Chapter 22 : Group B Coxsackievirus Diseases

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Two groups of coxsackieviruses, A and B, were subsequently defined according to their pathogenicity in suckling mice: the group A coxsackieviruses caused generalized myositis, while the coxsackieviruses group B (CVB) resulted in multiorgan infections. This chapter focuses on CVB, because this group includes major human pathogens and because extensive pathogenesis studies have been carried out on a number of viruses in this group. The chapter reviews salient aspects of CVB pathogenesis with an emphasis on recent findings related to CVB4 and CVB3. Recent reviews have examined the cell's responses to CVB infection in depth. Given the distance that an RNA virus genome can randomly wander in sequence space in a short length of time, comparing contemporary strains in such studies may be necessary when mapping genetic determinants of virulence. A mechanism by which enteroviruses can persist at low levels has been identified by recent work in which enteroviral RNA with genomic terminal deletions was detected in naturally infected human heart as well as in an experimental murine model of chronic myocarditis. Evidence from a murine model of myocarditis as well as a human case of myocarditis shows that the form in which CVB persist in the heart is through selection of a defective form of the virus with 5'- terminal deletions.

Citation: Tracy S, Chapman N. 2010. Group B Coxsackievirus Diseases, p 353-368. In Ehrenfeld E, Domingo E, Roos R (ed), The Picornaviruses. ASM Press, Washington, DC. doi: 10.1128/9781555816698.ch22
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