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Citation: Aguzzi A, Glatzel M. .

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Fourier Transform Infrared Spectroscopy
Nuclear Magnetic Resonance Spectroscopy
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Image of FIGURE 1

Histological features of prion diseases. CNS parenchyma of sCJD (A and B) and vCJD (C and D) shows astrogliosis and widespread spongiform changes. PrP depositions are synaptic (A and B) and in the form of florid plaques (asterisk, C and D). Panels A and C are hematoxylin and eosin stains, and panels B and D are immunohistochemical stains for PrP (scale bar 5 50 mm).

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Image of FIGURE 2

Western blot analysis of PrPSc. Depicted are PrPSc types according to two proposed schemes ( ) which discriminate PrPSc types based on the mobility of the unglycosylated band of PrPSc and the signal intensity of PrPSc di-, mono-, and unglycosylated forms. One scheme ( ) differentiates four principal PrPSc types (1 through 4). Three principal PrPSc types (1, 2a, and 2b) are proposed in the second scheme ( ).

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Generic image for table

Clinical, diagnostic, and neuropathological features of human prion diseases

PSWC, periodic sharp wave complexes.

WB, Western blotting.

—, age at onset depending on iatrogenic exposure: incubation period, 1 to 30 years.

Generic image for table

Disease-causing mutations in


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