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Chapter 11 : Mycoplasma Phages

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Abstract:

This chapter focuses on the temperate MAV1 phage that infects strains of . The major factor that has been implicated in the development of arthritis is the extensively studied superantigen MAM. In some respects, mycoplasmal phage infections resemble the viral infections of animal cells. The current hypothesis is that Vir prevents superinfection by interfering with the injection of phage DNA into the mycoplasma cell, as is the case for several other phage exclusion systems. Interesting examples of the ability of phages to cure of spiroplasma infection are reviewed and discussed. Some exotic restriction and modification systems have been identified in mycoplasmas. These include the phase-variable restriction systems of that were described and a restriction system in that restricts phage genomes that contain 5-methylcytosine without any nucleotide sequence specificity for DNA recognition. Alternatively, the genomes of MAV1 or other phages that infect may encode GATC-specific restriction systems that have influenced MAV1 DNA evolution. Research on mycoplasma phages is challenging because of the fastidious nature of the host, but such phages are important from the perspectives of host pathogenesis and evolution.

Citation: Dybvig K, Tu A, Clapper B. 2005. Mycoplasma Phages, p 223-237. In Waldor M, Friedman D, Adhya S (ed), Phages. ASM Press, Washington, DC. doi: 10.1128/9781555816506.ch11

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Cell Wall Biosynthesis
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Linear Double-Stranded DNA
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Single Nucleotide Polymorphism
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Major Histocompatibility Complex
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Image of FIGURE 1
FIGURE 1

Model of MAV1 DNA integration and excision. Recombination is proposed to occur via a staggered (e.g., 6-bp) cleavage reaction. Excision and circularization of the MAV1 DNA would result in a heteroduplex at the nucleotide position adjacent to the TATTTTT sequence that would be resolved after the first round of replication into one MAV1 DNA molecule with the sequence TATTTTTX and a second molecule with the sequence TATTTTTY.“X” and “Y” refer to any of the four nucleotides and base pair with the nucleotides “X′” and “Y′,” respectively.

Citation: Dybvig K, Tu A, Clapper B. 2005. Mycoplasma Phages, p 223-237. In Waldor M, Friedman D, Adhya S (ed), Phages. ASM Press, Washington, DC. doi: 10.1128/9781555816506.ch11
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Image of FIGURE 2
FIGURE 2

Organization of the MAV1 genome showing the locations of ORFs and promoters. ORFs for which no function can be assigned are shown as unlabeled arrows.

Citation: Dybvig K, Tu A, Clapper B. 2005. Mycoplasma Phages, p 223-237. In Waldor M, Friedman D, Adhya S (ed), Phages. ASM Press, Washington, DC. doi: 10.1128/9781555816506.ch11
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References

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1. Alivizatos, A. S.,, R. Townsend,, and P. G. Markham. 1982. Effects of infection with a spiroplasma virus on the symptoms produced by Spiroplasma citri. Ann.Appl. Biol. 101: 85 91.
2. Barile, M. F.,, K. Kapatais-Zoumbos,, P. Snoy,, M.W. Grabowski,, M. Sneller,, L. Miller,, and D. K. F. Chandler. 1994. Experimentally induced septic arthritis in chimpanzees infected with Mycoplasma hominis, Mycoplasma pneumoniae, and Ureaplasma urealyticum. Clin. Infect. Dis. 18: 694 703.
3. Baseman, J. B.,, M. Lange,, N. L. Criscimagna,, J. A. Giron,, and C. A. Thomas. 1995. Interplay between mycoplasmas and host cells. Microb.Pathog. 19: 105 116.
4. Bauer, F. A.,, D. J. Wear,, P. Angritt,, and S.-C. Lo. 1991. Mycoplasma fermentans (incognitus strain) infection in the kidneys of patients with acquired immunodeficiency syndrome and associated nephropathy. Hum. Pathol. 22: 63 69.
5. Bebear, C.-M.,, P. Aullo,, J.-M. Bove,, and J. Renaudin. 1996. Spiroplasma citri virus SpV1: characterization of viral sequences present in the spiroplasma host chromosome. Curr. Microbiol. 32: 134 140.
6. Bhugra, B.,, and K. Dybvig. 1992. Highfrequency rearrangements in the chromosome of Mycoplasma pulmonis correlate with phenotypic switching. Mol. Microbiol. 6: 1149 1154.
7. Bruce, J.,, R. N. Gourlay,, R. Hull,, and D. J. Garwes. 1972. Ultrastructure of Mycoplasmatales virus laidlawii 1. J. Gen.Virol. 16: 215 221.
8. Cartner, S. C.,, J. R. Lindsey,, J. Gibbs-Erwin,, G. H. Cassell,, and J. W. Simecka. 1998. Roles of innate and adaptive immunity in respiratory mycoplasmosis. Infect. Immun. 66: 3485 3491.
9. Cassell, G. H.,, K. B. Waites,, J. K. Davis,, S. A. Horowitz,, and J. Horowitz,. 1988. Mycoplasmal arthritis, p. 235 241. In L. Espinoza,, D. Goldenberg,, F. Arnett,, and G. Alarcon (ed.), Infections in the Rheumatic Diseases. Grune & Stratton, Orlando, Fla.
10. Chambaud, I.,, R. Heilig,, S. Ferris,, V. Barbe,, D. Samson,, F. Galisson,, I. Moszer,, K. Dybvig,, H. Wroblewski,, A. Viari,, E. P. C. Rocha,, and A. Blanchard. 2001. The complete genome of the murine respiratory pathogen Mycoplasma pulmonis. Nucleic Acids Res. 29: 2145 2153.
11. Clapper, B.,, A.-H.T. Tu,, A. Elgavish,, and K. Dybvig. 2004. The vir gene of bacteriophage MAV1 confers resistance to phage infection on Mycoplasma arthritidis. J. Bacteriol. 186: 5715 5720.
12. Clapper, B.,, A.-H.T. Tu,, W. L. Simmons,, and K. Dybvig. 2004. Bacteriophage MAV1 is not associated with virulence of Mycoplasma arthritidis. Infect. Immun. 72: 7322 7325.
13. Cohen, A. J.,, D. L. Williamson,, and K. Oishi. 1987. SpV3 viruses of Drosophila spiroplasmas. Isr. J. Med. Sci. 23: 429 433.
14. Cole, B. C. 1991. The immunobiology of Mycoplasma arthritidis and its superantigen. Curr. Top. Microbiol. Immunol. 174: 107 119.
15. Cole, B. C.,, R. A. Balderas,, E. A. Ahmed,, D. Kono,, and A. N. Theofilopoulos. 1993. Genomic composition and allelic polymorphisms influence Vb usage by the Mycoplasma arthritidis superantigen. J. Immunol. 150: 3291 3299.
16. Cole, B. C.,, R. A. Daynes,, and J. R. Ward. 1981. Stimulation of mouse lymphocytes by a mitogen derived from Mycoplasma arthritidis. I.Transformation is associated with an H-2-linked gene that maps to the I-E/I-C subregion. J. Immunol. 127: 1931 1936.
17. Cole, B.C.,, M.W. Piepkorn,, and E.C. Wright. 1985. Influence of genes of the major histocompatibility complex on ulcerative dermal necrosis induced in mice by Mycoplasma arthritidis. J. Investig. Dermatol. 85: 357 361.
18. Cole, B. C.,, A. D. Sawitzke,, E. A. Ahmed,, C. L. Atkins,, and C. S. David. 1997. Allelic polymorphisms at the H-2A and HLA-DQ loci influence the response of murine lymphocytes to the Mycoplasma superantigen Mam. Infect. Immun. 65: 4190 4198.
19. Cole, B. C.,, R.N. Thorpe,, L.A. Hassell,, L. R. Washburn,, and J. R. Ward. 1983. Toxicity but not arthritogenicity of Mycoplasma arthritidis for mice associates with the haplotype expressed at the major histocompatibility complex. Infect.Immun. 41: 1010 1015.
20. Cole, B. C.,, and J. R. Ward. 1973. Fate of intravenously injected Mycoplasma arthritidis in rodent and effect of vaccines. Infect. Immun. 7: 416 425.
21. Cole, B. C.,, J. R. Ward,, and L. Golightly- Rowland. 1973. Factors influencing the susceptibility of mice to Mycoplasma arthritidis. Infect.Immun. 7: 218 225.
22. Cole, B. C.,, J. R. Ward,, K. S. Jones,, and J. F. Cahill. 1971. Chronic proliferative arthritis of mice induced by Mycoplasma arthritidis. I. Induction of disease and histopathological characteristics. Infect. Immun. 4: 344 355.
23. Cole, B. C.,, L. R. Washburn,, and D. Taylor- Robinson,. 1985. Mycoplasma-induced arthritis, p. 108 160. In S. Razin, and M. F. Barile (ed.), The Mycoplasmas, vol. IV. Academic Press, New York, N.Y.
24. Cole, R. M.,, W.O. Mitchell,, E. Jablonska,, and J. M. Ranhand. 1977. Spiroplasmavirus citri 3: propagation, purification, proteins, and nucleic acid. Science 198: 1262 1263.
25. Congdon, A. L.,, E. S. Boatman,, and G. E. Kenny. 1979. Mycoplasmatales virus MV-M1: discovery in Acholeplasma modicum and preliminary characterization. Curr. Microbiol. 3: 111 115.
26. Dallo, S. F.,, and J. B. Baseman. 2000. Intracellular DNA replication and long-term survival of pathogenic mycoplasmas. Microb. Pathog. 29: 301 309.
27. Dickinson, M. J.,, R. Townsend,, and S. J. Curson. 1984. Characterization of a virus infecting the wall-free prokaryote Spiroplasma citri. Virology 135: 524 535.
28. Dybvig, K.,, J. Alderete,, and G. H. Cassell. 1988. Adsorption of Mycoplasma pulmonis virus P1 to host cells. J. Bacteriol. 170: 4373 4375.
29. Dybvig, K.,, A. Liss,, J. Alderete,, R.M. Cole,, and G. H. Cassell. 1987. Isolation of a virus from Mycoplasma pulmonis. Isr. J. Med. Sci. 23: 418 422.
30. Dybvig, K.,, J. A. Nowak,, T. L. Sladek,, and J. Maniloff. 1985. Identification of an enveloped phage,mycoplasma virus L172, that contains a 14-kilobase single-stranded DNA genome. J. Virol. 53: 384 390.
31. Dybvig, K.,, R. Sitaraman,, and C.T. French. 1998. A family of phase-variable restriction enzymes with differing specificities generated by high-frequency gene rearrangements. Proc. Natl. Acad. Sci. USA 95: 13923 13928.
32. Dybvig, K.,, and L. L. Voelker. 1996. Molecular biology of mycoplasmas. Annu. Rev. Microbiol. 50: 25 57.
33. Fraser, C. F.,, J. D. Gocayne,, O. White,, M. D. Adams,, R. A. Clayton,, R. D. Fleischmann,, C. J. Bult,, A. R. Kerlavage,, G. Sutton,, J. M. Kelley,, J. L. Fritchman,, J. F. Weidman,, K.V. Small,, M. Sandusky,, J. Fuhrmann,, D. Nguyen,, T. R. Utterback,, D. M. Saudek,, C.A. Phillips,, J. M. Merrick,, J.-F. Tomb,, B. A. Dougherty,, K. F. Bott,, P.-C. Hu,, T. S. Lucier,, S. N. Peterson,, H. O. Smith,, C. A. Hutchison III,, and J. C. Venter. 1995. The minimal gene complement of Mycoplasma genitalium. Science 270: 397 403.
34. Gawres, D. J.,, B. V. Pike,, S. G. Wyld,, D. H. Pocock,, and R. N. Gourlay. 1975. Characterization of mycoplasmatales virus -laidlawii 3. J.Gen. Virol. 29: 11 24.
35. Gilroy, C.B.,, A. Keat,, and D. Taylor-Robinson. 2001. The prevalence of Mycoplasma fermentans in patients with inflammatory arthritides. Rheumatology 40: 1355 1358.
36. Glass, J. I.,, E. J. Lefkowitz,, J. S. Glass,, C. R. Heiner,, E.Y. Chen,, and G. H. Cassell. 2000. The complete sequence of the mucosal pathogen Ureaplasma urealyticum. Nature 407: 757 762.
37. Gourlay, R. N. 1971. Mycoplasmatales viruslaidlawii 2, a new virus isolated from Acholeplasma laidlawii. J. Gen.Virol. 12: 65 67.
38. Gourlay, R. N.,, S. G. Wyld,, and D. J. Garwes. 1983. Some properties of mycoplasma virus. Br. Arch.Virol. 75: 1 15.
39. Gourlay, R.N.,, S.G. Wyld,, and M. E. Poulton. 1983. Some characteristics of mycoplasma virus Hr1, isolated from and infecting Mycoplasma hyorhinis. Arch.Virol. 77: 81 85.
40. Gumulak-Smith, J.,, A. Teachman,, A.-H. T. Tu,, J. W. Simecka,, J. R. Lindsey,, and K. Dybvig. 2001. Variations in the surface proteins and restriction enzyme systems of Mycoplasma pulmonis in the respiratory tract of infected rats. Mol. Microbiol. 40: 1037 1044.
41. Himmelreich, R.,, H. Hilbert,, H. Plagens,, E. Pirkl,, B.-C. Li,, and R. Herrmann. 1996. Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae. Nucleic Acids Res. 24: 4420 4449.
42. Hou, L.,, H. Sasaki,, and P. Stashenko. 2000. Toll-like receptor 4-deficient mice have reduced bone destruction following mixed anaerobic infection. Infect. Immun. 68: 4681 4687.
43. Johnson, S.,, D. Sidebottom,, F. Bruckner,, and D. Collins. 2000. Identification of Mycoplasma fermentans in synovial fluid samples from arthritis patients with inflammatory disease. J. Clin. Microbiol. 38: 90 93.
44. Just, W.,, and G. Klotz. 1990. Terminal redundancy and circular permutation of mycoplasma virus L3 DNA. J. Gen.Virol. 71: 2157 2162.
45. Kliem, M.,, and B. Dreiseikelmann. 1989. The superimmunity gene sim of bacteriophage P1 causes superinfection exclusion. Virology 171: 350 355.
46. Lee, A. H.,, T. Ramanujam,, P. Ware,, P.H. Edelstein,, J. J. Brooks,, B. Freundlich,, H. R. Schumache, Jr.,, R. B. Zurier,, D. B. Weiner,, and W. V. Williams. 1992. Molecular diagnosis of Ureaplasma urealyticum septic arthritis in a patient with hypogammaglobulinemia. Arthritis Rheum. 35: 443 448.
47. Letort, C.,, and V. Juillard. 2001. Development of a minimal chemically-defined medium for the exponential growth of Streptococcus thermophilus. J. Appl. Microbiol. 91: 1023 1029.
48. Lien, E.,, T. J. Sellati,, A. Yoshimura,, T. H. Flo,, G. Rowadi,, R.W. Finberg,, J. D. Carroll,, T. Espevik,, R. R. Ingalls,, and J. D. Radolf. 1999. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial cell wall products. J. Biol. Chem. 274: 33419 33425.
49. Liska, B. 1972. Isolation of a new Mycoplasmatales virus. Stud. Biophys. 34: 151 155.
50. Liss, A.,, and J. Maniloff. 1971. Isolation of Mycoplasmatales viruses and characterization of MVL1, MVL52, and MVG51. Science 173: 725 727.
51. Manganelli, R.,, S. Ricci,, and G. Pozzi. 1996. Conjugative transposon Tn 916: evidence for excision with formation of 5′-protruding termini. J. Bacteriol. 178: 5813 5816.
52. Maniloff, J., 1992. Mycoplasma viruses, p. 41 59. In J. Maniloff,, R. N. McElhaney,, L. R. Finch,, and J. B. Baseman (ed.), Mycoplasmas: Molecular Biology and Pathogenesis. American Society for Microbiology, Washington, D.C.
53. Maniloff, J. 1988. Mycoplasma viruses. Crit. Rev. Microbiol. 15: 339 389.
54. Maniloff, J., 1992. Phylogeny of mycoplasmas, p. 549 559. In J. Maniloff,, R. N. McElhaney,, L. R. Finch,, and J. B. Baseman (ed.), Mycoplasmas: Molecular Biology and Pathogenesis. American Society for Microbiology, Washington, D.C.
55. Maniloff, J.,, and K. Dybvig,. Phages of mycoplasma. In R. Calendar (ed.), The Bacteriophages, in press. Oxford University Press, New York, N.Y.
56. Maniloff, J.,, G. J. Kampo,, and C. C. Dascher. 1994. Sequence analysis of a unique temperate phage:mycoplasma virus L2. Gene 141: 1 8.
57. McGarrity, G. J.,, and D. L. Williamson,. 1989. Spiroplasma pathogenicity, p. 365 392. In R. F. Whitcomb, and J. G. Tully (ed.), The Mycoplasmas, vol.V. Academic Press, San Diego, Calif.
58. McGrath, S.,, G. F. Fitzgerald,, and D. van Sinderen. 2002. Identification and characterization of phage-resistance genes in temperate lactococcal bacteriophages. Mol. Microbiol. 43: 509 520.
59. Melcher, U.,, Y. Sha,, F. Ye,, and J. Fletcher. 1999. Mechanisms of spiroplasma genome variation associated with SpV1-like viral DNA inferred from sequence comparisons. Microb. Comp. Genomics 4: 29 46.
60. Nowak, J. A.,, J. Maniloff,, and J. Das. 1978. Electron microscopy of single-stranded mycoplasmavirus DNA. FEMS Microbiol. Lett. 4: 59 61.
61. Ogawa, H. I.,, and M. Nakamura. 1985. Characterization of a mycoplasma virus (MV-O1) derived from and infecting Acholeplasma oculi. J. Gen. Microbiol. 131: 3117 3126.
62. Oishi, K. 1971. Spirochaete-mediated abnormal sex-ratio (SR) condition in Drosophila: a second virus associated with spirochaetes and its use in the study of the SR condition. Genet. Res. (Cambridge) 18: 45 56.
63. Oishi, K.,, and D. F. Poulson. 1970. A virus associated with SR-spirochetes of Drosophila nebulosa. Proc. Natl.Acad. Sci. USA 67: 1565 1572.
64. Piec, G.,, J. Mirkovitch,, S. Palacio,, P. F. Muhlradt,, and R. Felix. 1999. Effect of MALP- 2, a lipopeptide from Mycoplasma fermentans, on bone resorption in vitro. Infect. Immun. 67: 6281 6285.
65. Renaudin, J.,, P. Aullo,, J. C. Vignault,, and J. M. Bove. 1990. Complete nucleotide sequence of the genome of Spiroplasma citri virus SpV1-R8A2 B. Nucleic Acids Res. 18: 1293.
66. Renaudin, J.,, and J. M. Bove. 1994. SpV1 and SpV4, spiroplasma viruses with circular, single-stranded DNA genomes, and their contribution to the molecular biology of spiroplasmas. Adv. Virus Res. 44: 429 463.
67. Renaudin, J.,, M.-C. Pascarel,, and J.-M. Bove. 1987. Spiroplasma virus 4: nucleotide sequence of the viral DNA, regulatory signals, and proposed genome organization. J. Bacteriol. 169: 4950 4961.
68. Renaudin, J.,, M. C. Pascarel,, M. Garnier,, P. Carle,, and J. M. Bove. 1984. Characterization of spiroplasma group 4 (SV4). Isr. J. Med. Sci. 20: 797 799.
69. Renaudin, J.,, M. C. Pascarel,, M. Garnier,, P. Carle-Junca,, and J. M. Bove. 1984. SpV4, a new spiroplasma virus with circular, single-stranded DNA. Ann.Virol.. 135E: 343 361.
70. Roberts, M. C.,, and G. E. Kenny. 1987. Conjugal transfer of transposon Tn 916 from Streptococcus faecalis to Mycoplasma hominis. J. Bacteriol. 169: 3836 3839.
71. Roske, K.,, M. J. Calcutt,, and K. S. Wise. 2004. The Mycoplasma fermentans prophage fMFV1: genome, organization, mobility and variable expression of an encoded surface protein. Mol. Microbiol. 52: 1703 1720.
72. Schaeverbeke, T.,, C. B. Gilroy,, C. Bebear,, J. Dehais,, and D. Taylor-Robinson. 1996. Mycoplasma fermentans in joints of patients with rheumatoid arthritis and other joint disorders. Lancet 347: 1418.
73. Schaeverbeke, T.,, C. B. Gilroy,, C. Bebear,, J. Dehais,, and D. Taylor-Robinson. 1996. Mycoplasma fermentans, but not M.penetrans, detected by PCR assays in synovium from patients with rheumatoid arthritis and other rheumatic disorders. J. Clin. Pathol. 49: 824 828.
74. Schaeverbeke, T.,, H. Renaudin,, M. Clerc,, L. Lequen,, J. P. Vernhes,, B. de Barbeyrac,, B. Bannwarth,, C. Bebear,, and J. Dehais. 1997. Systematic detection of mycoplasmas by culture and polymerase chain reaction (PCR) procedures in 209 synovial fluid samples. Br. J. Rheumatol. 36: 310 314.
75. Sha, Y.,, U. Melcher,, R. E. Davis,, and J. Fletcher. 2000. Common elements of spiroplasma plectroviruses revealed by nucleotide sequence of SVTS2. Virus Genes 20: 47 56.
76. Shen, X.,, H. Yu,, J. Gumulak,, C.T. French,, N. Zou,, and K. Dybvig. 2000. Gene rearrangements in the vsa locus of Mycoplasma pulmonis. J. Bacteriol. 182: 2900 2908.
77. Simecka, J.W.,, J. K. Davis,, M. K. Davidson,, S. E. Ross,, C.T. K.-H. Stadtlander,, and G. H. Cassell,. 1992. Mycoplasma diseases of animals, p. 391 415. In J. Maniloff,, R. N. McElhaney,, L. R. Finch,, and J. B. Baseman (ed.), Mycoplasmas: Molecular Biology and Pathogenesis. American Society for Microbiology, Washington, D.C.
78. Simmons, W. L.,, and K. Dybvig. 2003. The Vsa proteins modulate susceptibility of Mycoplasma pulmonis to complement killing, hemadsorption, and adherence to polystyrene. Infect. Immun. 71: 5733 5738.
79. Sitaraman, R.,, A. M. Denison,, and K. Dybvig. 2002. A unique, bifunctional site-specific DNA recombinase from Mycoplasma pulmonis. Mol. Microbiol. 46: 1033 1040.
80. Sladek, T. L.,, J. A. Nowak,, and J. Maniloff. 1986. Mycoplasma restriction: identification of a new type of restriction specificity for DNA containing 5-methylcytosine. J. Bacteriol. 165: 219 225.
81. Takeuchi, O.,, A. Kaufmann,, K. Grote,, T. Kawai,, K. Hoshino,, M. Morr,, P. F. Muhlradt,, and S. Akira. 2000. Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a Toll-like receptor 2- and MyD88-dependent signaling pathway. J. Immunol. 164: 554 557.
82. Takeuchi, O.,, T. Kawai,, P. F. Muhlradt,, M. Morr,, J. D. Radolf,, A. Zychlinsky,, K. Takeda,, and S. Akira. 2001. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int. Immunol. 13: 933 940.
83. Taylor-Robinson, D.,, H. A. Davies,, P. Sarathchandra,, and P. M. Furr. 1991. Intracellular location of mycoplasmas in cultured cells demonstrated by immunocytochemistry and electron microscopy. Int. J. Exp. Pathol. 72: 705 714.
84. Teachman, A. M.,, C.T. French,, H. Yu,, W. L. Simmons,, and K. Dybvig. 2002. Gene transfer in Mycoplasma pulmonis. J. Bacteriol. 184: 947 951.
85. Townsend, R. 1983. Viruses of Spiroplasma citri and their possible effects on pathogenicity. Yale J. Biol. Med. 56: 771 776.
86. Tu, A.-H.,, J. R. Lindsey,, T. R. Schoeb,, A. Elgavish,, H. Yu,, and K. Dybvig. 2002. Role of bacteriophage MAV1 as a mycoplasmal virulence factor for the development of arthritis in mice and rats. J. Infect. Dis. 186: 432 435.
87. Tu, A.-H.T.,, B. Clapper,, T. R. Schoeb,, A. Elgavish,, J. Zhang,, L. Liu,, H. Yu,, and K. Dybvig. 2005. Association of a major protein antigen of Mycoplasma arthritidis with virulence. Infect. Immun. 73: 245 249.
88. Tu, A.-H. T.,, L. L. Voelker,, X. Shen,, and K. Dybvig. 2001. Complete nucleotide sequence of the mycoplasma virus P1 genome. Plasmid 45: 122 126.
89. Voelker, L. L.,, and K. Dybvig. 1998. Characterization of the lysogenic bacteriophage MAV1 from Mycoplasma arthritidis. J. Bacteriol. 180: 5928 5931.
90. Voelker, L. L.,, and K. Dybvig. 1996. Gene transfer in Mycoplasma arthritidis: transformation, conjugal transfer of Tn 916, and evidence for a restriction system recognizing AGCT. J. Bacteriol. 178: 6078 6081.
91. Voelker, L. L.,, and K. Dybvig. 1999. Sequence analysis of the Mycoplasma arthritidis bacteriophage MAV1 genome identifies the putative virulence factor. Gene 233: 101 107.
92. Voelker, L. L.,, K. E. Weaver,, L. J. Ehle,, and L. R. Washburn. 1995. Association of lysogenic bacteriophage MAV1 with virulence of Mycoplasma arthritidis. Infect. Immun. 63: 4016 4023.
93. Washburn, L. R. 1987. Immunologic aspects of Mycoplasma arthritidis-induced arthritis. Isr. J. Med. Sci. 23: 326 333.
94. Washburn, L. R.,, D.W. Bird,, and K. Dybvig. 2003. Restoration of cytoadherence to an adherence- deficient mutant of Mycoplasma arthritidis by genetic complementation. Infect. Immun. 71: 671 675.
95. Washburn, L. R.,, S. Hirsch,, and L. L. Voelker. 1993. Mechanisms of attachment of Mycoplasma arthritidis to host cells in vitro. Infect. Immun. 61: 2670 2680.
96. Washburn, L. R.,, E. J. Miller,, S. Mukherjee,, and D. Dannenbring. 2004. Mycoplasma arthritidis bacteriophage MAV1 prophage integration, deletions, and strain-related polymorphisms. Plasmid 52: 31 47.
97. Washburn, L. R.,, and E. J. Weaver. 1997. Protection of rats against Mycoplasma arthritidis-induced arthritis by active and passive immunizations with two surface proteins. Clin. Diagn. Lab. Immunol. 4: 321 327.
98. Weinberg, E.D. 1997. The Lactobacillus anomaly: total iron abstinence. Perspect. Biol. Med. 40: 578 583.
99. Williamson, D. L.,, and D. F. Poulson,. 1979. Sex ratio organisms (spiroplasmas) of Drosophila, p. 175 208. In R. F. Whitcomb, and J. G. Tully (ed.), The Mycoplasmas, vol. III. Academic Press, New York, N.Y.
100. Winner, F.,, R. Rosengarten,, and C. Citti. 2000. In vitro cell invasion of Mycoplasma gallisepticum. Infect. Immun. 68: 4238 4244.
101. Yamao, F.,, A. Muto,, Y. Kawauchi,, M. Iwami,, S. Iwagami,, Y. Azumi,, and S. Osawa. 1985. UGA is read as tryptophan in Mycoplasma capricolum. Proc. Natl. Acad. Sci. USA 82: 2306 2309.
102. Zou, N.,, K. Park,, and K. Dybvig. 1995. Mycoplasma virus P1 has a linear, double-stranded DNA genome with inverted terminal repeats. Plasmid 33: 41 49.

Tables

Generic image for table
Table 1

Representative phages from

Citation: Dybvig K, Tu A, Clapper B. 2005. Mycoplasma Phages, p 223-237. In Waldor M, Friedman D, Adhya S (ed), Phages. ASM Press, Washington, DC. doi: 10.1128/9781555816506.ch11

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