Highlighted Text:
Show |
Hide
Full text loading...
Chapter 8 : Integrins on Phagocytes
Authors:
Wouter L. W. Hazenbos1,
Eric J. Brown2
VIEW AFFILIATIONS
HIDE AFFILIATIONS
Affiliations:
1: Department of Microbial Pathogenesis, Genentech, Inc., 1 DNA Way, M.S. 33, South San Francisco, CA 94080;
2: Department of Microbial Pathogenesis, Genentech, Inc., 1 DNA Way, M.S. 33, South San Francisco, CA 94080
Content Type: Monograph
Publication Year:
2009
Category: Microbial Genetics and Molecular Biology; Bacterial Pathogenesis
Book DOI:
10.1128/9781555816650
Chapter DOI:
10.1128/9781555816650.ch8
MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.
Preview this chapter:
Integrins on Phagocytes, Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781555816650/9781555814014_Chap08-1.gif /docserver/preview/fulltext/10.1128/9781555816650/9781555814014_Chap08-2.gif
Abstract:
This chapter reviews the expression, signaling mechanisms, and functions of integrins on phagocytes, summarizing their central roles in host defense and inflammatory processes. Expression of integrins on the plasma membrane requires interaction of the α- and β-chains in the endoplasmic reticulum; unpaired chains are presumably recognized as unfolded and ultimately degraded. Mutations in the β2 gene that lead to severe reduction in expression of the entire family cause leukocyte adhesion deficiency type I (LAD-I), a severe immunodeficiency. Neutrophils express fewer β1 integrins than β2, and most of the β1 integrins are in secretory granules prior to neutrophil activation. Recent studies showed that overexpression of Rap1, or of one of its effectors, regulator of adhesion and cell polarization enriched in lymphoid tissues (RAPL), leads to increased adhesion through αLβ2. In recent years there has been increasing appreciation that ligation of activated integrins not only leads to cell adhesion and spreading, but also transmits signals into cells, a phenomenon called outside-in signaling, to contrast it with inside-out signaling mediating integrin activation. Integrins can associate with several other proteins within the plane of the plasma membrane, which often results in enhanced integrin-mediated signaling. The chapter finally talks about phagocyte-endothelium interactions, neutrophil migration, and monocyte migration.
Citation:
Hazenbos W, Brown E.
2009.
Integrins on Phagocytes,
p 137-152.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch8
Figures
Integrins on Phagocytes
[com.pub2web.rdf.cci.facet.ContentItem[id=http://asm.metastore.ingenta.com/content/author/10.1128/9781555816650.ch08-1,webId=/content/author/10.1128/9781555816650.ch08-1,properties={foaf_givenname=Wouter L. W., foaf_name=Wouter L. W. Hazenbos, foaf_surname=Hazenbos, pub_isAffiliatedWith=[com.pub2web.rdf.cci.facet.ContentItem[id=http://asm.metastore.ingenta.com/content/affiliation/10.1128/9781555816650.ch08-aff1]]}], com.pub2web.rdf.cci.facet.ContentItem[id=http://asm.metastore.ingenta.com/content/author/10.1128/9781555816650.ch08-2,webId=/content/author/10.1128/9781555816650.ch08-2,properties={foaf_givenname=Eric J., foaf_name=Eric J. Brown, foaf_surname=Brown, pub_isAffiliatedWith=[com.pub2web.rdf.cci.facet.ContentItem[id=http://asm.metastore.ingenta.com/content/affiliation/10.1128/9781555816650.ch08-aff2]]}]]
Citation:
Hazenbos W, Brown E.
2009.
Integrins on Phagocytes,
p 137-152.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch8
/content/10.1128/9781555816650.ch08.ch08fig01
FIGURE 1
Model for integrin activation. In resting state, integrins do not efficiently bind their ligand; activation by inside-out signaling induces a conformational change that dramatically enhances integrin-ligand interactions. (A) Resting, low-affinity state. Structural analyses revealed that the low-affinity state of resting integrins correlates with a “bent” confirmation. The ligand binding site is unavailable for ligand recognition. In this state, integrins likely exist as monomers diffusely distributed on the plasma membrane. (B) Activated, enhanced affinity state. Cell activation induces inside-out signaling, leading to separation of the integrin α- and β-chain cytoplasmic tails. This separation results in an intramolecular conformational change propagated through the plasma membrane, resulting in unbending of the extracellular domains. The ligand binding site becomes exposed and undergoes additional conformational change, enhancing affinity. This conformational change is thought to occur for both I domain-containing and I domain-lacking integrins; for simplicity, only an I domain-containing molecule is shown. (C) Activated, enhanced avidity state. Inside-out signaling can also lead to clustering of multiple integrin molecules, resulting in enhanced avidity for a multivalent ligand. It has been proposed, at least for αIIbβ3, that this clustering involves oligomerization of β-chain transmembrane domains (
Li et al., 2003
).
10.1128/9781555816650/f0139-01_thmb.gif
10.1128/9781555816650/f0139-01.gif
FIGURE 1
Model for integrin activation. In resting state, integrins do not efficiently bind their ligand; activation by inside-out signaling induces a conformational change that dramatically enhances integrin-ligand interactions. (A) Resting, low-affinity state. Structural analyses revealed that the low-affinity state of resting integrins correlates with a “bent” confirmation. The ligand binding site is unavailable for ligand recognition. In this state, integrins likely exist as monomers diffusely distributed on the plasma membrane. (B) Activated, enhanced affinity state. Cell activation induces inside-out signaling, leading to separation of the integrin α- and β-chain cytoplasmic tails. This separation results in an intramolecular conformational change propagated through the plasma membrane, resulting in unbending of the extracellular domains. The ligand binding site becomes exposed and undergoes additional conformational change, enhancing affinity. This conformational change is thought to occur for both I domain-containing and I domain-lacking integrins; for simplicity, only an I domain-containing molecule is shown. (C) Activated, enhanced avidity state. Inside-out signaling can also lead to clustering of multiple integrin molecules, resulting in enhanced avidity for a multivalent ligand. It has been proposed, at least for αIIbβ3, that this clustering involves oligomerization of β-chain transmembrane domains ( Li et al., 2003 ).
Citation:
Hazenbos W, Brown E.
2009.
Integrins on Phagocytes,
p 137-152.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch8
References
/content/book/10.1128/9781555816650.ch08
1.
Abram, C. L.,, and C. A. Lowell. 2007. Convergence of immunoreceptor and integrin signaling. Immunol. Rev. 218:29–44.
2.
Agramonte-Hevia, J.,, A. Gonzalez-Arenas,, D. Barrera, and, M. Velasco-Velazquez. 2002. Gram-negative bacteria and phagocytic cell interaction mediated by complement receptor 3. FEMS Immunol. Med. Microbiol. 34:255–266.
3.
Albert, M. L.,, J. I. Kim, and, R. B. Birge. 2000. alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells. Nat. Cell Biol. 2:899–905.
4.
Allen, L. A.,, and A. Aderem. 1996a. Mechanisms of phagocytosis. Curr. Opin. Immunol. 8:36–40.
5.
Allen, L. A.,, and A. Aderem. 1996b. Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages. J. Exp. Med. 184:627–637.
6.
Alon, R.,, and A. Etzioni. 2003. LAD-III, a novel group of leukocyte integrin activation deficiencies. Trends Immunol. 24:561–566.
7.
Arias-Salgado, E. G.,, S. Lizano,, S. Sarkar,, J. S. Brugge,, M. H. Ginsberg, and, S. J. Shattil. 2003. Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc. Natl. Acad. Sci. USA 100:13298–13302.
8.
Arnaout, M. A.,, R. F. Todd III,, N. Dana,, J. Melamed,, S. F. Schlossman, and, H. R. Colten. 1983. Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol). J. Clin. Invest. 72:171–179.
9.
Barsukov, I. L.,, A. Prescot,, N. Bate,, B. Patel,, D. N. Floyd,, N. Bhanji,, C. R. Bagshaw,, K. Letinic,, G. Di Paolo,, P. De Camilli,, G. C. Roberts, and, D. R. Critchley. 2003. Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain. J. Biol. Chem. 278:31202–31209.
10.
Berditchevski, F.,, and E. Odintsova. 1999. Characterization of integrin-tetraspanin adhesion complexes: role of tetraspanins in integrin signaling. J. Cell Biol. 146:477–492.
11.
Berditchevski, F.,, and E. Odintsova. 2007. Tetraspanins as regulators of protein trafficking. Traffic 8:89–96.
12.
Bergmeier, W.,, T. Goerge,, H. W. Wang,, J. R. Crittenden,, A. C. Baldwin,, S. M. Cifuni,, D. E. Housman,, A. M. Graybiel, and, D. D. Wagner. 2007. Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III. J. Clin. Invest. 117:1699–1707.
13.
Berlin, C.,, R. F. Bargatze,, J. J. Campbell,, U. H. von Andrian,, M. C. Szabo,, S. R. Hasslen,, R. D. Nelson,, E. L. Berg,, S. L. Erlandsen, and, E. C. Butcher. 1995. alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 80:413–422.
14.
Berton, G.,, L. Fumagalli,, C. Laudanna, and, C. Sorio. 1994. Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils. J. Cell Biol. 126:1111–1121.
15.
Berton, G.,, C. Laudanna,, C. Sorio, and, F. Rossi. 1992. Generation of signals activating neutrophil functions by leukocyte integrins: LFA-1 and gp150/95, but not CR3, are able to stimulate the respiratory burst of human neutrophils. J. Cell Biol. 116:1007–1017.
16.
Berton, G.,, A. Mocsai, and, C. A. Lowell. 2005. Src and Syk kinases: key regulators of phagocytic cell activation. Trends Immunol. 26:208–214.
17.
Blystone, S. D.,, S. E. Slater,, M. P. Williams,, M. T. Crow, and, E. J. Brown. 1999. A molecular mechanism of integrin crosstalk: alphavbeta3 suppression of calcium/calmodulin-dependent protein kinase II regulates alpha5beta1 function. J. Cell Biol. 145:889–897.
18.
Bohuslav, J.,, V. Horejsi,, C. Hansmann,, J. Stockl,, U. H. Weidle,, O. Majdic,, I. Bartke,, W. Knapp, and, H. Stockinger. 1995. Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes. J. Exp. Med. 181:1381–1390.
19.
Bos, J. L. 2005. Linking Rap to cell adhesion. Curr. Opin. Cell Biol. 17:123–128.
20.
Bowden, R. A.,, Z. M. Ding,, E. M. Donnachie,, T. K. Petersen,, L. H. Michael,, C. M. Ballantyne, and, A. R. Burns. 2002. Role of alpha4 integrin and VCAM-1 in CD18-independent neutrophil migration across mouse cardiac endothelium. Circ. Res. 90:562–569.
21.
Brown, E. J. 1991. Complement receptors and phagocytosis. Curr. Opin. Immunol. 3:76–82.
22.
Brown, E. J.,, J. F. Bohnsack, and, H. D. Gresham. 1988. Mechanism of inhibition of immunoglobulin G-mediated phagocytosis by monoclonal antibodies that recognize the Mac-1 antigen. J. Clin. Invest. 81:365–375.
23.
Brown, E. J.,, and W. A. Frazier. 2001. Integrin-associated protein (CD47) and its ligands. Trends Cell. Biol. 11:130–135.
24.
Bullock, W. E.,, and S. D. Wright. 1987. Role of the adherence-promoting receptors, CR3, LFA-1, and p150,95, in binding of Histoplasma capsulatum by human macrophages. J. Exp. Med. 165:195–210.
25.
Bunting, M.,, E. S. Harris,, T. M. McIntyre,, S. M. Prescott, and, G. A. Zimmerman. 2002. Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands. Curr. Opin. Hematol. 9:30–35.
26.
Calderwood, D. A.,, B. Yan,, J. M. de Pereda,, B. G. Alvarez,, Y. Fujioka,, R. C. Liddington, and, M. H. Ginsberg. 2002. The phosphotyrosine binding-like domain of talin activates integrins. J. Biol. Chem. 277:21749–21758.
27.
Capo, C.,, F. P. Lindberg,, S. Meconi,, Y. Zaffran,, G. Tardei,, E. J. Brown,, D. Raoult, and, J. L. Mege. 1999. Subversion of monocyte functions by Coxiella burnetii: impairment of the cross-talk between alphavbeta3 integrin and CR3. J. Immunol. 163:6078–6085.
28.
Capo, C.,, A. Moynault,, Y. Collette,, D. Olive,, E. J. Brown,, D. Raoult, and, J. L. Mege. 2003. Coxiella burnetii avoids macrophage phagocytosis by interfering with spatial distribution of complement receptor 3. J. Immunol. 170:4217–4225.
29.
Carman, C. V.,, and T. A. Springer. 2004. A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J. Cell Biol. 167:377–388.
30.
Caron, E.,, and A. Hall. 1998. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases. Science 282:1717–1721.
31.
Caron, E.,, A. J. Self, and, A. Hall. 2000. The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators. Curr. Biol. 10:974–978.
32.
Chang, Y.,, and S. C. Finnemann. 2007. Tetraspanin CD81 is required for the {alpha}vbeta5-integrin-dependent particle-binding step of RPE phagocytosis. J. Cell Sci. 120:3053–3063.
33.
Chen, H.,, A. Mocsai,, H. Zhang,, R. X. Ding,, J. H. Morisaki,, M. White,, J. M. Rothfork,, P. Heiser,, E. Colucci-Guyon,, C. A. Lowell,, H. D. Gresham,, P. M. Allen, and, E. J. Brown. 2003. Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading. Immunity 19:95–104.
34.
Constantin, G.,, M. Majeed,, C. Giagulli,, L. Piccio,, J. Y. Kim,, E. C. Butcher, and, C. Laudanna. 2000. Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow. Immunity 13:759–769.
35.
Cougoule, C.,, A. Wiedemann,, J. Lim, and, E. Caron. 2004. Phagocytosis, an alternative model system for the study of cell adhesion. Semin. Cell Dev. Biol. 15:679–689.
36.
Damsky, C. H.,, and Z. Werb. 1992. Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information. Curr. Opin. Cell. Biol. 4:772–781.
37.
DeMali, K. A.,, C. A. Barlow, and, K. Burridge. 2002. Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion. J. Cell Biol. 159:881–891.
38.
DeMali, K. A.,, K. Wennerberg, and, K. Burridge. 2003. Integrin signaling to the actin cytoskeleton. Curr. Opin. Cell Biol. 15:572–582.
39.
De Nichilo, M. O.,, and G. F. Burns. 1993. Granulocyte-macrophage and macrophage colony-stimulating factors differentially regulate alpha v integrin expression on cultured human macrophages. Proc. Natl. Acad. Sci. USA 90:2517–2721.
40.
Ding, Z. M.,, J. E. Babensee,, S. I. Simon,, H. Lu,, J. L. Perrard,, D. C. Bullard,, X. Y. Dai,, S. K. Bromley,, M. L. Dustin,, M. L. Entman,, C. W. Smith, and, C. M. Ballantyne. 1999. Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J. Immunol. 163:5029–5038.
41.
Eissenberg, L. G.,, and W. E. Goldman. 1987. Histoplasma capsulatum fails to trigger release of superoxide from macrophages. Infect. Immun. 55:29–34.
42.
Etienne-Manneville, S.,, and A. Hall. 2002. Rho GTPases in cell biology. Nature 420:629–635.
43.
Faccio, R.,, S. L. Teitelbaum,, K. Fujikawa,, J. Chappel,, A. Zallone,, V. L. Tybulewicz,, F. P. Ross, and, W. Swat. 2005. Vav3 regulates osteoclast function and bone mass. Nat. Med. 11:284–290.
44.
Feigelson, S. W.,, V. Grabovsky,, R. Shamri,, S. Levy, and, R. Alon. 2003. The CD81 tetraspanin facilitates instantaneous leukocyte VLA-4 adhesion strengthening to vascular cell adhesion molecule 1 (VCAM-1) under shear flow. J. Biol. Chem. 278:51203–51212.
45.
Feng, D.,, J. A. Nagy,, K. Pyne,, H. F. Dvorak, and, A. M. Dvorak. 1998. Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP. J. Exp. Med. 187:903–915.
46.
Gakidis, M. A.,, X. Cullere,, T. Olson,, J. L. Wilsbacher,, B. Zhang,, S. L. Moores,, K. Ley,, W. Swat,, T. Mayadas, and, J. S. Brugge. 2004. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J. Cell Biol. 166:273–282.
47.
Gao, A. G.,, F. P. Lindberg,, M. B. Finn,, S. D. Blystone,, E. J. Brown, and, W. A. Frazier. 1996. Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin. J. Biol. Chem. 271:21–24.
48.
Ghandour, H.,, X. Cullere,, F. W. Luscinskas, and, T. N. Mayadas. 2007. Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin-mediated human T cell adhesion. Blood 110:3682–3690.
49.
Ginsberg, M. H.,, A. Partridge, and, S. J. Shattil. 2005. Integrin regulation. Curr. Opin. Cell Biol. 17:509–516.
50.
Gopalan, P. K.,, C. W. Smith,, H. Lu,, E. L. Berg,, L. V. McIntire, and, S. I. Simon. 1997. Neutrophil CD18-dependent arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow can be activated through L-selectin. J. Immunol. 158:367–375.
51.
Graham, I. L.,, J. B. Lefkowith,, D. C. Anderson, and, E. J. Brown. 1993. Immune complex-stimulated neutrophil LTB4 production is dependent on beta 2 integrins. J. Cell Biol. 120:1509–1517.
52.
Gresham, H. D.,, I. L. Graham,, D. C. Anderson, and, E. J. Brown. 1991. Leukocyte adhesion-deficient neutrophils fail to amplify phagocytic function in response to stimulation. Evidence for CD11b/CD18-dependent and -independent mechanisms of phagocytosis. J. Clin Invest. 88:588–597.
53.
Griffiths, E. K.,, and J. M. Penninger. 2002. Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. Curr. Opin. Immunol. 14:317–322.
54.
Guerau-de-Arellano, M.,, J. Alroy,, D. Bullard, and, B. T. Huber. 2005. Aggravated Lyme carditis in CD11a−/−and CD11c−/− mice. Infect. Immun. 73:7637–7643.
55.
Hall, A. B.,, M. A. Gakidis,, M. Glogauer,, J. L. Wilsbacher,, S. Gao,, W. Swat, and, J. S. Brugge. 2006. Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity 24:305–316.
56.
Han, H.,, M. Fuortes, and, C. Nathan. 2003. Critical role of the carboxyl terminus of proline-rich tyrosine kinase (Pyk2) in the activation of human neutrophils by tumor necrosis factor: separation of signals for the respiratory burst and degranulation. J. Exp. Med. 197:63–75.
57.
Han, H.,, A. Stessin,, J. Roberts,, K. Hess,, N. Gautam,, M. Kamenetsky,, O. Lou,, E. Hyde,, N. Nathan,, W. A. Muller,, J. Buck,, L. R. Levin, and, C. Nathan. 2005. Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. J. Exp. Med. 202:353–361.
58.
Han, J.,, C. J. Lim,, N. Watanabe,, A. Soriani,, B. Ratnikov,, D. A. Calderwood,, W. Puzon-McLaughlin,, E. M. Lafuente,, V. A. Boussiotis,, S. J. Shattil, and, M. H. Ginsberg. 2006. Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr. Biol. 16:1796–1806.
59.
Hazenbos, W. L.,, B. M. van den Berg,, C. W. Geuijen,, F. R. Mooi, and, R. van Furth. 1995. Binding of FimD on Bordetella pertussis to very late antigen-5 on monocytes activates complement receptor type 3 via protein tyrosine kinases. J. Immunol. 155:3972–3978.
60.
Hazenbos, W. L.,, B. M. van den Berg, and, R. van Furth. 1993. Very late antigen-5 and complement receptor type 3 cooperatively mediate the interaction between Bordetella pertussis and human monocytes. J. Immunol. 151:6274–6282.
61.
Heit, B.,, P. Colarusso, and, P. Kubes. 2005. Fundamentally different roles for LFA-1, Mac-1 and alpha4-integrin in neutrophil chemotaxis. J. Cell Sci. 118:5205–5220.
62.
Hemler, M. E. 2005. Tetraspanin functions and associated microdomains. Nat. Rev. Mol. Cell Biol. 6:801–811.
63.
Henderson, R. B.,, J. A. Hobbs,, M. Mathies, and, N. Hogg. 2003. Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood 102:328–335.
64.
Henderson, R. B.,, L. H. Lim,, P. A. Tessier,, F. N. Gavins,, M. Mathies,, M. Perretti, and, N. Hogg. 2001. The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha4 integrin in the inflammatory response of neutrophils. J. Exp. Med. 194:219–226.
65.
Hendey, B.,, M. Lawson,, E. E. Marcantonio, and, F. R. Maxfield. 1996. Intracellular calcium and calcineurin regulate neutrophil motility on vitronectin through a receptor identified by antibodies to integrins alphav and beta3. Blood 87:2038–2048.
66.
Hogg, N.,, and B. Leitinger. 2001. Shape and shift changes related to the function of leukocyte integrins LFA-1 and Mac-1. J. Leukoc. Biol. 69:893–898.
67.
Hynes, R. O. 2002. Integrins: bidirectional, allosteric signaling machines. Cell 110:673–687.
68.
Ibbotson, G. C.,, C. Doig,, J. Kaur,, V. Gill,, L. Ostrovsky,, T. Fairhead, and, P. Kubes. 2001. Functional alpha4-integrin: a newly identified pathway of neutrophil recruitment in critically ill septic patients. Nat. Med. 7:465–470.
69.
Imhof, B. A.,, and M. Aurrand-Lions. 2004. Adhesion mechanisms regulating the migration of monocytes. Nat. Rev. Immunol. 4:432–444.
70.
Ishibashi, Y.,, S. Claus, and, D. A. Relman. 1994. Bordetella pertussis filamentous hemagglutinin interacts with a leukocyte signal transduction complex and stimulates bacterial adherence to monocyte CR3 (CD11b/CD18). J. Exp. Med. 180:1225–1233.
71.
Jiang, P.,, C. F. Lagenaur, and, V. Narayanan. 1999. Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J. Biol. Chem. 274:559–562.
72.
Joiner, K. A.,, T. Ganz,, J. Albert, and, D. Rotrosen. 1989. The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes. J. Cell Biol. 109:2771–2782.
73.
Jones, S. L.,, U. G. Knaus,, G. M. Bokoch, and, E. J. Brown. 1998. Two signaling mechanisms for activation of alphaM beta2 avidity in polymorphonuclear neutrophils. J. Biol. Chem. 273:10556–10566.
74.
Kaplan, G. 1977. Differences in the mode of phagocytosis with Fc and C3 receptors in macrophages. Scand. J. Immunol. 6:797–807.
75.
Katagiri, K.,, M. Hattori,, N. Minato,, S. Irie,, K. Takatsu, and, T. Kinashi. 2000. Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase. Mol. Cell Biol. 20:1956–1969.
76.
Katagiri, K.,, A. Maeda,, M. Shimonaka, and, T. Kinashi. 2003. RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. Nat. Immunol. 4:741–748.
77.
Katagiri, K.,, N. Ohnishi,, K. Kabashima,, T. Iyoda,, N. Takeda,, Y. Shinkai,, K. Inaba, and, T. Kinashi. 2004. Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. Nat. Immunol. 5:1045–1051.
78.
Kim, M.,, C. V. Carman, and, T. A. Springer. 2003. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 301:1720–1725.
79.
Kinashi, T.,, and K. Katagiri. 2004. Regulation of lymphocyte adhesion and migration by the small GTPase Rap1 and its effector molecule, RAPL. Immunol. Lett. 93:1–5.
80.
Kucik, D. F.,, M. L. Dustin,, J. M. Miller, and, E. J. Brown. 1996. Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes. J. Clin. Invest. 97:2139–2144.
81.
Kurth, I.,, K. Willimann,, P. Schaerli,, T. Hunziker,, I. Clark-Lewis, and, B. Moser. 2001. Monocyte selectivity and tissue localization suggests a role for breast and kidney-expressed chemokine (BRAK) in macrophage development. J. Exp. Med. 194:855–861.
82.
Lafuente, E. M.,, A. A. van Puijenbroek,, M. Krause,, C. V. Carman,, G. J. Freeman,, A. Berezovskaya,, E. Constantine,, T. A. Springer,, F. B. Gertler, and, V. A. Boussiotis. 2004. RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev. Cell 7:585–595.
83.
Ley, K. 2002. Integration of inflammatory signals by rolling neutrophils. Immunol. Rev. 186:8–18.
84.
Li, R.,, N. Mitra,, H. Gratkowski,, G. Vilaire,, R. Litvinov,, C. Nagasami,, J. W. Weisel,, J. D. Lear,, W. F. DeGrado, and, J. S. Bennett. 2003. Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science 300:795–798.
85.
Lindberg, F. P.,, D. C. Bullard,, T. E. Caver,, H. D. Gresham,, A. L. Beaudet, and, E. J. Brown. 1996. Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Science 274:795–798.
86.
Lowell, C. A. 2006. Rewiring phagocytic signal transduction. Immunity 24:243–245.
87.
Lowell, C. A.,, and G. Berton. 1998. Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr. Proc. Natl. Acad. Sci. USA 95:7580–7584.
88.
Luo, B. H.,, C. V. Carman, and, T. A. Springer. 2007. Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 25:619–647.
89.
Martel, V.,, C. Racaud-Sultan,, S. Dupe,, C. Marie,, F. Paulhe,, A. Galmiche,, M. R. Block, and, C. Albiges-Rizo. 2001. Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides. J. Biol. Chem. 276:21217–21227.
90.
May, R. C.,, E. Caron,, A. Hall, and, L. M. Machesky. 2000. Involvement of the Arp2/3 complex in phagocytosis mediated by FcgammaR or CR3. Nat. Cell Biol. 2:246–248.
91.
McHugh, K. P.,, K. Hodivala-Dilke,, M. H. Zheng,, N. Namba,, J. Lam,, D. Novack,, X. Feng,, F. P. Ross,, R. O. Hynes, and, S. L. Teitelbaum. 2000. Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J. Clin. Invest. 105:433–440.
92.
Meng, F.,, and C. A. Lowell. 1998. A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. EMBO J. 17:4391–4403.
93.
Middleton, J.,, A. M. Patterson,, L. Gardner,, C. Schmutz, and, B. A. Ashton. 2002. Leukocyte extravasation: chemokine transport and presentation by the endothelium. Blood 100:3853–3860.
94.
Mocsai, A.,, C. L. Abram,, Z. Jakus,, Y. Hu,, L. L. Lanier, and, C. A. Lowell. 2006. Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat. Immunol. 7:1326–1333.
95.
Mocsai, A.,, M. B. Humphrey,, J. A. Van Ziffle,, Y. Hu,, A. Burghardt,, S. C. Spusta,, S. Majumdar,, L. L. Lanier,, C. A. Lowell, and, M. C. Nakamura. 2004. The immunomodula-tory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc. Natl. Acad. Sci. USA 101:6158–6163.
96.
Mocsai, A.,, M. Zhou,, F. Meng,, V. L. Tybulewicz, and, C. A. Lowell. 2002. Syk is required for integrin signaling in neutrophils. Immunity 16:547–558.
97.
Mosser, D. M.,, and P. J. Edelson. 1985. The mouse macrophage receptor for C3bi (CR3) is a major mechanism in the phagocytosis of Leishmania promastigotes. J. Immunol. 135:2785–2789.
98.
Mosser, D. M.,, and P. J. Edelson. 1987. The third component of complement (C3) is responsible for the intracellular survival of Leishmania major. Nature 327:329–331.
99.
Nathan, C.,, S. Srimal,, C. Farber,, E. Sanchez,, L. Kabbash,, A. Asch,, J. Gailit, and, S. D. Wright. 1989. Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins. J. Cell Biol. 109:1341–1349.
100.
Nishida, N.,, C. Xie,, M. Shimaoka,, Y. Cheng,, T. Walz, and, T. A. Springer. 2006. Activation of leukocyte beta2 integrins by conversion from bent to extended conformations. Immunity 25:583–594.
101.
Olazabal, I. M.,, E. Caron,, R. C. May,, K. Schilling,, D. A. Knecht, and, L. M. Machesky. 2002. Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcgammaR, phagocytosis. Curr. Biol. 12:1413–1418.
102.
Pasvolsky, R.,, S. W. Feigelson,, S. S. Kilic,, A. J. Simon,, G. Tal-Lapidot,, V. Grabovsky,, J. R. Crittenden,, N. Amariglio,, M. Safran,, A. M. Graybiel,, G. Rechavi,, S. Ben-Dor,, A. Etzioni, and, R. Alon. 2007. A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets. J. Exp. Med. 204:1571–1582.
103.
Pereira, S.,, H. Zhang,, T. Takai, and, C. A. Lowell. 2004. The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling. J. Immunol. 173:5757–5765.
104.
Pfeiffer, A.,, A. Bottcher,, E. Orso,, M. Kapinsky,, P. Nagy,, A. Bodnar,, I. Spreitzer,, G. Liebisch,, W. Drobnik,, K. Gempel,, M. Horn,, S. Holmer,, T. Hartung,, G. Multhoff,, G. Schutz,, H. Schindler,, A. J. Ulmer,, H. Heine,, F. Stelter,, C. Schutt,, G. Rothe,, J. Szollosi,, S. Damjanovich, and, G. Schmitz. 2001. Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts. Eur. J. Immunol. 31:3153–3164.
105.
Prince, J. E.,, C. F. Brayton,, M. C. Fossett,, J. A. Durand,, S. L. Kaplan,, C. W. Smith, and, C. M. Ballantyne. 2001. The differential roles of LFA-1 and Mac-1 in host defense against systemic infection with Streptococcus pneumoniae. J. Immunol. 166:7362–7369.
106.
Reedquist, K. A.,, E. Ross,, E. A. Koop,, R. M. Wolthuis,, F. J. Zwartkruis,, Y. van Kooyk,, M. Salmon,, C. D. Buckley, and, J. L. Bos. 2000. The small GTPase, Rap1, mediates CD31-induced integrin adhesion. J. Cell Biol. 148:1151–1158.
107.
Relman, D.,, E. Tuomanen,, S. Falkow,, D. T. Golenbock,, K. Saukkonen, and, S. D. Wright. 1990. Recognition of a bacterial adhesion by an integrin: macrophage CR3 (alpha M beta 2, CD11b/CD18) binds filamentous hemagglutinin of Bordetella pertussis. Cell 61:1375–1382.
108.
Rose, D. M.,, R. Alon, and, M. H. Ginsberg. 2007. Integrin modulation and signaling in leukocyte adhesion and migration. Immunol. Rev. 218:126–134.
109.
Ross, F. P.,, and S. L. Teitelbaum. 2005. alphavbeta3 and macrophage colony-stimulating factor: partners in osteoclast biology. Immunol. Rev. 208:88–105.
110.
Russell, D. G.,, and S. D. Wright. 1988. Complement receptor type 3 (CR3) binds to an Arg-Gly-Asp-containing region of the major surface glycoprotein, gp63, of Leishmania promastigotes. J. Exp. Med. 168:279–292.
111.
Saukkonen, K.,, C. Cabellos,, M. Burroughs,, S. Prasad, and, E. Tuomanen. 1991. Integrin-mediated localization of Bordetella pertussis within macrophages: role in pulmonary colonization. J. Exp. Med. 173:1143–1149.
112.
Savill, J.,, I. Dransfield,, N. Hogg, and, C. Haslett. 1990. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature 343:170–173.
113.
Sebzda, E.,, M. Bracke,, T. Tugal,, N. Hogg, and, D. A. Cantrell. 2002. Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling. Nat. Immunol. 3:251–258.
114.
Sheppard, D. 2005. Integrin-mediated activation of latent transforming growth factor beta. Cancer Metastasis Rev. 24:395–402.
115.
Shimaoka, M.,, C. Lu,, R. T. Palframan,, U. H. von Andrian,, A. McCormack,, J. Takagi, and, T. A. Springer. 2001. Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo. Proc. Natl. Acad. Sci. USA 98:6009–6014.
116.
Simon, D. I.,, Y. Wei,, L. Zhang,, N. K. Rao,, H. Xu,, Z. Chen,, Q. Liu,, S. Rosenberg, and, H. A. Chapman. 2000. Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function. J. Biol. Chem. 275:10228–10234.
117.
Singer, I. I.,, S. Scott,, D. W. Kawka, and, D. M. Kazazis. 1989. Adhesomes: specific granules containing receptors for laminin, C3bi/fibrinogen, fibronectin, and vitronectin in human polymorphonuclear leukocytes and monocytes. J. Cell Biol. 109:3169–3182.
118.
Soriano, P.,, C. Montgomery,, R. Geske, and, A. Bradley. 1991. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64:693–702.
119.
Springer, T. A. 1990. Adhesion receptors of the immune system. Nature 346:425–434.
120.
Stouffer, G. A.,, and S. S. Smyth. 2003. Effects of thrombin on interactions between beta3-integrins and extracellular matrix in platelets and vascular cells. Arterioscler. Thromb. Vasc. Biol. 23:1971–1978.
121.
Suen, P. W.,, D. Ilic,, E. Caveggion,, G. Berton,, C. H. Damsky, and, C. A. Lowell. 1999. Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages. J. Cell Sci. 112(Pt 22):4067–4078.
122.
Suzuki, S.,, and Y. Naitoh. 1990. Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells. EMBO J. 9:757–763.
123.
Tadokoro, S.,, S. J. Shattil,, K. Eto,, V. Tai,, R. C. Liddington,, J. M. de Pereda,, M. H. Ginsberg, and, D. A. Calderwood. 2003. Talin binding to integrin beta tails: a final common step in integrin activation. Science 302:103–106.
124.
Talamas-Rohana, P.,, S. D. Wright,, M. R. Lennartz, and, D. G. Russell. 1990. Lipophosphoglycan from Leishmania mexicana promastigotes binds to members of the CR3, p150,95 and LFA-1 family of leukocyte integrins. J. Immunol. 144:4817–4824.
125.
Tang, T.,, A. Rosenkranz,, K. J. Assmann,, M. J. Goodman,, J. C. Gutierrez-Ramos,, M. C. Carroll,, R. S. Cotran, and, T. N. Mayadas. 1997. A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis. J. Exp. Med. 186:1853–1863.
126.
Teitelbaum, S. L. 2007. Osteoclasts: what do they do and how do they do it? Am. J. Pathol. 170:427–435.
127.
Teitelbaum, S. L.,, and F. P. Ross. 2003. Genetic regulation of osteoclast development and function. Nat. Rev. Genet. 4:638–649.
128.
Thrasher, A. J. 2002. WASp in immune-system organization and function. Nat. Rev. Immunol. 2:635–646.
129.
Travis, M. A.,, B. Reizis,, A. C. Melton,, E. Masteller,, Q. Tang,, J. M. Proctor,, Y. Wang,, X. Bernstein,, X. Huang,, L. F. Reichardt,, J. A. Bluestone, and, D. Sheppard. 2007. Loss of integrin alpha(v)beta(8) on dendritic cells causes autoimmunity and colitis in mice. Nature 449:361–365.
130.
Van, V. Q.,, S. Lesage,, S. Bouguermouh,, P. Gautier,, M. Rubio,, M. Levesque,, S. Nguyen,, L. Galibert, and, M. Sarfati. 2006. Expression of the self-marker CD47 on dendritic cells governs their trafficking to secondary lymphoid organs. EMBO J. 25:5560–5568.
131.
Van Furth, R.,, and Z. A. Cohn. 1968. The origin and kinetics of mononuclear phagocytes. J. Exp. Med. 128:415–435.
132.
Van Furth, R.,, M. M. C. Diesselhoff-den Dulk,, W. Sluiter, and, J. T. Van Dissel. 1985. New perspectives on the kinetics of mononuclear phagocytes. In R. Van Furth (ed.), Mono-nuclear Phagocytes: Characteristics, Physiology, & Function. Proceedings of the Fourth Conference on Mononuclear Phagocytes. Martinus Nijhoff, Leiden, The Netherlands.
133.
Van Spriel, A. B.,, J. H. Leusen,, M. van Egmond,, H. B. Dijkman,, K. J. Assmann,, T. N. Mayadas, and, J. G. van de Winkel. 2001. Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation. Blood 97:2478–2486.
134.
Van Strijp, J. A.,, D. G. Russell,, E. Tuomanen,, E. J. Brown, and, S. D. Wright. 1993. Ligand specificity of purified complement receptor type three (CD11b/CD18, alpha m beta 2, Mac-1). Indirect effects of an Arg-Gly-Asp (RGD) sequence. J. Immunol. 151:3324–3336.
135.
Vedder, N. B.,, and J. M. Harlan. 1988. Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium. J. Clin. Invest. 81:676–682.
136.
Vestweber, D. 2007. Adhesion and signaling molecules controlling the transmigration of leukocytes through endothelium. Immunol. Rev. 218:178–196.
137.
Vicentini, L.,, P. Mazzi,, E. Caveggion,, S. Continolo,, L. Fumagalli,, J. A. Lapinet-Vera,, C. A. Lowell, and, G. Berton. 2002. Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation. J. Immunol. 168:6446–6454.
138.
Vinogradova, O.,, A. Velyvis,, A. Velyviene,, B. Hu,, T. Haas,, E. Plow, and, J. Qin. 2002. A structural mechanism of integrin alpha(IIb)beta(3) “inside-out” activation as regulated by its cytoplasmic face. Cell 110:587–597.
139.
Wang, J.,, and E. J. Brown. 1999. Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A. J. Biol. Chem. 274:24349–24356.
140.
Wetzel, A.,, T. Chavakis,, K. T. Preissner,, M. Sticherling,, U. F. Haustein,, U. Anderegg, and, A. Saalbach. 2004. Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J. Immunol. 172:3850–3859.
141.
Wright, S. D. 1991. Multiple receptors for endotoxin. Curr. Opin. Immunol. 3:83–90.
142.
Wright, S. D.,, M. R. Licht,, L. S. Craigmyle, and, S. C. Silverstein. 1984. Communication between receptors for different ligands on a single cell: ligation of fibronectin receptors induces a reversible alteration in the function of complement receptors on cultured human monocytes. J. Cell Biol. 99:336–339.
143.
Wright, S. D.,, and S. C. Silverstein. 1983. Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes. J. Exp. Med. 158:2016–2023.
144.
Xiong, J. P.,, T. Stehle,, B. Diefenbach,, R. Zhang,, R. Dunker,, D. L. Scott,, A. Joachimiak,, S. L. Goodman, and, M. A. Arnaout. 2001. Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science 294:339–345.
145.
Xue, W.,, A. L. Kindzelskii,, R. F. Todd III, and, H. R. Petty. 1994. Physical association of complement receptor type 3 and urokinase-type plasminogen activator receptor in neutrophil membranes. J. Immunol. 152:4630–4640.
146.
Yan, S. R.,, M. Huang, and, G. Berton. 1997. Signaling by adhesion in human neutrophils: activation of the p72syk tyrosine kinase and formation of protein complexes containing p72syk and Src family kinases in neutrophils spreading over fibrinogen. J. Immunol. 158:1902–1910.
147.
Yang, Z.,, Z. Mu,, B. Dabovic,, V. Jurukovski,, D. Yu,, J. Sung,, X. Xiong, and, J. S. Munger. 2007. Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice. J. Cell Biol. 176:787–793.
148.
Zhang, H.,, U. Y. Schaff,, C. E. Green,, H. Chen,, M. R. Sarantos,, Y. Hu,, D. Wara,, S. I. Simon, and, C. A. Lowell. 2006. Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils. Immunity 25:285–295.
149.
Zhou, M.,, R. F. Todd, 3rd,, J. G. van de Winkel, and, H. R. Petty. 1993. Cocapping of the leukoadhesin molecules complement receptor type 3 and lymphocyte function-associated antigen-1 with Fc gamma receptor III on human neutrophils. Possible role of lectin-like interactions. J. Immunol. 150:3030–3041.
150.
Zou, W.,, H. Kitaura,, J. Reeve,, F. Long,, V. L. Tybulewicz,, S. J. Shattil,, M. H. Ginsberg,, F. P. Ross, and, S. L. Teitelbaum. 2007. Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J. Cell Biol. 176:877–888.
Tables
Integrins on Phagocytes
[com.pub2web.rdf.cci.facet.ContentItem[id=http://asm.metastore.ingenta.com/content/author/10.1128/9781555816650.ch08-1,webId=/content/author/10.1128/9781555816650.ch08-1,properties={foaf_givenname=Wouter L. W., foaf_name=Wouter L. W. Hazenbos, foaf_surname=Hazenbos, pub_isAffiliatedWith=[com.pub2web.rdf.cci.facet.ContentItem[id=http://asm.metastore.ingenta.com/content/affiliation/10.1128/9781555816650.ch08-aff1]]}], com.pub2web.rdf.cci.facet.ContentItem[id=http://asm.metastore.ingenta.com/content/author/10.1128/9781555816650.ch08-2,webId=/content/author/10.1128/9781555816650.ch08-2,properties={foaf_givenname=Eric J., foaf_name=Eric J. Brown, foaf_surname=Brown, pub_isAffiliatedWith=[com.pub2web.rdf.cci.facet.ContentItem[id=http://asm.metastore.ingenta.com/content/affiliation/10.1128/9781555816650.ch08-aff2]]}]]
Citation:
Hazenbos W, Brown E.
2009.
Integrins on Phagocytes,
p 137-152.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch8
/content/10.1128/9781555816650.ch08.ch08tab01
TABLE 1
Integrins on phagocytes
a
TABLE 1
Integrins on phagocytes a
Citation:
Hazenbos W, Brown E.
2009.
Integrins on Phagocytes,
p 137-152.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch8