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Chapter 24 : Pneumococcal Vaccines

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Pneumococcal Vaccines, Page 1 of 2

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Abstract:

This chapter provides a summary of issues critical to the development and application of pneumococcal vaccines. In the preantibiotic era, vaccination attempts utilized whole killed pneumococci injected parenterally. Although such vaccines were sometimes protective in humans, they were also highly reactogenic. These killed vaccines were mainly used to elicit antibody in animals for passive treatment of infected humans. In 1933 it was clearly demonstrated that antibody to type-specific capsular polysaccharides (PS) could be highly protective. However, it soon became apparent that different strains of each expressed one of many different PS. Most subsequent vaccine attempts focused on the use of mixtures of the isolated PSs to elicit protection. However, the inability of young children to make adequate responses to most soluble PS led to the development and licensing of an immunogenic PS-protein conjugate vaccine for children. The problem of poor vaccine immunogenicity in children is being addressed by conjugation of the PS to protein carriers, thereby converting the PS from T-cell-independent to T-cell-dependent antigens. These antigens include the pneumococcal surface protein PspA; autolysin (lytA), an enzyme on the pneumococcal cell wall; and pneumolysin, a cytoplasmic protein that is released when pneumococci are autolyzed.

Citation: Briles D, Paton J, Swiatlo E, Crain M. 2006. Pneumococcal Vaccines, p 289-298. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch24

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Pneumococcal Conjugate Vaccine
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References

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