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Chapter 8 : Extracellular Matrix Interactions with Gram-Positive Pathogens

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Abstract:

This chapter discusses the interaction of extracellular matrix (ECM) components with gram-positive pathogens. It first describes the structure and function of ECM, and then deals with the interactions of gram-positive pathogens with ECM components and their biological consequences. The chapter explains binding of collagen, laminin, elastin, fibronectin, vitronectin, fibrinogen, and thrombospondin, to gram-positive bacteria in detail. Adherence and invasion are the important disease-causing mechanisms of gram-positive pathogens. As interaction of these pathogens with the components of host ECM is involved both in adherence and in invasion, the underlying mechanisms of this interaction are of utmost importance for designing novel therapeutic strategies. A classic example of the potential use of bacterial cell surface components interacting with ECM is documented with fibronectin-binding protein SfbI from . This and other examples clearly demonstrate the potential use of components involved in the interaction of ECM and gram-positive pathogens and justify further research in this field.

Citation: Chhatwal G, Preissner K. 2006. Extracellular Matrix Interactions with Gram-Positive Pathogens, p 89-99. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch8

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Heparan Sulfate Proteoglycans
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Tables

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TABLE 1

Properties of ECM components involved in interaction with gram-positive pathogens

Citation: Chhatwal G, Preissner K. 2006. Extracellular Matrix Interactions with Gram-Positive Pathogens, p 89-99. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch8

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