1887

Chapter 29 : Human Parvoviruses

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Preview this chapter:
Zoom in
Zoomout

Human Parvoviruses, Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555815981/9781555814250_Chap29-1.gif /docserver/preview/fulltext/10.1128/9781555815981/9781555814250_Chap29-2.gif

Abstract:

The family is divided into two subfamilies: the , which infect insects, and the , which infect vertebrates. The members of the that infect humans are the focus of this chapter. The parvoviruses known to infect humans include B19 parvovirus in the genus , adeno-associated viruses (AAVs) in the genus , human bocavirus (HBoV) in the genus , and PARV4 and PARV5, not yet placed into a genus. With the appropriate helper virus, AAVs can replicate in a variety of tissue culture systems. If a helper virus is not present, AAV integrates into the host cell genomic DNA in a site-specific fashion. Nosocomial transmission can, however, occur, and standard precautions are recommended for all B19-infected patients and droplet precautions are recommended for those most likely to have high-titer infection, i.e., those with chronic B19 infection and those with transient aplastic crisis. The occurrence of rash in an immunocompromised patient after treatment with immune globulin and again after the patient mounts an antibody response suggests that anti-B19 antibody is important to the pathogenesis of the rash. The majority of recent studies of AAVs and studies of PARV4 and PARV5 and HBoV have been based on a variety of PCR assays to detect the viral DNA. A serologic assay for HBoV has recently been described based on cloned expressed capsid proteins forming empty capsids.

Citation: Anderson L, Erdman D. 2009. Human Parvoviruses, p 645-661. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch29

Key Concept Ranking

Hepatitis B virus
0.43214157
0.43214157
Highlighted Text: Show | Hide
Loading full text...

Full text loading...

Figures

Image of FIGURE 1
FIGURE 1

Phylogenetic relationships between NS genes of selected members of the subfamily Shown is an estimated-maximum-parsimony tree generated with PAUP* software showing clustering of different parvovirus genera and ungrouped parvoviruses. The parvoviruses that infect humans are indicated with lighter gray shading. aa, amino acids; AAV, adeno-associated virus; CMV, canine minute virus; BPV, bovine parvovirus; PPV, porcine parvovirus; KRV, Kilham rat virus; MPV, mouse parvovirus; LuIIIV, LuIII virus; RPV, rat parvovirus; CPV, canine parvovirus; MEV, mink enteritis virus; AMDV, Aleutian mink disease virus; MDPV, muscovy duck parvovirus; GPV, goose parvovirus; ChPV, chipmunk parvovirus; RmPV, rhesus macaque parvovirus; PmPV, pig-tailed macaque parvovirus. B19, V9, and A6 are human parvovirus B19 strains; PARV4 and PARV5 are human parvovirus strains.

Citation: Anderson L, Erdman D. 2009. Human Parvoviruses, p 645-661. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch29
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of FIGURE 2
FIGURE 2

Electron micrograph of B19 empty particles in a serum specimen from a patient with transient aplastic crisis. Magnification, ×170,000. (Courtesy of G. William Gary, CDC, Atlanta, GA.)

Citation: Anderson L, Erdman D. 2009. Human Parvoviruses, p 645-661. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch29
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of FIGURE 3
FIGURE 3

Schematic of B19 mRNA produced in erythroid progenitor cells. The thin line represents introns, and the thick line represents the nontranslated portion of exons. The solid boxes represent translated portions of exons. The numbers below the line indicate the start or end of the respective exon. All mRNAs are initiated at the same promoter (P6). The NS protein (first mRNA) is encoded in one reading frame; the 7.5-kDa, VP1, and VP2 proteins are encoded in a second reading frame (–1 relative to the NS protein); and the 11.0-kDa protein is encoded in the third reading frame. (Based on data from references and .)

Citation: Anderson L, Erdman D. 2009. Human Parvoviruses, p 645-661. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch29
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of FIGURE 4
FIGURE 4

Schematic of replication of B19 virion DNA. Replication is initiated at the 3′-terminal hairpin by host DNA polymerases and proceeds to form monomer duplex DNA and then dimer duplex DNA. The dimer duplex DNA is cleaved by cellular endonucleases into positive- and negative-sense single-stranded DNAs (ssDNAs), which are packaged with equal frequencies into B19 virions. (Reprinted from reference with permission of the American Association for the Advancement of Science.)

Citation: Anderson L, Erdman D. 2009. Human Parvoviruses, p 645-661. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch29
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of FIGURE 5
FIGURE 5

(A) Wright-Giemsa stain of a bone marrow aspirate from a patient with B19 infection. Note the giant pronormoblasts (arrow) with multiple vacuoles in the darkly stained (basophilic) cytoplasm, high nucleus-to-cytoplasm ratio, and prominent nucleoli. (B) Hematoxylin and eosin stain of bone marrow biopsy section from a patient with B19 infection. Note the prominent nuclear inclusions, marginated chromatin, and high nucleus-to-cytoplasm ratio in erythroid precursor cells (arrow). (C) Hematoxylin and eosin stain of placental tissue from a fetus that died with B19 infection. Note the ground-glass-appearing nuclear inclusions and marginated chromatin in erythroid precursor cells within fetal vessels. Magnifications, ×625. (All panels courtesy of Sherif R. Zaki, CDC, Atlanta, GA.)

Citation: Anderson L, Erdman D. 2009. Human Parvoviruses, p 645-661. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch29
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of FIGURE 6
FIGURE 6

Rates of B19 IgG antibody positivity by age. (Adapted from reference .)

Citation: Anderson L, Erdman D. 2009. Human Parvoviruses, p 645-661. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch29
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of FIGURE 7
FIGURE 7

Schematic of clinical and laboratory findings during the course of B19 infection in adult volunteers. Note the drop in reticulocyte (Retic) and platelet counts and the presence of symptoms (fever, myalgias, and malaise) associated with peak viremia (days 6 to 12). During this period, there is also a transient drop in neutrophil and lymphocyte counts. Associated with the drop in reticulocyte counts, there is a progressive drop in hemoglobin levels to about 90% of normal by days 14 to 16. The timing of the drop in hemoglobin levels corresponds to the time of anemia in patients with transient aplastic crisis. Note the second period of symptoms (rash, arthritis, and arthralgias) on days 18 to ≥22. This second period of illness corresponds to symptoms of erythema infectiosum. (Data from reference .)

Citation: Anderson L, Erdman D. 2009. Human Parvoviruses, p 645-661. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch29
Permissions and Reprints Request Permissions
Download as Powerpoint

References

/content/book/10.1128/9781555815981.ch29
1. Ager, E. A.,, T. D. Y. Chin, and, J. D. Poland. 1966. Epidemic erythema infectiosum. N. Engl. J. Med. 275:13261331.
2. Allander, T.,, T. Jartti,, S. Gupta,, H. G. Niesters,, P. Lehtinen,, R. Osterback,, T. Vuorinen,, M. Waris,, A. Bjerkner,, A. Tiveljung-Lindell,, B. G. van den Hoogen,, T. Hyypia, and, O. Ruuskanen. 2007. Human bocavirus and acute wheezing in children. Clin. Infect. Dis. 44:904910.
3. Allander, T.,, M. T. Tammi,, M. Eriksson,, A. Bjerkner,, A. Tiveljung-Lindell, and, B. Andersson. 2005. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc. Natl. Acad. Sci. USA 102:1289112896.
4. Anderson, L. J. 1987. Role of parvovirus B19 in human disease. Pediatr. Infect. Dis. J. 6:711718.
5. Anderson, L. J.,, T. J. Torok, and, S. R. Zaki. 1998. Human parvovirus B19, p. 3.0–3.20. In C. M. Wilfert (ed.), Pediatric Infectious Diseases. Current Medicine, Inc., and Churchill Livingstone, Philadelphia, PA.
6. Anderson, L. J.,, C. Tsou,, R. A. Parker,, T. L. Chorba,, H. Wulff,, P. Tattersall, and, P. P. Mortimer. 1986. Detection of antibodies and antigens of human parvovirus B19 by enzyme-linked immunosorbent assay. J. Clin. Microbiol. 24:522526.
7. Anderson, M. J.,, L. R. Davis,, S. E. Jones, and, J. R. Pattison. 1982. The development and use of an antibody capture radioimmunoassay for specific IgM to a human parvovirus-like agent. J. Hyg. 88:309324.
8. Anderson, M. J.,, P. G. Higgins,, L. R. Davis,, J. S. Willman,, S. E. Jones,, I. M. Kidd,, J. R. Pattison, and, D. A. J. Tyrrell. 1985. Experimental parvoviral infection in humans. J. Infect. Dis. 152:257265.
9. Arnold, J. C.,, K. K. Singh,, S. A. Spector, and, M. H. Sawyer. 2006. Human bocavirus: prevalence and clinical spectrum at a children’s hospital. Clin. Infect. Dis. 43:283288.
10. Azzi, A.,, E. Manaresi,, K. Zakrzewska,, R. DeSantis,, M. Musiani, and, M. Zerbini. 2004. Antibody response to B19 parvovirus VP1 and VP2 linear epitopes in patients with haemophilic arthritis. J. Med. Virol. 72:679682.
11. Ballou, W. R.,, J. L. Reed,, W. Noble,, N. S. Young, and, S. Koenig. 2003. Safety and immunogenicity of a recombinant parvovirus B19 vaccine formulated with MF59C.1. J. Infect. Dis. 187:675678.
12. Barah, F.,, P. J. Vallely,, M. L. Chiswick,, G. M. Cleator, and, J. R. Kerr. 2001. Association of human parvovirus B19 infection with acute meningoencephalitis. Lancet 358:729730.
13. Bastien, N.,, N. Chui,, J. L. Robinson,, B. E. Lee,, K. Dust,, L. Hart, and, Y. Li. 2007. Detection of human bocavirus in Canadian children in a 1-year study. J. Clin. Microbiol. 45:610613.
14. Baylis, S. A.,, N. Shah, and, P. D. Minor. 2004. Evaluation of different assays for the detection of parvovirus B19 DNA in human plasma. J. Virol. Methods 121:716.
15. Berns, K.,, and C. R. Parrish. 2006. Parvoviridae, p. 2437–2477. In D. M. Knipe,, P. M. Howley,, D. E. Griffin,, R. A. Lamb,, M. A. Martin,, B. Roizman, and, S. E. Straus (ed.), Fields Virology, 5th ed., vol. 2. Lippincott Williams & Wilkins, Philadelphia, PA.
16. Beske, F.,, S. Modrow,, J. Sorensen,, H. Schmidt,, S. Kriener,, R. Allwinn,, T. Klingebiel,, D. Schwabe, and, T. Lehrnbecher. 2007. Parvovirus B19 pneumonia in a child undergoing allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 40:8991.
17. Bonvicini, F.,, G. Gallinella,, G. A. Gentilomi,, S. Ambretti,, M. Musiani, and, M. Zerbini. 2006. Prevention of iatrogenic transmission of B19 infection: different approaches to detect, remove or inactivate virus contamination. Clin. Lab. 52:263268.
18. Bousvaros, A.,, R. Sundel,, G. M. Thorne,, K. McIntosh,, M. Cohen,, D. D. Erdman,, A. Perez-Atayde,, T. H. Finkel, and, A. A. Colin. 1998. Parvovirus B19-associated interstitial lung disease, hepatitis, and myositis. Pediatr. Pulmonol. 26:365369.
19. Brown, K. E. 1997. Human parvovirus B19 epidemiology and clinical manifestations. Monogr. Virol. 20:4260.
20. Brown, K. E.,, S. M. Anderson, and, N. S. Young. 1993. Erythrocyte P antigen: cellular receptor for B19 parvovirus. Science 262:114117.
21. Brown, K. E.,, Z. Liu,, G. Gallinella,, S. Wong,, I. P. Mills, and, M. G. O’Sullivan. 2004. Simian parvovirus infection: a potential zoonosis. J. Infect. Dis. 190:19001907.
22. Bruu, A.-L.,, and S. A. Nordbo. 1995. Evaluation of five commercial tests for detection of immunoglobulin M antibodies to human parvovirus B19. J. Clin. Microbiol. 33:13631365.
23. Caillet-Fauquet, P.,, M. L. Draps,, M. Di Giambattista,, Y. de Launoit, and, R. Laub. 2004. Hypoxia enables B19 erythrovirus to yield abundant infectious progeny in a pluripotent erythroid cell line. J. Virol. Methods 121:145153.
24. Carrascosa, J.,, M. Just,, M. Ribera, and, C. Ferrandiz. 1998. Papular acrodermatitis of childhood related to poxvirus and parvovirus B19 infection. Cutis 61:265267.
25. Cartter, M. L.,, T. A. Farley,, S. Rosengren,, D. L. Quinn,, S. M. Gillespie,, G. W. Gary, and, J. L. Hadler. 1991. Occupational risk factors for infection with parvovirus B19 among pregnant women. J. Infect. Dis. 163:282285.
26. Centers for Disease Control. 1989. Risks associated with human parvovirus B19 infection. Morb. Mortal. Wkly. Rep. 38:8188, 93–97.
27. Chen, J.,, Q. Wu,, P. Yang,, H. C. Hsu, and, J. D. Mountz. 2006. Determination of specific CD4 and CD8 T cell epitopes after AAV2- and AAV8-hF.IX gene therapy. Mol. Ther. 13:260269.
28. Chisaka, H.,, K. Ito,, H. Niikura,, J. Sugawara,, T. Takano,, T. Murakami,, Y. Terada,, K. Okamura,, H. Shiroishi,, K. Sugamura, and, N. Yaegashi. 2006. Clinical manifestations and outcomes of parvovirus B19 infection during pregnancy in Japan. Tohoku J. Exp. Med. 209:277283.
29. Chorba, T.,, P. Coccia,, R. C. Holman,, T. Tattersall,, L. J. Anderson,, J. Sudman,, N. S. Young,, E. Kurczynski,, U. M. Saarinen,, R. Moir,, D. N. Lawrence,, J. M. Jason, and, B. Evatt. 1986. The role of parvovirus B19 in aplastic crisis and erythema infectiosum (fifth disease). J. Infect. Dis. 154:383393.
30. Cohen, B. J.,, and M. M. Buckley. 1988. The prevalence of antibody to human parvovirus B19 in England and Wales. J. Med. Microbiol. 25:151153.
31. Cohen, B. J.,, P. P. Mortimer, and, M. S. Pereira. 1983. Diagnostic assays with monoclonal antibodies for the human serum parvovirus-like virus (SPLV). J. Hyg. 91:113130.
32. Cossart, Y. E.,, A. M. Field,, B. Cant, and, D. Widdows. 1975. Parvovirus-like particles in human sera. Lancet i:7273.
33. Cotmore, S. F.,, and P. Tattersall. 2007. Parvoviral host range and cell entry mechanisms. Adv. Virus Res. 70:183232.
34. Dereure, O.,, B. Montes, and, J. J. Guilhou. 1995. Acute generalized livedo reticularis with myasthenialike syndrome revealing parvovirus B19 primary infection. Arch. Dermatol. 131:744745.
35. Dowell, S. F.,, T. J. Torok,, J. A. Thorp,, J. Hedrick,, D. D. Erdman,, S. R. Zaki,, C. J. Hinkle,, W. L. Bayer, and, L. J. Anderson. 1995. Parvovirus B19 infection in hospital workers: community or hospital acquisition? J. Infect. Dis. 172:10761079.
36. Eid, A. J.,, R. A. Brown,, R. Patel, and, R. R. Razonable. 2006. Parvovirus B19 infection after transplantation: a review of 98 cases. Clin. Infect. Dis. 43:4048.
37. Ekman, A.,, K. Hokynar,, L. Kakkola,, K. Kantola,, L. Hedman,, H. Bonden,, M. Gessner,, C. Aberham,, P. Norja,, S. Miettinen,, K. Hedman, and, M. Soderlund-Venermo. 2007. Biological and immunological relations among human parvovirus B19 genotypes 1 to 3. J. Virol. 81:69276935.
38. Enders, M.,, A. Weidner, and, G. Enders. 2007. Current epidemiological aspects of human parvovirus B19 infection during pregnancy and childhood in the western part of Germany. Epidemiol. Infect. 135:563569.
39. Endo, R.,, N. Ishiguro,, H. Kikuta,, S. Teramoto,, R. Shirkoohi,, X. Ma,, T. Ebihara,, H. Ishiko, and, T. Ariga. 2007. Seroepidemiology of human bocavirus in Hokkaido Prefecture, Japan. J. Clin. Microbiol. 45:32183223.
40. Erdman, D. D.,, J. Usher,, C. Tsou,, E. O. Caul,, G. W. Gary,, S. Kajigaya,, N. S. Young, and, L. J. Anderson. 1991. Human parvovirus B19 specific IgG, IgA, and IgM antibodies and DNA in serum specimens from persons with erythema infectiosum. J. Med. Virol. 35:110115.
41. Ergaz, Z.,, and A. Ornoy. 2006. Parvovirus B19 in pregnancy. Reprod. Toxicol. 21:421435.
42. Erles, K.,, P. Sebokova, and, J. R. Schlehofer. 1999. Update on the prevalence of serum antibodies (IgG and IgM) to adeno-associated virus (AAV). J. Med. Virol. 59:406411.
43. Essary, L.,, C. Vnencak-Jones,, S. Manning,, S. Olson, and, J. Johnson. 1998. Frequency of parvovirus B19 infection in nonimmune hydrops fetalis and utility of three diagnostic methods. Hum. Pathol. 29:696701.
44. Fairley, C. K.,, J. S. Smoleniec,, O. E. Caul, and, E. Miller. 1995. Observational study of effect of intrauterine transfusions on outcome of fetal hydrops after parvovirus B19. Lancet 346:13351337.
45. Ferguson, M.,, and A. Heath. 2004. Report of a collaborative study to calibrate the Second International Standard for parvovirus B19 antibody. Biologicals 32:207212.
46. Forestier, F.,, J.-D. Tissot,, Y. Vial,, F. Daffos,, D. Fernand, and, P. Hohlfeld. 1999. Haematological parameters of parvovirus B19 infection in 13 fetuses with hydrops foetalis. Br. J. Haematol. 104:925927.
47. Friedman-Einat, M.,, Z. Grossman,, F. Mileguir,, Z. Smetana,, M. Ashkenazi,, G. Barkai,, N. Varsano,, E. Glick, and, E. Mendelson. 1997. Detection of adeno-associated virus type 2 sequences in the human genital tract. J. Clin. Microbiol. 35:7178.
48. Fry, A. M.,, X. Lu,, M. Chittaganpitch,, T. Peret,, J. Fischer,, S. F. Dowell,, L. J. Anderson,, D. Erdman, and, S. J. Olsen. 2007. Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand. J. Infect. Dis. 195:10381045.
49. Fryer, J. F.,, E. Delwart,, F. Bernardin,, P. W. Tuke,, V. V. Lukashov, and, S. A. Baylis. 2007. Analysis of two human parvovirus PARV4 genotypes identified in human plasma for fractionation. J. Gen. Virol. 88:21622167.
50. Gao, G.,, L. H. Vandenberghe,, M. R. Alvira,, Y. Lu,, R. Calcedo,, X. Zhou, and, J. M. Wilson. 2004. Clades of adeno-associated viruses are widely disseminated in human tissues. J. Virol. 78:63816388.
51. Garcia-Tapia, A. M.,, C. F.-M. del Alamo,, J. A. Giron,, J. Mira,, F. de la Rubia,, A. Martinez-Rodriguez,, M. V. Martin-Reina,, R. Lopez-Caparrox,, R. Caliz,, M. S. Caballero, and, A. Bascunana. 1996. Spectrum of parvovirus B19 infection: analysis of an outbreak of 43 cases in Cadiz, Spain. Clin. Infect. Dis. 21:14241430.
52. Garner, J. S., and The Hospital Infection Control Practices Advisory Committee. 1996. Guideline for isolation precautions in hospitals, 2nd ed., part 2. Rationale and recommendations. Infect. Control Hosp. Epidemiol. 17:5380.
53. Geng, Y.,, C. G. Wu,, S. P. Bhattacharyya,, D. Tan,, Z. P. Guo, and, M. Y. Yu. 2007. Parvovirus B19 DNA in Factor VIII concentrates: effects of manufacturing procedures and B19 screening by nucleic acid testing. Transfusion 47:883889.
54. Gillespie, S. M.,, M. L. Cartter,, S. Asch,, J. B. Rokos,, G. W. Gary,, C. J. Tsou,, D. B. Hall,, L. J. Anderson, and, E. S. Hurwitz. 1990. Occupational risk of human parvovirus B19 infection for school and day-care personnel during an outbreak of erythema infectiosum. JAMA 263:20612065.
55. Goldstein, A. R.,, M. J. Anderson, and, G. R. Serjeant. 1987. Parvovirus associated aplastic crisis in homozygous sickle cell disease. Arch. Dis. Child. 62:585588.
56. Gray, J. J.,, B. J. Cohen, and, U. Desselberger. 1993. Detection of human parvovirus B19-specific IgM and IgG antibodies using a recombinant viral VP1 antigen expressed in insect cells and estimation of the time of infection by testing for antibody avidity. J. Virol. Methods 44:1124.
57. Green, S. W.,, I. Malkovska,, M. G. O’Sullivan, and, K. E. Brown. 2000. Rhesus and pig-tailed macaque parvoviruses: identification of two new members of the Erythrovirus genus in monkeys. Virology 269:105112.
58. Harel, L.,, I. Straussberg,, A. Zeharia,, D. Praiss, and, J. Amir. 2002. Papular purpuric rash due to parvovirus B19 with distribution on the distal extremities and the face. Clin. Infect. Dis. 35:15581561.
59. Harger, J.,, S. Adler,, W. Koch, and, G. Harger. 1998. Prospective evaluation of 618 pregnant women exposed to parvovirus B19: risks and symptoms. Obstet. Gynecol. 91:413420.
60. Hattori, S.,, M. Yunoki,, M. Tsujikawa,, T. Urayama,, Y. Tachibana,, I. Yamamoto,, S. Yamamoto, and, K. Ikuta. 2007. Variability of parvovirus B19 to inactivation by liquid heating in plasma products. Vox Sang. 92:121124.
61. Hemauer, A.,, A. Gigler,, K. Searle,, K. Beckenlehner,, U. Raab,, K. Broliden,, H. Wolf,, G. Enders, and, S. Modrow. 1999. Seroprevalence of parvovirus B19 NS1-specific IgG in B19-infected and uninfected individuals and in infected pregnant women. J. Med. Virol. 60:4855.
62. Hindiyeh, M. Y.,, N. Keller,, M. Mandelboim,, D. Ram,, J. Rubinov,, L. Regev,, V. Levy,, S. Orzitzer,, H. Shaharabani,, R. Azar,, E. Mendelson, and, Z. Grossman. 2008. High rate of human bocavirus and adenovirus coinfection in hospitalized Israeli children. J. Clin. Microbiol. 46:334337.
63. Hobbs, J. A. 2006. Detection of adeno-associated virus 2 and parvovirus B19 in the human dorsolateral prefrontal cortex. J. Neurovirol. 12:190199.
64. Hokynar, K.,, J. Brunstein,, M. Soderlund-Venermo,, O. Kiviluoto,, E. K. Partio,, Y. Konttinen, and, K. Hedman. 2000. Integrity and full coding sequence of B19 virus DNA persisting in human synovial tissue. J. Gen. Virol. 81:10171025.
65. Ieiri, N.,, O. Hotta, and, Y. Taguma. 2005. Characteristics of acute glomerulonephritis associated with human parvovirus B19 infection. Clin. Nephrol. 64:249257.
66. Isumi, H.,, T. Nunoue,, A. Nishida, and, S. Takashima. 1999. Fetal brain infection with human parvovirus B19. Pediatr. Neurol. 21:661663.
67. Jensen, I.,, P. Thorsen,, B. Jeune,, B. Moller, and, B. Vestergaard. 2000. An epidemic of parvovirus B19 in a population of 3,596 pregnant women: a study of sociodemographic and medical risk factors. Br. J. Obstet. Gynaecol. 107:637643.
68. Jones, L.,, D. D. Erdman, and, L. Anderson. 1999. Prevalence of antibodies to human parvovirus B19 nonstructural protein (NS1) in persons with varied clinical outcomes following B19 infection. J. Infect. Dis. 180:500504.
69. Jones, M. S.,, A. Kapoor,, V. V. Lukashov,, P. Simmonds,, F. Hecht, and, E. Delwart. 2005. New DNA viruses identified in patients with acute viral infection syndrome. J. Virol. 79:82308236.
70. Kajigaya, S.,, H. Fujii,, A. Field,, S. Anderson,, S. Rosenfeld,, L. J. Anderson,, T. Shimada, and, N. S. Young. 1991. Self-assembled B19 parvovirus capsids, produced in a baculovirus system, are antigenically and immunogenically similar to native virions. Proc. Natl. Acad. Sci. USA 88:46464650.
71. Kajigaya, S.,, and M. Momeoda. 1997. Immune response to B19 infection. Monogr. Virol. 20:120136.
72. Kaufmann, B.,, A. Lopez-Bueno,, M. G. Mateu,, P. R. Chipman,, C. D. Nelson,, C. R. Parrish,, J. M. Almendral, and, M. G. Rossmann. 2007. Minute virus of mice, a parvovirus, in complex with the Fab fragment of a neutralizing monoclonal antibody. J. Virol. 81:98519858.
73. Kaufmann, B.,, A. A. Simpson, and, M. G. Rossmann. 2004. The structure of human parvovirus B19. Proc. Natl. Acad. Sci. USA 101:1162811633.
74. Kelly, H.,, D. Siebert,, R. Hammond,, J. Leydon,, P. Kiely, and, W. Maskill. 2000. The age-specific prevalence of human parvovirus immunity in Victoria, Australia compared with other parts of the world. Epidemiol. Infect. 124:449457.
75. Kempe, A.,, B. Rosing,, C. Berg,, D. Kamil,, A. Heep,, U. Gembruch, and, A. Geipel. 2007. First-trimester treatment of fetal anemia secondary to parvovirus B19 infection. Ultrasound Obstet. Gynecol. 29:226228.
76. Kesebir, D.,, M. Vazquez,, C. Weibel,, E. D. Shapiro,, D. Ferguson,, M. L. Landry, and, J. S. Kahn. 2006. Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus. J. Infect. Dis. 194:12761282.
77. Kobayashi, S.,, A. Maruta,, T. Yamamoto,, N. Katayama,, R. Higuchi,, Y. Sakano,, H. Fujita,, H. Koharazawa,, N. Tomita,, J. Taguchi,, F. Kodama,, Y. Nakamura, and, A. Shimizu. 1998. Human parvovirus B19 capsid antigen in granulocytes in parvovirus-B19-induced pancytopenia after bone marrow transplantation. Acta Haematol. 100:195199.
78. Koch, W.,, J. Harger,, B. Barnstein, and, S. Adler. 1998. Serologic and virologic evidence for frequent intrauterine transmission of human parvovirus B19 with a primary maternal infection during pregnancy. Pediatr. Infect. Dis. J. 17:489494.
79. Koch, W. C.,, and S. P. Adler. 1989. Human parvovirus B19 infections in women of childbearing age and within families. Pediatr. Infect. Dis. J. 8:8387.
80. Koduri, P.,, R. Kumapley,, J. Valladares, and, C. Teter. 1999. Chronic pure red cell aplasia caused by parvovirus B19 in AIDS: use of intravenous immunoglobulin—a report of eight patients. Am. J. Hematol. 61:1620.
81. Kurtzman, G.,, N. Frickhofen,, J. Kimball,, D. W. Jenkins,, A. W. Nienhuis, and, N. S. Young. 1989. Pure red-cell aplasia of ten years’ duration due to persistent parvovirus B19 infection and its cure with immunoglobulin therapy. N. Engl. J. Med. 321:519523.
82. Kurtzman, G. J.,, B. Cohen,, P. Meyers,, A. Amunullah, and, N. S. Young. 1988. Persistent B19 parvovirus infection as a cause of severe chronic anaemia in children with acute lymphocytic leukaemia. Lancet ii:11591162.
83. Lau, S. K.,, C. C. Yip,, T. L. Que,, R. A. Lee,, R. K. Au-Yeung,, B. Zhou,, L. Y. So,, Y. L. Lau,, K. H. Chan,, P. C. Woo, and, K. Y. Yuen. 2007. Clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in Hong Kong. J. Infect. Dis. 196:986993.
84. Laurenz, M.,, B. Winkelmann,, J. Roigas,, M. Zimmering,, U. Querfeld, and, D. Müller. 2006. Severe parvovirus B19 encephalitis after renal transplantation. Pediatr. Transplant. 10:978981.
85. Lee, J. I.,, J. Y. Chung,, T. H. Han,, M. O. Song, and, E. S. Hwang. 2007. Detection of human bocavirus in children hospitalized because of acute gastroenteritis. J. Infect. Dis. 196:994997.
86. Lefrere, J. J.,, A. Servant-Delmas,, D. Candotti,, M. Mariotti,, I. Thomas,, Y. Brossard,, F. Lefrere,, R. Girot,, J. P. Allain, and, S. Laperche. 2005. Persistent B19 infection in immunocompetent individuals: implications for transfusion safety. Blood 106:28902895.
87. Lindblom, A.,, A. Isa,, O. Norbeck,, S. Wolf,, B. Johansson,, K. Broliden, and, T. Tolfvenstam. 2005. Slow clearance of human parvovirus B19 viremia following acute infection. Clin. Infect. Dis. 41:12011203.
88. Lu, J.,, N. Zhi,, S. Wong, and, K. E. Brown. 2006. Activation of synoviocytes by the secreted phospholipase A2 motif in the VP1-unique region of parvovirus B19 minor capsid protein. J. Infect. Dis. 193:582590.
89. Lu, X.,, M. Chittaganpitch,, S. J. Olsen,, I. M. Mackay,, T. P. Sloots,, A. M. Fry, and, D. D. Erdman. 2006. Realtime PCR assays for detection of bocavirus in human specimens. J. Clin. Microbiol. 44:32313235.
90. Luo, W.,, and C. R. Astell. 1993. A novel protein encoded by small RNAs of parvovirus B19. Virology 195:448455.
91. Mackay, I. M. 2007. Human bocavirus: multisystem detection raises questions about infection. J. Infect. Dis. 196:968970.
92. Manaresi, E.,, G. Gallinella,, M. Zerbini,, S. Venturoli,, G. Gentilomi, and, M. Musiami. 1999. IgG immune response to B19 parvovirus VP1 and VP2 linear epitopes by immunoblot assay. J. Med. Virol. 57:174178.
93. Manning, A.,, V. Russell,, K. Eastick,, G. H. Leadbetter,, N. Hallam,, K. Templeton, and, P. Simmonds. 2006. Epidemiological profile and clinical associations of human bocavirus and other human parvoviruses. J. Infect. Dis. 194:12831290.
94. Manning, A.,, S. J. Willey,, J. E. Bell, and, P. Simmonds. 2007. Comparison of tissue distribution, persistence, and molecular epidemiology of parvovirus B19 and novel human parvoviruses PARV4 and human bocavirus. J. Infect. Dis. 195:13451352.
95. McNeely, M.,, J. Friedman, and, E. Pope. 2005. Generalized petechial eruption induced by parvovirus B19 infection. J. Am. Acad. Dermatol. 52:S109S113.
96. Miller, E.,, C. Fairley,, B. J. Cohen, and, C. Seng. 1998. Immediate and long term outcome of human parvovirus B19 infection during pregnancy. Br. J. Obstet. Gynaecol. 105:174178.
97. Miyagawa, E.,, T. Yoshida,, H. Takahashi,, K. Yamaguchi,, T. Nagano,, Y. Kiriyama,, K. Okochi, and, H. Sato. 1999. Infection of the erythroid cell line, KU812ep6 with human parvovirus B19 and its application to titration of B19 infectivity. J. Virol. Methods 83:4554.
98. Modrow, S. 2006. Parvovirus B19: the causative agent of dilated cardiomyopathy or a harmless passenger of the human myocard? Ernst Schering Res. Found. Workshop 2006:6382.
99. Morey, A. L.,, D. J. P. Ferguson,, K. O. Leslie,, D. J. Taatjes, and, K. A. Fleming. 1993. Intracellular localization of parvovirus B19 nucleic acid at the ultra-structural level by in situ hybridization with digoxigenin-labelled probes. Histochem. J. 25:421429.
100. Morey, A. L.,, G. Patou,, S. Myint, and, K. Fleming. 1992. In vitro culture for the detection of infectious human parvovirus B19 and B19-specific antibodies using foetal haematopoietic precursor cells. J. Gen. Virol. 73:33133317.
101. Morey, A. L.,, H. J. Porter,, J. W. Keeling, and, K. A. Fleming. 1992. Non-isotopic in situ hybridisation and immunophenotyping of infected cells in the investigation of human fetal parvovirus infection. J. Clin. Pathol. 45:673678.
102. Munakata, Y.,, T. Saito-Ito,, K. Kumura-Ishii,, J. Huang,, T. Kodera,, T. Ishii,, Y. Hirabayashi,, Y. Koyanagi, and, T. Sasaki. 2005. Ku80 autoantigen as a cellular coreceptor for human parvovirus B19 infection. Blood 106:34493456.
103. Myamoto, K.,, M. Ogami,, Y. Takahashi,, T. Mori,, S. Akimoto,, H. Terashita, and, T. Terashita. 2000. Outbreak of human parvovirus B19 in hospital workers. J. Hosp. Infect. 45:238241.
104. Nagel, H. T.,, T. R. de Haan,, F. P. Vandenbussche,, D. Oepkes, and, F. J. Walther. 2007. Long-term outcome after fetal transfusion for hydrops associated with parvovirus B19 infection. Obstet. Gynecol. 109:4247.
105. Naides, S. J. 1988. Erythema infectiosum (fifth disease) occurrence in Iowa. Am. J. Public Health 78:12301231.
106. Naides, S. J.,, and C. P. Weiner. 1989. Antenatal diagnosis and palliative treatment of non-immune hydrops fetalis secondary to fetal parvovirus B19 infection. Prenatal Diagn. 9:105114.
107. O’Sullivan, M. G.,, D. K. Anderson,, J. A. Goodrich,, H. Tulli,, S. W. Green,, N. S. Young, and, K. E. Brown. 1997. Experimental infection of cynomolgus monkeys with simian parvovirus. J. Virol. 71:45174521.
108. Ozawa, K.,, J. Ayub, and, N. Young. 1988. Functional mapping of the genome of the B19 (human) parvovirus by in vitro translation after negative hybrid selection. J. Virol. 62:25082511.
109. Ozawa, K.,, J. Ayub,, H. Yu-Shu,, G. Kurtzman,, T. Shimada, and, N. Young. 1987. Novel transcription map for the B19 (human) pathogenic parvovirus. J. Virol. 61:23952406.
110. Ozawa, K.,, G. Kurtzman, and, N. Young. 1986. Replication of the B19 parvovirus in human bone marrow cell cultures. Science 233:883886.
111. Ozawa, K.,, and N. Young. 1987. Characterization of capsid and noncapsid proteins of B19 parvovirus propagated in human erythroid bone marrow cell cultures. J. Virol. 61:26272630.
112. Padron, E.,, V. Bowman,, N. Kaludov,, L. Govindasamy,, H. Levy,, P. Nick,, R. McKenna,, N. Muzyczka,, J. A. Chiorini,, T. S. Baker, and, M. Agbandje-McKenna. 2005. Structure of adeno-associated virus type 4. J. Virol. 79:50475058.
113. Peterlana, D.,, A. Puccetti,, R. Beri,, M. Ricci,, S. Simeoni,, L. Borgato,, L. Scilanga,, S. Ceru,, R. Corrocher, and, C. Lunardi. 2003. The presence of parvovirus B19 VP and NS1 genes in the synovium is not correlated with rheumatoid arthritis. J. Rheumatol. 30:19071910.
114. Peterlana, D.,, A. Puccetti,, R. Corrocher, and, C. Lunardi. 2006. Serologic and molecular detection of human parvovirus B19 infection. Clin. Chim. Acta 372:1423.
115. Plummer, F. A.,, G. W. Hammond,, K. Forward,, L. Sekla,, L. M. Thompson,, S. E. Jones,, I. M. Kidd, and, M. J. Anderson. 1985. An erythema infectiosum-like illness caused by human parvovirus infection. N. Engl. J. Med. 313:7479.
116. Porter, H. J.,, T. Y. Khong,, M. F. Evans,, V. T.-W. Chan, and, K. A. Fleming. 1988. Parvovirus as a cause of hydrops fetalis: detection by in situ DNA hybridisation. J. Clin. Pathol. 41:381383.
117. Porter, H. J.,, A. M. Quantrill, and, K. A. Fleming. 1988. B19 parvovirus infection of myocardial cells. Lancet i:535536.
118. Pozo, F.,, M. L. Garcia-Garcia,, C. Calvo,, I. Cuesta,, P. Perez-Brena, and, I. Casas. 2007. High incidence of human bocavirus infection in children in Spain. J. Clin. Virol. 40:224228.
119. Public Health Laboratory Service Working Party on Fifth Disease. 1990. Prospective study of human parvovirus (B19) infection in pregnancy. Br. Med. J. 300:11661170.
120. Qu, X. W.,, Z. J. Duan,, Z. Y. Qi,, Z. P. Xie,, H. C. Gao,, W. P. Liu,, C. P. Huang,, F. W. Peng,, L. S. Zheng, and, Y. D. Hou. 2007. Human bocavirus infection, People’s Republic of China. Emerg. Infect. Dis. 13:165168.
121. Rodis, J. F.,, C. Rodner,, A. A. Hansen,, A. F. Borgida,, I. Deoliveira, and, S. S. Rosengren. 1998. Long-term outcome of children following maternal human parvovirus B19 infection. Obstet. Gynecol. 91:125128.
122. Ros, C.,, M. Gerber, and, C. Kempf. 2006. Conformational changes in the VP1-unique region of native human parvovirus B19 lead to exposure of internal sequences that play a role in virus neutralization and infectivity. J. Virol. 80:1201712024.
123. Saag, K. G.,, C. A. True, and, S. J. Naides. 1993. Intravenous immunoglobulin treatment of chronic parvovirus B19 arthropathy. Arthritis Rheum. 36(Suppl.): S67.
124. Saarinen, U. A.,, T. L. Chorba,, P. Tattersall,, N. S. Young,, L. J. Anderson,, E. Palmer, and, P. F. Coccia. 1986. Human parvovirus B19-induced epidemic red cell aplasia in patients with hereditary hemolytic anemia. Blood 67:14111417.
125. Santagostino, E.,, P. Mannucci,, A. Gringeri,, A. Azzi,, M. Morfini,, R. Musso,, R. Santoro, and, M. Schiavoni. 1997. Transmission of parvovirus B19 by coagulation factor concentrates exposed to 100°C heat after lyophilization. Transfusion 37:517522.
126. Sattar, S. A.,, V. S. Springthorpe,, Y. Karim, and, P. Loro. 1989. Chemical disinfection of non-porous inanimate surfaces experimentally contaminated with four human pathogenic viruses. Epidemiol. Infect. 102:493505.
127. Schmid, S.,, W. Bossart,, B. A. Michel, and, P. Bruhlmann. 2007. Outcome of patients with arthritis and parvovirus B19 DNA in synovial membranes. Rheumatol. Int. 27:747751.
128. Schmidt, M.,, A. Themann,, C. Drexler,, M. Bayer,, G. Lanzer,, E. Menichetti,, S. Lechner,, D. Wessin,, B. Prokoph,, J. P. Allain,, E. Seifried, and, M. K. Hourfar. 2007. Blood donor screening for parvovirus B19 in Germany and Austria. Transfusion 47:17751782.
129. Schwarz, T. F.,, G. Jager, and, S. Gilch. 1997. Comparison of seven commercial tests for the detection of parvovirus B19-specific IgM. Zentbl. Bakteriol. 285:525530.
130. Seng, C.,, P. Watkins,, D. Morse,, S. P. Barrett,, M. Zambon,, N. Andrews,, M. Atkins,, S. Hall,, Y. K. Lau, and, B. J. Cohen. 1994. Parvovirus B19 outbreak on an adult ward. Epidemiol. Infect. 113:345353.
131. Serjeant, G. R.,, G. E. Serjeant,, P. W. Thomas,, M. J. Anderson,, G. Patou, and, J. R. Pattison. 1993. Human parvovirus infection in homozygous sickle cell disease. Lancet 341:12371240.
132. Shneerson, J. M.,, P. P. Mortimer, and, E. M. Vandervelde. 1980. Febrile illness due to a parvovirus. Br. Med. J. 1:1580.
133. Soderlund, M.,, C. S. Brown,, W. J. M. Spaan,, L. Hedman, and, K. Hedman. 1995. Epitope type-specific IgG responses to capsid proteins VP1 and VP2 of human parvovirus B19. J. Infect. Dis. 172:14311436.
134. Soderlund, M.,, R. von Essen,, J. Haapasarri,, U. Kiistala,, O. Kiviluoto, and, K. Hedman. 1997. Persistence of parvovirus B19 DNA in synovial membranes of young patients with and without chronic arthropathy. Lancet 349:10631065.
135. St. Amand, J.,, and C. R. Astell. 1993. Identification and characterization of a family of 11-kDa proteins encoded by the human parvovirus B19. Virology 192:121131.
136. Takahashi, M.,, M. Ito,, F. Sakamoto,, N. Shimizu,, T. Furukawa,, M. Takahashi, and, Y. Matsunaga. 1995. Human parvovirus B19 infection: immunohistochemical and electron microscopic studies of skin lesions. J. Cutan. Pathol. 22:168172.
137. Takeda, S.,, C. Takaeda,, E. Takazakura, and, J. Hara-take. 2001. Renal involvement induced by human parvovirus B19 infection. Nephron 89:280285.
138. Tattersall, P.,, M. Bergoin,, M. E. Bloom,, K. E. Brown,, R. M. Linden,, N. Muzyczka,, C. R. Parrish, and, P. Tijssen. 2005. Parvoviridae, p. 353–369. In C. M. Fauquet,, M. A. Mayo,, J. Maniloff,, U. Desselberger, and, L. A. Ball (ed.), Virus Taxonomy: VIIIth Report of the International Committee on Taxonomy of Viruses. Elsevier Academic Press, London, England.
139. Torok, T. J. 1997. Unusual clinical manifestations reported in patients with parvovirus B19 infection. Monogr. Virol. 20:6192.
140. Torok, T. J.,, Q.-Y. Wang,, G. W. Gary,, C.-F. Yang,, T. M. Finch, and, L. J. Anderson. 1992. Prenatal diagnosis of intrauterine infection with parvovirus B19 by the polymerase chain reaction technique. Clin. Infect. Dis. 14:149155.
141. Tuckerman, J. G.,, T. Brown, and, B. J. Cohen. 1986. Erythema infectiosum in a village primary school: clinical and virological studies. J. R. Coll. Gen. Practitioners 36:267270.
142. van Gessel, P. H.,, M. A. Gaytant,, A. C. Vossen,, J. M. Galama,, N. T. Ursem,, E. A. Steegers, and, H. I. Wild-schut. 2006. Incidence of parvovirus B19 infection among an unselected population of pregnant women in the Netherlands: a prospective study. Eur. J. Obstet. Gynecol. Reprod. Biol. 128:4649.
143. Vicente, D.,, G. Cilla,, M. Montes,, E. G. Perez-Yarza, and, E. Perez-Trallero. 2007. Human bocavirus, a respiratory and enteric virus. Emerg. Infect. Dis. 13:636637.
144. von Kaisenberg, C. S.,, and W. Jonat. 2001. Fetal parvovirus B19 infection. Ultrasound Obstet. Gynecol. 18:280288.
145. Vyse, A. J.,, N. J. Andrews,, L. M. Hesketh, and, R. Pebody. 2007. The burden of parvovirus B19 infection in women of childbearing age in England and Wales. Epidemiol. Infect. 135:13541362.
146. Warrington, K. H., Jr.,, and R. W. Herzog. 2006. Treatment of human disease by adeno-associated viral gene transfer. Hum. Genet. 119:571603.
147. Weigel-Kelley, K. A.,, M. C. Yoder, and, A. Srivastava. 2003. α5β1 integrin as a cellular coreceptor for human parvovirus B19: requirement of functional activation of β1 integrin for viral entry. Blood 102:39273933.
148. Wong, S.,, M. Momoeda,, A. Field,, S. Kajigaya, and, N. S. Young. 1994. Formation of empty B19 parvovirus capsids by the truncated minor capsid protein. J. Virol. 68:46904694.
149. Wong, S.,, N. S. Young, and, K. E. Brown. 2003. Prevalence of parvovirus B19 in liver tissue: no association with fulminant hepatitis or hepatitis-associated aplastic anemia. J. Infect. Dis. 187:15811586.
150. Woolf, A. D.,, G. V. Campion,, A. Chishick,, S. Wise,, B. J. Cohen,, P. T. Klouda,, O. Caul, and, P. A. Dieppe. 1989. Clinical manifestations of human parvovirus B19 in adults. Arch. Intern. Med. 149:11531156.
151. Yoshida, M.,, and T. Tezuka. 1994. Conjunctivitis caused by human parvovirus B19 infection. Ophthalmologica 208:161162.
152. Young, N. S.,, and K. E. Brown. 2004. Parvovirus B19. N. Engl. J. Med. 350:586597.
153. Zakrzewska, K.,, A. Azzi,, E. De Biasi,, P. Radossi,, R. De Santis,, P. G. Davoli, and, G. Tagariello. 2001. Persistence of parvovirus B19 DNA in synovium of patients with haemophilic arthritis. J. Med. Virol. 65:402407.

Tables

Generic image for table
TABLE 1

Proteins of human parvovirus B19

Citation: Anderson L, Erdman D. 2009. Human Parvoviruses, p 645-661. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch29

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error