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Chapter 19 : Macrophage Classical Activation

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Abstract:

This chapter focuses on the critical steps of classical macrophage activation that have been emphasized by rare human diseases in which key components such as macrophages, are naturally deficient. In conjunction with other cells, macrophages will form granulomas. Numerous molecules are definitely or putatively involved in this process, and a few have been identified by natural mutations. The author reviews these through an arbitrary and artificial division of the proinflammatory response into premacrophage, intramacrophage, and post-macrophage phases. The activated TAK-1 activates the IκB kinase (IKK) complex; this complex is composed of two catalytic subunits, IKK αand IKK β, and the regulatory subunit IKKγ. Peripheral blood monocytes and primary macrophage cultures from patients with classical Wiskott-Aldrich syndrome (WAS) also demonstrate impaired FcγR-mediated phagocytosis due to defective phagocytic cup formation. Previous explanations for the selective infection susceptibility in chronic granulomatous disease (CGD) relied on microbial catalase as a critical virulence factor. The argument was that, whereas CGD phagocytes lacked superoxide and hydrogen peroxide production, hydrogen peroxide-producing microbes would complement the defect in the CGD cell unless they also produced catalase to degrade their own hydrogen peroxide. In summary, CGD neutrophils and macrophages are defective in O production. The phagosome gradually acquires molecules necessary for lysosomal fusion to produce the phagolysosome. Defects in lysosomal degradation typically result in intracellular accumulation of undegraded substrates, characterized by neurodegeneration without associated immunodeficiency. The classically activated macrophage is an IFN-γ -primed cell that recognizes, via specific cell surface receptors, microbes and their products.

Citation: Vinh D, Holland S. 2009. Macrophage Classical Activation, p 301-323. In Russell D, Gordon S (ed), Phagocyte-Pathogen Interactions. ASM Press, Washington, DC. doi: 10.1128/9781555816650.ch19

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Figures

Image of FIGURE 1
FIGURE 1

TLRs are pattern-recognition receptors that distinguish among PAMPs. Structurally, TLRs contain extracellular leucine-rich repeats responsible for recognition of their respective PAMPs, a transmembrane domain that determines their cellular localization and an intracellular domain that mediates signaling pathways. Ligand binding induces TLR oligomerization or heterodimerization, responsible for PAMP specificity; subsequent recruitment of a particular network of adaptor proteins allows for specific intracellular signaling. Here, TLR4-mediated signaling is depicted (see text for details). Selected ligands for the 10 human TLRs are shown here as follows: TLR1, triacyl lipopeptides (LP); TLR2, peptidoglycan (PG); TLR3, double-stranded RNA (dsRNA); TLR4, lipopolysaccharide (LPS); TLR5, flagellin (Fl); TLR6, diacyl lipopeptides (DALP); TLR7, imiquimod (Im); TLR8, single-stranded RNA (ssRNA); TLR9, unmethylated CpG dinucleotides (CpG); TLR10, undefined.

Citation: Vinh D, Holland S. 2009. Macrophage Classical Activation, p 301-323. In Russell D, Gordon S (ed), Phagocyte-Pathogen Interactions. ASM Press, Washington, DC. doi: 10.1128/9781555816650.ch19
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Image of FIGURE 2
FIGURE 2

Critical components for macrophage phagocytosis and phagosomal maturation to form the phagolysosome. Key molecules are listed (see text for details). Opsonization with IgG allows for FcγR-mediated internalization of pathogens or particles (ingestion). Subsequently, various kinases and secondary messenger molecules allow for reorganization of the macrophage cytoskeleton, specifically, actin assembly at the plasma membrane area engaged with the opsonized pathogen and the formation of cell membrane protrusions (phagocytic cup). Continuous growth of these protrusions allows for pseudopods to surround the pathogen, allowing for subsequent engulfment. The nascent phagosome, containing the pathogen, moves centripetally via myosins and other intracellular machinery. Maturation of the phagosome requires coordinated fusion with various vesicles, including the early endosome, the late endosome, and the lysosome, during which the protein content of both the phagosome membrane and the phagosome lumen are modified.

Citation: Vinh D, Holland S. 2009. Macrophage Classical Activation, p 301-323. In Russell D, Gordon S (ed), Phagocyte-Pathogen Interactions. ASM Press, Washington, DC. doi: 10.1128/9781555816650.ch19
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Image of FIGURE 3
FIGURE 3

The macrophage respiratory burst. Early in the process following phagocytosis, the NADPH oxidase assembles on the phagosome. This multisubunit enzyme complex allows for the respiratory (or oxidative) burst, whereby ROS (i.e., superoxide anion [O ] and hydrogen peroxide [HO]) are generated within the phagosome. The ROS contribute to pathogen killing, primarily by activating pathways culminating in the expression of proinflammatory genes.

Citation: Vinh D, Holland S. 2009. Macrophage Classical Activation, p 301-323. In Russell D, Gordon S (ed), Phagocyte-Pathogen Interactions. ASM Press, Washington, DC. doi: 10.1128/9781555816650.ch19
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Image of FIGURE 4
FIGURE 4

Cytokine networks critical for classical macrophage activation. On interaction with select intracellular pathogens, activated macrophages produce proinflammatory cytokines that act in a paracrine or autocrine manner to augment intracellular killing mechanisms.

Citation: Vinh D, Holland S. 2009. Macrophage Classical Activation, p 301-323. In Russell D, Gordon S (ed), Phagocyte-Pathogen Interactions. ASM Press, Washington, DC. doi: 10.1128/9781555816650.ch19
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References

/content/book/10.1128/9781555816650.ch19
1. Ackerman, A. L.,, and P. Cresswell. 2004. Cellular mechanisms governing cross-presentation of exogenous antigens. Nat. Immunol. 5:678684.
2. Adams, D. O.,, and T. A. Hamilton. 1984. The cell biology of macrophage activation. Annu. Rev. Immunol. 2:283318.
3. Akira, S.,, and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4:499511.
4. Almyroudis, N. G.,, S. M. Holland, and, B. H. Segal. 2005. Invasive aspergillosis in primary immunodeficiencies. Med. Mycol. 43:247259.
5. Ambruso, D. R.,, C. Knall,, A. N. Abell,, J. Panepinto,, A. Kurkchubasche,, G. Thurman,, G. Gonzalez-Aller,, A. Hiester,, M. deBoer,, R. J. Harbeck,, R. Oyer,, G. L. Johnson, and, D. Roos. 2000. Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. Proc. Natl. Acad. Sci. USA 97:46544659.
6. Anderson, P.,, K. Phillips,, G. Stoecklin, and, N. Kedersha. 2004. Post-transcriptional regulation of proinflammatory proteins. J. Leukoc. Biol. 76:4247.
7. Babior, B. M. 1984. The respiratory burst of phagocytes. J. Clin. Investig. 73:599601.
8. Bach, E. A.,, M. Aguet, and, R. D. Schreiber. 1997. The IFN[gamma] receptor: a paradigm for cytokine receptor signaling. Annu. Rev. Immunol. 15:563591.
9. Brode, S.,, and P. A. Macary. 2004. Cross-presentation: dendritic cells and macrophages bite off more than they can chew! Immunology 112:345351.
10. Brown, G. D.,, P. R. Taylor,, D. M. Reid,, J. A. Willment,, D. L. Williams,, L. Martinez-Pomares,, S. Y. Wong, and, S. Gordon. 2002. Dectin-1 is a major [beta]-glucan receptor on macrophages. J. Exp. Med. 196:40712.
11. Burgdorf, S.,, V. Lukacs-Kornek, and, C. Kurts. 2006. The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation. J. Immunol. 176:67706776.
12. Cai, H.,, K. Reinisch, and, S. Ferro-Novick. 2007. Coats, tethers, rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle. Dev. Cell 12:671682.
13. Carmody, R. J.,, and Y. H. Chen. 2007. Nuclear factor-kappaB: activation and regulation during toll-like receptor signaling. Cell. Mol. Immunol. 4:3141.
14. Carreno, B. M.,, and M. Collins. 2002. The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu. Rev. Immunol. 20:2953.
15. Cathcart, M. K. 2004. Regulation of superoxide anion production by NADPH oxidase in monocytes/macrophages: contributions to atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 24:2328.
16. Celada, A.,, M. J. Klemsz, and, R. A. Maki. 1989. Interferon-gamma activates multiple pathways to regulate the expression of the genes for major histocompatibility class II I-A beta, tumor necrosis factor and complement component C3 in mouse macrophages. Eur. J. Immunol. 19:11031109.
17. Cerretti, D. P.,, K. Poindexter,, B. J. Castner,, G. Means,, N. G. Copeland,, D. J. Gilbert,, N. A. Jenkins,, R. A. Black, and, N. Nelson. 1999. Characterization of the cDNA and gene for mouse tumour necrosis factor [alpha] converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25. Cytokine 11:541551.
18. Chang, Y. C.,, B. H. Segal,, S. M. Holland,, G. F. Miller, and, K. J. Kwon-Chung. 1998. Virulence of catalase-deficient aspergillus nidulans in p47(phox)−/− mice. Implications for fungal pathogenicity and host defense in chronic granulomatous disease. J. Clin. Investig. 101:18431845.
19. Chapgier, A.,, S. Boisson-Dupuis,, E. Jouanguy,, G. Vogt,, J. Feinberg,, A. Prochnicka-Chalufour,, A. Casrouge,, K. Yang,, C. Soudais,, C. Fieschi,, O. F. Santos,, J. Bustamante,, C. Picard,, L. de Beaucoudrey,, J. F. Emile,, P. D. Arkwright,, R. D. Schreiber,, C. Rolinck-Werninghaus,, A. Rösen-Wolff,, K. Magdorf,, J. Roesler, and, J. L. Casanova. 2006. Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease. PLoS Genet. 2:e131.
20. Chapgier, A.,, R. F. Wynn,, E. Jouanguy,, O. Filipe-Santos,, S. Zhang,, J. Feinberg,, K. Hawkins,, J. L. Casanova, and, P. D. Arkwright. 2006. Human complete Stat-1 deficiency is associated with defective type I and II IFN responses in vitro but immunity to some low virulence viruses in vivo. J. Immunol. 176:50785083.
21. Chavrier, P.,, and B. Goud. 1999. The role of ARF and Rab GTPases in membrane transport. Curr. Opin. Cell. Biol. 11:466475.
22. Chua, J.,, and V. Deretic. 2004. Mycobacterium tuberculosis reprograms waves of phosphatidylinositol 3-phosphate on phagosomal organelles. J. Biol. Chem. 279:3698236992.
23. Claus, V.,, A. Jahraus,, T. Tjelle,, T. Berg,, H. Kirschke,, H. Faulstich, and, G. Griffiths. 1998. Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages. Enrichment of cathepsin H in early endosomes. J. Biol. Chem. 273:98429851.
24. Clemens, D. L.,, B. Y. Lee, and, M. A. Horwitz. 2000a. Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate. Infect. Immun. 68:26712684.
25. Clemens, D. L.,, B.-Y. Lee, and, M. A. Horwitz. 2000b. Mycobacterium tuberculosis and Legionella pneumophila phagosomes exhibit arrested maturation despite acquisition of Rab7. Infect. Immun. 68:51545166.
26. Courtois, G. 2005. The NF-kappaB signaling pathway in human genetic diseases. Cell. Mol. Life Sci. 62:16821691.
27. Courtois, G.,, A. Smahi,, J. Reichenbach,, R. Döffinger,, C. Cancrini,, M. Bonnet,, A. Puel,, C. Chable-Bessia,, S. Yamaoka,, J. Feinberg,, S. Dupuis-Girod,, C. Bodemer,, S. Livadiotti,, F. Novelli,, P. Rossi,, A. Fischer,, A. Israël,, A. Munnich,, F. Le Deist, and, J. L. Casanova. 2003. A hypermorphic I[kappa]B[alpha] mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency. J. Clin. Investig. 112:11081115.
28. Cross, A. R. 2000. p40(phox) participates in the activation of NADPH oxidase by increasing the affinity of p47(phox) for flavocytochrome b(558). Biochem. J. 349:113117.
29. Crowley, M. T.,, P. S. Costello,, C. J. Fitzer-Attas,, M. Turner,, F. Meng,, C. Lowell,, V. L. Tybulewicz, and, A. L. DeFranco. 1997. A critical role for Syk in signal transduction and phagocytosis mediated by fcgamma receptors on macrophages. J. Exp. Med. 186:10271039.
30. DeLeo, F. R.,, L. A. Allen,, M. Apicella, and, W. M. Nauseef. 1999. NADPH oxidase activation and assembly during phagocytosis. J. Immunol. 163:67326740.
31. Deretic, V.,, S. Singh,, S. Master,, J. Harris,, E. Roberts,, G. Kyei,, A. Davis,, S. de Haro,, J. Naylor,, H. H. Lee, and, I. Vergne. 2006. Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism. Cell. Microbiol. 8:719727.
32. Doffinger, R.,, E. Jouanguy,, S. Dupuis,, M. C. Fondanèche,, J. L. Stephan,, J. F. Emile,, S. Lamhamedi-Cherradi,, F. Altare,, A. Pallier,, G. Barcenas-Morales,, E. Meinl,, C. Krause,, S. Pestka,, R. D. Schreiber,, F. Novelli, and, J. L. Casanova. 2000. Partial interferon gamma receptor signaling chain deficiency in a patient with Bacille Calmette Guérin and Mycobacterium abscessus infection. J. Infect. Dis. 181:379384.
33. Dorman, S. E.,, and S. M. Holland. 1998. Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection. J. Clin. Investig. 101:23642369.
34. Dorman, S. E.,, C. Picard,, D. Lammas,, K. Heyne,, J. T. van Dissel,, R. Baretto,, S. D. Rosenzweig,, M. Newport,, M. Levin,, J. Roesler,, D. Kumararatne,, J. L. Casanova, and, S. M. Holland. 2004. Clinical features of dominant and recessive interferon [gamma] receptor 1 deficiencies. Lancet 364:21132121.
35. Drose, S.,, and K. Altendorf. 1997. Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases. J. Exp. Biol. 200:18.
36. D’Souza-Schorey, C.,, R. L. Boshans,, M. McDonough,, P. D. Stahl, and, L. Van Aelst. 1997. A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. EMBO J. 16:54455454.
37. Dupuis, S.,, C. Dargemont,, C. Fieschi,, N. Thomassin,, S. Rosenzweig,, J. Harris,, S. M. Holland,, R. D. Schreiber, and, J. L. Casanova. 2001. Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation. Science 293:300303.
38. Dupuis, S.,, E. Jouanguy,, S. Al-Hajjar,, C. Fieschi,, I. Z. Al-Mohsen,, S. Al-Jumaah,, K. Yang,, A. Chapgier,, C. Eidenschenk,, P. Eid,, A. Al Ghonaium,, H. Tufenkeji,, H. Frayha,, S. Al-Gazlan,, H. Al-Rayes,, R. D. Schreiber,, I. Gresser, and, J. L. Casanova. 2003. Impaired response to interferon[alpha]/[beta] and lethal viral disease in human STAT1 deficiency. Nat. Genet. 33:388391.
39. Edgar, J. D. M.,, A. E. Smyth,, J. Pritchard,, D. Lammas,, E. Jouanguy,, R. Hague,, V. Novelli,, S. Dempsey,, L. Sweeney,, A. J. Taggart,, D. O’Hara,, J. L. Casanova, and, D. S. Kumararatne. 2001. Interferon-[gamma] receptor deficiency mimicking Langerhans’ cell histiocytosis. J. Pediatr. 139:600603.
40. Edwards, D. C.,, L. C. Sanders,, G. M. Bokoch, and, G. N. Gill. 1999. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat. Cell Biol. 1:253259.
41. Eskelinen, E. L. 2006. Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. Mol. Asp. Med. 27:495502.
42. Fang, F. C. 2004. Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Nat. Rev. Microbiol. 2:820832.
43. Fenton, M. J.,, and D. T. Golenbock. 1998. LPS-binding proteins and receptors. J. Leukoc. Biol. 64:2532.
44. Fevrier, M.,, J. L. Birrien,, C. Leclerc,, L. Chedid, and, P. Liacopoulos. 1978. The macrophage, target cell of the synthetic adjuvant muramyl dipeptide. Eur. J. Immunol. 8:558562.
45. Fieschi, C.,, S. Dupuis,, E. Catherinot,, J. Feinberg,, J. Bustamante,, A. Breiman,, F. Altare,, R. Baretto,, F. Le Deist,, S. Kayal,, H. Koch,, D. Richter,, M. Brezina,, G. Aksu,, P. Wood,, S. Al-Jumaah,, M. Raspall,, A. J. Da Silva Duarte,, D. Tuerlinckx,, J. L. Virelizier,, A. Fischer,, A. Enright,, J. Bernhöft,, A. M. Cleary,, C. Vermylen,, C. Rodriguez-Gallego,, G. Davies,, R. Blütters-Sawatzki,, C. A. Siegrist,, M. S. Ehlayel,, V. Novelli,, W. H. Haas,, J. Levy,, J. Freihorst,, S. Al-Hajjar,, D. Nadal,, D. De Moraes Vasconcelos,, O. Jeppsson,, N. Kutukculer,, K. Frecerova,, D. Lammas,, D. S. Kumararatne,, L. Abel, and, J. L. Casanova. 2003. Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor beta1 deficiency: medical and immunological implications. J. Exp. Med. 197:527535.
46. Filipe-Santos, O.,, J. Bustamante,, M. H. Haverkamp,, E. Vinolo,, C. L. Ku,, A. Puel,, D. M. Frucht,, K. Christel,, H. von Bernuth,, E. Jouanguy,, J. Feinberg,, A. Durandy,, B. Senechal,, A. Chapgier,, G. Vogt,, L. de Beaucoudrey,, C. Fieschi,, C. Picard,, M. Garfa,, J. Chemli,, M. Bejaoui,, M. N. Tsolia,, N. Kutukculer,, A. Plebani,, L. Notarangelo,, C. Bodemer,, F. Geissmann,, A. Israël,, M. Véron,, M. Knackstedt,, R. Barbouche,, L. Abel,, K. Magdorf,, D. Gendrel,, F. Agou,, S. M. Holland, and, J. L. Casanova. 2006. X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production. J. Exp. Med. 203:17451745.
47. Filler, S.,, M. Yeaman, and, D. Sheppard. 2005. Tumor necrosis factor inhibition and invasive fungal infections. Clin. Infect. Dis. 41:S208S212.
48. Florido, M.,, and R. Appelberg. 2007. Characterization of the deregulated immune activation occurring at late stages of mycobacterial infection in TNF-deficient mice. J. Immunol. 179:77027708.
49. Forgac, M. 2007. Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Nat. Rev. Mol. Cell Biol. 8:917929.
50. Forman, H. J.,, and M. Torres. 2001. Redox signaling in macrophages. Mol. Asp Med. 22:189216.
51. Forman, H. J.,, and M. Torres. 2002. Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling. Am. J. Respir. Crit. Care Med. 166:4S8S.
52. Fratti, R. A.,, J. M. Backer,, J. Gruenberg,, S. Corvera, and, V. Deretic. 2001. Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest. J. Cell Biol. 154:631644.
53. Fratti, R. A.,, J. Chua, and, V. Deretic. 2002. Cellubrevin alterations and Mycobacterium tuberculosis phagosome maturation arrest. J. Biol. Chem. 277:1732017326.
54. Furchgott, R. F.,, and J. V. Zawadzki. 1980. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288:373376.
55. Gadola, S. D.,, H. T. Moins-Teisserenc,, J. Trowsdale,, W. L. Gross, and, V. Cerundolo. 2000. TAP deficiency syndrome. Clin. Exp. Immunol. 121:173178.
56. Gallin, J. I.,, D. W. Alling,, H. L. Malech,, R. Wesley,, D. Koziol,, B. Marciano,, E. M. Eisenstein,, M. L. Turner,, E. S. DeCarlo,, J. M. Starling, and, S. M. Holland. 2003. Itraconazole to prevent fungal infections in chronic granulomatous disease. N. Engl. J. Med. 348:24162422.
57. Garcia-Garcia, E.,, and C. Rosales. 2002. Signal transduction during Fc receptor-mediated phagocytosis. J. Leukoc. Biol. 72:10921108.
58. Gardam, M. A.,, E. C. Keystone,, R. Menzies,, S. Manners,, E. Skamene,, R. Long, and, D. C. Vinh. 2003. Anti-tumour necrosis factor agents and tuberculosis risk: mechanisms of action and clinical management. Lancet Infect. Dis. 3:148155.
59. Genuardi, M.,, and G. F. Saunders. 1988. Localization of the HLA class II-associated invariant chain gene to human chromosome band 5q32. Immunogenetics 28:5356.
60. Gissen, P.,, and E. R. Maher. 2007. Cargos and genes: insights into vesicular transport from inherited human disease. J. Med. Genet. 44:545555.
61. Gomez, L. M.,, J. M. Anaya,, J. R. Vilchez,, J. Cadena,, R. Hinojosa,, L. Vélez,, M. A. Lopez-Nevot, and, J. Martín. 2007. A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis. Tuberculosis 87:288294.
62. Grohmann, U.,, M. L. Belladonna,, C. Vacca,, R. Bianchi,, F. Fallarino,, C. Orabona,, M. C. Fioretti, and, P. Puccetti. 2001. Positive regulatory role of IL-12 in macrophages and modulation by IFN-[gamma]. J. Immunol. 167:221227.
63. Grunfeld, C.,, M. Marshall,, J. K Shigenaga,, A. H. Moser,, P. Tobias, and, K. R. Feingold. 1999. Lipoproteins inhibit macrophage activation by lipoteichoic acid. J. Lipid Res. 40:245252.
64. Gupta, D.,, Y. P. Jin, and, R. Dziarski. 1995. Peptidoglycan induces transcription and secretion of TNF-alpha and activation of lyn, extracellular signal-regulated kinase, and rsk signal transduction proteins in mouse macrophages. J. Immunol. 155:26202630.
65. Hackam, D. J.,, O. D. Rotstein,, W. J. Zhang,, N. Demaurex,, M. Woodside,, O. Tsai, and, S. Grinstein. 1997. Regulation of phagosomal acidification. Differential targeting of Na+/H+ exchangers, Na+/K+-ATPases, and vacuolar-type H+-ATPases. J. Biol. Chem. 272:2981029820.
66. Haggie, P. M.,, and A. S. Verkman. 2007. Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages. J. Biol. Chem. 282:3142231428.
67. Haziot, A.,, S. Chen,, E. Ferrero,, M. G. Low,, R. Silber, and, S. M. Goyert. 1988. The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage. J. Immunol. 141:547552.
68. Hehlgans, T.,, and D. N. Männel. 2002. The TNF-TNF receptor system. Biol. Chem. 383:15811585.
69. Hehlgans, T.,, and K. Pfeffer. 2005. The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games. Immunology 115:120.
70. Henri, S.,, F. Stefani,, D. Parzy,, C. Eboumbou,, A. Dessein, and, C. Chevillard. 2002. Description of three new polymorphisms in the intronic and 3ʹUTR regions of the human interferon gamma gene. Genes Immun. 3:14.
71. Henry, R. M.,, A. D. Hoppe,, N. Joshi, and, J. A. Swanson. 2004. The uniformity of phagosome maturation in macrophages. J. Cell Biol. 164:185194.
72. Hill, G. R.,, J. M. Crawford,, K. R. Cooke,, Y. S. Brinson,, L. Pan, and, J. L. Ferrara. 1997. Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines. Blood 90:32043213.
73. Höflich, C.,, R. Sabat,, S. Rosseau,, B. Temmesfeld,, H. Slevogt,, W. D. Döcke,, G. Grütz,, C. Meisel,, E. Halle,, U. B. Göbel,, H. D. Volk, and, N. Suttorp. 2004. Naturally occurring anti-IFN-gamma autoantibody and severe infections with Mycobacterium chelonae and Burkholderia cocovenenans. Blood 103:673675.
74. Hornell, T. M. C.,, G. W. Beresford,, A. Bushey,, J. M. Boss, and, E. D. Mellins. 2003. Regulation of the class II MHC pathway in primary human monocytes by granulocyte-macrophage colony-stimulating factor. J. Immunol. 171:23742383.
75. Huynh, K. K.,, E. L. Eskelinen,, C. C. Scott,, A. Malevanets,, P. Saftig, and, S. Grinstein. 2007. LAMP proteins are required for fusion of lysosomes with phagosomes. EMBO J. 26:313324.
76. Iles, K. E.,, and H. J. Forman. 2002. Macrophage signaling and respiratory burst. Immunol. Res. 26:95105.
77. Jain, A.,, C. A. Ma,, S. Liu,, M. Brown,, J. Cohen, and, W. Strober. 2001. Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohidrotic ectodermal dysplasia. Nat. Immunol. 2:223228.
78. Janssen, R.,, A. van Wengen,, M. A. Hoeve,, M. ten Dam,, M. van der Burg,, J. van Dongen,, E. van de Vosse,, M. van Tol,, R. Bredius,, T. H. Ottenhoff,, C. Weemaes,, J. T. van Dissel, and, A. Lankester. 2004. The same I[kappa]B[alpha] mutation in two related individuals leads to completely different clinical syndromes. J. Exp. Med. 200:559568.
79. Johansson, A.,, A. J. Jesaitis,, H. Lundqvist,, K. E. Magnusson,, C. Sjölin,, A. Karlsson, and, C. Dahlgren. 1995. Different subcellular localization of cytochrome b and the dormant NADPH-oxidase in neutrophils and macrophages: effect on the production of reactive oxygen species during phagocytosis. Cell. Immunol. 161:6171.
80. Jouanguy, E.,, F. Altare,, S. Lamhamedi,, P. Revy,, J. F. Emile,, M. Newport,, M. Levin,, S. Blanche,, E. Seboun,, A. Fischer, and, J. L. Casanova. 1996. Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection. N. Engl. J. Med. 335:19561961.
81. Jouanguy, E.,, S. Lamhamedi-Cherradi,, D. Lammas,, S. E. Dorman,, M. C. Fondanèche,, S. Dupuis,, R. Döffinger,, F. Altare,, J. Girdlestone,, J. F. Emile,, H. Ducoulombier,, D. Edgar,, J. Clarke,, V. A. Oxelius,, M. Brai,, V. Novelli,, K. Heyne,, A. Fischer,, S. M. Holland,, D. S. Kumararatne,, R. D. Schreiber, and, J. L. Casanova. 1997. Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid Bacillus Calmette-Guerin infection and a sibling with clinical tuberculosis. J. Clin. Investig. 100:26582664.
82. Jouanguy, E.,, S. Lamhamedi-Cherradi,, D. Lammas,, S. E. Dorman,, M. C. Fondanèche,, S. Dupuis,, R. Döffinger,, F. Altare,, J. Girdlestone,, J. F. Emile,, H. Ducoulombier,, D. Edgar,, J. Clarke,, V. A. Oxelius,, M. Brai,, V. Novelli,, K. Heyne,, A. Fischer,, S. M. Holland,, D. S. Kumararatne,, R. D. Schreiber, and, J. L. Casanova. 1999. A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection. Nat. Genet. 21:370378.
83. Joyce, D. A.,, G. Gimblett, and, J. H. Steer. 2001. Targets of glucocorticoid action on TNF-a release by macrophages. Inflamm. Res. 50:337340.
84. Kanai, F.,, H. Liu,, S. J. Field,, H. Akbary,, T. Matsuo,, G. E. Brown,, L. C. Cantley, and, M. B. Yaffe. 2001. The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat. Cell Biol. 3:675678.
85. Karlsson, L. 2005. DM and DO shape the repertoire of peptide-MHC-class-II complexes. Curr. Opin. Immunol. 17:6570.
86. Kastelein, R. A.,, C. A. Hunter, and, D. J. Cua. 2007. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu. Rev. Immunol. 25:221242.
87. Kato, M.,, S. Khan,, E. d’Aniello,, K. J. McDonald, and, D. N. Hart. 2007. The novel endocytic and phagocytic C-type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration. J. Immunol. 179:60526063.
88. Kim, H. S.,, and M.-S. Lee. 2007. STAT1 as a key modulator of cell death. Cell Signal. 19:454465.
89. Kloetzel, P. M.,, and F. Ossendorp. 2004. Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Curr. Opin. Immunol. 16:7681.
90. Kol, A.,, A. H. Lichtman,, R. W. Finberg,, P. Libby, and, E. A. Kurt-Jones. 2000. Cutting edge: heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells. J. Immunol. 164:1317.
91. Kontoyiannis, D.,, M. Pasparakis,, T. T. Pizarro,, F. Cominelli, and, G. Kollias. 1999. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10:387398.
92. Krawczyk, M.,, and W. Reith. 2006. Regulation of MHC class II expression, a unique regulatory system identified by the study of a primary immunodeficiency disease. Tissue Antigens 67:183197.
93. Ku, C. L.,, H. von Bernuth,, C. Picard,, S. Y. Zhang,, H. H. Chang,, K. Yang,, M. Chrabieh,, A. C. Issekutz,, C. K. Cunningham,, J. Gallin,, S. M. Holland,, C. Roifman,, S. Ehl,, J. Smart,, M. Tang,, F. J. Barrat,, O. Levy,, D. McDonald,, N. K. Day-Good,, R. Miller,, H. Takada,, T. Hara,, S. Al-Hajjar,, A. Al-Ghonaium,, D. Speert,, D. Sanlaville,, X. Li,, F. Geissmann,, E. Vivier,, L. Maródi,, B. Z. Garty,, H. Chapel,, C. Rodriguez-Gallego,, X. Bossuyt,, L. Abel,, A. Puel, and, J. L. Casanova. 2007. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J. Exp. Med. 204:24072422.
94. Kyei, G. B.,, I. Vergne,, J. Chua,, E. Roberts,, J. Harris,, J. R. Junutula, and, V. Deretic. 2006. Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest. EMBO J. 25:52505259.
95. Levesque, M.,, M. R. Hobbs,, N. M. Anstey,, T. N. Vaughn,, J. A. Chancellor,, A. Pole,, D. J. Perkins,, M. A. Misukonis,, S. J. Chanock,, D. L. Granger, and, J. B. Weinberg. 1999. Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria. J. Infect. Dis. 180:19942002.
96. Liu, M. T.,, B. P. Chen,, P. Oertel,, M. J. Buchmeier,, D. Armstrong,, T. A. Hamilton, and, T. E. Lane. 2000. Cutting edge: the t cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease. J. Immunol. 165:23272330.
97. Lukacs, G. L.,, O. D. Rotstein, and, S. Grinstein. 1990. Phagosomal acidification is mediated by a vacuolar-type H(+)-ATPase in murine macrophages. J. Biol. Chem. 265:2109921107.
98. MacLennan, C.,, C. Fieschi,, D. A. Lammas,, C. Picard,, S. E. Dorman,, O. Sanal,, J. M. MacLennan,, S. M. Holland,, T. H. Ottenhoff,, J. L. Casanova, and, D. S. Kumararatne. 2004. Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans. J. Infect. Dis. 190:17551757.
99. Marino, S.,, D. Sud,, H. Plessner,, P. L. Lin,, J. Chan,, J. L. Flynn, and, D. E. Kirschner. 2007. Differences in reactivation of tuberculosis induced from anti-TNF treatments are based on bioavailability in granulomatous tissue. PLoS Comput. Biol. 3:19091924.
100. Matsuda, M.,, J. G. Park,, D. C. Wang,, S. Hunter,, P. Chien, and, A. D. Schreiber. 1996. Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides. Mol. Biol. Cell 7:10951106.
101. May, M. J.,, F. D’Acquisto,, L. A. Madge,, J. Glöckner,, J. S. Pober, and, S. Ghosh. 2000. Selective inhibition of NF-kappa B activation by a peptide that blocks the interaction of NEMO with the Ikappa B kinase complex. Science 289:15501554.
102. Messina, C. G.,, E. P. Reeves,, J. Roes, and, A. W. Segal. 2002. Catalase negative Staphylococcus aureus retain virulence in mouse model of chronic granulomatous disease. FEBS Lett. 518:107110.
103. Miletic, A. V.,, D. B. Graham,, V. Montgrain,, K. Fujikawa,, T. Kloeppel,, K. Brim,, B. Weaver,, R. Schreiber,, R. Xavier, and, W. Swat. 2007. Vav proteins control MyD88-dependent oxidative burst. Blood 109:33603368.
104. Minegishi, Y.,, M. Saito,, T. Morio,, K. Watanabe,, K. Agematsu,, S. Tsuchiya,, H. Takada,, T. Hara,, N. Kawamura,, T. Ariga,, H. Kaneko,, N. Kondo,, I. Tsuge,, A. Yachie,, Y. Sakiyama,, T. Iwata,, F. Bessho,, T. Ohishi,, K. Joh,, K. Imai,, K. Kogawa,, M. Shinohara,, M. Fujieda,, H. Wakiguchi,, S. Pasic,, M. Abinun,, H. D. Ochs,, E. D. Renner,, A. Jansson,, B. H. Belohradsky,, A. Metin,, N. Shimizu,, S. Mizutani,, T. Miyawaki,, S. Nonoyama, and, H. Karasuyama. 2006. Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity 25:745755.
105. Mombo, L.-E.,, F. Ntoumi,, C. Bisseye,, S. Ossari,, C. Y. Lu,, R. L. Nagel, and, R. Krishnamoorthy. 2003. Human genetic polymorphisms and asymptomatic Plasmodium falciparum malaria in Gabonese schoolchildren. Am. J. Trop. Med. Hyg. 68:186190.
106. Müller, M.,, R. Althaus,, D. Fröhlich,, K. Frei, and, H. P. Eugster. 1999. Reduced antilisterial activity of TNF-deficient bone marrow-derived macrophages is due to impaired super-oxide production. Eur. J. Immunol. 29:30893097.
107. Nathan, C. 2006. Role of iNOS in human host defense. Science 312:18741875
108. Nathan, C.,, and M. U. Shiloh. 2000. Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc. Natl. Acad. Sci. USA 97:88418848.
109. Naylor, S. L.,, A. Y. Sakaguchi,, T. B. Shows,, M. L. Law,, D. V. Goeddel, and, P. W. Gray. 1983. Human immune interferon gene is located on chromosome 12. J. Exp. Med. 157:10201027.
110. Newman, S. L.,, L. Gootee,, J. Hilty, and, R. E. Morris. 2006. Human macrophages do not require phagosome acidification to mediate fungistatic/fungicidal activity against Histoplasma capsulatum. J. Immunol. 176:18061813.
111. Newport, M. J.,, C. M. Huxley,, S. Huston,, C. M. Hawrylowicz,, B. A. Oostra,, R. Williamson, and, M. Levin. 1996. A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. N. Engl. J. Med. 335:19411949.
112. Niedergang, F.,, E. Colucci-Guyon,, T. Dubois,, G. Raposo, and, P. Chavrier. 2003. ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages. J. Cell Biol. 161:11431150.
113. Niehues, T.,, J. Reichenbach,, J. Neubert,, S. Gudowius,, A. Puel,, G. Horneff,, E. Lainka,, U. Dirksen,, H. Schroten,, R. Döffinger,, J. L. Casanova, and, V. Wahn. 2004. Nuclear factor [kappa]B essential modulator-deficient child with immunodeficiency yet without anhidrotic ectodermal dysplasia. J. Allergy Clin. Immunol. 114:14561462.
114. Niikura, T.,, R. Hirata, and, S. C. Weil. 1997. A novel interferon-inducible gene expressed during myeloid differentiation. Blood Cells Mol. Dis. 23:337349.
115. Ochs, H. D. 2001. The Wiskott-Aldrich syndrome. Clin. Rev. Allergy Immunol. 20:6186.
116. Ochs, H. D.,, and L. D. Notarangelo. 2005. Structure and function of the Wiskott-Aldrich syndrome protein. Curr. Opin. Hematol. 12:284291.
117. Olazabal, I. M.,, E. Caron,, R. C. May,, K. Schilling,, D. A. Knecht, and, L. M. Machesky. 2002. Rho-kinase and myosin-II control phagocytic cup formation during CR, but not Fc[gamma]R, phagocytosis. Curr. Biol. 12:14131418.
118. Orange, J. S.,, A. Jain,, Z. K. Ballas,, L. C. Schneider,, R. S. Geha, and, F. A. Bonilla. 2004. The presentation and natural history of immunodeficiency caused by nuclear factor [kappa]B essential modulator mutation. J. Allergy Clin. Immunol. 113:725733.
119. Orange, J. S.,, O. Levy, and, R. S. Geha. 2005. Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation. Immunol. Rev. 203:2137.
120. Orozco, G.,, E. Sánchez,, M. A. López-Nevot,, A. Caballero,, M. J. Bravo,, P. Morata,, J. de Dios Colmenero,, A. Alonso, and, J. Martín. 2003. Inducible nitric oxide synthase promoter polymorphism in human brucellosis. Microbes Infect. 5:11651169.
121. Pace, J. L.,, S. W. Russell,, R. D. Schreiber,, A. Altman, and, D. H. Katz. 1983. Macrophage activation: priming activity from a T-cell hybridoma is attributable to interferon-gamma. Proc. Natl. Acad. Sci. USA 80:37823786.
122. Parham, C.,, M. Chirica,, J. Timans,, E. Vaisberg,, M. Travis,, J. Cheung,, S. Pflanz,, R. Zhang,, K. P. Singh,, F. Vega,, W. To,, J. Wagner,, A. M. O’Farrell,, T. McClanahan,, S. Zurawski,, C. Hannum,, D. Gorman,, D. M. Rennick,, R. A. Kastelein,, R. de Waal Malefyt, and, K. W. Moore. 2002. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12R[beta]1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168:56995708.
123. Paulnock-King, D.,, K. C. Sizer,, Y. R. Freund,, P. P. Jones, and, J. R. Parnes. 1985. Coordinate induction of Ia alpha, beta, and Ii mRNA in a macrophage cell line. J. Immunol. 135:632636.
124. Picard, C.,, C. Fieschi,, F. Altare,, S. Al-Jumaah,, S. Al-Hajjar,, J. Feinberg,, S. Dupuis,, C. Soudais,, I. Z. Al-Mohsen,, E. Génin,, D. Lammas,, D. S. Kumararatne,, T. Leclerc,, A. Rafii,, H. Frayha,, B. Murugasu,, L. B. Wah,, R. Sinniah,, M. Loubser,, E. Okamoto,, A. Al-Ghonaium,, H. Tufenkeji,, L. Abel, and, J. L. Casanova. 2002. Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds. Am. J. Hum. Genet. 70:336348.
125. Popov, A.,, Z. Abdullah,, C. Wickenhauser,, T. Saric,, J. Driesen,, F. G. Hanisch,, E. Domann,, E. L. Raven,, O. Dehus,, C. Hermann,, D. Eggle,, S. Debey,, T. Chakraborty,, M. Krönke,, O. Utermöhlen, and, J. L. Schultze. 2006. Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection. J. Clin. Invest. 116:31603170.
126. Puel, A.,, J. Reichenbach,, J. Bustamante,, C. L. Ku,, J. Feinberg,, R. Döffinger,, M. Bonnet,, O. Filipe-Santos,, L. de Beaucoudrey,, A. Durandy,, G. Horneff,, F. Novelli,, V. Wahn,, A. Smahi,, A. Israel,, T. Niehues, and, J. L. Casanova. 2006. The NEMO mutation creating the most-upstream premature stop codon is hypomorphic because of a reinitiation of translation. Am. J. Hum. Genet. 78:691701.
127. Quezada, S. A.,, L. Z. Jarvinen,, E. F. Lind, and, R. J. Noelle. 2004. CD40/CD154 interactions at the interface of tolerance and immunity. Annu. Rev. Immunol. 22:307328.
128. Radosavljevic, M.,, B. Cuillerier,, M. J. Wilson,, O. Clément,, S. Wicker,, S. Gilfillan,, S. Beck,, J. Trowsdale, and, S. Bahram. 2002. A cluster of ten novel MHC class I related genes on human chromosome 6q24. 2-q25. 3. Genomics 79:114123.
129. Ramachandra, L.,, E. Noss,, W. H. Boom, and, C. V. Harding. 1999. Phagocytic processing of antigens for presentation by class II major histocompatibility complex molecules. Cell. Microbiol. 1:205214.
130. Randolph, G. J.,, C. Jakubzick, and, C. Qu. 2008. Antigen presentation by monocytes and monocyte-derived cells. Curr. Opin. Immunol. 20:5260.
131. Rapoport, T. A. 2007. Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes. Nature 450:663669.
132. Reeves, E. P.,, H. Lu,, H. L. Jacobs,, C. G. Messina,, S. Bolsover,, G. Gabella,, E. O. Potma,, A. Warley,, J. Roes, and, A. W. Segal. 2002. Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature 416:291297.
133. Ren, G.,, P. Vajjhala,, J. S. Lee,, B. Winsor, and, A. L. Munn. 2006. The BAR domain proteins: molding membranes in fission, fusion, and phagy. Microbiol. Mol. Biol. Rev. 70:37120.
134. Rink, J.,, E. Ghigo,, Y. Kalaidzidis, and, M. Zerial. 2005. Rab conversion as a mechanism of progression from early to late endosomes. Cell 122:735749.
135. Roach, T. I.,, C. H. Barton,, D. Chatterjee, and, J. M. Blackwell. 1993. Macrophage activation: lipoarabinomannan from avirulent and virulent strains of Mycobacterium tuberculosis differentially induces the early genes c-fos, KC, JE, and tumor necrosis factor-alpha. J. Immunol. 150:18861896.
136. Roach, D. R.,, A. G. Bean,, C. Demangel,, M. P. France,, H. Briscoe, and, W. J. Britton. 2002. TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection. J. Immunol. 168:46204627.
137. Roberts, E. A.,, J. Chua,, G. B. Kyei, and, V. Deretic. 2006. Higher order Rab programming in phagolysosome biogenesis. J. Cell Biol. 174:923929.
138. Roesler, J.,, M. E. Horwitz,, C. Picard,, P. Bordigoni,, G. Davies,, E. Koscielniak,, M. Levin,, P. Veys,, U. Reuter,, A. Schulz,, C. Thiede,, T. Klingebiel,, A. Fischer,, S. M. Holland,, J. L. Casanova, and, W. Friedrich. 2004. Hematopoietic stem cell transplantation for complete IFN-[gamma] receptor 1 deficiency: a multi-institutional survey. J. Pediatr. 145:806812.
139. Rosenzweig, S.,, S. E. Dorman,, J. Roesler,, J. Palacios,, M. Zelazko, and, S. M. Holland. 2002. 561del4 defines a novel small deletion hotspot in the interferon-[gamma] receptor 1 chain. Clin. Immunol. 102:2527.
140. Rosenzweig, S. D.,, S. E. Dorman,, G. Uzel,, S. Shaw,, A. Scurlock,, M. R. Brown,, R. H. Buckley, and, S. M. Holland. 2004. A novel mutation in IFN-[gamma] receptor 2 with dominant negative activity: biological consequences of homozygous and heterozygous states. J. Immunol. 173:40004008.
141. Rossouw, M.,, H. J. Nel,, G. S. Cooke,, P. D. van Helden, and, E. G. Hoal. 2003. Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene. Lancet 361:18711872.
142. Rzomp, K. A.,, A. R. Moorhead, and, M. A. Scidmore. 2003. Rab GTPases are recruited to chlamydial inclusions in both a species-dependent and species-independent manner. Infect. Immun. 71:58555870.
143. Saccani, S.,, S. Pantano, and, G. Natoli. 2001. Two waves of nuclear factor [kappa]B recruitment to target promoters. J. Exp. Med. 193:13511360.
144. Sasahara, Y.,, R. Rachid,, M. J. Byrne,, M. A. de la Fuente,, R. T. Abraham,, N. Ramesh, and, R. S. Geha. 2002. Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. Mol. Cell 10:12691281.
145. Savina, A.,, and S. Amigorena. 2007. Phagocytosis and antigen presentation in dendritic cells. Immunol. Rev. 219:143156.
146. Schiffer, R.,, J. Baron,, G. Dagtekin,, W. Jahnen-Dechent, and, G. Zwadlo-Klarwasser. 2002. Differential regulation of the expression of transporters associated with antigen processing, TAP1 and TAP2, by cytokines and lipopolysaccharide in primary human macrophages. Inflamm. Res. 51:403408.
147. Schroder, K.,, M. J. Sweet, and, D. A. Hume. 2006. Signal integration between IFN[gamma] and TLR signalling pathways in macrophages. Immunobiology 211:511524.
148. Scianimanico, S.,, M. Desrosiers,, J. F. Dermine,, S. Méresse,, A. Descoteaux, and, M. Desjardins. 1999. Impaired recruitment of the small GTPase rab7 correlates with the inhibition of phagosome maturation by Leishmania donovani promastigotes. Cell. Microbiol. 1:1932.
149. Seabra, M. C.,, E. H. Mules, and, A. N. Hume. 2002. Rab GTPases, intracellular traffic and disease. Trends Mol. Med. 8:2330.
150. Segal, A. W. 2005. How neutrophils kill microbes. Annu. Rev. Immunol. 23:197223.
151. Segal, B.,, L. A. Barnhart,, V. L. Anderson,, T. J. Walsh,, H. L. Malech, and, S. M. Holland. 2005. Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection. Clin. Infect. Dis. 40:16841688.
152. Segal, B. H.,, T. L. Leto,, J. I. Gallin,, H. L. Malech, and, S. M. Holland. 2000. Genetic, biochemical, and clinical features of chronic granulomatous disease. Medicine (Baltimore) 79:170200.
153. Sharpe, A. H.,, and G. J. Freeman. 2002. The B7-CD28 superfamily. Nat. Rev. Immunol. 2:116126.
154. Shintani, T.,, and D. J. Klionsky. 2004. Autophagy in health and disease: a double-edged sword. Science 306:990995.
155. Smahi, A.,, G. Courtois,, P. Vabres,, S. Yamaoka,, S. Heuertz,, A. Munnich,, A. Israël,, N. S. Heiss,, S. M. Klauck,, P. Kioschis,, S. Wiemann,, A. Poustka,, T. Esposito,, T. Bardaro,, E. Gianfrancesco,, A. Ciccodicola,, M. D’Urso,, H. Woffendin,, T. Jakins,, D. Donnai,, H. Stewart,, S. J. Kenwrick,, S. Aradhya,, T. Yamagata,, M. Levy,, R. A. Lewis, and, D. L. Nelson. 2000. Genomic rearrangement in NEMO impairs NF-[kappa]B activation and is a cause of incontinentia pigmenti. Nature 405:466472.
156. Smirnova, I.,, N. Mann,, A. Dols,, H. H. Derkx,, M. L. Hibberd,, M. Levin, and, B. Beutler. 2003. Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc. Natl. Acad. Sci. USA 100:60756080.
157. Smith, A. C.,, W. D. Heo,, V. Braun,, X. Jiang,, C. Macrae,, J. E. Casanova,, M. A. Scidmore,, S. Grinstein,, T. Meyer, and, J. H. Brumell. 2007. A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium. J. Cell Biol. 176:263268.
158. Speer, C. P.,, M. J. Pabst,, H. B. Hedegaard,, R. F. Rest, and, R. B. Johnston, Jr. 1984. Enhanced release of oxygen metabolites by monocyte-derived macrophages exposed to proteolytic enzymes: activity of neutrophil elastase and cathepsin G. J. Immunol. 133:21512156.
159. Stark, G. R.,, I. M. Kerr,, B. R. Williams,, R. H. Silverman, and, R. D. Schreiber. 1998. How cells respond to interferons. Annu. Rev. Biochem. 67:227264.
160. Stergiopoulou, T.,, J. Meletiadis,, E. Roilides,, D. E. Kleiner,, R. Schaufele,, M. Roden,, S. Harrington,, L. Dad,, B. Segal, and, T. J. Walsh. 2007. Host-dependent patterns of tissue injury in invasive pulmonary aspergillosis. Am. J. Clin. Pathol. 127:349355.
161. Sturgill-Koszycki, S.,, P. H. Schlesinger,, P. Chakraborty,, P. L. Haddix,, H. L. Collins,, A. K. Fok,, R. D. Allen,, S. L. Gluck,, J. Heuser, and, D. G. Russell. 1994. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science 263:678681.
162. Sullivan, K. E.,, C. A. Mullen,, R. M. Blaese, and, J. A. Winkelstein. 1994. A multiinstitutional survey of the Wiskott-Aldrich syndrome. J. Pediatr. 125:876885.
163. Sullivan, K. E.,, A. B. Reddy,, K. Dietzmann,, A. R. Suriano,, V. P. Kocieda,, M. Stewart, and, M. Bhatia. 2007. Epigenetic regulation of tumor necrosis factor alpha. Mol. Cell Biol. 27:51475160.
164. Sun, J.,, A. E. Deghmane,, H. Soualhine,, T. Hong,, C. Bucci,, A. Solodkin, and, Z. Hmama. 2007. Mycobacterium bovis BCG disrupts the interaction of Rab7 with RILP contributing to inhibition of phagosome maturation. J. Leukoc. Biol. 82:14371445.
165. Sun-Wada, G. H.,, Y. Wada, and, M. Futai. 2003. Lysosome and lysosome-related organelles responsible for specialized functions in higher organisms, with special emphasis on vacuolar-type proton ATPase. Cell. Struct. Funct. 28:455463.
166. Swanson, J. A.,, and A. D. Hoppe. 2004. The coordination of signaling during Fc receptor-mediated phagocytosis. J. Leukoc. Biol. 76:10932103.
167. Tephly, L. A.,, and A. B. Carter. 2007a. Constitutive NADPH oxidase and increased mitochondrial respiratory chain activity regulate chemokine gene expression. Am. J. Physiol. 293:L1143L1155.
168. Tephly, L. A.,, and A. B. Carter. 2007b. Differential expression and oxidation of MKP-1 modulates TNF-alpha gene expression. Am. J. Respir. Cell. Mol. Biol. 37:366367.
169. Tkalcevic, J.,, M. Novelli,, M. Phylactides,, J. P. Iredale,, A. W. Segal, and, J. Roes. 2000. Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity 12:201210.
170. Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3:133146.
171. Tsuboi, S. 2006. A complex of Wiskott-Aldrich syndrome protein with mammalian verprolins plays an important role in monocyte chemotaxis. J. Immunol. 176:65766585.
172. Tsuboi, S. 2007. Requirement for a complex of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein in podosome formation in macrophages. J. Immunol. 178:29872995.
173. Tsuboi, S.,, and J. Meerloo. 2007. Wiskott-Aldrich syndrome protein is a key regulator of the phagocytic cup formation in macrophages. J. Biol. Chem. 282:3419434203.
174. Ulevitch, R. J. 2004. Therapeutics targeting the innate immune system. Nat. Rev. Immunol. 4:512520.
175. Vachon, E.,, R. Martin,, J. Plumb,, V. Kwok,, R. W. Vandivier,, M. Glogauer,, A. Kapus,, X. Wang,, C. W. Chow,, S. Grinstein, and, G. P. Downey. 2006. CD44 is a phagocytic receptor. Blood 107:41494158.
176. van Crevel, R.,, T. H. M. Ottenhoff, and, J. W. M. van der Meer. 2002. Innate immunity to Mycobacterium tuberculosis. Clin. Microbiol. Rev. 15:294309.
177. van der Veen, R. C.,, T. A. Dietlin,, F. M. Hofman,, L. Pen,, B. H. Segal, and, S. M. Holland. 2000. Superoxide prevents nitric oxide-mediated suppression of helper T lymphocytes: decreased autoimmune encephalomyelitis in nicotinamide adenine dinucleotide phosphate oxidase knockout mice. J. Immunol. 164:51775783.
178. van de Vosse, E.,, and T. H. M. Ottenhoff. 2006. Human host genetic factors in mycobacterial and Salmonella infection: lessons from single gene disorders in IL-12/IL-23-dependent signaling that affect innate and adaptive immunity. Microbes Infect. 8:11671173.
179. Vazquez-Torres, A.,, G. Fantuzzi,, C. K. Edwards III,, C. A. Dinarello, and, F. C. Fang. 2001. Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages. Proc. Natl. Acad. Sci. USA 98:25612565.
180. Vergne, I.,, J. Chua,, H. H. Lee,, M. Lucas,, J. Belisle, and, V. Deretic. 2005. Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 102:40334038.
181. Verhoeven, K,, P. De Jonghe,, K. Coen,, N. Verpoorten,, M. Auer-Grumbach,, J. M. Kwon,, D. FitzPatrick,, E. Schmedding,, E. De Vriendt,, A. Jacobs,, V. Van Gerwen,, K. Wagner,, H. P. Hartung, and, V. Timmerman. 2003. Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. Am. J. Hum. Genet. 72:722727.
182. Via, L. E.,, D. Deretic,, R. J. Ulmer,, N. S. Hibler,, L. A. Huber, and, V. Deretic. 1997. Arrest of mycobacterial phagosome maturation is caused by a block in vesicle fusion between stages controlled by rab5 and rab7. J. Biol. Chem. 272:1332613331.
183. Vinolo, E.,, H. Sebban,, A. Chaffotte,, A. Israël,, G. Courtois,, M. Véron, and, F. Agou. 2006. A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-[kappa]B activation. J. Biol. Chem. 281:63346348.
184. Vogt, G.,, A. Chapgier,, K. Yang,, N. Chuzhanova,, J. Feinberg,, C. Fieschi,, S. Boisson-Dupuis,, A. Alcais,, O. Filipe-Santos,, J. Bustamante,, L. de Beaucoudrey,, I. Al-Mohsen,, S. Al-Hajjar,, A. Al-Ghonaium,, P. Adimi,, M. Mirsaeidi,, S. Khalilzadeh,, S. Rosenzweig,, O. de la Calle Martin,, T. R. Bauer,, J. M. Puck,, H. D. Ochs,, D. Furthner,, C. Engelhorn,, B. Belohradsky,, D. Mansouri,, S. M. Holland,, R. D. Schreiber,, L. Abel,, D. N. Cooper,, C. Soudais, and, J. L. Casanova. 2005. Gains of glycosylation comprise an unexpectedly large group of pathogenic mutations. Nat. Genet. 37:692700.
185. Vowells, S. J.,, T. A. Fleisher,, S. Sekhsaria,, D. W. Alling,, T. E. Maguire, and, H. L. Malech. 1996. Genotype-dependent variability in flow cytometric evaluation of reduced nicotinamide adenine dinucleotide phosphate oxidase function in patients with chronic granulomatous disease. J. Pediatr. 128:104107.
186. Wahl, S. M.,, L. M. Wahl,, J. B. McCarthy,, L. Chedid, and, S. E. Mergenhagen. 1979. Macrophage activation by myco-bacterial water soluble compounds and synthetic muramyl di-peptide. J. Immunol. 122:22262231.
187. Wallis, R. S.,, M. S. Broder,, J. Y. Wong,, M. E. Hanson, and, D. O. Beenhouwer. 2004. Granulomatous infectious diseases associated with tumor necrosis factor antagonists. Clin. Infect. Dis. 39:12551256.
188. Watters, T. M.,, E. F. Kenny, and, L. A. O’Neill. 2007. Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins. Immunol. Cell Biol. 85:411419.
189. Wells, C. M.,, M. Walmsley,, S. Ooi,, V. Tybulewicz, and, A. J. Ridley. 2004. Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration. J. Cell Sci. 117:12591268.
190. Wiedemann, A.,, J. C. Patel,, J. Lim,, A. Tsun,, Y. van Kooyk, and, E. Caron. 2006. Two distinct cytoplasmic regions of the [beta]2 integrin chain regulate RhoA function during phagocytosis. J. Cell Biol. 172:10691079.
191. Williams, D. A.,, W. Tao,, F. Yang,, C. Kim,, Y. Gu,, P. Mansfield,, J. E. Levine,, B. Petryniak,, C. W. Derrow,, C. Harris,, B. Jia,, Y. Zheng,, D. R. Ambruso,, J. B. Lowe,, S. J. Atkinson,, M. C. Dinauer, and, L. Boxer. 2000. Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. Blood 96:16461654.
192. Winkelstein, J. A.,, M. C. Marino,, R. B. Johnston, Jr.,, J. Boyle,, J. Curnutte,, J. I. Gallin,, H. L. Malech,, S. M. Holland,, H. Ochs,, P. Quie,, R. H. Buckley,, C. B. Foster,, S. J. Chanock, and, H. Dickler. 2000. Chronic granulomatous disease. Report on a national registry of 368 patients. Medicine (Baltimore) 79:155169.
193. Winthrop, K. L.,, S. Yamashita,, S. E. Beekmann,, P. M. Pol-green; Infectious Diseases Society of America Emerging Infections Network. 2008. Mycobacterial and other serious infections in patients receiving anti-tumor necrosis factor and other newly approved biologic therapies: case finding through the emerging infections network. Clin. Infect. Dis. 46:17381740.
194. Wood, P. M.,, C. Fieschi,, C. Picard,, T. H. Ottenhoff,, J. L. Casanova, and, D. S. Kumararatne. 2005. Inherited defects in the interferon-gamma receptor or interleukin-12 signalling pathways are not sufficient to cause allergic disease in children. Eur. J. Pediatr. 164:741747.
195. Yamaoka, K.,, P. Saharinen,, M. Pesu,, V. E. Holt III,, O. Silvennoinen, and, J. J. O’Shea. 2004. The Janus kinases (Jaks). Genome Biol. 5:253.
196. Zerbe, C.,, and S. Holland. 2005. Disseminated histoplasmosis in persons with interferon gamma receptor 1 deficiency. Clin. Infect. Dis. 41:e38e41.
197. Zhan, Y.,, J. V. Virbasius,, X. Song,, D. P. Pomerleau, and, G. W. Zhou. 2002. The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides. J. Biol. Chem. 277:45124518.
198. Zhang, P.,, S. Snyder,, P. Feng,, P. Azadi,, S. Zhang,, S. Bulgheresi,, K. E. Sanderson,, J. He,, J. Klena, and, T. Chen. 2006. Role of N-acetylglucosamine within core lipopolysaccharide of several species of gram-negative bacteria in targeting the DC-SIGN (CD209). J. Immunol. 177:40024011.
199. Zhang, Q.,, D. Cox,, C. C. Tseng,, J. G. Donaldson, and, S. Greenberg. 1998. A requirement for ARF6 in Fcgamma receptor-mediated phagocytosis in macrophages. J. Biol. Chem. 273:1997719981.
200. Zhao, X.,, K. A. Carnevale, and, M. K. Cathcart. 2003. Human monocytes use Rac1, not Rac2, in the NADPH oxidase complex. J. Biol. Chem. 278:4078840792.
201. Zhao, X.,, B. Xu,, A. Bhattacharjee,, C. M. Oldfield,, F. B. Wientjes,, G. M. Feldman, and, M. K. Cathcart. 2005. Protein kinase Cdelta regulates p67phox phosphorylation in human monocytes. J. Leukoc. Biol. 77:414420.
202. Zhou, H.,, J. Gu,, S. J. Lamont, and, X. Gu. 2007. Evolutionary analysis for functional divergence of the toll-like receptor gene family and altered functional constraints. J. Mol. Evol. 65:119123.