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Chapter 38 : Mumps Virus

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Abstract:

Mumps virus is classified as a member of the order Mononegavirales, family , subfamily , and genus . Penetration of mumps virus virions into target cells begins with binding of the hemagglutininneuraminidase (HN) surface glycoprotein to sialic acid-containing receptors on the cell surface. Humans can be experimentally infected by inoculation of mumps virus onto the nasal or buccal mucosa, suggesting that natural infection results from airborne spread of droplets of respiratory secretions from infected to susceptible individuals. Mumps virus can establish persistent infection in neuronal cell lines and chronic central nervous system (CNS) infection in animal models, but it does not routinely cause chronic infections in humans. In the suckling hamster model, mumps virus CNS infection is associated with the development of stenosis of the sylvian aqueduct and with granular ependymitis. The majority of mumps patients with CNS involvement will have signs of meningeal irritation but no evidence of cortical dysfunction. The pathogenesis of mumps-related arthritis is uncertain; virus has not been isolated from joint fluid, and there is no evidence of immune complex deposition. Although clinical experience with this assay is currently limited, reverse transcriptase (RT)-PCR is likely to become the diagnostic method of choice for mumps virus CNS infection. Therapy of patients with uncomplicated mumps consists of conservative measures to provide symptomatic relief, such as analgesics, antipyretics, rest, and hydration. Symptomatic measures to alleviate the pain and swelling of mumps orchitis include bed rest, scrotal support and opioid analgesics.

Citation: Gnann, Jr. J. 2009. Mumps Virus, p 877-888. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch38

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Lymphocytic choriomeningitis virus
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Image of FIGURE 1
FIGURE 1

Structure of the mumps virus virion. Molecular masses of viral proteins as measured by gel electrophoresis are shown in parentheses. (Data from reference .)

Citation: Gnann, Jr. J. 2009. Mumps Virus, p 877-888. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch38
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Image of FIGURE 2
FIGURE 2

Genome organization of mumps virus. Number of nucleotides in mRNA and amino acid residues in corresponding protein are shown below map. (Data from reference .)

Citation: Gnann, Jr. J. 2009. Mumps Virus, p 877-888. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch38
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Image of FIGURE 3
FIGURE 3

Replication strategy of mumps virus.

Citation: Gnann, Jr. J. 2009. Mumps Virus, p 877-888. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch38
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References

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Tables

Generic image for table
TABLE 1

Clinical manifestations of mumps

Citation: Gnann, Jr. J. 2009. Mumps Virus, p 877-888. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch38
Generic image for table
TABLE 2

Initial clinical findings in patients with CNS mumps virus infection

Citation: Gnann, Jr. J. 2009. Mumps Virus, p 877-888. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch38
Generic image for table
TABLE 3

Initial CSF findings in patients with CNS mumps virus infection

Citation: Gnann, Jr. J. 2009. Mumps Virus, p 877-888. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch38

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