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Chapter 6 : Systemic Infections

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Abstract:

Systemic infections can be caused by many different infectious agents: bacterial, fungal, viral, and parasitic. One common finding for all systemic infections is the need for a portal of entry. The portal of entry can be via the skin (as in mosquito-borne diseases such as malaria), via the oral route (as in typhoid fever), via sexual contact (as in HIV infection), as a bloodborne pathogen (as in hepatitis B virus infection), via the respiratory tract (as in measles), and by vertical transmission via transplacental infection (as in congenital cytomegalovirus infection). In many cases of systemic infection, colonization occurs prior to the dissemination of the infectious agent throughout the body. In some diseases (e.g., tetanus and diphtheria) the infection itself is caused by a noninvasive organism and the systemic symptoms are caused by the dissemination of a toxin that is responsible for the disease. In most cases, however, the etiologic agent is disseminated via the hematogenous route. Protection of the host from a systemic infection can occur as a result of acquired immunity due to a prior infection or due to a vaccination to that agent. Important agents of systemic infection are listed in this chapter. This section discusses nine different cases of systemic infections that represent contemporary trends in infectious diseases.

Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6

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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6
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Tables

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TABLE 6

SELECTED SYSTEMIC PATHOGENS

Citation: Gilligan P, Smiley M, Shapiro D. 2003. Systemic Infections, p 299-352. In Cases in Medical Microbiology and Infectious Diseases, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816353.ch6

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