Chapter 28 : Interaction of with Phagocytes

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Interaction of with Phagocytes, Page 1 of 2

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One of the central players in antifungal immunity is phagocytic cells. Recognition by these cells leads to fungal uptake and killing and the induction of an inflammatory response. The increased risk of fungal infection resulting from perturbations in the levels of the number of phagocytes emphasizes the importance of these cells in the control of mycoses. This chapter covers the mechanisms that phagocytic cells use to recognize, ingest, and kill this pathogen, as well as those mechanisms involved in the induction of inflammatory and adaptive response to these organisms. Although involving multiple interactions with multiple receptors, different phagocytes appear to utilize different combinations of receptors to recognize . Recognition of leads to ingestion of the fungus through the actin-dependent process of phagocytosis. The uptake of involves several different phagocytic mechanisms which depend on the cell type, presence of opsonins, and the morphological form of the fungus. Phagocytes play essential roles in killing extracellular and internalized , and defects in their antimicrobial functions lead to an increased risk of fungal infection. has a number of mechanisms to defend against the antimicrobial activities of phagocytes. The induction of a correct adaptive response to can be influenced by the morphological form of the fungus and the phagocyte receptors with which it interacts.

Citation: Faro-Trindade I, Brown G. 2009. Interaction of with Phagocytes, p 437-451. In Russell D, Gordon S (ed), Phagocyte-Pathogen Interactions. ASM Press, Washington, DC. doi: 10.1128/9781555816650.ch28

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Candida albicans
Tumor Necrosis Factor
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Image of FIGURE 1

Cartoon representation of the various morphologies (yeast, hyphae, and pseudohyphae) of . Reprinted with permission from .

Citation: Faro-Trindade I, Brown G. 2009. Interaction of with Phagocytes, p 437-451. In Russell D, Gordon S (ed), Phagocyte-Pathogen Interactions. ASM Press, Washington, DC. doi: 10.1128/9781555816650.ch28
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Image of FIGURE 2

DC phagocytosis of yeast and hyphae of . (a) Phagocytosis of yeasts occurs through coiling phagocytosis, whereas (b) phagocytosis of hyphae occurs through a “zipper-like” mechanism. Reprinted with permission from .

Citation: Faro-Trindade I, Brown G. 2009. Interaction of with Phagocytes, p 437-451. In Russell D, Gordon S (ed), Phagocyte-Pathogen Interactions. ASM Press, Washington, DC. doi: 10.1128/9781555816650.ch28
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Image of FIGURE 3

Transmission electron microscopy image demonstrating undergoing yeast-to-hyphal transition following phagocytosis in macrophages. Reprinted with permission from .

Citation: Faro-Trindade I, Brown G. 2009. Interaction of with Phagocytes, p 437-451. In Russell D, Gordon S (ed), Phagocyte-Pathogen Interactions. ASM Press, Washington, DC. doi: 10.1128/9781555816650.ch28
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Image of FIGURE 4

Exposure of β-glucans, detected by soluble recombinant Dectin-1 (sDectin), on selected regions of yeast, but not hyphae. Reprinted with permission from .

Citation: Faro-Trindade I, Brown G. 2009. Interaction of with Phagocytes, p 437-451. In Russell D, Gordon S (ed), Phagocyte-Pathogen Interactions. ASM Press, Washington, DC. doi: 10.1128/9781555816650.ch28
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Image of FIGURE 5

Photomicrograph showing the presence of invasive candidiasis in the kidney of a Dectin-1-deficient mouse. Reprinted with permission from .

Citation: Faro-Trindade I, Brown G. 2009. Interaction of with Phagocytes, p 437-451. In Russell D, Gordon S (ed), Phagocyte-Pathogen Interactions. ASM Press, Washington, DC. doi: 10.1128/9781555816650.ch28
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Selected nonopsonic PRRs that recognize C.

Citation: Faro-Trindade I, Brown G. 2009. Interaction of with Phagocytes, p 437-451. In Russell D, Gordon S (ed), Phagocyte-Pathogen Interactions. ASM Press, Washington, DC. doi: 10.1128/9781555816650.ch28

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