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Chapter 125 : and

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Abstract:

In the past 100 years the microbial pathogens described in this chapter have been classified as fungal and/or parafungal protistan pathogens. , and are the most prominent features of the pathogens covered in this chapter. Clinical samples from patients suspected of having lacaziosis submitted to the laboratory comprise deep-skin scrapings and tissue biopsy samples. The samples have to be processed and evaluated for the presence of uniform yeast like cells connected by small tubules forming short chains. In contrast with the other hydrophilic pathogens covered in the chapter, can be cultured on various media. The first molecular approach for the diagnosis of from clinical specimens was carried out with a patient with keratitis. The hyphal elements present in the specimen were identified by sequencing part of the 18S ribosomal DNA region using the NS1 and NS2 and internal transcribed spacer (ITS) universal primers. The identification of using molecular methods are described in this chapter. The first two cases of rhinosporidiosis were reported in 1900 by Guillermo Rodolfo Seeber in his M.D. thesis in Argentina. Ashworth in 1923 stated that the genus proposed by Minchin and Fanthan should be adopted and that, based on the description of Seeber and the name Coccidioides seeberia reintroduced by Belou, the binomial has priority.

Citation: Mendoza L, Vilela R. 2011. and , p 1981-1991. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch125

Key Concept Ranking

Fungal Infections
0.5104759
Enzyme-Linked Immunosorbent Assay
0.47420847
Skin Infections
0.429001
Cutaneous Leishmaniasis
0.42321837
Humoral Immune Response
0.4198343
0.5104759
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Figures

Image of FIGURE 1
FIGURE 1

. Histological sections stained with H & E (A) and silver stain (B) show the typical morphological features found in patients with cutaneous lacaziosis. (A) The yeastlike cells of are poorly stained with H & E and are observed as empty round structures surrounded by an area of granulomatous reaction. (B) The presence of abundant yeastlike cells in chains is the main feature in silver-stained sections. (C) Numerous yeastlike cells of in chains connected with slender tubules and containing small dancing bodies in their cytoplasm. Magnification for all panels, ×40. Panels A and B are courtesy of P. S. Rosa.

Citation: Mendoza L, Vilela R. 2011. and , p 1981-1991. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch125
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Image of FIGURE 2
FIGURE 2

. (A) Colony of on Sabouraud dextrose agar. produces cream to white submerged colonies at 25 and 37°C. (B) Sparsely septate hyphae are found on agar plates. No fruiting bodies can be found on dry cultures. Panel B magnification, ×40.

Citation: Mendoza L, Vilela R. 2011. and , p 1981-1991. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch125
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Image of FIGURE 3
FIGURE 3

. (A) Low magnification (×10) tissue section showing several eosinophilic microabscesses. (B) Numerous eosinophils around the unstained hyphal elements of (Splendore-Hoeppli phenomenon [arrows]), a typical feature of pythiosis. Magnification, ×40. (C) Silver stain showing the typical hyphal features of Magnification, ×40. Panel courtesy of M. G. Rinaldi. (D) 10% KOH wet-mount preparation. Note sparsely septate slender hyaline hyphae with branches at 90° angles. Magnification, ×40.

Citation: Mendoza L, Vilela R. 2011. and , p 1981-1991. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch125
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Image of FIGURE 4
FIGURE 4

Citation: Mendoza L, Vilela R. 2011. and , p 1981-1991. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch125
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References

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Tables

Generic image for table
TABLE 1

Taxonomical, epidemiological, clinical, and mycological features of the hydrophilic microbes , and

Citation: Mendoza L, Vilela R. 2011. and , p 1981-1991. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch125

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