1887

Chapter 24 :

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Ebook: Choose a downloadable PDF or ePub file. Chapter is a downloadable PDF file. File must be downloaded within 48 hours of purchase

Buy this Chapter
Digital (?) $15.00

Preview this chapter:
Zoom in
Zoomout

, Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555816544/9781555812928_Chap24-1.gif /docserver/preview/fulltext/10.1128/9781555816544/9781555812928_Chap24-2.gif

Abstract:

The gram-negative legionellae are common inhabitants of natural and man-made aquatic environments, surviving free, in biofilms, and as intracellular parasites of protozoa. Indeed, has been isolated from lakes, streams, rivers, and wet soil throughout the world and may be present within approximately 60% of large-building plumbing systems. Given the greater clinical significance of , our understanding of the legionellae, including their mechanisms of iron transport, derives mainly from studies of . Other risk factors for contracting Legionnaires’ disease infections include smoking, the male sex, advanced age, and alcoholism. The Mip protein is a surface-exposed propyl-proline isomerase that is required for the early stages of intracellular infection and for full virulence in animals, and the 60-kDa heat shock protein enhances epithelial cell invasion. Interestingly, the siderophore-like activity is observed only when the cultures are inoculated with bacteria that had been grown to log or early stationary phase. To assess the role of ferrous iron transport in physiology and pathogenesis, the author identified and mutated the gene in virulent strain 130b. The existence of multiple iron uptake systems in is quite compatible with the fact that the bacterium resides within such a variety of environments. It is likely that several iron acquisition pathways will prove to be relevant for intracellular infection and pathogenesis.

Citation: Cianciotto N. 2004. , p 372-386. In Crosa J, Mey A, Payne S, Iron Transport in Bacteria. ASM Press, Washington, DC. doi: 10.1128/9781555816544.ch24
Highlighted Text: Show | Hide
Loading full text...

Full text loading...

Figures

Image of FIGURE 1
FIGURE 1

Model of iron acquisition. See the text for details.

Citation: Cianciotto N. 2004. , p 372-386. In Crosa J, Mey A, Payne S, Iron Transport in Bacteria. ASM Press, Washington, DC. doi: 10.1128/9781555816544.ch24
Permissions and Reprints Request Permissions
Download as Powerpoint

References

/content/book/10.1128/9781555816544.chap24
1. Byrd, T. F.,, and M. A. Horwitz. 2000. Aberrantly low transferrin receptor expression on human monocytes is associated with nonpermissiveness for Legionella pneumophila growth. J. Infect. Dis. 181:13941400.
2. Fields, B. S.,, R. F. Benson,, and R. E. Besser. 2002. Legionella and Legionnaires disease: 25 years of investigation. Clin. Microbiol. Rev. 15:506526.
3. Gebran, S. J.,, C. Newton,, Y. Yamamoto,, R. Widen,, T. W. Klein,, and H. Friedman. 1994. Macrophage permissiveness for Legionella pneumophila growth modulated by iron. Infect. Immun. 62:564568.
4. Goldoni, P.,, P. Visca,, M. C. Pastoris,, P. Valenti,, and N. Orsi. 1991. Growth of Legionella spp. under conditions of iron restriction. J. Med. Microbiol. 34:113118.
5. Hickey, E. K.,, and N. P. Cianciotto. 1994. Cloning and sequencing of the Legionella pneumophila fur gene. Gene 143:117121.
6. Hickey, E. K.,, and N. P. Cianciotto. 1997. An iron- and Fur-repressed Legionella pneumophila gene that promotes intracellular infection and encodes a protein with similarity to the Escherichia coli aerobactin synthetases. Infect. Immun. 65:133143.
7. James, B. W.,, W. S. Mauchline,, P. J. Dennis,, and C. W. Keevil. 1997. A study of iron acquisition mechanisms of Legionella pneumophila grown in chemostat culture. Curr. Microbiol. 34:238243.
8. James, B. W.,, W. S. Mauchline,, R. B. Fitzgeorge,, P. J. Dennis,, and C. W. Keevil. 1995. Influence of iron-limited continuous culture on physiology and virulence of Legionella pneumophila. Infect. Immun. 63:42244230.
9. Johnson, W.,, L. Varner,, and M. Poch. 1991. Acquisition of iron by Legionella pneumophila: role of iron reductase. Infect. Immun. 59:23762381.
10. Liles, M. R.,, T. Aber Scheel,, and N. P. Cianciotto. 2000. Discovery of a nonclassical siderophore, legiobactin, produced by strains of Legionella pneumophila. J. Bacteriol. 182: 749757.
11. Liles, M. R.,, and N. P. Cianciotto. 1996. Absence of siderophore-like activity in Legionella pneumophila supernatants. Infect. Immun. 64:18731875.
12. Mengaud, J. M.,, and M. A. Horwitz. 1993. The major iron-containing protein of Legionella pneumophila is an aconitase homologous with the human iron-responsive element-binding protein. J. Bacteriol. 175:56665676.
13. O’Connell, W. A.,, E. K. Hickey,, and N. P. Cianciotto. 1996. A Legionella pneumophila gene that promotes hemin binding. Infect. Immun. 64:842848.
14. Poch, M. T.,, and W. Johnson. 1993. Ferric reductases of Legionella pneumophila. Biometals 6:107114.
15. Pope, C. D.,, W. O’Connell,, and N. P. Cianciotto. 1996. Legionella pneumophila mutants that are defective for iron acquisition and assimilation and intracellular infection. Infect. Immun. 64:629636.
16. Reeves, M. W.,, L. Pine,, S. H. Hutner,, J. R. George,, and W. K. Harrell. 1981. Metal requirements of Legionella pneumophila. J. Clin. Microbiol. 13:688695.
17. Reeves, M. W.,, L. Pine,, J. B. Neilands,, and A. Balows. 1983. Absence of siderophore activity in Legionella species grown in iron-deficient media. J. Bacteriol. 154:324329.
18. Robey, M.,, and N. Cianciotto. 2002. Legionella pneumophila feoAB promotes ferrous iron uptake and intracellular infection. Infect. Immun. 70:56595669.
19. Viswanathan, V. K.,, P. H. Edelstein,, C. D. Pope,, and N. P. Cianciotto. 2000. The Legionella pneumophila iraAB locus is required for iron assimilation, intracellular infection, and virulence. Infect. Immun. 68:10691079.
20. Viswanathan, V. K.,, S. Kurtz,, L. L. Pedersen,, Y. Abu-Kwaik,, K. Krcmarik,, S. Mody,, and N. P. Cianciotto. 2002. The cytochrome c maturation locus of Legionella pneumophila promotes iron assimilation and intracellular infection and contains a strain-specific insertion sequence element. Infect. Immun. 70:18421852.

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error