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Chapter 8 : The Urban Neglected Tropical Diseases: Leptospirosis, Dengue, and Rabies

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The Urban Neglected Tropical Diseases: Leptospirosis, Dengue, and Rabies, Page 1 of 2

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Abstract:

The neglected tropical diseases (NTDs) leptospirosis, dengue, and rabies have particular importance as urban health problems in developing countries. For both leptospirosis and dengue, urban flooding is a key component of transmission. Dengue virus replicates in the salivary glands of mosquitoes. Once contracted and once clinical signs become evident, rabies is almost invariably fatal. The first rabies vaccine was developed by Louis Pasteur in the 19th century. This development led to the establishment of Pasteur Institutes all over the Francophone world, which made available first-generation rabies vaccine to many developing countries. Unless significant steps are taken to reduce squalor in the urban areas of the developing world, one can anticipate increases in dengue, leptospirosis, rabies, and other urban NTDs. Dengue fever is one of the most common NTDs of urban areas, with an estimated 50 million cases worldwide. Like leptospirosis, most dengue cases present as a nonspecific febrile illness. However, classical dengue is sometimes known as break bone fever because of the severe myalgias and headache that can accompany the illness. Many developing-country manufacturers still produce rabies vaccines derived from neural tissues.

Citation: Hotez, M.D., Ph.D. P. 2008. The Urban Neglected Tropical Diseases: Leptospirosis, Dengue, and Rabies, p 103-112. In Forgotten People, Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555816339.ch8

Key Concept Ranking

Vector-Borne Diseases
0.6811268
Human African Trypanosomiasis
0.6341593
West Nile Fever
0.6145462
Japanese Encephalitis
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Figure 8.1

A. , the mosquito vector of dengue fever (Public Health Image Library, CDC [http://phil.cdc.gov]).

Citation: Hotez, M.D., Ph.D. P. 2008. The Urban Neglected Tropical Diseases: Leptospirosis, Dengue, and Rabies, p 103-112. In Forgotten People, Forgotten Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555816339.ch8
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