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Chapter 29 : Genome Mapping

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Genome Mapping, Page 1 of 2

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Abstract:

This chapter illustrates how polymorphic loci are used in genetic mapping, using a human disease gene as an example. The Student Activity contains extensive introductory material, including an example of using genetic mapping to determine the relative locations of three chromosomal markers (the ABO blood group locus, the nail-patella syndrome locus, and a hypothetical polymorphic short tandem repeat [STR] locus). The chapter provides students with an idea of how scientists figure out where genes are and how physical markers like STRs are used in mapping process. It also includes a reading about the Human Genome Project. One of the terms introduced in the chapter is haplotype, a contraction of haploid genotype. The term haplotype refers to the DNA content of one contiguous molecule, such as a mitochondrial genome, a single chromosome, or part of a chromosome, even down to very small regions. Occasionally, haplotype is used to refer to half of a genome, in the sense that a gamete contains a haplotype, and it is often used to refer to a specific mitochondrial genotype. A microsatellite haplotype would be the exact configuration of repeated sequences along a single chromosome.

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29

Key Concept Ranking

Restriction Fragment Length Polymorphism
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Figures

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Key to pedigree shown in Figures 29.4 . The genotypes of the BFNC gene and the STR locus are shown for each individual. *, recombinant haplotype.

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
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Figure 29.1

Linked and unlinked inheritance of alleles. +, normal allele of gene; −, mutant, disease-causing allele of gene; 8, STR allele with 8 repeats; 15, STR allele with 15 repeats.

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
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Figure 29.2

Inheritance of NPS and the ABO blood group.

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
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Figure 29.3

Genetic mapping based on recombination frequency.

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
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Figure 29.4

Pedigree of a family afflicted with BFNC.

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
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Pedigree A and Gel Diagram A (generations I and II). Shaded symbols mean afflicted with BNCS. M, molecular size marker.

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
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Pedigree B and Gel Diagram B (generation III). M, molecular size marker.

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
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Pedigree C and Gel Diagram C (generation IV). M, molecular size marker.

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
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Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
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References

/content/book/10.1128/9781555816100.chap29a
1. Collins, F.,, M. Morgan,, and A. Patrinos. 2003. The Human Genome Project: lessons from large-scale biology. Science 300:286290.
2. Frazier, M.,, G. Johnson,, D. Thomassen,, C. Oliver,, and A. Patrinos. 2003. Realizing the potential of the genome revolution: the Genomes to Life Program. Science 300: 290293.

Tables

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Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
Generic image for table

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
Generic image for table

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
Generic image for table

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
Generic image for table

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
Generic image for table
Untitled

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
Generic image for table

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
Generic image for table
Table 29.1

Paternal haplotypes inherited by members of Generation II in Figure 29.2

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29
Generic image for table
Table 29.2

Frequency of allele combinations in generation IIa

Citation: Kreuzer H, Massey A. 2008. Genome Mapping, p 415-431. In Molecular Biology and Biotechnology: A Guide for Teachers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816100.ch29

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