Chapter 16 : Relapsing Fever

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Relapsing fever is an arthropod-borne infection that occurs in two forms: tick-borne relapsing fever (TBRF) and louse-borne relapsing fever (LBRF). The etiologic agents of relapsing fever are several species of spirochetes in the genus . TBRF is usually a zoonosis and is endemic on most continents, each with a characteristic species. Examples are in North America and in Africa. LBRF is caused by a single species, . The multiple episodes of fever and disease relapses in both TBRF and LBRF are due to antigenic variation by the spirochetes. But elucidation of the pathogenesis and genetics of relapsing fever agents awaited the developments in the field of molecular biology. This chapter first talks about biology, genetics, phylogenetic classification, life cycle and ecology of relapsing fever species. Antigenic variation by relapsing fever spp. is among the most extensive of any vector-borne bacterial or protozoal parasite. Its characteristics most closely resemble the antigenic variation manifested by African trypanosomes. The chapter ends with a discussion on epidemiology, clinical manifestations, diagnosis, treatment, and prevention of relapsing fever.

Citation: Barbour A. 2005. Relapsing Fever, p 268-291. In Goodman J, Dennis D, Sonenshine D, Tick-Borne Diseases of Humans. ASM Press, Washington, DC. doi: 10.1128/9781555816490.ch16

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Image of Figure 1
Figure 1

Unrooted, distance criterion phylogram of partial 16S ribosomal RNA genes of selected relapsing fever and other species ( ). The species known to cause relapsing fever of humans are underlined. Representative arthropod vectors are shown in parentheses by each species; all the vectors are soft ticks ( and ) or hard ticks (, , and ), except for the human louse, . . . of . was isolated in Japan ( ), and the sensu lato organism of . was isolated in the northeastern United States ( ). The “Owl” sp. was isolated from a northern spotted owl in the northwestern United States ( ).

Citation: Barbour A. 2005. Relapsing Fever, p 268-291. In Goodman J, Dennis D, Sonenshine D, Tick-Borne Diseases of Humans. ASM Press, Washington, DC. doi: 10.1128/9781555816490.ch16
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Image of Figure 2
Figure 2

Body temperature (in degrees Centigrade) of a patient with tick-borne relapsing fever over time and in relation to exposure to ticks in the northwestern United States. Adapted from Thompson et al. ( ).

Citation: Barbour A. 2005. Relapsing Fever, p 268-291. In Goodman J, Dennis D, Sonenshine D, Tick-Borne Diseases of Humans. ASM Press, Washington, DC. doi: 10.1128/9781555816490.ch16
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Figure 3

Schematic representation of three mechanisms for changing expression of a variable major protein gene of during relapsing fever: intermolecular gene conversion, intramolecular DNA rearrangement, and in situ activation of a promoter. For each mechanism, the states and locations of selected genes on two linear plasmids before and after a change (downward arrow) in a serotype are shown. The genotype of the expressed variable major protein gene, which is downstream of an active promoter (P →), and the serotype phenotype of the spirochete are indicated by the same fill pattern. Other genes are designated by other fill patterns. In the middle, an intramolecular DNA recombination between two direct repeats (short white bars) of tandemly arrayed variable major protein genes is shown. A product of this recombination is a nonreplicative circle ( ).

Citation: Barbour A. 2005. Relapsing Fever, p 268-291. In Goodman J, Dennis D, Sonenshine D, Tick-Borne Diseases of Humans. ASM Press, Washington, DC. doi: 10.1128/9781555816490.ch16
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Figure 4

Nymphs and an adult of , the vector of .

Citation: Barbour A. 2005. Relapsing Fever, p 268-291. In Goodman J, Dennis D, Sonenshine D, Tick-Borne Diseases of Humans. ASM Press, Washington, DC. doi: 10.1128/9781555816490.ch16
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Figure 5

Collection of , , and ticks from the western United States and Canada. Figure adapted from Boyer et al. ( ), who used the data of Cooley and Kohls ( ). The identification of in western Montana was reported by Schwan et al. ( ).

Citation: Barbour A. 2005. Relapsing Fever, p 268-291. In Goodman J, Dennis D, Sonenshine D, Tick-Borne Diseases of Humans. ASM Press, Washington, DC. doi: 10.1128/9781555816490.ch16
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1. Adler, S.,, O. Theodor,, and H. Schieber. 1937. Observations on tick-transmitted human spirochaetosis in Palestine. Ann. Trop. Med. Parasitol. 31: 25 35.
2. Ahmed, M.,, S. Abdel Wahab,, M. Abdel Malik,, A. Abdel Gadir,, S. Salih,, A. Omer,, and A. Al Hassan. 1980. Louseborne relapsing fever in the Sudan. A historical review and a clinico-pathological study. Trop. Geogr. Med. 32: 106 111.
3. Alugupalli, K. R.,, R. M. Gerstein,, J. Chen,, E. Szomolanyi-Tsuda,, R. T. Woodland,, and J. M. Leong. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J. Immunol. 170: 3819 3827.
4. Alugupalli, K. R.,, A. D. Michelson,, M. R. Barnard,, D. Robbins,, J. Coburn,, E. K. Baker,, M. H. Ginsberg,, T. G. Schwan,, and J. M. Leong. 2001. Platelet activation by a relapsing fever spirochaete results in enhanced bacterium-platelet interaction via integrin αIIb3β activation. Mol. Microbiol. 39: 330 340.
5. Alugupalli, K. R.,, A. D. Michelson,, I. Joris,, T. G. Schwan,, K. Hodivala-Dilke,, R. O. Hynes,, and J. M. Leong. 2003. Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis. Blood 102: 2843 2850.
6. Anda, P.,, W. Sanchez-Yebra,, M. del Mar Vitutia,, E. Perez Pastrana,, I. Rodriguez,, N. S. Miller,, P. B. Backenson,, and J. L. Benach. 1996. A new Borrelia species isolated from patients with relapsing fever in Spain. Lancet 348: 162 165.
7. Anderson, T. R.,, and L. E. Zimmerman. 1955. Relapsing fever in Korea. A clinicopathologic study of eleven fatal cases with special attention to association with salmonella infections. Am. J. Pathol. 31: 1083 1109.
8. Arimitsu, Y.,, and K. Akama. 1973. Characterization of protective antibodies produced in mice infected with Borrelia duttonii. Jpn. J. Med. Sci. Biol. 26: 229 237.
9. Babes, V. 1916. Hemorragies meningees et autres manifestations hemorragiques dans la fievre recurrente. C. R. Seances Soc. Biol. (Paris) 79: 855 857.
10. Baltazard, M.,, M. Bahmanyar,, and M. Chamsa. 1954. Sur l’usage du cobaye pour la differenciation des spirochetes recurrents. Bull. Soc. Pathol. Exot. 47: 864 877.
11. Baltazard, M.,, C. Mofidi,, and M. Bahmanyar. 1947. Solution aux difficulties de l’experimentation avec le spirochete d’Obermeier, S. recurrentis, agent de la fievre recurrente a poux. C. R. Acad. Sci. 224: 1858 1860.
12. Barbour, A. G., 2003. Antigenic variation in Borrelia: relapsing fever and Lyme borreliosis, p. 319 356. In A. Craig, and A. Scherf (ed.), Antigenic Variation. Academic Press, London, England.
13. Barbour, A. G., 2002. Antigenic variation by relapsing fever Borrelia species and other bacterial pathogens, p. 972 996. In N. L. Craig,, R. Craigie,, M. Gellert,, and A. M. Lambowitz (ed.), Mobile DNA II. American Society for Microbiology, Washington, D.C.
14. Barbour, A. G., 2000. Borrelia infections: relapsing fever and Lyme disease, p. 57 70. In M. W. Cunningham, and R. S. Fujinami (ed.), Effects of Microbes on the Immune System. Lippincott, Williams and Wilkins, Philadelphia, Pa.
15. Barbour, A. G., 2001. Borrelia: a diverse and ubiquitous genus of tick-borne pathogens, p. 153 174. In W. M. Scheld,, W. A. Craig,, and J. M. Hughes (ed.), Emerging Infections 5. ASM Press, Washington, D.C.
16. Barbour, A. G. 1986. Cultivation of Borrelia: a historical overview. Zentralbl. Bakteriol. Mikrobiol. Hyg. A 263: 11 14.
17. Barbour, A. G. 1987. Immunobiology of relapsing fever. Contrib. Microbiol. Immunol. 8: 125 137.
18. Barbour, A. G. 1984. Isolation and cultivation of Lyme disease spirochetes. Yale J. Biol. Med. 57: 521 525.
19. Barbour, A. G. 1988. Laboratory aspects of Lyme borreliosis. Clin. Microbiol. Rev. 1: 399 414.
20. Barbour, A. G. 1993. Linear DNA of Borrelia species and antigenic variation. Trends Microbiol. 1: 236 239.
21. Barbour, A. G., 1999. Relapsing fever and other Borrelia infections, p. 535 546. In R. L. Guerrant,, D. H. Walker,, and P. F. Weller (ed.), Tropical Infectious Diseases. Principles Pathogens and Practice. Churchill Livingston, Philadelphia, Pa.
22. Barbour, A. G., 2004. Specificity of Borrelia-tick vector relationships, p. 75 90. In S. H. Gillespie,, G. L. Smith,, and A. Osbourn (ed.), SGM Symposium 63: Microbe-Vector Interactions in Vector-Borne Disease. Cambridge University Press, Cambridge, England.
23. Barbour, A. G.,, O. Barrera,, and R. C. Judd. 1983. Structural analysis of the variable major proteins of Borrelia hermsii. J. Exp. Med. 158: 2127 2140.
24. Barbour, A. G.,, and V. Bundoc. 2001. In vitro and in vivo neutralization of the relapsing fever agent Borrelia hermsii with serotype-specific immunoglobulin M antibodies. Infect. Immun. 69: 1009 1015.
25. Barbour, A. G.,, N. Burman,, C. J. Carter,, T. Kitten,, and S. Bergstrom. 1991. Variable antigen genes of the relapsing fever agent Borrelia hermsii are activated by promoter addition. Mol. Microbiol. 5: 489 493.
26. Barbour, A. G.,, C. J. Carter,, and C. D. Sohaskey. 2000. Surface protein variation by expression site switching in the relapsing fever agent Borrelia hermsii. Infect. Immun. 78: 7114 7121.
27. Barbour, A. G.,, and S. F. Hayes. 1986. Biology of Borrelia species. Microbiol. Rev. 50: 381 400.
28. Barbour, A. G.,, G. O. Maupin,, G. J. Teltow,, C. J. Carter,, and J. Piesman. 1996. Identification of an uncultivable Borrelia species in the hard tick Amblyomma americanum: possible agent of a Lyme disease-like illness. J. Infect. Dis. 173: 403 409.
29. Barbour, A. G.,, and B. I. Restrepo. 2000. Antigenic variation in vector-borne pathogens. Emerg. Infect. Dis. 6: 449 457.
30. Barbour, A. G.,, and H. G. Stoenner,. 1985. Antigenic variation of Borrelia hermsii, p. 123 135. In M. I. Simon, and I. Herskowitz (ed.), Genome Rearrangement. Alan R. Liss, Inc., New York, N.Y.
31. Barbour, A. G.,, S. L. Tessier,, and H. G. Stoenner. 1982. Variable major proteins of Borrelia hermsii. J. Exp. Med. 156: 1312 1324.
32. Barclay, A. J.,, and J. B. Coulter. 1990. Tick-borne relapsing fever in central Tanzania. Trans. R. Soc. Trop. Med. Hyg. 84: 852 856.
33. Barstad, P. A.,, J. E. Coligan,, M. G. Raum,, and A. G. Barbour. 1985. Variable major proteins of Borrelia hermsii. Epitope mapping and partial sequence analysis of CNBr peptides. J. Exp. Med. 161: 1302 1314.
34. Beck, M. 1937. California field and laboratory studies on relapsing fever. J. Infect. Dis. 60: 64 80.
35. Beunders, B.,, and P. Van Thiel. 1932. Untersuchungen ueber die persistenz von Spirochaeta duttoni in mausegehirnen bei experimenteller febris recurrens. Z. Hyg. Infektionskr. 114: 568 583.
36. Bodman, R. I.,, and I. S. Stewart. 1948. Louse-borne relapsing fever in Persia. Br. Med. J. 1948: 291 292.
37. Bohls, S. W.,, and V. T. Schuhardt. 1933. Relapsing fever in Texas and the laboratory method of diagnosis. Texas State J. Med. 13: 425 427.
38. Borgnolo, G.,, B. Hailu,, A. Ciancarelli,, M. Alaviva,, and T. Woldemariam. 1993. Louse-borne relapsing fever. A clinical and an epidemiological study of 389 patients in Asella Hospital, Ethiopia. Trop. Geograph. Med. 45: 66 69.
39. Boyer, K. M.,, R. S. Munford,, G. O. Maupin,, C. P. Pattison,, M. D. Fox,, A. M. Barnes,, W. L. Jones,, and J. E. Maynard. 1977. Tick-borne relapsing fever: an interstate outbreak originating at Grand Canyon National Park. Am. J. Epidemiol. 105: 469 479.
40. Breitschwerdt, E. B.,, F. J. Geoly,, D. J. Meuten,, J. F. Levine,, P. Howard,, B. C. Hegarty,, and L. C. Stafford. 1996. Myocarditis in mice and guinea pigs experimentally infected with a canine-origin Borrelia isolate from Florida. Am. J. Vet. Res. 57: 505 511.
41. Breitschwerdt, E. B.,, W. L. Nicholson,, A. R. Kiehl,, C. Steers,, D. J. Meuten,, and J. F. Levine. 1994. Natural infections with Borrelia spirochetes in two dogs from Florida. J. Clin. Microbiol. 32: 352 357.
42. Briggs, L. H. 1935. Relapsing fever. Calif. West. Med. 42: 1 13.
43. Briggs, L. H. 1922. Relapsing fever in California. JAMA 79: 941 944.
44. Brocklesby, D. W.,, G. R. Scott,, and C. S. Rampton. 1963. Borrelia theileri and transient fevers in cattle. Vet. Rec. 75: 103 104.
45. Brown, V.,, B. Larouze,, G. Desve,, J. J. Rousset,, M. Thibon,, A. Fourrier,, and V. Schwoebel. 1988. Clinical presentation of louse-borne relapsing fever among Ethiopian refugees in northern Somalia. Ann. Trop. Med. Parasitol. 82: 499 502.
46. Bryceson, A. 1976. Clinical pathology of the Jarisch-Herxheimer reaction. J. Infect. Dis. 133: 696 704.
47. Bryceson, A.,, E. Parry,, P. Perine,, D. Warrel,, D. Vukotich,, and C. Leithead. 1970. Louse-borne relapsing fever: a clinical and laboratory study of 62 cases in Ethiopia and a reconsideration of the literature. Q. J. Med. 153: 129 170.
48. Bryceson, A. D.,, K. E. Cooper,, D. A. Warrell,, P. L. Perine,, and E. H. Parry. 1972. Studies of the mechanism of the Jarisch-Herxheimer reaction in louse-borne relapsing fever: evidence for the presence of circulating Borrelia endotoxin. Clin. Sci. 43: 343 354.
49. Bunikis, J.,, U. Garpmo,, J. Tsao,, J. Berglund,, D. Fish,, and A. G. Barbour. 2004. Sequence typing reveals extensive strain diversity of the Lyme borreliosis agents Borrelia burgdorferi in North America and Borrelia afzelii in Europe. Microbiology 150: 1741 1755.
50. Bunikis, J.,, U. Garpmo,, J. Tsao,, J. Berglund,, D. Fish,, and A. G. Barbour. 2004. Strain typing of relapsing fever Borrelia spp., including newly discovered species in hard ticks. Emerg. Infect. Dis. 10: 1661 1664.
51. Burgdorfer, W. 1951. Analyse des Infektionsverlaufes bei Ornithodorus moubata und der natürlichen Uebertragung von Spirochaeta duttoni. Acta Trop. 8: 196 262.
52. Burgdorfer, W.,, and M. G. Varma. 1967. Transstadial and transovarial development of disease agents in arthropods. Annu. Rev. Entomol. 12: 347 376.
53. Burman, N.,, S. Bergstrom,, B. I. Restrepo,, and A. G. Barbour. 1990. The variable antigens Vmp7 and Vmp21 of the relapsing fever bacterium Borrelia hermsii are structurally analogous to the VSG proteins of the African trypanosome. Mol. Microbiol. 4: 1715 1726.
54. Burman, N.,, A. Shamaei-Tousi,, and S. Bergstrom. 1998. The spirochete Borrelia crocidurae causes erythrocyte rosetting during relapsing fever. Infect. Immun. 66: 815 819.
55. Butler, T.,, P. Hazen,, C. K. Wallace,, S. Awoke,, and A. Habte-Michael. 1979. Infection with Borrelia recurrentis: pathogenesis of fever and petechiae. J. Infect. Dis. 140: 665 675.
56. Butler, T.,, P. K. Jones,, and C. K. Wallace. 1978. Borrelia recurrentis infection: single-dose antibiotic regimens and management of the Jarisch-Herxheimer reaction. J. Infect. Dis. 137: 573 577.
57. Cadavid, D.,, and A. G. Barbour. 1998. Neuroborreliosis during relapsing fever: review of the clinical manifestations, pathology, and treatment of infections in humans and experimental animals. Clin. Infect. Dis. 26: 151 164.
58. Cadavid, D.,, V. Bundoc,, and A. G. Barbour. 1993. Experimental infection of the mouse brain by a relapsing fever Borrelia species: a molecular analysis. J. Infect. Dis. 168: 143 151.
59. Cadavid, D.,, A. R. Pachner,, L. Estanislao,, R. Patalapati,, and A. G. Barbour. 2001. Isogenic serotypes of Borrelia turicatae show different localization in the brain and skin of mice. Infect. Immun. 69: 3389 3397.
60. Cadavid, D.,, P. M. Pennington,, T. A. Kerentseva,, S. Bergstrom,, and A. G. Barbour. 1997. Immunologic and genetic analyses of VmpA of a neurotropic strain of Borrelia turicatae. Infect. Immun. 65: 3352 3360.
61. Cadavid, D.,, D. D. Thomas,, R. Crawley,, and A. G. Barbour. 1994. Variability of a bacterial surface protein and disease expression in a possible mouse model of systemic Lyme borreliosis. J. Exp. Med. 179: 631 642.
62. Calero, C. 1946. Relapsing fever on the isthmus of Panama. Report of 106 cases. Am. J. Trop. Med. 26: 761 769.
63. Campbell, G. L.,, W. S. Paul,, M. E. Schriefer,, R. B. Craven,, K. E. Robbins,, and D. T. Dennis. 1995. Epidemiologic and diagnostic studies of patients with suspected early Lyme disease, Missouri, 1990-1993. J. Infect. Dis. 172: 470 480.
64. Carley, J. G.,, and J. H. Pope. 1962. A new species of Borrelia ( B. queenslandia) from Rattus villosissimus in Queensland. Aust. J. Exp. Biol. Med. Sci. 40: 255 262.
65. Carter, C. J.,, S. Bergstrom,, S. J. Norris,, and A. G. Barbour. 1994. A family of surface-exposed proteins of 20 kilodaltons in the genus Borrelia. Infect. Immun. 62: 2792 2799.
66. Casjens, S.,, N. Palmer,, R. van Vugt,, W. M. Huang,, B. Stevenson,, P. Rosa,, R. Lathigra,, G. Sutton,, J. Peterson,, R. J. Dodson,, D. Haft,, E. Hickey,, M. Gwinn,, O. White,, and C. M. Fraser. 2000. A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi. Mol. Microbiol. 35: 490 516.
67. Charters, A. 1942. Relapsing fever in Abyssinia. Trans. R. Soc. Trop. Med. Hyg. 35: 271 279.
68. Cherry, J. 1955. The prevention and treatment of tick-borne relapsing fever with special reference to aureomycin and terramycin. Trans. R. Soc. Trop. Med. Hyg. 49: 563 573.
69. Chohan, I. S. 1967. Tick-borne relapsing fever in Kashmir: mice inoculation—a diagnostic method of choice. Ind. J. Pathol. Bacteriol. 10: 289 294.
70. Chorine, V.,, and O. Crouge. 1942. Virulence du sang du cobaye infecte avec le Spirochaeta hispanica. Ann. Inst. Pasteur 68: 518 523.
71. Clark, H. C.,, L. H. Dunn,, and J. Benavides. 1931. Experimental transmission to man of a relapsing fever spirochete in a wild monkey of Panama, Leontocebus geoffroyi. Am. J. Trop. Med. 11: 243 257.
72. Clastrier, J. 1941. Etude experimentale de deux souches de Spirochaeta hispanicum isolees en Algerie. Arch. Inst. Pasteur Alger. 19: 228 239.
73. Cobey, F. C.,, S. H. Goldbarg,, R. A. Levine,, and C. L. Patton. 2001. Short report: Detection of borrelia (relapsing fever) in rural Ethiopia by means of the quantitative buffy coat technique. Am. J. Trop. Med. Hyg. 65: 164 165.
74. Coffey, E. M.,, and W. C. Eveland. 1967. Experimental relapsing fever initiated by Borrelia hermsi. II. Sequential appearance of major serotypes in the rat. J. Infect. Dis. 117: 29 34.
75. Coghill, N. 1949. Clinical manifestations of tick-borne relapsing fever with special reference to the disease in Cyprus. J. R. Army Med. Corps 92: 2 33.
76. Connolly, S. E.,, and J. L. Benach. 2001. Cutting edge: the spirochetemia of murine relapsing fever is cleared by complement-independent bactericidal antibodies. J. Immunol. 167: 3029 3032.
77. Cooley, R. A.,, and G. M. Kohls. 1944. The Argasidae of North America, Central America, and Cuba. Notre Dame University Press, South Bend, Ind.
78. Cunningham, J.,, and A. G. L. Fraser. 1937. Further observations on Indian relapsing fever. III. Persistence of spirochaetes in the blood and organs of infected animals. Indian J. Med. Res. 24: 581 592.
79. Cutler, S. J.,, C. O. Akintunde,, J. Moss,, M. Fukunaga,, K. Kurtenbach,, A. Talbert,, H. Zhang,, D. J. Wright,, and D. A. Warrell. 1999. Successful in vitro cultivation of Borrelia duttonii and its comparison with Borrelia recurrentis. Int. J. Syst. Bacteriol. 49: 1793 1799.
80. Cutler, S. J.,, D. Fekade,, K. Hussein,, K. A. Knox,, A. Melka,, K. Cann,, A. R. Emilianus,, D. A. Warrell,, and D. J. Wright. 1994. Successful in-vitro cultivation of Borrelia recurrentis. Lancet 343: 242.
81. DaMassa, A. J.,, and H. E. Adler. 1979. Avian spirochetosis: natural transmission by Argas (Persicargas) sanchezi (Ixodoidea: argasidae) and existence of different serologic and immunologic types of Borrelia anserina in the United States. Am. J. Vet. Res. 40: 154 157.
82. Davis, G. E. 1952. Biology as an aid to the identification of two closely related species of ticks of the genus Ornithodoros. J. Parasitol. 38: 477 480.
83. Davis, G. E. 1952. Observations on the biology of the argasid tick, Ornithodoros brasiliensis Aragao, 1923; with the recovery of a spirochete, Borrelia brasiliensis, n. sp. J. Parasitol. 38: 473 476.
84. Davis, G. E. 1956. A relapsing fever spirochete, Borrelia mazzottii (sp. nov.) from Ornithodoros talaje from Mexico. Am. J. Hyg. 63: 13 17.
85. Davis, G. E. 1943. Relapsing fever: the tick Ornithodoros turicata as a spirochetal reservoir. Public Health Rep. 58: 839 842.
86. Davis, G. E. 1952. The relapsing fevers: tick-spirochete specificity studies. Exp. Parasitol. 1: 406 410.
87. Davis, G. E. 1940. Ticks and relapsing fever in the United States. Public Health Rep. 55: 2347 2351.
88. Davis, G. E.,, H. L. Wynns,, and M. D. Beck. 1941. Relapsing fever: Ornithodoros parkeri, a vector in California. Public Health Rep. 56: 2426 2428.
89. Davis, H.,, J. M. Vincent,, and J. Lynch. 2002. Tick-borne relapsing fever caused by Borrelia turicatae. Pediatr. Infect. Dis. J. 21: 703 705.
90. Dennis, D.,, S. Awoke,, E. Doberstein,, and J. Fresh. 1976. Bleeding in louse-borne relapsing fever in Ethiopia. East Afr. Med. J. 53: 220 225.
91. Dewar, H.,, and R. Walmsley. 1945. Relapsing fever with nephritis and subarachnoid haemorrhage. Lancet i: 630 631.
92. Diab, F. M.,, and Z. R. Soliman. 1977. An experimental study of Borrelia anserina in four species of Argas ticks. 1. Spirochete localization and densities. Z. Parasitenkd. 53: 201 212.
93. Donelson, J. E. 1995. Mechanisms of antigenic variation in Borrelia hermsii and African trypanosomes. J. Biol. Chem. 270: 7783 7786.
94. Dunn, L. H. 1933. Notes on relapsing fever in Panama with special reference to animal hosts. Am. J. Trop. Med. 13: 201 209.
95. Dunn, L. H. 1927. Studies on the South American tick Ornithodoros venezuelensis Brumpt in Colombia. J. Parasitol. 13: 249 255.
96. Dupont, H. T.,, B. La Scola,, R. Williams,, and D. Raoult. 1997. A focus of tick-borne relapsing fever in southern Zaire. Clin. Infect. Dis. 25: 139 144.
97. Duray, P. H. 1987. The surgical pathology of human Lyme disease: an enlarging picture. Am. J. Surg. Pathol. 11: 47 60.
98. Dworkin, M. S.,, D. E. Anderson, Jr.,, T. G. Schwan,, P. C. Shoemaker,, S. N. Banerjee,, B. O. Kassen,, and W. Burgdorfer. 1998. Tick-borne relapsing fever in the northwestern United States and southwestern Canada. Clin. Infect. Dis. 26: 122 131.
99. Dworkin, M. S.,, T. G. Schwan,, and D. E. Anderson, Jr. 2002. Tick-borne relapsing fever in North America. Med. Clin. North. Am. 86: 417 433.
100. Dworkin, M. S.,, P. C. Shoemaker,, C. L. Fritz,, M. E. Dowell,, and D. E. Anderson, Jr. 2002. The epidemiology of tickborne relapsing fever in the United States. Am. J. Trop. Med. Hyg. 66: 753 758.
101. Dykhuizen, D. E.,, and G. Baranton. 2001. The implications of a low rate of horizontal transfer in Borrelia. Trends Microbiol. 9: 344 350.
102. Eicken, C.,, V. Sharma,, T. Klabunde,, M. B. Lawrenz,, J. M. Hardham,, S. J. Norris,, and J. C. Sacchettini. 2002. Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi. J. Biol. Chem. 277: 21691 21696.
103. Elsdon-Dew, R. 1943. Relapsing fever and B. proteus X Kingbury. Nature 152: 565.
104. Fekade, D.,, K. Knox,, K. Hussein,, A. Melka,, D. G. Lalloo,, R. E. Coxon,, and D. A. Warrell. 1996. Prevention of Jarisch- Herxheimer reactions by treatment with antibodies against tumor necrosis factor alpha. N. Engl. J. Med. 335: 311 315.
105. Felsenfeld, O. 1965. Borrelia, human relapsing fever, and parasite-vector-host relationships. Bacteriol. Rev. 29: 46 74.
106. Felsenfeld, O. 1971. Borrelia: Strains, Vectors, Human and Animal Borreliosis. Warren H. Greene, Inc., St. Louis, Mo.
107. Ferdows, M. S.,, P. Serwer,, G. A. Griess,, S. J. Norris,, and A. G. Barbour. 1996. Conversion of a linear to a circular plasmid in the relapsing fever agent Borrelia hermsii. J. Bacteriol. 178: 793 800.
108. Filippova, N. A. 1966. Argasidae. Nauka, Moscow, Russia.
109. Fraenkel, C. J.,, U. Garpmo,, and J. Berglund. 2002. Determination of novel Borrelia genospecies in Swedish Ixodes ricinus ticks. J. Clin. Microbiol. 40: 3308 3312.
110. Fraser, C. M.,, S. Casjens,, W. M. Huang,, G. G. Sutton,, R. Clayton,, R. Lathigra,, O. White,, K. A. Ketchum,, R. Dodson,, E. K. Hickey,, M. Gwinn,, B. Dougherty,, J. F. Tomb,, R. D. Fleischmann,, D. Richardson,, J. Peterson,, A. R. Kerlavage,, J. Quackenbush,, S. Salzberg,, M. Hanson,, R. van Vugt,, N. Palmer,, M. D. Adams,, J. Gocayne,, J. C. Venter, et al. 1997. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 390: 580 586.
111. Fuchs, P. C.,, and A. A. Oyama. 1969. Neonatal relapsing fever due to transplacental transmission of Borrelia. JAMA 208: 690 692.
112. Fukunaga, M.,, and Y. Koreki. 1995. The flagellin gene of Borrelia miyamotoi sp. nov. and its phylogenetic relationship among Borrelia species. FEMS Microbiol. Lett. 134: 255 258.
113. Fukunaga, M.,, K. Okada,, M. Nakao,, T. Konishi,, and Y. Sato. 1996. Phylogenetic analysis of Borrelia species based on flagellin gene sequences and its application for molecular typing of Lyme disease borreliae. Int. J. Syst. Bacteriol. 46: 898 905.
114. Fukunaga, M.,, Y. Takahashi,, Y. Tsuruta,, O. Matsushita,, D. Ralph,, M. McClelland,, and M. Nakao. 1995. Genetic and phenotypic analysis of Borrelia miyamotoi sp. nov., isolated from the ixodid tick Ixodes persulcatus, the vector for Lyme disease in Japan. Int. J. Syst. Bacteriol. 45: 804 810.
115. Fukunaga, M.,, Y. Ushijima,, L. Y. Aoki,, and A. Talbert. 2001. Detection of Borrelia duttonii, a tick-borne relapsing fever agent in central Tanzania, within ticks by flagellin gene-based nested polymerase chain reaction. Vector Borne Zoonotic Dis. 1: 331 338.
116. Galloway, R. E.,, J. Levin,, T. Butler,, G. B. Naff,, G. H. Goldsmith,, H. Saito,, S. Awoke,, and C. K. Wallace. 1977. Activation of protein mediators of inflammation and evidence for endotoxemia in Borrelia recurrentis infection. Am. J. Med. 63: 933 938.
117. Gambles, R. M.,, and N. F. Coghill. 1948. Relapsing fever in Cyprus. Ann. Trop. Med. Parasitol. 42: 288 303.
118. Garcia-Monco, J. C.,, N. S. Miller,, P. B. Backenson,, P. Anda,, and J. L. Benach. 1997. A mouse model of Borrelia meningitis after intradermal injection. J. Infect. Dis. 175: 1243 1245.
119. Garnham, P.,, C. Davis,, R. Heisch,, and G. Timms. 1947. An epidemic of louse-borne relapsing fever in Kenya. Trans. R. Soc. Trop. Med. Hyg. 41: 141 170.
120. Geigy, R.,, and G. Sarasin. 1958. Isolatstamme von Borrelia duttoni und immunisierungsverhalten gegenuber der weissen maus. Acta Trop. 15: 254 258.
121. Godeluck, B.,, J. M. Duplantier,, K. Ba,, and J. F. Trape. 1994. A longitudinal survey of Borrelia crocidurae prevalence in rodents and insectivores in Senegal. Am. J. Trop. Med. Hyg. 50: 165 168.
122. Gylfe, A.,, S. Bergstrom,, J. Lundstrom,, and B. Olsen. 2000. Reactivation of Borrelia infection in birds. Nature 403: 724 725.
123. Hamase, A.,, Y. Takahashi,, K. Nohgi,, and M. Fukunaga. 1996. Homology of variable major protein genes between Borrelia hermsii and Borrelia miyamotoi. FEMS Microbiol. Lett. 140: 131 137.
124. Hamilton, J. B. 1943. Ocular complications in relapsing fever. Br. J. Ophthalmol. 27: 68 80.
125. Hardy, P. H., Jr.,, and J. Levin. 1983. Lack of endotoxin in Borrelia hispanica and Treponema pallidum. Proc. Soc. Exp. Biol. Med. 174: 47 52.
126. Hayes, L. J.,, D. J. Wright,, and L. C. Archard. 1988. Segmented arrangement of Borrelia duttonii DNA and location of variant surface antigen genes. J. Gen. Microbiol. 134: 1785 1793.
127. Hendson, M.,, and R. S. Lane. 2000. Genetic characteristics of Borrelia coriaceae isolates from the soft tick Ornithodoros coriaceus (Acari: Argasidae). J. Clin. Microbiol. 38: 2678 2682.
128. Herms, W. B.,, and C. M. Wheeler. 1935. Tick transmission of California relapsing fever. J. Econ. Entomol. 28: 846 855.
129. Hinnebusch, B. J.,, A. G. Barbour,, B. I. Restrepo,, and T. G. Schwan. 1998. Population structure of the relapsing fever spirochete Borrelia hermsii as indicated by polymorphism of two multigene families that encode immunogenic outer surface lipoproteins. Infect. Immun. 66: 432 440.
130. Hinnebusch, J.,, and K. Tilly. 1993. Linear plasmids and chromosomes in bacteria. Mol. Microbiol. 10: 917 922.
131. Hirschfeld, M.,, C. J. Kirschning,, R. Schwandner,, H. Wesche,, J. H. Weis,, R. M. Wooten,, and J. J. Weis. 1999. Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J. Immunol. 163: 2382 2386.
132. Holt, S. C. 1978. Anatomy and chemistry of spirochetes. Microbiol. Rev. 38: 114 160.
133. Hoogstraal, H. 1985. Argasid and nuttalliellid ticks as parasites and vectors. Adv. Parasitol. 24: 135 238.
134. Hoogstraal, H. 1979. Ticks and spirochetes. Acta Trop. 36: 133 136.
135. Horrenberger, R. 1954. Spirochaeta hispanica chez les rats d’Alger (nouvelle enquete). Arch. l’Inst. Pasteur Alger. 32: 18 22.
136. Horton, J.,, and M. Blaser. 1985. The spectrum of relapsing fever in the Rocky Mountains. Arch. Intern. Med. 145: 871 875.
137. Hovind-Hougen, K., 1976. Treponema and Borrelia morphology, p. 7 18. In R. C. Johnson (ed.), The Biology of Parasitic Spirochetes. Academic Press, New York, N.Y.
138. James, A. M.,, D. Liveris,, G. P. Wormser,, I. Schwartz,, M. A. Montecalvo,, and B. J. Johnson. 2001. Borrelia lonestari infection after a bite by an Amblyomma americanum tick. J. Infect. Dis. 183: 1810 1814.
139. Johnson, R. C., 1976. Comparative spirochete physiology and cellular composition, p. 39 48. In R. C. Johnson (ed.), The Biology of Parasitic Spirochetes. Academic Press, New York, N.Y.
140. Jongen, V. H.,, J. van Roosmalen,, J. Tiems,, J. Van Holten,, and J. C. Wetsteyn. 1997. Tick-borne relapsing fever and pregnancy outcome in rural Tanzania. Acta Obstet. Gynecol. Scand. 76: 834 838.
141. Judge, D.,, I. Samuel,, P. Perine,, and D. Vukotic. 1974. Louseborne relapsing fever in man. Arch. Pathol. 97: 136 140.
142. Judge, D. M.,, J. T. La Croix,, and P. L. Perine. 1974. Experimental louse-borne relapsing fever in the grivet monkey, Cercopithecus aethiops. II. Pathology. Am. J. Trop. Med. Hyg. 23: 962 968.
143. Kazragis, R. J.,, L. L. Dever,, J. H. Jorgensen,, and A. G. Barbour. 1996. In vivo activities of ceftriaxone and vancomycin against Borrelia spp. in the mouse brain and other sites. Antimicrob. Agents Chemother. 40: 2632 2636.
144. Kelly, R. 1971. Cultivation of Borrelia hermsi. Science 173: 443 444.
145. Kemp, H. A.,, W. H. Moursund,, and H. E. Wright. 1935. Relapsing fever in Texas. V. A survey of the epidemiology and clinical manifestations of the disease as it occurs in Texas. Am. J. Trop. Med. 15: 495 506.
146. Kisinza, W. N.,, P. J. McCall,, H. Mitani,, A. Talbert,, and M. Fukunaga. 2003. A newly identified tick-borne Borrelia species and relapsing fever in Tanzania. Lancet 362: 1283 1284.
147. Kitten, T.,, and A. G. Barbour. 1990. Juxtaposition of expressed variable antigen genes with a conserved telomere in the bacterium Borrelia hermsii. Proc. Natl. Acad. Sci. USA 87: 6077 6081.
148. Kitten, T.,, and A. G. Barbour. 1992. The relapsing fever agent Borrelia hermsii has multiple copies of its chromosome and linear plasmids. Genetics 132: 311 324.
149. Kitten, T.,, A. V. Barrera,, and A. G. Barbour. 1993. Intragenic recombination and a chimeric outer membrane protein in the relapsing fever agent Borrelia hermsii. J. Bacteriol. 175: 2516 2522.
150. Konishi, H.,, M. G. Morshed,, H. Akitomi,, and T. Nakazawa. 1993. In vitro cultivation of Borrelia duttonii on cultures of SflEp cells. Microbiol. Immunol. 37: 229 232.
151. Korenberg, E. I., 1993. Borrelioses, p. 382 391. In V. I. Pokrovsky (ed.), Epidemiology of Infectious Diseases: A Manual. Meditsina, Moscow, Russia. ( In Russian.)
152. Krakowski, J.,, and E. Edelstein. 1949. A survey of 25 cases of tick-borne relapsing fever observed at number 9 army hospital. Harefuah (Tel-Aviv foreign ed.) 5/ 6: 23 24.
153. Kurtti, T. J.,, U. G. Munderloh,, G. G. Ahlstrand,, and R. C. Johnson. 1988. Borrelia burgdorferi in tick cell culture: growth and cellular adherence. J. Med. Entomol. 25: 256 261.
154. Lane, R. S.,, W. Burgdorfer,, S. F. Hayes,, and A. G. Barbour. 1985. Isolation of a spirochete from the soft tick, Ornithodoros coriaceus: a possible agent of epizootic bovine abortion. Science 230: 85 87.
155. Lane, R. S.,, and S. A. Manweiler. 1988. Borrelia coriaceae in its tick vector, Ornithodoros coriaceus (Acari: Argasidae), with emphasis on transstadial and transovarial infection. J. Med. Entomol. 25: 172 177.
156. Longanecker, D. S. 1951. Laboratory and field studies on the biology of the relapsing fever tick vector (Ornithodoros hermsi) in the high mountains of California. Am. J. Trop. Med. 31: 373 380.
157. Magoun, L.,, W. R. Zuckert,, D. Robbins,, N. Parveen,, K. R. Alugupalli,, T. G. Schwan,, A. G. Barbour,, and J. M. Leong. 2000. Variable small protein (Vsp)-dependent and vsp-independent pathways for glycosaminoglycan recognition by relapsing fever spirochaetes. Mol. Microbiol. 36: 886 897.
158. Matton, P.,, and H. Van Melckebeke. 1990. Bovine borreliosis: comparison of simple methods for detection of the spirochaete in the blood. Trop. Anim. Health Prod. 22: 147 152.
159. Mazzotti, L. 1943. Transmission experiments with Spirochaeta turicatae and S. venezuelensis with four species of Ornithodoros. Am. J. Hyg. 38: 203 206.
160. McDowell, J. V.,, E. Tran,, D. Hamilton,, J. Wolfgang,, K. Miller,, and R. T. Marconi. 2003. Analysis of the ability of spirochete species associated with relapsing fever, avian borreliosis, and epizootic bovine abortion to bind factor H and cleave c3b. J. Clin. Microbiol. 41: 3905 3910.
161. Meier, J. T.,, M. I. Simon,, and A. G. Barbour. 1985. Antigenic variation is associated with DNA rearrangements in a relapsing fever Borrelia. Cell 41: 403 409.
162. Meleney, H. E. 1928. Relapse phenomena of Spironema recurrentis. J. Exp. Med. 48: 65 82.
163. Melkert, P. W. 1988. Relapsing fever in pregnancy: analysis of high-risk factors. Br. J. Obstet. Gynaecol. 95: 1070 1072.
164. Mitiku, K.,, and G. Mengistu. 2002. Relapsing fever in Gondar, Ethiopia. East Afr. Med. J. 79: 85 87.
165. Negussie, Y.,, D. G. Remick,, L. E. DeForge,, S. L. Kunkel,, A. Eynon,, and G. E. Griffin. 1992. Detection of plasma tumor necrosis factor, interleukins 6, and 8 during the Jarisch- Herxheimer reaction of relapsing fever. J. Exp. Med. 175: 1207 1212.
166. Newman, K., Jr.,, and R. C. Johnson. 1981. In vivo evidence that an intact lytic complement pathway is not essential for successful removal of circulating Borrelia turicatae from mouse blood. Infect. Immun. 31: 465 469.
167. Newman, K., Jr.,, and R. C. Johnson. 1984. T-cell-independent elimination of Borrelia turicatae. Infect. Immun. 45: 572 576.
168. Nicolle, C.,, and C. Anderson. 1927. Etude comparative de quelques viru recurrents, pathogenes pour l’homme. Arch. Inst. Pasteur Tunis 16: 123 206.
169. Nordstrand, A.,, A. Shamaei-Tousi,, A. Ny,, and S. Bergstrom. 2001. Delayed invasion of the kidney and brain by Borrelia crocidurae in plasminogen-deficient mice. Infect. Immun. 69: 5832 5839.
170. Ordman, D. 1943. Epidemiological observations on an outbreak of tick relapsing fever in Northern Transvaal. S. Afr. Med. J. 1943(June 12): 180 182.
171. Ordman, D.,, and F. Jones. 1940. Some clinical aspects of tick relapsing fever in natives in South Africa. S. Afr. Med. J. 14: 81 83.
172. Parsons, L. 1947. Relapsing fever at Lake Tahoe, California- Nevada. Am. J. Clin. Pathol. 17: 388 392.
173. Paster, B. J.,, and F. E. Dewhirst. 2000. Phylogenetic foundation of spirochetes. J. Mol. Microbiol. Biotechnol. 2: 341 344.
174. Paul, W. S.,, G. Maupin,, A. O. Scott-Wright,, R. B. Craven,, and D. T. Dennis. 2002. Outbreak of tick-borne relapsing fever at the north rim of the Grand Canyon: evidence for effectiveness of preventive measures. Am. J. Trop. Med. Hyg. 66: 71 75.
175. Pavlovsky, Y. N., 1963. Tick-borne relapsing fever, p. 138 184. In Y. N. Pavlovsky (ed.), Human Disease with Natural Foci. Foreign Languages Publishing House, Moscow, Russia.
176. Penningon, P. M.,, D. Cadavid,, J. Bunikis,, S. J. Norris,, and A. G. Barbour. 1999. Extensive interplasmidic duplications change the virulence phenotype of the relapsing fever agent borrelia turicatae. Mol. Microbiol. 34: 1120 1132.
177. Pennington, P. M.,, C. D. Allred,, C. S. West,, R. Alvarez,, and A. G. Barbour. 1997. Arthritis severity and spirochete burden are determined by serotype in the Borrelia turicataemouse model of Lyme disease. Infect. Immun. 65: 285 292.
178. Pennington, P. M.,, D. Cadavid,, and A. G. Barbour. 1999. Characterization of VspB of Borrelia turicatae, a major outer membrane protein expressed in blood and tissues of mice. Infect. Immun. 67: 4637 4645.
179. Perine, P.,, E. Parry,, D. Vukotich,, D. A. Warrell,, and A. D. Bryceson. 1971. Bleeding in louse-borne relapsing fever. I. Clinical studies in 37 patients. Trans. R. Soc. Trop. Med. Hyg. 65: 776 781.
180. Perine, P. L.,, D. W. Krause,, S. Awoke,, and J. E. McDade. 1974. Single-dose doxycycline treatment of louse-borne relapsing fever and epidemic typhus. Lancet ii: 742 744.
181. Perine, P. L.,, and B. Teklu. 1983. Antibiotic treatment of louse-borne relapsing fever in Ethiopia: a report of 377 cases. Am. J. Trop. Med. Hyg. 32: 1096 1100.
182. Plasterk, R. H.,, M. I. Simon,, and A. G. Barbour. 1985. Transposition of structural genes to an expression sequence on a linear plasmid causes antigenic variation in the bacterium Borrelia hermsii. Nature 318: 257 263.
183. Porcella, S. F.,, S. J. Raffel,, M. E. Schrumpf,, M. E. Schriefer,, D. T. Dennis,, and T. G. Schwan. 2000. Serodiagnosis of louse-borne relapsing fever with glycerophosphodiester phosphodiesterase (GlpQ) from Borrelia recurrentis. J. Clin. Microbiol. 38: 3561 3571.
184. Quin, C.,, and E. Perkins. 1946. Tick-borne relapsing fever in East Africa. Trop. Med. Hyg. 49: 30 32.
185. Ras, N. M.,, B. Lascola,, D. Postic,, S. J. Cutler,, F. Rodhain,, G. Baranton,, and D. Raoult. 1996. Phylogenesis of relapsing fever Borrelia spp. Int. J. Syst. Bacteriol. 46: 859 865.
186. Rawlings, J. A. 1995. An overview of tick-borne relapsing fever with emphasis on outbreaks in Texas. Tex. Med. 91: 56 59.
187. Remick, D. G.,, Y. Negussie,, D. Fekade,, and G. Griffin. 1996. Pentoxifylline fails to prevent the Jarisch-Herxheimer reaction or associated cytokine release. J. Infect. Dis. 174: 627 630.
188. Restrepo, B. I.,, and A. G. Barbour. 1994. Antigen diversity in the bacterium B. hermsii through “somatic” mutations in rearranged vmp genes. Cell 78: 867 876.
189. Restrepo, B. I.,, C. J. Carter,, and A. G. Barbour. 1994. Activation of a vmp pseudogene in Borrelia hermsii: an alternate mechanism of antigenic variation during relapsing fever. Mol. Microbiol. 13: 287 299.
190. Restrepo, B. I.,, T. Kitten,, C. J. Carter,, D. Infante,, and A. G. Barbour. 1992. Subtelomeric expression regions of Borrelia hermsii linear plasmids are highly polymorphic. Mol. Microbiol. 6: 3299 3311.
191. Rich, S. M.,, P. M. Armstrong,, R. D. Smith,, and S. R. Telford III. 2001. Lone star tick-infecting borreliae are most closely related to the agent of bovine borreliosis. J. Clin. Microbiol. 39: 494 497.
192. Rich, S. M.,, S. A. Sawyer,, and A. G. Barbour. 2001. Antigen polymorphism in Borrelia hermsii, a clonal pathogenic bacterium. Proc. Natl. Acad. Sci. USA 98: 15038 15043.
193. Russell, H. 1936. Observations on immunity in relapsing fever and trypanosomiasis. Trans. R. Soc. Trop. Med. Hyg. 30: 179 190.
194. Sadziene, A.,, M. Jonsson,, S. Bergstrom,, R. K. Bright,, R. C. Kennedy,, and A. G. Barbour. 1994. A bactericidal antibody to Borrelia burgdorferi is directed against a variable region of the OspB protein. Infect. Immun. 62: 2037 2045.
195. Salih, S.,, D. Mustafa,, S. Abdel-Wahab,, M. Ahmed,, and A. Omer. 1977. Louse-borne relapsing fever. I. A clinical and laboratory study of 363 cases in the Sudan. Trans. R. Soc. Trop. Med. Hyg. 71: 43 48.
196. Schmidtmann, E. T.,, R. B. Bushnell,, E. C. Loomis,, M. N. Oliver,, and J. H. Theis. 1976. Experimental and epizootiologic evidence associating Ornithodoros coriaceus (Acari: Agrasidae) with the exposure of cattle to epizootic bovine abortion in California. J. Med. Entomol. 13: 292 299.
197. Schuhardt, V.,, and E. Hemphill. 1946. Brain involvement as a possible cause of relapse after treatment in spirochaetal relapsing fever. Science 103: 422 423.
198. Schuhardt, V. T.,, and M. Wilkerson. 1951. Relapse phenomena in rats infected with single spirochetes ( Borrelia recurrenis var. turicatae). J. Bacteriol. 62: 215 219.
199. Schwan, T. G.,, J. M. Battisti,, S. F. Porcella,, S. J. Raffel,, M. E. Schrumpf,, E. R. Fischer,, J. A. Carroll,, P. E. Stewart,, P. Rosa,, and G. A. Somerville. 2003. Glycerol-3-phosphate acquisition in spirochetes: distribution and biological activity of glycerophosphodiester phosphodiesterase (GlpQ) among Borrelia species. J. Bacteriol. 185: 1346 1356.
200. Schwan, T. G.,, and B. J. Hinnebusch. 1998. Bloodstreamversus tick-associated variants of a relapsing fever bacterium. Science 280: 1938 1940.
201. Schwan, T. G.,, P. F. Policastro,, Z. Miller,, R. L. Thompson,, T. Damrow,, and J. E. Keirans. 2003. Tick-borne relapsing fever caused by Borrelia hermsii, Montana. Emerg. Infect. Dis. 9: 1151 1154.
202. Schwan, T. G.,, M. E. Schrumpf,, B. J. Hinnebusch,, D. E. Anderson, Jr.,, and M. E. Konkel. 1996. GlpQ: an antigen for serological discrimination between relapsing fever and Lyme borreliosis. J. Clin. Microbiol. 34: 2483 2492.
203. Sciotto, C. G.,, B. A. Lauer,, W. L. White,, and G. R. Istre. 1983. Detection of Borrelia in acridine orange-stained blood smears by fluorescence microscopy. Arch. Pathol. Lab. Med. 107: 384 386.
204. Scoles, G. A.,, M. Papero,, L. Beati,, and D. Fish. 2001. A relapsing fever group spirochete transmitted by Ixodes scapularis ticks. Vector Borne Zoonotic Dis. 1: 21 34.
205. Scragg, I. G.,, D. Kwiatkowski,, V. Vidal,, A. Reason,, T. Paxton,, M. Panico,, A. Dell,, and H. Morris. 2000. Structural characterization of the inflammatory moiety of a variable major lipoprotein of Borrelia recurrentis. J. Biol. Chem. 275: 937 941.
206. Seboxa, T.,, and S. I. Rahlenbeck. 1995. Treatment of louseborne relapsing fever with low dose penicillin or tetracycline: a clinical trial. Scand. J. Infect. Dis. 27: 29 31.
207. Shamaei-Tousi, A.,, M. J. Burns,, J. L. Benach,, M. B. Furie,, E. I. Gergel,, and S. Bergstrom. 2000. The relapsing fever spirochaete, Borrelia crocidurae, activates human endothelial cells and promotes the transendothelial migration of neutrophils. Cell. Microbiol. 2: 591 599.
208. Shamaei-Tousi, A.,, O. Collin,, A. Bergh,, and S. Bergstrom. 2001. Testicular damage by microcirculatory disruption and colonization of an immune-privileged site during Borrelia crocidurae infection. J. Exp. Med. 193: 995 1004.
209. Shamaei-Tousi, A.,, P. Martin,, A. Bergh,, N. Burman,, T. Brännström,, and S. Bergström. 1999. Erythrocyte-aggregating relapsing fever spirochete Borrelia crocidurae induces formation of microemboli. J. Infect. Dis. 180: 1929 1938.
210. Shanbaky, N. M.,, and N. Helmy. 2000. First record of natural infection with Borrelia in Ornithodoros (Ornithodoros) savignyi. Reservoir potential and specificity of the tick to Borrelia. J. Egypt Soc. Parasitol. 30: 765 780.
211. Sharma, S. P.,, W. Amanfu,, and T. C. Losho. 2000. Bovine borreliosis in Botswana. Onderstepoort J. Vet. Res. 67: 221 223.
212. Smith, R. D.,, J. Brener,, M. Osorno,, and M. Ristic. 1978. Pathobiology of Borrelia theileri in the tropical cattle tick, Boophilus microplus. J. Invertebr. Pathol. 32: 182 190.
213. Southern, P.,, and J. Sanford. 1969. Relapsing fever. A clinical and microbiological review. Medicine 48: 129 149.
214. Stoenner, H. G. 1974. Biology of Borrelia hermsii in Kelly medium. Appl. Microbiol. 28: 540 543.
215. Stoenner, H. G.,, T. Dodd,, and C. Larsen. 1982. Antigenic variation of Borrelia hermsii. J. Exp. Med. 156: 1297 1311.
216. Sundnes, K.,, and A. Haimanot. 1993. Epidemic of louseborne relapsing fever in Ethiopia. Lancet 342: 1213.
217. Tabuchi, N.,, H. Mitani,, S. Seino,, and M. Fukunaga. 2002. The 44-kb linear plasmid molecule in the relapsing fever agent Borrelia duttonii strain Ly serve as a preservation of vmp genes. Microbiol. Immunol. 46: 159 165.
218. Takahashi, Y.,, S. J. Cutler,, and M. Fukunaga. 2000. Size conversion of a linear plasmid in the relapsing fever agent Borrelia duttonii. Microbiol. Immunol. 44: 1071 1074.
219. Takayama, K.,, R. J. Rothenberg,, and A. G. Barbour. 1987. Absence of lipopolysaccharide in the Lyme disease spirochete, Borrelia burgdorferi. Infect. Immun. 55: 2311 2313.
220. Thomas, N. J.,, J. Bunikis,, A. G. Barbour,, and M. J. Wolcott. 2002. Fatal spirochetosis due to a relapsing fever-like Borrelia sp. in a northern spotted owl. J. Wildl. Dis. 38: 187 193.
221. Thompson, R. S.,, W. Burgdorfer,, R. Russell,, and B. J. Francis. 1969. Outbreak of tick-borne relapsing fever in Spokane County, Washington. JAMA 210: 1045 1050.
222. Trape, J. F.,, J. M. Duplantier,, H. Bouganali,, B. Godeluck,, F. Legros,, J. P. Cornet,, and J. L. Camicas. 1991. Tick-borne borreliosis in west Africa. Lancet 337: 473 475.
223. Trape, J. F.,, B. Godeluck,, G. Diatta,, C. Rogier,, F. Legros,, J. Albergel,, Y. Pepin,, and J. M. Duplantier. 1996. The spread of tick-borne borreliosis in West Africa and its relationship to sub-Saharan drought. Am. J. Trop. Med. Hyg. 54: 289 293.
224. van Holten, J.,, J. Tiems,, and V. H. Jongen. 1997. Neonatal Borrelia duttoni infection: a report of three cases. Trop. Doct. 27: 115 116.
225. Varma, M. G. R. 1956. Infections of Ornithodoros ticks with relapsing fever spirochaetes, and the mechanisms of their transmission. Ann. Trop. Med. Parasitol. 50: 18 31.
226. Vidal, V.,, S. Cutler,, I. G. Scragg,, D. J. Wright,, and D. Kwiatkowski. 2002. Characterisation of silent and active genes for a variable large protein of Borrelia recurrentis. BMC Infect. Dis. 2: 25
227. Vidal, V.,, I. G. Scragg,, S. J. Cutler,, K. A. Rockett,, D. Fekade,, D. A. Warrell,, D. J. Wright,, and D. Kwiatkowski. 1998. Variable major lipoprotein is a principal TNF-inducing factor of louse-borne relapsing fever. Nat. Med. 4: 1416 1420.
228. Walker, T.,, M. G. Luna,, J. Bunikis,, and A. G. Barbour. Tick-borne relapsing fever in the eastern Sierra mountains. Submitted for publication.
229. Warrell, D. A.,, P. L. Perine,, D. W. Krause,, D. H. Bing,, and S. J. MacDougal. 1983. Pathophysiology and immunology of the Jarisch-Herxheimer-like reaction in louse-borne relapsing fever: comparison of tetracycline and slow- release penicillin. J. Infect. Dis. 147: 898 909.
230. Webster, G.,, J. D. Schiffman,, A. S. Dosanjh,, M. R. Amieva,, H. A. Gans,, and T. C. Sectish. 2002. Jarisch-Herxheimer reaction associated with ciprofloxacin administration for tickborne relapsing fever. Pediatr. Infect. Dis. J. 21: 571 573.
231. Wengrower, D.,, H. Knobler,, S. Gillis,, and T. Chajek-Shaul. 1984. Myocarditis in tick-borne relapsing fever. J. Infect. Dis. 149: 1033.
232. Wheeler, C.,, W. Herms,, and K. Meyer. 1935. A new tick vector of relapsing fever in California. Proc. Soc. Exp. Biol. Med. 32: 1290 1292.
233. Wood, R. C.,, and K. C. Dixon. 1945. Tick-borne relapsing fever in Cyprus. Br. Med. J. 2: 526 528.
234. World Health Organization. 2001. WHO Model Prescribing Information. Drugs Used in Bacterial Infections. World Health Organization, Geneva, Switzerland.
235. Yagupsky, P.,, and S. Moses. 1985. Neonatal Borrelia species infection (relapsing fever). Am. J. Dis. Child. 139: 74 76.
236. Zaher, M. A.,, Z. R. Soliman,, and F. M. Diab. 1977. An experimental study of Borrelia anserina in four species of Argas ticks. 2. Transstadial survival and transovarial transmission. Z. Parasitenkd. 53: 213 223.
237. Zarafonetis, C. J. D.,, H. S. Ingraham,, and J. F. Berrry. 1946. Weil-Felix and typhus complementation fixation tests, with special reference to B. proteus OX-K agglutination. J. Immunol. 52: 189 199.
238. Zhang, J. R.,, J. M. Hardham,, A. G. Barbour,, and S. J. Norris. 1997. Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes. Cell 89: 275 285.
239. Zhong, J.,, and A. G. Barbour. 2004. Cross-species hybridization of a Borrelia burgdorferi DNA array reveals infection- and culture associated genes of the unsequenced genome of the relapsing fever agent Borrelia hermsii. Mol. Microbiol. 51: 729 748.
240. Zückert, W. R.,, T. A. Kerentseva,, C. L. Lawson,, and A. G. Barbour. 2001. Structural conservation of neurotropismassociated VspA within the variable Borrelia Vsp-OspC lipoprotein family. J. Biol. Chem. 276: 457 463.
241. Zückert, W. R.,, J. E. Lloyd,, P. E. Stewart,, P. A. Rosa,, and A. G. Barbour. 2004. Cross-species surface display of functional spirochetal lipoproteins by recombinant Borrelia burgdorferi. Infect. Immun. 72: 1463 1469.


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Table 1

species that cause relapsing fever and related species

Citation: Barbour A. 2005. Relapsing Fever, p 268-291. In Goodman J, Dennis D, Sonenshine D, Tick-Borne Diseases of Humans. ASM Press, Washington, DC. doi: 10.1128/9781555816490.ch16

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