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Bacterial Ion Channels and Their Eukaryotic Homologs

Editors: Andrzej Kubalski1, Boris Martinac2
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Affiliations: 1: Department of Cell Biology Nencki Institute of Experimental Biology, Warsaw, Poland; 2: School of Biomedical Sciences University of Queensland, Brisbane, Queensland, Australia
Content Type: Monograph
Publication Year: 2005

Category: Bacterial Pathogenesis; Microbial Genetics and Molecular Biology

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is a succinct summarization of the past ten years of research in the field. Emphasizing a multidisciplinary approach, this book will serve as an important reference for ion channel specialists and as a useful introduction to the topic for non-specialists in such fields as microbiology, structural and developmental biology, neuroscience, and biophysics who wish to acquaint themselves with these molecules.

Written by acknowledged experts, this comprehensive volume examines the accumulated knowledge of channel structures and considers how it has advanced the understanding of basic bacterial ion channel properties. The first compendium of its kind, provides a historical background and presents an analysis of the structure and function of several types of channels, including potassium, CIC chloride, and sodium ion channels. Chapters delve into such topics as diversity of potassium channels in prokaryotic and eukaryotic cells, selectivity and permeability of bacterial ion channels, voltage- and mechano-sensing, simulation studies of ion channels using molecular modeling, and the role of bacterial ion channels in cell physiology.

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Doody Enterprises

17 August 2013

At A Glance

Bacterial Ion Channels and Their Eukaryotic Homologs is a succinct summarization of the past ten years of research in the field. Emphasizing a multidisciplinary approach, this book will serve as an important reference for ion channel specialists and as a useful introduction to the topic for nonspecialists in such fields as microbiology, structural and developmental biology, neuroscience, and biophysics who wish to acquaint themselves with these molecules. Written by acknowledged experts, this comprehensive volume examines the accumulated knowledge of channel structures and considers how it has advanced the understanding of basic bacterial ion channel properties. The first compendium of its kind, Bacterial Ion Channels provides a historical background and presents an analysis of the structure and function of several types of channels, including potassium, CIC chloride, and sodium ion channels. Chapters delve into such topics as diversity of potassium channels in prokaryotic and eukaryotic cells, selectivity and permeability of bacterial ion channels, voltage- and mechano-sensing, simulation studies of ion channels using molecular modeling, and the role of bacterial ion channels in cell physiology.

Description

This is a series of reviews focused on bacterial ion channels. Included are potassium, sodium, chloride and water. Structural information obtained from these channels is related to corresponding activities in eukaryotic cells.

Purpose

The goal is to provide an up-to-date review of work in the area of bacterial ion channels. This worthwhile goal is well met.

Audience

The intended audience is investigators working in the ion channel field (both pro- and eukaryotic) and other scientists with a general interest in the topic. Those likely to profit from reading this book range from post-doctoral fellows to senior investigators. The editors have assembled a diverse group of well qualified contributors.

Features

A major section is devoted to the various types of potassium channels (ligand, voltage, etc.) with subsequent sections covering sodium, chloride, and water transport mechanisms. The chapters are up-to-date and cover the diverse approaches used in studying these transmembrane molecules. Each chapter is accompanied by a thorough bibliography that allows easy access to primary sources. Of particular value are discussions of the relationships between the bacterial channels and their eukaryotic counterparts. Thus, crystal structures are available for some of the prokaryotic channels providing data that should help our understanding of these processes in higher animals. Two of the chapters review modeling and molecular dynamic approaches, areas of growing interest. Similarly, the discussion of a glutamate receptor potassium channel will be of particular interest to investigators working in neuronal systems. One minor concern is that illustrations are sparse within the text, with a set of color plates in the center
of the book. This is always difficult for the reader. Nonetheless, the book is a strong contribution and of interest to investigators in fields other than the ion channels themselves.

Assessment

This is a very interesting book. Although removed from my own interest, I enjoyed reading it and learned a good deal. I expect that others will have a similar experience.

Doody Enterprises

Reviewer: Eugene Davidson, PhD (Georgetown University School of Medicine)

Review Date: Unknown

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