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Citation: Garcia-Hermoso D, Dannaoui E, Lortholary O, Dromer F. .

Key Concept Ranking

Fungal Infections
Antifungal Agents
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Image of FIGURE 1

Flow diagram following the processing of a sample in the mycology/microbiology laboratory or the histopathology laboratory. PE, paraffin embedded; HE, hematoxylin-eosin stain; PAS, periodic acid-Schiff stain; GMS, Gomori methenamine silver stain.

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Image of FIGURE 2

Schematic drawings of morphological structures observed in Mucorales. Sporangiophores (A) bear sporangia containing sporangiospores (D), can be anchored to the substrate by rhizoids (B), and expand by the means of stolons (C). The columella (E) is produced at the apex of the sporangiophore, and in some species an apophysis (G) is present. (F) For some species, after liberation of sporangiospores, a thin sporangium membrane may be visible. Sporangia with single or few spores are called sporangiola (H), and sporangia with few spores aligned in rows are called merosporangia (I). Thick-walled chlamydospores (J) and oidia (thin-walled swollen vesicles) (K) can be observed. (Drawings by Dea Garcia-Hermoso.)

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Image of FIGURE 3

Culture variability of some of the genera of Mucorales and their branching development.

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Image of FIGURE 4

Flow diagram for the identification of the different genera of Mucorales. Data from references and .

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Image of FIGURE 5

. (A) Branched sporangiophores; (B) hemispheric columellae and sporangiospores; (C) pyriform multispored sporangium and marked conical apophysis; (D) sporangiospores.

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Image of FIGURE 6

Typical microscopic features of . (A) Melanized sporangiophore arising opposite rhizoids; (B) striate angular sporangiospores.

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Image of FIGURE 7

Short pigmented sporangiophores arising in pairs in . (A and C) Rhizoids; (B) conical columella; (D) chlamydospores.

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Image of FIGURE 8

. Sporangiophores with apical branching (A), simple rhizoids (B), and globose sporangia with round and smooth-walled sporangiospores (C and D) are shown.

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Image of FIGURE 9

Micromorphology of . (A) Sporangiophore; (B) sporangia; (B and C) ellipsoidal sporangiospores; (D) oidia.

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Image of FIGURE 10

. (A) Unbranched sporangiophores bearing multispored sporangia with a vase-shaped apophysis (B and C); (D) cylindrical sporangiospores.

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Image of FIGURE 11

. (A and B) Mostly unbranched sporangiophores without rhizoids; (C) young sporangiolum; (D to F) recurved stalks arising from terminal vesicles and bearing few spored sporangiola.

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Image of FIGURE 12

. (A, B, and D) Development of single-spored sporangiola on the surfaces of globose vesicles, with frequent apical branching (C); (E) mature sporangiola grow to be single echinulate sporangiospores; (F) rhizoids.

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Image of FIGURE 13

Short sporangiophores arising from rhizoids (A), terminal vesicles covered by merosporangia (B, C, and E), and merospores (D) characteristic of .

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Image of FIGURE 14

. (A and B) Unbranched sporangiophores with dark rhizoids and typical multispored flask-shaped sporangia.

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Image of FIGURE 15

. (A) Ten-day-old powdery colony on PDA medium; (B) primary conidia with papilla; (C) passively released secondary conidium (arrow); (D) villose conidium.

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Image of FIGURE 16

. (A) Ten-day-old wrinkled colony on PDA medium; (B) uninucleated hyphal elements; (C) young zygospores.

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Species of Mucorales (subphylum Mucoromycotina Benny, subphylum nova) involved in human mucormycosis

Data from references and .

Implication in human infection is not confirmed.

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Differential characteristics of zygospores in genera involved in mucormycosis

Data from reference .

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Main characteristics allowing distinction between species and varieties

Data from references and

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Macroscopic and microscopic features of species involved in human infection

Data from reference .


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