1887

DNA Repair and Mutagenesis, Second Edition

Authors: C. Friedberg Errol1, C. Walker Graham2, Siede Wolfram3, D. Wood Richard4, A. Schultz Roger5, Ellenberger Tom6
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Affiliations: 1: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas; 2: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts; 3: Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth, Texas; 4: Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania; 5: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas; 6: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts
Content Type: Reference
Format: Hardcover, Electronic
Publication Year: 2006

Category: Microbial Genetics and Molecular Biology

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Featuring more than 10,000 references and a text lavishly complemented by over 700 illustrations, , is a timely update to the original edition published in 1995. The addition of three new authors, including an expert in the field of structural biology, ensures a comprehensive review of the most current research in diverse subject areas. An ideal textbook for advanced undergraduate and graduate students, the book is also an essential resource for all scientists researching cellular responses to DNA damage.

Completely reorganized, the new edition presents a significant overhaul of the existing chapters and introduces important new material, reflective of the major changes and developments that have occurred in the field over the last decade. As with the first edition, this new volume presents the field within a strong historical framework and all aspects of biological responses to DNA damage are detailed.

The book consists of 30 chapters divided into five main parts, covering: sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage. Basic principles are appropriately stressed; however, the book focuses on the significant progress to date and future research directions.

There are no separately available contributors for this publication.

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Doody Enterprises

18 August 2013

At A Glance

Featuring more than 10,000 references and a text lavishly complemented by over 700 illustrations, DNA Repair and Mutagenesis, 2nd Edition, is a timely update to the original edition published in 1995. The addition of three new authors, including an expert in the field of structural biology, ensures a comprehensive review of the most current research in diverse subject areas. An ideal textbook for advanced undergraduate and graduate students, the book is also an essential resource for all scientists researching cellular responses to DNA damage. Completely reorganized, the new edition presents a significant overhaul of the existing chapters and introduces important new material, reflective of the major changes and developments that have occurred in the field over the last decade. As with the first edition, this new volume presents the field within a strong historical framework and all aspects of biological responses to DNA damage are detailed. The book consists of 30 chapters divided into five main parts,
covering: sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage. Basic principles are appropriately stressed; however, the book focuses on the significant progress to date and future research directions.

Description

DNA repair and mutagenesis from A to Z is an apt description of this book. The coverage is complete and well ordered. The prior edition was published about 10 years ago but sufficient new material has appeared that this update is justified.

Purpose

The goal is to provide a current look at all aspects of DNA repair. This is a commendable objective and is well met.

Audience

The target audience includes research fellows/investigators working in the area of DNA repair/mutagenesis, etc. The authors are recognized in the field and highly qualified.

Features

The complexity of DNA replication and the need to carefully regulate this process is clear to all investigators. Equally important is the task of maintaining the integrity of that structure in the face of stochastic changes (depurination, for example) and external insults such as radiation or toxic chemical agents. This book provides a comprehensive discussion of all aspects of DNA repair, initiating with the types of damage and causes thereof and proceeding to detailed analysis of the various methods of repair as well as host responses. A final section reviews disease states associated with defects in these various processes. Each of the chapters (30 in all) is accompanied by a comprehensive bibliography (over 10,000 primary references in all) and a short summary. Appendixes provide a list of enzyme systems and a catalogue of the diseases. Any investigator working in this area will want this book available -- the coverage is extensive and at a high standard, information on closely related damage control strategies is likely to be useful, and the literature citations constitute a general resource. In addition, those wishing a better understanding of the current status of this area of science will find key aspects readily accessible.

Assessment

This book has something for almost any scientist in the life science arena. This is an important area, well served by the authors and this is the most comprehensive book available in this field. An amply justified second edition.

Doody Enterprises

Reviewer: Eugene Davidson, PhD (Georgetown University School of Medicine)

Review Date: Unknown

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