1887

Chapter 7 : The Kinetoplastid Infections: Human African Trypanosomiasis (Sleeping Sickness), Chagas’ Disease, and the Leishmaniases

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Ebook: Choose a downloadable PDF or ePub file. Chapter is a downloadable PDF file. File must be downloaded within 48 hours of purchase

Buy this Chapter
Digital (?) $7.00

Preview this chapter:
Zoom in
Zoomout

The Kinetoplastid Infections: Human African Trypanosomiasis (Sleeping Sickness), Chagas’ Disease, and the Leishmaniases, Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555816339/9781555816711_Chap07-1.gif /docserver/preview/fulltext/10.1128/9781555816339/9781555816711_Chap07-2.gif

Abstract:

The kinetoplastid infections constitute a group of three major human protozoan infections caused by single-celled parasites with a flagellum and an unusual DNA-containing cell organelle known as the kinetoplastid. Together, the three major kinetoplastid infections of humans, human African trypanosomiasis (HAT), Chagas’ disease, and leishmaniasis, kill an approximately 150,000 people annually, making them among the most lethal neglected tropical diseases (NTDs). West African HAT typically occurs around rivers, especially in areas of dense vegetation where tsetses of the group are abundant. The chapter shows how the fact that Rhodesian HAT is primarily a zoonosis, i.e., a disease transmitted from animals to humans, has important implications for controlling epidemics of this disease. In addition to melarsoprol, there are two other drugs, pentamidine and suramin, still in widespread use for the earlier stage of HAT. The treatment of the chronic complications of Chagas’ disease requires complex modalities. There are no simple preventive chemotherapy approaches for the control of Chagas’ disease, nor is it practical to apply wide-scale case detection and management with antitrypanosomal drugs such as what occurred with the pentamidization campaigns against HAT launched in the 20th century. Approximately 12 million people are infected with Leishmania parasites. There are two major forms of the disease—visceral leishmaniasis, and cutaneous leishmaniasis (CL). Both CL and VL are treatable infections, but many of the drugs used produce severe toxicities, and in many cases they are not available.

Citation: Hotez, M.D., Ph.D. P. 2008. The Kinetoplastid Infections: Human African Trypanosomiasis (Sleeping Sickness), Chagas’ Disease, and the Leishmaniases, p 81-102. In Forgotten People, Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555816339.ch7

Key Concept Ranking

Chagas' Disease
0.85087985
Infectious Diseases
0.7601299
Infectious Pathogens
0.7572175
Human African Trypanosomiasis
0.71118337
Parasitic Diseases
0.65130264
Skin Infections
0.62700105
0.85087985
Highlighted Text: Show | Hide
Loading full text...

Full text loading...

Figures

Image of Figure 7.1
Figure 7.1

The life cycle of human trypanosomes and HAT (Public Health Image Library, CDC [http://phil.cdc.gov]).

Citation: Hotez, M.D., Ph.D. P. 2008. The Kinetoplastid Infections: Human African Trypanosomiasis (Sleeping Sickness), Chagas’ Disease, and the Leishmaniases, p 81-102. In Forgotten People, Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555816339.ch7
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 7.2
Figure 7.2

Triatomine bug (Public Health Image Library, CDC [http://phil.cdc.gov]).

Citation: Hotez, M.D., Ph.D. P. 2008. The Kinetoplastid Infections: Human African Trypanosomiasis (Sleeping Sickness), Chagas’ Disease, and the Leishmaniases, p 81-102. In Forgotten People, Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555816339.ch7
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 7.3
Figure 7.3

Life cycle of and Chagas’ disease (Public Health Image Library, CDC [http://phil.cdc.gov]).

Citation: Hotez, M.D., Ph.D. P. 2008. The Kinetoplastid Infections: Human African Trypanosomiasis (Sleeping Sickness), Chagas’ Disease, and the Leishmaniases, p 81-102. In Forgotten People, Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555816339.ch7
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 7.4
Figure 7.4

Life cycle of human leishmaniasis infection (Public Health Image Library, CDC [http://phil.cdc.gov]).

Citation: Hotez, M.D., Ph.D. P. 2008. The Kinetoplastid Infections: Human African Trypanosomiasis (Sleeping Sickness), Chagas’ Disease, and the Leishmaniases, p 81-102. In Forgotten People, Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555816339.ch7
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 7.5
Figure 7.5

The “pizza-like” lesion of CL (Public Health Image Library, CDC [http://phil.cdc.gov]).

Citation: Hotez, M.D., Ph.D. P. 2008. The Kinetoplastid Infections: Human African Trypanosomiasis (Sleeping Sickness), Chagas’ Disease, and the Leishmaniases, p 81-102. In Forgotten People, Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555816339.ch7
Permissions and Reprints Request Permissions
Download as Powerpoint

References

/content/book/10.1128/9781555816339.ch07

Tables

Generic image for table
Table 7.1

The major species of HAT and animal trypanosomiasis

Citation: Hotez, M.D., Ph.D. P. 2008. The Kinetoplastid Infections: Human African Trypanosomiasis (Sleeping Sickness), Chagas’ Disease, and the Leishmaniases, p 81-102. In Forgotten People, Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555816339.ch7
Generic image for table
Table 7.2

Simplified summary of the human leishmaniases

Citation: Hotez, M.D., Ph.D. P. 2008. The Kinetoplastid Infections: Human African Trypanosomiasis (Sleeping Sickness), Chagas’ Disease, and the Leishmaniases, p 81-102. In Forgotten People, Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555816339.ch7

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error