMK cells for sensitive and rapid detection of enteroviruses. J. Clin. Microbiol. 40:366371.
126. Huber, S. 2008. Host immune responses to coxsackievirus B3, p. 199–221. In S. Tracy,, M. S. Oberste, and, K. M. Drescher (ed.), Group B Coxsackieviruses. Springer-Verlag, Berlin, Germany.
127. Hughes, M. S.,, E. M. Hoey, and, P. V. Coyle. 1993. A nucleotide sequence comparison of coxsackievirus B4 isolates from aquatic samples and clinical specimens. Epidemiol. Infect. 110:389398.
128. Hughes, P. J.,, C. North,, P. D. Minor, and, G. Stanway. 1989. The complete nucleotide sequence of coxsackievirus A21. J. Gen. Virol. 70:29432952.
129. Huovilainen, A.,, T. Hovi,, L. Kinnunen,, K. Takkinen,, M. Ferguson, and, P. Minor. 1987. Evolution of poliovirus during an outbreak: sequential type 3 poliovirus isolates from several persons show shifts of neutralization determinants. J. Gen. Virol. 68:13731378.
130. Hyypiä, T.,, C. Horsnell,, M. Maaronen,, M. Khan,, N. Kalkkinen,, P. Auvinen,, L. Kinnunen, and, G. Stanway. 1992. A distinct picornavirus group identified by sequence analysis. Proc. Natl. Acad. Sci. USA 89:88478851.
131. Ida-Hosonuma, M.,, T. Iwasaki,, T. Yoshikawa,, N. Nagata,, Y. Sato,, T. Sata,, M. Yoneyama,, T. Fujita,, C. Taya,, H. Yonekawa, and, S. Koike. 2005. The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirus. J. Virol. 79:44604469.
132. Iizuka, N.,, S. Kuge, and, A. Nomoto. 1987. Complete nucleotide sequence of the genome of coxsackievirus B1. Virology 156:6473.
133. Ikeda, R. M.,, S. F. Kondracki,, P. D. Drabkin,, G. S. Birkhead, and, D. L. Morse. 1993. Pleurodynia among football players at a high school. An outbreak associated with coxsackievirus B1. JAMA 270:22052206.
134. Inoue, T.,, T. Suzuki, and, K. Sekiguchi. 1989. The complete nucleotide sequence of swine vesicular disease virus. J. Gen. Virol. 70:919934.
135. Ishiko, H.,, N. Takeda,, K. Miyamura,, N. Kato,, M. Tanimura,, K. H. Lin,, M. Yin-Murphy,, J. S. Tam,, G. F. Mu, and, S. Yamazaki. 1992a. Phylogenetic analysis of a coxsackievirus A24 variant: the most recent worldwide pandemic was caused by progenies of a virus prevalent around 1981. Virology 187:748759.
136. Ishiko, H.,, N. Takeda,, K. Miyamura,, M. Tanimura,, T. Yamanaka,, K. Kasuga,, K. Oda,, K. Imai,, Y. Yamamoto,, Y. Mochida,, K. Uchida,, H. Nakagawa, and, S. Yamazaki. 1992b. Phylogenetically different strains of a variant of coxsackievirus A 24 were repeatedly introduced but discontinued circulating in Japan. Arch. Virol. 126:179193.
137. Itagaki, A.,, J. Ishihara,, K. Mochida,, Y. Ito,, K. Saito,, Y. Nishino,, S. Koike, and, T. Kurimura. 1983. A clustering outbreak of hand, foot, and mouth disease caused by coxsackie virus A10. Microbiol. Immunol. 27:929935.
138. Ito, M.,, T. Yamashita,, H. Tsuzuki,, N. Takeda, and, K. Sakae. 2004. Isolation and identification of a novel human parechovirus. J. Gen. Virol. 85:391398.
139. Jackson, G. G.,, and R. L. Muldoon. 1973. Viruses causing common respiratory infections in man. II. Enteroviruses and paramyxoviruses. J. Infect. Dis. 128:387469.
140. Jacques, J.,, H. Moret,, D. Minette,, N. Leveque,, N. Jovenin,, G. Deslee,, F. Lebargy,, J. Motte, and, L. Andreoletti. 2008. Epidemiological, molecular, and clinical features of enterovirus respiratory infections in French children between 1999 and 2005. J. Clin. Microbiol. 46:206213.
141. Jenkins, O.,, J. D. Booth,, P. D. Minor, and, J. W. Almond. 1987. The complete nucleotide sequence of coxsackievirus B4 and its comparison to other members of the Picornaviridae. J. Gen. Virol. 68:18351848.
142. Jensen, M. M. 1964. Inactivation of airborne viruses by ultraviolet radiation. Appl. Environ. Microbiol. 12:418420.
143. Johansson, E. S.,, B. Niklasson,, R. B. Tesh,, D. R. Shafren,, A. P. Travassos da Rosa, and, A. M. Lindberg. 2003. Molecular characterization of M1146, an American isolate of Ljungan virus (LV) reveals the presence of a new LV genotype. J. Gen. Virol. 84:837844.
144. Johansson, S.,, B. Niklasson,, J. Maizel,, A. E. Gorbalenya, and, A. M. Lindberg. 2002. Molecular analysis of three Ljungan virus isolates reveals a new, close-to-root lineage of the Picornaviridae with a cluster of two unrelated 2A proteins. J. Virol. 76:89208930.
145. John, T. J.,, N. K. Patoria,, S. Christopher, and, S. George. 1978. Epidemiology of enterovirus infections in children in Nagpur. Indian J. Med. Res. 68:549554.
146. John, T. J.,, S. Christopher, and, J. Abraham. 1981. Neurological manifestation of acute haemorrhagic conjunctivitis due to enterovirus 70. Lancet ii:12831284. (Letter.)
147. Jokela, P.,, P. Joki-Korpela,, M. Maaronen,, V. Glumoff, and, T. Hyypiä. 2005. Detection of human picornaviruses by multiplex reverse transcription-PCR and liquid hybridization. J. Clin. Microbiol. 43:12391245.
148. Joki-Korpela, P.,, and T. Hyypia. 1998. Diagnosis and epidemiology of echovirus 22 infections. Clin. Infect. Dis. 27:129136.
149. Junttila, N.,, N. Leveque,, J. P. Kabue,, G. Cartet,, F. Mushiya,, J. J. Muyembe-Tamfum,, A. Trompette,, B. Lina,, L. O. Magnius,, J. J. Chomel, and, H. Norder. 2007. New enteroviruses, EV-93 and EV-94, associated with acute flaccid paralysis in the Democratic Republic of the Congo. J. Med. Virol. 79:393400.
150. Kaida, A.,, H. Kubo,, N. Iritani,, T. Murakami, and, K. Haruki. 2004. Isolation of echovirus type 13 in Osaka City during 2001–2002. Jpn. J. Infect. Dis. 57:127128.
151. Kapoor, A.,, D. D. Patel,, S. Kumar,, A. Ayyagari, and, T. N. Dhole. 2004. Molecular characterization of echovirus 11 isolates from India. Indian J. Med. Res. 119:149156.
152. Katiyar, B. C.,, S. Misra,, R. B. Singh,, A. K. Singh,, S. Gupta,, A. K. Gulati,, S. Christopher, and, T. J. John. 1983. Adult poliolike syndrome following enterovirus 70 conjunctivitis (natural history of the disease). Acta Neurol. Scand. 67:263274.
153. Keswick, B. H.,, C. P. Gerba, and, S. M. Goyal. 1981. Occurrence of enteroviruses in community swimming pools. Am. J. Public Health 71:10261030.
154. Kew, O.,, and N. Nathanson. 1995. Introduction: molecular epidemiology of viruses. Semin. Virol. 6:357358.
155. Kew, O.,, V. Morris-Glasgow,, M. Landaverde,, C. Burns,, J. Shaw,, Z. Garib,, J. Andre,, E. Blackman,, C. J. Freeman,, J. Jorba,, R. Sutter,, G. Tambini,, L. Venczel,, C. Pedreira,, F. Laender,, H. Shimizu,, T. Yoneyama,, T. Miyamura,, H. van Der Avoort,, M. S. Oberste,, D. Kilpatrick,, S. Cochi,, M. Pallansch, and, C. de Quadros. 2002. Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus. Science 296:356359.
156. Kew, O. M.,, M. N. Mulders,, G. Y. Lipskaya,, E. E. da Silva, and, M. A. Pallansch. 1995b. Molecular epidemiology of polio-viruses. Semin. Virol. 6:401414.
157. Kew, O. M.,, R. W. Sutter,, E. M. de Gourville,, W. R. Dowdle, and, M. A. Pallansch. 2005. Vaccine-derived polioviruses and the endgame strategy for global polio eradication. Annu. Rev. Microbiol. 59:587635.
158. Khetsuriani, N.,, E. S. Quiroz,, R. C. Holman, and, L. J. Anderson. 2003. Viral meningitis-associated hospitalizations in the United States, 1988–1999. Neuroepidemiology 22:345352.
159. Khetsuriani, N.,, A. LaMonte,, M. S. Oberste, and, M. A. Pallansch. 2006. Enterovirus surveillance—United States, 1970–2005. MMWR Surveill. Summ. 55:120.
160. Kibrick, S.,, L. Meléndez, and, J. F. Enders. 1957. Clinical associations of enteric viruses with particular reference to agents exhibiting properties of the ECHO group. Ann. N. Y. Acad. Sci. 67:311325.
161. Kim, K.-S.,, K. Höfling,, S. D. Carson,, N. M. Chapman, and, S. Tracy. 2003. The primary viruses of myocarditis, p. 23–53. In L. T. J. Cooper (ed.), Myocarditis: from Bench to Bedside. Humana Press, Totowa, NJ.
162. Kitamura, N.,, B. L. Semler,, P. G. Rothberg,, G. R. Larsen,, C. J. Adler,, A. J. Dorner,, E. A. Emini,, R. Hanecak,, J. J. Lee,, S. van der Werf,, C. W. Anderson, and, E. Wimmer. 1981. Primary structure, gene organization and polypeptide expression of poliovirus RNA. Nature 291:547553.
163. Klump, W. M.,, I. Bergmann,, B. C. Muller,, D. Ameis, and, R. Kandolf. 1990. Complete nucleotide sequence of infectious coxsackievirus B3 cDNA: two initial 5′ uridine residues are regained during plus-strand RNA synthesis. J. Virol. 64:15731583.
164. Knowlton, K. U. 2008. CVB infection and mechanisms of viral cardiomyopathy, p. 315–335. In S. Tracy and, M. S. Oberste (ed.), Group B Coxsackieviruses. Springer-Verlag, Berlin, Germany.
165. Kogon, A.,, I. Spigland,, T. E. Frothingham,, L. Elveback,, C. Williams,, C. E. Hall, and, J. P. Fox. 1969. The virus watch program: a continuing surveillance of viral infections in metropolitan New York families. VII. Observations on viral excretion, seroimmunity, intrafamilial spread and illness association in coxsackie and echovirus infections. Am. J. Epidemiol. 89:5161.
166. Kohler, K. A.,, K. Banerjee,, W. G. Hlady,, J. K. Andrus, and, R. W. Sutter. 2002. Vaccine-associated paralytic poliomyelitis in India during 1999: decreased risk despite massive use of oral polio vaccine. Bull. W. H. O. 80:210216.
167. Koike, S.,, I. Ise, and, A. Nomoto. 1991a. Functional domains of the poliovirus receptor. Proc. Natl. Acad. Sci. USA 88:41044108.
168. Koike, S.,, C. Taya,, T. Kurata,, S. Abe,, I. Ise,, H. Yonekawa, and, A. Nomoto. 1991b. Transgenic mice susceptible to polio-virus. Proc. Natl. Acad. Sci. USA 88:951955.
169. Kok, T. W.,, T. Pryor, and, L. Payne. 1998. Comparison of rhabdomyosarcoma, buffalo green monkey kidney epithelial, A549 (human lung epithelial) cells and human embryonic lung fibroblasts for isolation of enteroviruses from clinical samples. J. Clin. Virol. 11:6165.
170. Kono, R.,, A. Sasagawa,, K. Ishii,, S. Sugiura,, M. Ochi,, H. Matsumiya,, H. Uchida,, K. Kameyama,, M. Kaneko, and, N. Sakurai. 1972. Pandemic of a new type of conjunctivitis. Lancet i:11911194.
171. Kono, R. 1975. Apollo 11 disease or acute hemorrhagic conjunctivitis: a pandemic of a new enterovirus infection of the eyes. Am. J. Epidemiol. 101:383390.
172. Kopecka, H.,, B. Brown, and, M. Pallansch. 1995. Genotypic variation in coxsackievirus B5 isolates from three different outbreaks in the United States. Virus Res. 38:125136.
173. Kraus, W.,, H. Zimmermann,, A. Zimmermann,, H. J. Eggers, and, B. Nelsen-Salz. 1995. Infectious cDNA clones of echovirus 12 and a variant resistant against the uncoating inhibitor rhodanine differ in seven amino acids. J. Virol. 69:58535858.
174. Lancet. 2007. Vaccine-derived poliomyelitis in Nigeria. Lancet 370:1394.
175. Landry, M. L. 2005. Frequency of normal cerebrospinal fluid protein level and leukocyte count in enterovirus meningitis. J. Clin. Virol. 32:7374.
176. Landsteiner, K.,, and E. Popper. 1908. Mikroskopische Praparate von einem Menschlichen und zwei Affenruckenmarken. Wien. Klin. Wochenschr. 21:1830.
177. Lee, B. E.,, and H. D. Davies. 2007. Aseptic meningitis. Curr. Opin. Infect. Dis. 20:272277.
178. Lee, L. H.,, C. A. Phillips,, M. A. South,, J. L. Melnick, and, M. D. Yow. 1965. Enteric virus isolation in different cell cultures. Bull. W. H. O. 32:657663.
179. Legay, V.,, J. J. Chomel, and, B. Lina. 2002. Specific RT-PCR procedure for the detection of human parechovirus type 1 genome in clinical samples. J. Virol. Methods 102:157160.
180. Lentz, K. N.,, A. D. Smith,, S. C. Geisler,, S. Cox,, P. Buontempo,, A. Skelton,, J. DeMartino,, E. Rozhon,, J. Schwartz,, V. Girijavallabhan,, J. O’Connell, and, E. Arnold. 1997. Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of three poliovirus serotypes. Structure 5:961978.
181. Leonardi, G. P.,, A. J. Greenberg,, P. Costello, and, K. Szabo. 1993. Echovirus type 30 infection associated with aseptic meningitis in Nassau County, New York, USA. Intervirology 36:5356.
182. Leveque, N.,, I. L. Amine,, G. Cartet,, A. B. Hammani,, Y. C. Khazraji,, B. Lina,, J. J. Muyembe,, H. Norder, and, J. J. Chomel. 2006. Two outbreaks of acute hemorrhagic conjunctivitis in Africa due to genotype III coxsackievirus A24 variant. Eur. J. Clin. Microbiol. Infect. Dis. 26:199202.
183. Lewis, P.,, and C. A. Glaser. 2005. Encephalitis. Pediatr. Rev. 26:353363.
184. Li, L.,, Y. He,, H. Yang,, J. Zhu,, X. Xu,, J. Dong,, Y. Zhu, and, Q. Jin. 2005. Genetic characteristics of human enterovirus 71 and coxsackievirus A16 circulating from 1999 to 2004 in Shenzhen, People’s Republic of China. J. Clin. Microbiol. 43:38353839.
185. Liang, X.,, Y. Zhang,, W. Xu,, N. Wen,, S. Zuo,, L. A. Lee, and, J. Yu. 2006. An outbreak of poliomyelitis caused by type 1 vaccine-derived poliovirus in China. J. Infect. Dis. 194:545551.
186. Lim, K. A.,, and M. Benyesh-Melnick. 1960. Typing of viruses by combinations of antiserum pools. Application to typing of enteroviruses (coxsackie and ECHO). J. Immunol. 84:309317.
187. Lim, K. H. 1973. Epidemic conjunctivitis: discovery of a new aetiologic agent. Singapore Med. J. 14:8285.
188. Lin, K. H.,, N. Takeda,, K. Miyamura,, S. Yamazaki, and, C. W. Chen. 1991. The nucleotide sequence of 3C proteinase region of the coxsackievirus A24 variant: comparison of the isolates in Taiwan in 1985–1988. Virus Genes 5:121131.
189. Lin, K. H.,, H. L. Wang,, M. M. Sheu,, W. L. Huang,, C. W. Chen,, C. S. Yang,, N. Takeda,, N. Kato,, K. Miyamura, and, S. Yamazaki. 1993. Molecular epidemiology of a variant of coxsackievirus A24 in Taiwan: two epidemics caused by phylo-genetically distinct viruses from 1985 to 1989. J. Clin. Microbiol. 31:11601166.
190. Lin, K. H.,, C. L. Chern,, P. Y. Chu,, C. H. Chang,, H. L. Wang,, M. M. Sheu,, W. L. Huang,, Y. Pongsuwanna,, S. Yamamoto,, S. Yoshino,, H. Ishiko, and, N. Takeda. 2001. Genetic analysis of recent Taiwanese isolates of a variant of coxsackievirus A24. J. Med. Virol. 64:269274.
191. Lin, K. H.,, K. P. Hwang,, G. M. Ke,, C. F. Wang,, L. Y. Ke,, Y. T. Hsu,, Y. C. Tung,, P. Y. Chu,, B. H. Chen,, H. L. Chen,, C. L. Kao,, J. R. Wang,, H. L. Eng,, S. Y. Wang,, L. C. Hsu, and, H. Y. Chen. 2006. Evolution of EV71 genogroup in Taiwan from 1998 to 2005: an emerging of subgenogroup C4 of EV71. J. Med. Virol. 78:254262.
192. Lin, T. L.,, Y. S. Li,, C. W. Huang,, C. C. Hsu,, H. S. Wu,, T. C. Tseng, and, C. F. Yang. 2008. Rapid and highly sensitive coxsackievirus a indirect immunofluorescence assay typing kit for enterovirus serotyping. J. Clin. Microbiol. 46:785788.
193. Lindberg, A. M.,, P. O. Stalhandske, and, U. Pettersson. 1987. Genome of coxsackievirus B3. Virology 156:5063.
194. Lindberg, A. M.,, S. Johansson, and, A. Andersson. 1999. Echo-virus 5: infectious transcripts and complete nucelotide sequence from uncloned cDNA. Virus Res. 59:7587.
195. Lindberg, A. M.,, and C. Polacek. 2000. Molecular analysis of the prototype coxsackievirus B5 genome. Arch. Virol. 145:205221.
196. Lukashev, A. N.,, V. A. Lashkevich,, G. A. Koroleva, and, G. G. Karganova. 2002. Phylogenetic and serological characterization of echovirus 11 and echovirus 19 strains causing uveitis. Arch. Virol. 147:131142.
197. Lukashev, A. N.,, V. A. Lashkevich,, G. A. Koroleva,, J. Ilonen,, G. G. Karganova,, V. I. Reznik, and, A. E. Hinkkanen. 2003. Molecular epidemiology of enteroviruses causing uveitis and multisystem hemorrhagic disease of infants. Virology 307:4553.
198. Lukashev, A. N.,, O. E. Ivanova,, T. P. Eremeeva,, V. A. Lash-kevich, and, K. E. Chernenko. 2004. Molecular epidemiology of the ECHO 30 virus in Russia and CIS countries. Vopr. Virusol. 49:1216. (In Russian.)
199. Lukashev, A. N.,, O. E. Ivanova,, T. P. Eremeeva, and, L. V. Gmyl. 2008. Analysis of echovirus 30 isolates from Russia and new independent states revealing frequent recombination and reemergence of ancient lineages. J. Clin. Microbiol. 46:665670.
200. Ma, J. F.,, T. M. Straub,, I. L. Pepper, and, C. P. Gerba. 1994. Cell culture and PCR determination of poliovirus inactivation by disinfectants. Appl. Environ. Microbiol. 60:42034206.
201. MacLennan, C.,, G. Dunn,, A. P. Huissoon,, D. S. Kumararatne,, J. Martin,, P. O’Leary,, R. A. Thompson,, H. Osman,, P. Wood,, P. Minor,, D. J. Wood, and, D. Pillay. 2004. Failure to clear persistent vaccine-derived neurovirulent poliovirus infection in an immunodeficient man. Lancet 363:15091513.
202. Magnani, J. W.,, and G. W. Dec. 2006. Myocarditis: current trends in diagnosis and treatment. Circulation 113:876890.
203. Mandelboim, O.,, S. B. Wilson,, M. Vales-Gomez,, H. T. Reyburn, and, J. L. Strominger. 1997. Self and viral peptides can initiate lysis by autologous natural killer cells. Proc. Natl. Acad. Sci. USA 94:46044609.
204. Margalith, M.,, E. Margalith, and, N. Goldblum. 1968. Genetic characteristics of echovirus type 9 strains: selection and characterization of variants. J. Gen. Virol. 3:7785.
205. Martino, T. A.,, R. Tellier,, M. Petric,, D. M. Irwin,, A. Afshar, and, P. P. Liu. 1999. The complete consensus sequence of coxsackievirus B6 and generation of infectious clones by long RT-PCR. Virus Res. 64:7786.
206. Mateu, M. G. 1995. Antibody recognition of picornaviruses and escape from neutralization: a structural view. Virus Res. 38:124.
207. McKinney, R. E., Jr.,, S. L. Katz, and, C. M. Wilfert. 1987. Chronic enteroviral meningoencephalitis in agammaglobulinemic patients. Rev. Infect. Dis. 9:334356.
208. McMinn, P.,, K. Lindsay,, D. Perera,, H. M. Chan,, K. P. Chan, and, M. J. Cardosa. 2001. Phylogenetic analysis of enterovirus 71 strains isolated during linked epidemics in Malaysia, Singapore, and Western Australia. J. Virol. 75:77327738.
209. Melchers, W.,, M. de Visser,, P. Jongen,, A. van Loon,, R. Nibbeling,, P. Oostvogel,, D. Willemse, and, J. Galama. 1992. The postpolio syndrome: no evidence for poliovirus persistence. Ann. Neurol. 32:728732.
210. Melnick, J. L.,, E. W. Shaw, and, E. C. Curnen. 1949. A virus isolated from patients diagnosed as non-paralytic poliomyelitis or aseptic meningitis. Proc. Soc. Exp. Biol. Med. 71:344349.
211. Melnick, J. L.,, and K. Ågren. 1952. Poliomyelitis and coxsackie viruses isolated from normal infants in Egypt. Proc. Soc. Exp. Biol. Med. 81:621624.
212. Melnick, J. L. 1954. Application of tissue culture methods to epidemiological studies of poliomyelitis. Am. J. Public Health 44:571580.
213. Melnick, J. L.,, and B. Hampil. 1965. WHO collaborative studies on enterovirus reference antisera. Bull. W. H. O. 33:761772.
214. Melnick, J. L.,, and B. Hampil. 1970. WHO collaborative studies on enterovirus reference antisera. Third report. Bull. W. H. O. 42:847863.
215. Melnick, J. L.,, and B. Hampil. 1973. WHO collaborative studies on enterovirus reference antisera; fourth report. Bull. W. H. O. 48:381396.
216. Melnick, J. L.,, I. Tagaya, and, H. von Magnus. 1974. Enteroviruses 69, 70, and 71. Intervirology 4:369370.
217. Melnick, J. L.,, H. A. Wenner, and, C. A. Phillips. 1979. Enteroviruses, p. 471–534. In E. H. Lennette and, N. J. Schmidt (ed.), Diagnostic Procedures for Viral, Rickettsial, and Chlamydial Infections, 5th ed. American Public Health Association, Washington, DC.
218. Melnick, J. L. 1984. Enterovirus type 71 infections: a varied clinical pattern sometimes mimicking paralytic poliomyelitis. Rev. Infect. Dis. 6:S387390.
219. Melnick, J. L. 1996. Current status of poliovirus infections. Clin. Microbiol. Rev. 9:293300.
220. Mendelsohn, C.,, B. Johnson,, K. A. Lionetti,, P. Nobis,, E. Wimmer, and, V. R. Racaniello. 1986. Transformation of a human poliovirus receptor gene into mouse cells. Proc. Natl. Acad. Sci. USA 83:78457849.
221. Mendelsohn, C. L.,, E. Wimmer, and, V. R. Racaniello. 1989. Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily. Cell 56:855865.
222. Mertens, T.,, U. Pika, and, H. J. Eggers. 1983. Cross antigenicity among enteroviruses as revealed by immunoblot technique. Virology 129:431442.
223. Minor, P. D. 1986. Antigenic structure of poliovirus. Microbiol. Sci. 3:141144.
224. Mirand, A.,, C. Henquell,, C. Archimbaud,, H. Peigue-Lafeuille, and, J. L. Bailly. 2007. Emergence of recent echovirus 30 lineages is marked by serial genetic recombination events. J. Gen. Virol. 88:166176.