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Chapter 17 : Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses

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Abstract:

Rickettsioses, caused by members of the typhus group and spotted fever group (SFG) rickettsiae, are significant, underrecognized diseases found worldwide. Rocky Mountain spotted fever (RMSF) was first described in the 1890s, and researchers have worked to characterize its manifestations, develop effective therapeutics, examine the biological aspects of the agent, and in particular to understand its survival and multiplication within its arthropod host. As this chapter deals primarily with human health and tick-borne SFG rickettsiae described in North, Central, and South America, the majority of the content is in reference to . Furthermore, because a number of excellent reviews have been published regarding the biology of , the various aspects of RMSF, including issues of ecology and clinical characteristics, the chapter aims to expand on that base of knowledge and update the reader on the current trends of research on tick-borne rickettsioses.

Citation: Macaluso K, Azad A. 2005. Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, p 292-301. In Goodman J, Dennis D, Sonenshine D, Tick-Borne Diseases of Humans. ASM Press, Washington, DC. doi: 10.1128/9781555816490.ch17

Key Concept Ranking

Rocky Mountain Spotted Fever
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Outer Membrane Protein A
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Restriction Fragment Length Polymorphism
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Figures

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Figure 1

Transmission electron micrograph of strain DaE100R (R) within the cytoplasm of DAE100 (embryonic cell line) host cell. The arrow identifies the translucent zone that has been termed the slime layer. Bar, 0.2 µm. Image courtesy of A. T. Palmer and T. J. Kurtti.

Citation: Macaluso K, Azad A. 2005. Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, p 292-301. In Goodman J, Dennis D, Sonenshine D, Tick-Borne Diseases of Humans. ASM Press, Washington, DC. doi: 10.1128/9781555816490.ch17
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Image of Figure 2
Figure 2

RMSF cases reported to the CDC from 1942 to 1996. (Image from http://www.cdc.gov/ncidod/dvrd/rmsf/Epidemiology. htm.)

Citation: Macaluso K, Azad A. 2005. Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, p 292-301. In Goodman J, Dennis D, Sonenshine D, Tick-Borne Diseases of Humans. ASM Press, Washington, DC. doi: 10.1128/9781555816490.ch17
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Image of Figure 3
Figure 3

Regional distribution of reported RMSF as determined by cases reported to the CDC by individual states from 1994 to 1998. (Image redrawn from http://www.cdc.gov/ncidod/dvrd/rmsf/Epidemiology.htm.)

Citation: Macaluso K, Azad A. 2005. Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, p 292-301. In Goodman J, Dennis D, Sonenshine D, Tick-Borne Diseases of Humans. ASM Press, Washington, DC. doi: 10.1128/9781555816490.ch17
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Figure 4

Seasonal distribution of RMSF cases reported to the CDC during each month for the years 1993 to 1996. (Image redrawn from http://www.cdc.gov/ncidod/dvrd/rmsf/Epidemiology. htm.)

Citation: Macaluso K, Azad A. 2005. Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, p 292-301. In Goodman J, Dennis D, Sonenshine D, Tick-Borne Diseases of Humans. ASM Press, Washington, DC. doi: 10.1128/9781555816490.ch17
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Tables

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Table 1

Spotted fever group species, arthropod vector, and distribution described in the United States

Citation: Macaluso K, Azad A. 2005. Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, p 292-301. In Goodman J, Dennis D, Sonenshine D, Tick-Borne Diseases of Humans. ASM Press, Washington, DC. doi: 10.1128/9781555816490.ch17

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