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Abstract:

The genus is classified in the family "" of the class , formerly known as the epsilon subclass of the , with as the type species. Phylogenetic analyses reliant on 16S rRNA gene sequences alone have sensitivity limitations in investigations of closely related helicobacters, which have a high degree of natural transformation and genetic plasticity. Further insights into the taxonomy of the genus are now possible with the availability of complete genome sequences for five strains of , and for strains of , , and . Enterohepatic helicobacters inhabit the intestinal and hepatobiliary tracts of various mammal and bird hosts, and several species, such as , , , , , , and “,” infect humans with clinical symptoms. From the microbiology laboratory perspective, microscopic examinations of a smear prepared directly from a biopsy specimen or from imprint cytology provide rapid bacteriological test results for observation of cells of . There is currently no ”gold standard” method for use in the clinical laboratory setting for PCR of gastric biopsy specimens, and so it is advised that PCR based assays should not be the sole basis of determining the status of a patient. To perform antimicrobial susceptibility testing, bacteriological culture of from gastric biopsy specimens is recommended, especially in cases of repeated treatment failure.

Citation: Lawson A. 2011. , p 900-915. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch54

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Antimicrobial Susceptibility Testing
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Restriction Fragment Length Polymorphism
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Lower Gastrointestinal Tract
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FIGURE 1

Phylogenetic tree of the genus based on 16S rRNA gene sequence similarity constructed using the neighbor-joining method. The bar represents percentage sequence divergence. Species marked in boldface type are urease positive; those in lightface are urease negative. indicates species for which a genome sequence either is available or currently is being determined. Strain collection catalogue and 16S rRNA gene sequence reference numbers (in parentheses) are given where available.

Citation: Lawson A. 2011. , p 900-915. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch54
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References

/content/book/10.1128/9781555816728.chap54
1. Alm, R. A.,, and B. Noonan,. 2001. The genome, p. 295 311. In H. L. T. Mobley,, G. L. Mendz,, and S. L. Hazell (ed.), Helicobacter pylori: Physiology and Genetics. ASM Press, Washington, D. C.
2. Andersen, L. P.,, K. Boye,, J. Blom,, S. Holck,, A. Norgaard,, and L. Elsborg. 1999. Characterization of a culturable “Gastrospirillum hominis” (Helicobacter heilmannii) strain isolated from human gastric mucosa. J. Clin. Microbiol. 37: 1069 1076.
3. Atherton, J. C.,, T. L. Cover,, R. J. Twells,, M. R. Morales,, C. J. Hawkey,, and M. J. Blaser. 1999. Simple and accurate PCR-based system for typing vacuolating cytotoxin alleles of Helicobacter pylori. J. Clin. Microbiol. 37: 2979 2982.
4. Avenaud, P.,, A. Marais,, L. Monteiro,, B. Le Bail,, P. Bioulac Sage,, C. Balabaud,, and F. Megraud. 2000. Detection of Helicobacter species in the liver of patients with and without primary liver carcinoma. Cancer 89: 1431 1439.
5. Baele, M.,, A. Decostere,, P. Vandamme,, L. Ceelen,, A. Hellemans,, J. Mast,, K. Chiers,, R. Ducatelle,, and F. Haesebrouck. 2008. Isolation and characterization of Helicobacter suis sp. nov from pig stomachs. Int. J. Syst. Evol. Microbiol. 58: 1350 1358.
6. Blanco, S.,, M. Forne,, A. Lacoma,, C. Prat,, M. A. Cuesta,, I. Latorre,, J. M. Viver,, G. Fernandez,, S. Molinos,, and J. Dominguez. 2008. Comparison of stool antigen immunoassay methods for detecting Helicobacter pylori infection before and after eradication treatment. Diagn. Microbiol. Infect. Dis. 61: 150 155.
7. Branca, G.,, T. Spanu,, G. Cammarota,, A. M. Schito,, A. Gasbarrini,, G. B. Gasbarrini,, and G. Fadda. 2004. High levels of dual resistance to clarithromycin and metronidazole and in vitro activity of levofloxacin against Helicobacter pylori isolates from patients after failure of therapy. Int. J. Antimicrob. Agents 24: 433 438.
8. Bruce, M. G.,, and H. I. Maaroos. 2008. Epidemiology of Helicobacter pylori infections. Helicobacter 13(Suppl.1): 1 6.
9. Bunn, J. E.,, W. G. MacKay,, J. E. Thomas,, D. C. Reid,, and L. T. Weaver. 2002. Detection of Helicobacter pylori DNA in drinking water biofilms: implications for transmission in early life. Lett. Appl. Microbiol. 34: 450 454.
10. Carothers, J. J.,, M. G. Bruce,, T. W. Hennessy,, M. Bensler,, J. M. Morris,, A. L. Reasonover,, D. A. Hurlburt,, A. J. Parkinson,, J. M. Coleman,, and B. J. McMahon. 2007. The relationship between previous fluoroquinolone use and levofloxacin resistance in Helicobacter pylori infection. Clin. Infect. Dis. 44: e5 e8.
11. Ceelen, L.,, A. Decostere,, G. Verschraegen,, R. Ducatelle,, and F. Haesebrouck. 2005. Prevalence of Helicobacter pullorum among patients with gastrointestinal disease and clinically healthy persons. J. Clin. Microbiol. 43: 2984 2986.
12. Ceelen, L. M.,, A. Decostere,, K. Van den Bulck,, S. L. On,, M. Baele,, R. Ducatelle,, and F. Haesebrouck. 2006. Helicobacter pullorum in chickens, Belgium. Emerg. Infect. Dis. 12: 263 267.
13. Chisholm, S. A.,, R. J. Owen,, E. L. Teare,, and S. Saverymuttu. 2001. PCR-based diagnosis of Helicobacter pylori infection and real-time determination of clarithromycin resistance directly from human gastric biopsy samples. J. Clin. Microbiol. 39: 1217 1220.
14. Chisholm, S. A.,, E. L. Teare,, B. Patel,, and R. J. Owen. 2002. Determination of Helicobacter pylori vacA allelic types by single-step multiplex PCR. Lett. Appl. Microbiol. 35: 42 46.
15. Chisholm, S. A.,, and R. J. Owen. 2003. Mutations in Helicobacter pylori rdxA gene sequences may not contribute to metronidazole resistance. J. Antimicrob. Chemother. 51: 995 999.
16. Chisholm, S. A.,, and R. J. Owen. 2003. Development and application of a novel screening PCR assay for direct detection of “Helicobacter heilmannii”-like organisms in human gastric biopsies in southeast England. Diagn. Microbiol. Infect. Dis. 46: 1 7.
17. Chisholm, S. A.,, and R. J. Owen. 2004. Frameshift mutations in frxA occur frequently and do not provide a reliable marker for metronidazole resistance in UK isolates of Helicobacter pylori. J. Med. Microbiol. 53: 135 140.
18. Chisholm, S. A.,, C. L. Watson,, E. L. Teare,, S. Saverymuttu,, and R. J. Owen. 2004. Non-invasive diagnosis of Helicobacter pylori infection in adult dyspeptic patients by stool antigen detection: does the rapid immunochromatography test provide a reliable alternative to conventional ELISA kits? J. Med. Microbiol. 53: 623 627.
19. Chisholm, S. A.,, and R. J. Owen. 2006. From Nobel to no cure: a case for monitoring antibiotic resistance in the gastric pathogen Helicobacter pylori. Expert. Rev. Anti Infect. Ther. 4: 349 351.
20. Chisholm, S. A.,, E. L. Teare,, K. Davies,, and R. J. Owen. 2007. Surveillance of primary antibiotic resistance of Helicobacter pylori at centres in England and Wales over a six-year period (2000-2005). Euro Surveill. 12: E3 E4.
21. Chisholm, S. A.,, and R. J. Owen. 2008. Application of polymerase chain reaction-based assays for rapid identification and antibiotic resistance screening of Helicobacter pylori in gastric biopsies. Diagn. Microbiol. Infect. Dis. 61: 67 71.
22. Chisholm, S. A.,, and R. J. Owen. 2009. Frequency and molecular characteristics of ciprofloxacin- and rifampicin-resistant Helicobacter pylori from gastric infections in the United Kingdom. J. Med. Microbiol. 58: 1322 1328.
23. Cindoruk, M.,, M. Y. Cirak,, S. Unal,, T. Karakan,, G. Erkan,, D. Engin,, S. Dumlu,, and S. Turet. 2008. Identification of Helicobacter species by 16S rDNA PCR and sequence analysis in human liver samples from patients with various etiologies of benign liver diseases. Eur. J. Gastroenterol. Hepatol. 20: 33 36.
24. Cirak, M. Y.,, Y. Akyon,, and F. Megraud. 2007. Diagnosis of Helicobacter pylori. Helicobacter 12(Suppl. 1): 4 9.
25.Clinical and Laboratory Standards Institute. 2006. Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria, vol. 26 (no. 19). Approved guideline M45-A. Clinical and Laboratory Standards Institute, Wayne, PA.
26. De Groote, D.,, L. J. Van Doorn,, B. K. Van den,, P. Vandamme,, M. Vieth,, M. Stolte,, J. C. Debongnie,, A. Burette,, F. Haesebrouck,, and R. Ducatelle. 2005. Detection of non-pylori Helicobacter species in “Helicobacter heilmannii” infected humans. Helicobacter 10: 398 406.
27. de Martel, C.,, M. Plummer,, J. Parsonnet,, L. J. Van Doorn,, and S. Franceschi. 2009. Helicobacter species in cancers of the gallbladder and extrahepatic biliary tract. Br. J. Cancer 100: 194 199.
28. Dewhirst, F. E.,, J. G. Fox,, and S. L. On. 2000. Recommended minimal standards for describing new species of the genus Helicobacter Int. J. Syst. Evol. Microbiol. 50: 2231 2237.
29. Dewhirst, F. E.,, Z. Shen,, L. Stokes,, M. Scimeca,, and J. G. Fox. 2005. Discordant 16S rRNA and 23S rRNA phylogenies for the genus Helicobacter: implications for phylogenetic inference and systematics. J. Bacteriol. 187: 6106 6118.
30. Dewhirst, F. E.,, J. G. Fox,, E. N. Mendes,, B. J. Paster,, C. E. Gates,, C. A. Kirkbride,, and K. A. Eaton. 2000. ‘Flexispira rappini’ strains represent at least 10 Helicobacter taxa. Int. J. Syst. Evol. Microbiol. 50: 1781 1787.
31. Duck, W. M.,, J. Sobel,, J. M. Pruckler,, Q. Song,, D. Swerdlow,, C. Friedman,, A. Sulka,, B. Swaminathan,, T. Taylor,, M. Hoekstra,, P. Griffin,, D. Smoot,, R. Peek,, D. C. Metz,, P. B. Bloom,, S. Goldschmidt,, J. Parsonnet,, G. Triadafilopoulos,, G. I. Perez-Perez,, N. Vakil,, P. Ernst,, S. Czinn,, D. Dunne,, and B. D. Gold. 2004. Antimicrobial resistance incidence and risk factors among Helicobacter pylori-infected persons, United States. Emerg. Infect. Dis. 10: 1088 1094.
32. Elitsur, Y.,, V. Tolia,, M. A. Gilger,, J. Reeves-Garcia,, E. Schmidt-Sommerfeld,, A. R. Opekun,, H. El Zimaity,, D. Y. Graham,, and K. Enmei. 2009. Urea breath test in children: the United States prospective, multicenter study. Helicobacter 14: 134 140.
33. Elwyn, G.,, M. Taubert,, S. Davies,, G. Brown,, M. Allison, and C. Phillips. 2007. Which test is best for Helicobacter pylori? A cost-effectiveness model using decision analysis. Br. J. Gen. Pract. 57: 401 403.
34. Fischbach, L.,, and E. L. Evans. 2007. Meta-analysis: the effect of antibiotic resistance status on the efficacy of triple and quadruple first-line therapies for Helicobacter pylori. Aliment. Pharmacol. Ther. 26: 343 357.
35. Flores, B. M.,, C. L. Fennell,, and W. E. Stamm. 1989. Characterization of Campylobacter cinaedi and C. fennelliae antigens and analysis of the human immune response. J. Infect. Dis. 159: 635 640.
36. Fox, J. G. 2002. The non- H. pylori helicobacters: their expanding role in gastrointestinal and systemic diseases. Gut 50: 273 283.
37. Fox, J. G.,, C. C. Chien,, F. E. Dewhirst,, B. J. Paster,, Z. Shen,, P. L. Melito,, D. L. Woodward,, and F. G. Rodgers. 2000. Helicobacter canadensis sp. nov. isolated from humans with diarrhea as an example of an emerging pathogen. J. Clin. Microbiol. 38: 2546 2549.
38. Fox, J. G.,, F. E. Dewhirst,, Z. Shen,, Y. Feng,, N. S. Taylor,, B. J. Paster,, R. L. Ericson,, C. N. Lau,, P. Correa,, J. C. Araya,, and I. Roa. 1998. Hepatic Helicobacter species identified in bile and gallbladder tissue from Chileans with chronic cholecystitis. Gastroenterology 114: 755 763.
39. Fox, J. G.,, and F. Megraud,. 2007. Helicobacter, p. 947 963. In P. R. Murray,, E. J. Baron,, J. H. Jorgensen,, M. L. Landry,, and M. A. Pfaller (ed.), Manual of Clinical Microbiology, 9th ed. ASM Press, Washington, D. C.
40. Gibson, J. R.,, M. A. Ferrus,, D. Woodward,, J. Xerry,, and R. J. Owen. 1999. Genetic diversity in Helicobacter pullorum from human and poultry sources identified by an amplified fragment length polymorphism technique and pulsed-field gel electrophoresis. J. Appl. Microbiol. 87: 602 610.
41. Gisbert, J. P.,, and J. M. Pajares. 2004. Stool antigen test for the diagnosis of Helicobacter pylori infection: a systematic review. Helicobacter 9: 347 368.
42. Gisbert, J. P.,, M. F. de la Morena,, and V. Abraira. 2006. Accuracy of monoclonal stool antigen test for the diagnosis of H. pylori infection: a systematic review and meta-analysis. Am. J. Gastroenterol. 101: 1921 1930.
43. Glocker, E.,, and M. Kist. 2004. Rapid detection of point mutations in the gyrA gene of Helicobacter pylori conferring resistance to ciprofloxacin by a fluorescence resonance energy transfer-based real-time PCR approach. J. Clin. Microbiol. 42: 2241 2246.
44. Glocker, E.,, C. Bogdan,, and M. Kist. 2007. Characterization of rifampicin-resistant clinical Helicobacter pylori isolates from Germany. J. Antimicrob. Chemother. 59: 874 879.
45. Glupczynski, Y.,, N. Broutet,, A. Cantagrel,, L. P. Andersen,, T. Alarcon,, M. Lopez-Brea,, and F. Megraud. 2002. Comparison of the E test and agar dilution method for antimicrobial susceptibility testing of Helicobacter pylori. Eur. J. Clin. Microbiol. Infect. Dis. 21: 549 552.
46. Goddard, A. F.,, R. P. Logan,, J. C. Atherton,, D. Jenkins,, and R. C. Spiller. 1997. Healing of duodenal ulcer after eradication of Helicobacter heilmannii. Lancet 349: 1815 1816.
47. González, A.,, P. Piqueres,, Y. Moreno,, I. Cañigral,, R. J. Owen,, J. Hernández,, and M. A. Ferrús. 2008. A novel real-time PCR assay for the detection of Helicobacter pullorum-like organisms in chicken products. Int. Microbiol. 11: 203 208.
48. Goodwin, C.,, T. Armstrong,, T. Chilvers,, M. Peters,, M. J. Collins,, L. Sly,, W. McConnell,, and W. Harper. 1989. Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen. nov. as Helicobacter pylori comb. nov. and Helicobacter mustelae comb. nov., respectively. Int. J. Syst. Bacteriol. 39: 397 405.
49. Goosen, C.,, J. Theron,, M. Ntsala,, F. F. Maree,, A. Olckers,, S. J. Botha,, A. J. Lastovica,, and S. W. van der Merwe. 2002. Evaluation of a novel heminested PCR assay based on the phosphoglucosamine mutase gene for detection of Helicobacter pylori in saliva and dental plaque. J. Clin. Microbiol. 40: 205 209.
50. Graham, D. Y.,, and A. Shiotani. 2008. New concepts of resistance in the treatment of Helicobacter pylori infections. Nat. Clin. Pract. Gastroenterol. Hepatol. 5: 321 331.
51. Grignon, B.,, J. Tankovic,, F. Megraud,, Y. Glupczynski,, M. O. Husson,, M. C. Conroy,, J. P. Emond,, J. Loulergue,, J. Raymond,, and J. L. Fauchere. 2002. Validation of diffusion methods for macrolide susceptibility testing of Helicobacter pylori. Microb. Drug Resist. 8: 61 66.
52. Haesebrouck, F.,, F. Pasmans,, B. Flahou,, K. Chiers,, M. Baele,, T. Meyns,, A. Decostere,, and R. Ducatelle. 2009. Gastric helicobacters in domestic animals and nonhuman primates and their significance for human health. Clin. Microbiol. Rev. 22: 202 223.
53. Haggerty, T. D.,, S. Perry,, L. Sanchez,, G. Perez-Perez,, and J. Parsonnet. 2005. Significance of transiently positive enzyme-linked immunosorbent assay results in detection of Helicobacter pylori in stool samples from children. J. Clin. Microbiol. 43: 2220 2223.
54. Hanninen, M. L.,, M. Utriainen,, I. Happonen,, and F. E. Dewhirst. 2003. Helicobacter sp. flexispira 16S rDNA taxa 1, 4, and 5 and Finnish porcine Helicobacter isolates are members of the species Helicobacter trogontum (taxon 6). Int. J. Syst. Evol. Microbiol. 53: 425 433.
55. Hanninen, M. L.,, R. I. Karenlampi,, J. M. Koort,, T. Mikkonen,, and K. J. Bjorkroth. 2005. Extension of the species Helicobacter bilis to include the reference strains of Helicobacter sp. flexispira taxa 2, 3 and 8 and Finnish canine and feline flexispira strains. Int. J. Syst. Evol. Microbiol. 55: 891 898.
56. Husmann, M.,, C. Gries,, P. Jehnichen,, T. Woelfel,, G. Gerken,, W. Ludwig,, and S. Bhakdi. 1994. Helicobacter sp. strain Mainz isolated from an AIDS patient with septic arthritis: case report and nonradioactive analysis of 16S rRNA sequence. J. Clin. Microbiol. 32: 3037 3039.
57. Jalava, K.,, S. L. On,, C. S. Harrington,, L. P. Andersen,, M. L. Hanninen, and P. Vandamme. 2001. A cultured strain of ‘Helicobacter heilmannii,’ a human gastric pathogen identified as H. bizzozeronii: evidence for zoonotic potential of Helicobacter. Emerg. Infect. Dis. 7: 1036 1038.
58. Iwashita, H.,, S. Fujii,, Y. Kawamura,, T. Okamoto,, T. Sawa,, T. Masaki,, A. Nishizono,, S. Higashi,, T. Kitamura,, F. Tamura,, Y. Sasaki,, and T. Akaike. 2008. Identification of the major antigenic protein of Helicobacter cinaedi and its immunogenicity in humans with H. cinaedi infections. Clin. Vac. Immunol. 15: 513 521.
59. Jothimani, D. K.,, U. Zanetto,, R. J. Owen,, A. J. Lawson,, and P. G. Wilson. 2009. A rare case of gastric erosions. Gut 58: 1669.
60. Kaakoush, N. O.,, C. Asencio,, F. Megraud,, and G. L. Mendz. 2009. A redox basis for metronidazole resistance in Helicobacter pylori. Antimicrob. Agents Chemother. 53: 1884 1891.
61. Kabir, S. 2004. Detection of Helicobacter pylori DNA in feces and saliva by polymerase chain reaction: a review. Helicobacter 9: 115 123.
62. Kiehlbauch, J. A.,, D. J. Brenner,, D. N. Cameron,, A. G. Steigerwalt,, J. M. Makowski,, C. N. Baker,, C. M. Patton,, and I. K. Wachsmuth. 1995. Genotypic and phenotypic characterization of Helicobacter cinaedi and Helicobacter fennelliae strains isolated from humans and animals. J. Clin. Microbiol. 33: 2940 2947.
63. Kiehlbauch, J. A.,, R. V. Tauxe,, C. N. Baker,, and I. K. Wachsmuth. 1994. Helicobacter cinaedi-associated bacteremia and cellulitis in immunocompromised patients. Ann. Intern. Med. 121: 90 93.
64. Kim, J. M.,, J. S. Kim,, N. Kim,, S. G. Kim,, H. C. Jung,, and I. S. Song. 2006. Comparison of primary and secondary antimicrobial minimum inhibitory concentrations for Helicobacter pylori isolated from Korean patients. Int. J. Antimicrob. Agents 28: 6 13.
65. Kist, M. 2007. Helicobacter pylori: primary antimicrobial resistance and first-line treatment strategies. Euro Surveill. 12: E1 E2.
66. Kitamura, T.,, Y. Kawamura,, K. Ohkusu,, T. Masaki,, H. Iwashita,, T. Sawa,, S. Fujii,, T. Okamoto,, and T. Akaike. 2007. Helicobacter cinaedi cellulitis and bacteremia in immunocompetent hosts after orthopedic surgery. J. Clin. Microbiol. 45: 31 38.
67. Kolho, K. L.,, T. Klemola,, A. Koivusalo,, and H. Rautelin. 2006. Stool antigen tests for the detection of Helicobacter pylori in children. Diagn. Microbiol. Infect. Dis. 55: 269 273.
68. Laharie, D.,, C. Asencio,, J. Asselineau,, P. Bulois,, A. Bourreille,, J. Moreau,, P. Bonjean,, D. Lamarque,, A. Pariente,, J. C. Soule,, A. Charachon,, B. Coffin,, P. Perez,, F. Megraud,, and F. Zerbib. 2009. Association between enterohepatic Helicobacter species and Crohn’s disease: a prospective cross-sectional study. Aliment. Pharmacol. Ther. 30: 283 293.
69. Laheij, R. J.,, H. Straatman,, J. B. Jansen,, and A. L. Verbeek. 1998. Evaluation of commercially available Helicobacter pylori serology kits: a review. J. Clin. Microbiol. 36: 2803 2809.
70. Lastovica, A. J.,, and E. le Roux. 2000. Efficient isolation of campylobacteria from stools. J. Clin. Microbiol. 38: 2798 2799.
71. Latham, S. R.,, R. J. Owen,, N. C. Elviss,, A. Labigne,, and P. J. Jenks. 2001. Differentiation of metronidazole-sensitive and -resistant clinical isolates of Helicobacter pylori by immunoblotting with antisera to the RdxA protein. J. Clin. Microbiol. 39: 3052 3055.
72. Lawson, A. J.,, N. C. Elviss,, and R. J. Owen. 2005. Real-time PCR detection and frequency of 16S rDNA mutations associated with resistance and reduced susceptibility to tetracycline in Helicobacter pylori from England and Wales. J. Antimicrob. Chemother. 56: 282 286.
73. Leal, Y. A.,, L. F. Flores,, L. B. Garcia-Cortes,, R. Cedillo-Rivera,, and J. Tores. 2008. Antibody-based detection tests for the diagnosis of Helicobacter pylori infection in children: a meta-analysis. PLoS ONE 3: e3751. doi:10.1371/journal.pone.0003751.
74. Leemann, C.,, E. Gambillara,, G. Prod’hom,, K. Jaton,, R. Panizzon,, J. Bille,, P. Francioli,, G. Greub,, E. Laffitte,, and P. E. Tarr. 2006. First case of bacteraemia and multifocal cellulitis due to Helicobacter canis in an immunocompetent patient. J. Clin. Microbiol. 44: 4598 4600.
75. Li, C.,, T. Ha,, D. S. Chi,, D. A. Ferguson, Jr.,, C. Jiang,, J. J. Laffan,, and E. Thomas. 1997. Differentiation of Helicobacter pylori strains directly from gastric biopsy specimens by PCR-based restriction fragment length polymorphism analysis without culture. J. Clin. Microbiol. 35: 3021 3025.
76. Logan, J. M. J.,, A. Burnens,, D. Linton,, A. Lawson,, and J. Stanley. 2000. Campylobacter lanienae sp. nov., a new species isolated from workers in an abattoir. Int. J. Syst. Evol. Microbiol. 50: 865 872.
77. Lottspeich, C.,, A. Schwarzer,, K. Panthel,, S. Koletzko,, and H. Russmann. 2007. Evaluation of the novel Helicobacter pylori ClariRes real-time PCR assay for detection and clarithromycin susceptibility testing of H. pylori in stool specimens from symptomatic children. J. Clin. Microbiol. 45: 1718 1722.
78. Luzza, F.,, M. Maletta,, M. Imeneo,, A. Marcheggiano,, C. Iannoni,, L. Biancone,, and F. Pallone. 1995. Salivary-specific immunoglobulin G in the diagnosis of Helicobacter pylori infection in dyspeptic patients. Am. J. Gastroenterol. 90: 1820 1823.
79. Maiden, M. C. 2006. Multilocus sequence typing of bacteria. Annu. Rev. Microbiol. 60: 561 588.
80. Makristathis, A.,, A. M. Hirschl,, H. Russmann,, and S. Koletzko. 2007. Detection and clarithromycin susceptibility testing of Helicobacter pylori in stool specimens by real-time PCR: how to get accurate test results. J. Clin. Microbiol. 45: 2756 2757.
81. Malaty, H. M.,, N. D. Logan,, D. Y. Graham,, J. E. Ramchatesingh,, and S. G. Reddy. 2000. Helicobacter pylori infection in asymptomatic children: comparison of diagnostic tests. Helicobacter 5: 155 159.
82. Malfertheiner, P.,, F. Megraud,, C. O’Morain,, F. Bazzoli,, E. El Omar,, D. Graham,, R. Hunt,, T. Rokkas,, N. Vakil,, and E. J. Kuipers. 2007. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut 56: 772 781.
83. Matsui, H.,, C. Aikawa,, Y. Sekiya,, S. Takahashi,, S. Y. Murayama,, and M. Nakamura. 2008. Evaluation of antibiotic therapy for eradication of “ Candidatus Helicobacter heilmannii.” Antimicrob. Agents Chemother. 52: 2988 2989.
84. Matsumoto, T.,, M. Kawakubo,, M. Shiohara,, T. Kumagai,, E. Hidaka,, K. Yamauchi,, K. Oana,, K. Matsuzawa,, H. Ota,, and Y. Kawakami. 2009. Phylogeny of a novel “Helicobacter heilmannii” organism from a Japanese patient with chronic gastritis based on DNA sequence analysis of 16S rRNA and urease genes. J. Microbiol. 47: 201 207.
85. Mbulaiteye, S. M.,, M. Hisada,, and E. M. El Omar. 2009. Helicobacter pylori associated global gastric cancer burden. Front. Biosci. 14: 1490 1504.
86. McClain, M. S.,, C. L. Shaffer,, D. A. Israel,, R. M. Peek, Jr.,, and T. L. Cover. 2009. Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer. BMC Genomics 10: 3. doi.:10.1186/ 1471-2164-10-3.
87. McNulty, C.,, L. Teare,, R. Owen,, D. Tompkins,, P. Hawtin,, and K. McColl. 2005. Test and treat for dyspepsia—but which test? BMJ 330: 105 106.
88. McNulty, C. A. M.,, and J. W. Whiting. 2007. Patients’ attitudes to Helicobacter pylori breath and stool antigen tests compared to blood serology. J. Infect. 55: 19 22.
89. Mégraud, F.,, and P. Lehours. 2007. Helicobacter pylori detection and antimicrobial susceptibility testing. Clin. Microbiol. Rev. 20: 280 322.
90. Melito, P. L.,, C. Munro,, P. R. Chipman,, D. L. Woodward,, T. F. Booth,, and F. G. Rodgers. 2001. Helicobacter winghamensis sp. nov., a novel Helicobacter sp. isolated from patients with gastroenteritis. J. Clin. Microbiol. 39: 2412 2417.
91. Mills, S. D.,, L. A. Kurjanczyk,, and J. L. Penner. 1992. Antigenicity of Helicobacter pylori lipopolysaccharides. J. Clin. Microbiol. 30: 3175 3180.
92. Moayyedi, P.,, J. Deeks,, N. J. Talley,, B. Delaney,, and D. Forman. 2003. An update of the Cochrane systematic review of Helicobacter pylori eradication therapy in nonulcer dyspepsia: resolving the discrepancy between systematic reviews. Am. J. Gastroenterol. 98: 2621 2626.
93. Monteiro, L.,, N. Gras,, R. Vidal,, J. Cabrita,, and F. Megraud. 2001. Detection of Helicobacter pylori DNA in human feces by PCR: DNA stability and removal of inhibitors. J. Microbiol. Methods 45: 89 94.
94. Moreno, Y.,, P. Piqueres,, J. L. Alonso,, A. Jimenez,, A. Gonzalez,, and M. A. Ferrus. 2007. Survival and viability of Helicobacter pylori after inoculation into chlorinated drinking water. Water Res. 41: 3490 3496.
95. Morgner, A.,, N. Lehn,, L. P. Andersen,, C. Thiede,, M. Bennedsen,, K. Trebesius,, B. Neubauer,, A. Neubauer,, M. Stolte,, and E. Bayerdorffer. 2000. Helicobacter heilmannii-associated primary gastric low-grade MALT lymphoma: complete remission after curing the infection. Gastroenterology 118: 821 828.
96. Moyaert, H.,, A. Decostere,, P. Vandamme,, L. Debruyne,, J. Mast,, M. Baele,, L. Ceelen,, R. Ducatelle,, and F. Haesebrouck. 2007. Helicobacter equorum sp. nov., a urease-negative Helicobacter species isolated from horse faeces. Int. J. Syst. Evol. Microbiol. 57: 213 218.
97. Moyaert, H.,, F. Franceschi,, D. Roccarina,, R. Ducatelle,, F. Haesebrouck,, and A. Gasbarrini. 2008. Extragastric manifestations of Helicobacter pylori infection: other helicobacters. Helicobacter 13(Suppl. 1): 47 57.
98. Murakami, H.,, M. Goto,, E. Ono,, E. Sawabe,, M. Iwata,, K. Okuzumi,, K. Yamaguchi,, and T. Takahashi. 2003. Isolation of Helicobacter cinaedi from blood of an immunocompromised patient in Japan. J. Infect. Chemother. 9: 344 347.
99. Nilsson, H. O.,, R. Mulchandani,, K. G. Tranberg,, U. Stenram,, and T. Wadstrom. 2001. Helicobacter species identified in liver from patients with cholangiocarcinoma and hepatocellular carcinoma. Gastroenterology 120: 323 324.
100. Oleastro, M.,, A. Menard,, A. Santos,, H. Lamouliatte,, L. Monteiro,, P. Barthelemy,, and F. Megraud. 2003. Real-time PCR assay for rapid and accurate detection of point mutations conferring resistance to clarithromycin in Helicobacter pylori. J. Clin. Microbiol. 41: 397 402.
101. On, S. L. W.,, A. Lee,, J. L. O’Rourke,, F. E. Dewhirst,, B. J. Paster,, J. G. Fox,, and P. Vandamme,. 2005. Genus I., Helicobacter, p. 1169ndash; 1189. In D. J. Brenner,, N. R. Krieg,, J. T. Staley,, and G. Garrity (ed.), Bergey’s Manual of Systematic Bacteriology, 2nd ed. Springer, New York, NY.
102. O’Rourke, J. L.,, M. Grehan,, and A. Lee. 2001. Non-pylori Helicobacter species in humans. Gut 49: 601 606.
103. Osato, M. S.,, R. Reddy,, S. G. Reddy,, R. L. Penland,, H. M. Malaty,, and D. Y. Graham. 2001. Pattern of primary resistance of Helicobacter pylori to metronidazole or clarithromycin in the United States. Arch. Intern. Med. 161: 1217 1220.
104. Owen, R. J.,, D. E. Taylor,, G. Wang,, and L.-J. van Doorn,. 2001. Heterogeneity and subtyping, p. 363 378. In H. L. T. Mobley,, G. L. Mendz,, and S. L. Hazell (ed.), Helicobacter pylori: Physiology and Genetics. ASM Press, Washington, DC.
105. Owen, R. J. 2002. Molecular testing for antibiotic resistance in Helicobacter pylori. Gut 50: 285 289.
106. Owen, R. J.,, and J. Xerry. 2003. Tracing clonality of Helicobacter pylori infecting family members from analysis of DNA sequences of three housekeeping genes (ureI, atpA and ahpC), deduced amino acid sequences, and pathogenicity-associated markers (cagA and vacA). J. Med. Microbiol. 52: 515 524.
107. Owen, R. J.,, and J. Xerry. 2007. Geographical conservation of short inserts in the signal and middle regions of the Helicobacter pylori vacuolating cytotoxin gene. Microbiology 153: 1176 1186.
108. Parsonnet, J.,, H. Shmuely,, and T. Haggerty. 1999. Fecal and oral shedding of Helicobacter pylori from healthy infected adults. JAMA 282: 2240 2245.
109. Pena, J. A.,, K. McNeil,, J. G. Fox,, and J. Versalovic. 2002. Molecular evidence of Helicobacter cinaedi organisms in human gastric biopsy specimens. J. Clin. Microbiol. 40: 1511 1513.
110. Powers, C. N. 1998. Diagnosis of infectious diseases: a cytopathologist’s perspective. Clin. Microbiol. Rev. 11: 341 365.
111. Prag, J.,, J. Blom,, and K. A. Krogfelt. 2007. Helicobacter canis bacteraemia in a 7-month-old child. FEMS Immunol. Med. Microbiol. 50: 264 267.
112. Puz, S.,, Z. Kovach,, A. M. Hirschl,, M. Hafner,, A. Innerhofer,, M. Rotter,, and A. Makristathis. 2006. Evaluation of the novel Helicobacter pylori ClariRes real-time PCR assay for detection and clarithromycin susceptibility testing of H. pylori in stool specimens and gastric biopsies; comparison with the stool antigen test. Helicobacter 11: 396.
113. Puz, S.,, A. Innerhofer,, M. Ramharter,, M. Haefner,, A. M. Hirschl,, Z. Kovach,, M. Rotter,, and A. Makristathis. 2008. A novel noninvasive genotyping method of Helicobacter pylori using stool specimens. Gastroenterology 135: 1543 1551.
114. Qualia, C. M.,, P. J. Katzman,, M. R. Brown,, and K. Kooros. 2007. A report of two children with Helicobacter heilmannii gastritis and review of the literature. Pediatr. Dev. Pathol. 10: 391 394.
115. Robertson, B. R.,, J. L. O’Rourke,, P. Vandamme,, S. L. On,, and A. Lee. 2001. Helicobacter ganmani sp. nov., a urease-negative anaerobe isolated from the intestines of laboratory mice. Int. J. Syst. Evol. Microbiol. 51: 1881ndash; 1889.
116. Rocha, M.,, P. Avenaud,, A. Menard,, B. Le Bail,, C. Balabaud,, P. Bioulac-Sage,, D. M. de Magalhaes Queiroz,, and F. Megraud. 2005. Association of Helicobacter species with hepatitis C cirrhosis with or without hepatocellular carcinoma. Gut 54: 396 401.
117. Sanches, B.,, L. Coelho,, L. Moretzsohn,, and G. Vieira, Jr. 2008. Failure of Helicobacter pylori treatment after regimes containing clarithromycin: new practical therapeutic options. Helicobacter 13: 572 576.
118. Schabereiter-Gurtner, C.,, A. M. Hirschl,, B. Dragosics,, P. Hufnagl,, S. Puz,, Z. Kovach,, M. Rotter,, and A. Makristathis. 2004. Novel real-time PCR assay for detection of Helicobacter pylori infection and simultaneous clarithromycin susceptibility testing of stool and biopsy specimens. J. Clin. Microbiol. 42: 4512 4518.
119. Schwarz, S.,, G. Morelli,, B. Kusecek,, A. Manica,, F. Balloux,, R. J. Owen,, D. Y. Graham,, S. van der Merwe,, M. Achtman,, and S. Suerbaum. 2008. Horizontal versus familial transmission of Helicobacter pylori. PLoS Pathog. 4: e1000180.
120. She, R. C.,, A. R. Wilson,, and C. M. Litwin. 2009. Evaluation of Helicobacter pylori immunoglobulin G (IgG), IgA, and IgM serologic testing compared to stool antigen testing. Clin. Vac. Immunol. 16: 1253 1255.
121. Solnick, J. V.,, and D. B. Schauer. 2001. Emergence of diverse Helicobacter species in the pathogenesis of gastric and enterohepatic diseases. Clin. Microbiol. Rev. 14: 59 97.
122. Stanley, J.,, D. Linton,, A. P. Burnens,, F. E. Dewhirst,, S. L. On,, A. Porter,, R. J. Owen,, and M. Costas. 1994. Helicobacter pullorum sp. nov.—genotype and phenotype of a new species isolated from poultry and from human patients with gastroenteritis. Microbiology 140: 3441 3449.
123. Steinbrueckner, B.,, G. Haerter,, K. Pelz,, S. Weiner,, J. A. Rump,, W. Deissler,, S. Bereswill,, and M. Kist. 1997. Isolation of Helicobacter pullorum from patients with enteritis. Scand. J. Infect. Dis. 29: 315 318.
124. Suerbaum, S.,, and P. Michetti. 2002. Helicobacter pylori infection. N. Engl. J. Med. 347: 1175 1186.
125. Sugimoto, M.,, J. Y. Wu,, S. Abudayyeh,, J. Hoffman,, H. Brahem,, K. Al Khatib,, Y. Yamaoka,, and D. Y. Graham. 2009. Unreliability of results of PCR detection of Helicobacter pylori in clinical or environmental samples. J. Clin. Microbiol. 47: 738 742.
126. Suzuki, N.,, M. Yoneda,, T. Naito,, T. Iwamoto,, Y. Masuo,, K. Yamada,, K. Hisama,, I. Okada,, and T. Hirofuji. 2008. Detection of Helicobacter pylori DNA in the saliva of patients complaining of halitosis. J. Med. Microbiol. 57: 1553 1559.
127. Tan, H. J.,, and K. L. Goh. 2008. Changing epidemiology of Helicobacter pylori in Asia. J. Dig. Dis. 9: 186 189.
128. Tolia, V.,, H. O. Nilsson,, K. Boyer,, A. Wuerth,, W. A. Al Soud,, R. Rabah,, and T. Wadstrom. 2004. Detection of Helicobacter ganmani-like 16S rDNA in pediatric liver tissue. Helicobacter 9: 460 468.
129. Totten, P. A.,, C. L. Fennell,, F. C. Tenover,, J. M. Wezenberg,, P. L. Perine,, W. E. Stamm,, and K. K. Holmes. 1985. Campylobacter cinaedi (sp. nov.) and Campylobacter fennelliae (sp.nov.): two new Campylobacter species associated with enteric disease in homosexual men. J. Infect. Dis. 151: 131 139.
130. Trebesius, K.,, K. Adler,, M. Vieth,, M. Stolte,, and R. Haas. 2001. Specific detection and prevalence of Helicobacter heilmannii-like organisms in the human gastric mucosa by fluorescent in situ hybridization and partial 16S ribosomal DNA sequencing. J. Clin. Microbiol. 39: 1510 1516.
131. Uçkay, I.,, J. Garbino,, P. Y. Dietrich,, B. Ninet,, P. Rohner,, and V. Jacomo. 2006. Recurrent bacteraemia with Helicobacter cinaedi: case report and review of the literature. BMC Infect. Dis. 23: 86.
132. Vandamme, P.,, E. Falsen,, R. Rossau,, B. Hoste,, P. Segers,, R. Tytgat,, and J. De Ley. 1991. Revision of Campylobacter, Helicobacter, and Wolinella taxonomy: emendation of generic descriptions and proposal of Arcobacter gen. nov. Int. J. Syst. Bacteriol. 41: 88 103.
133. Vandamme, P.,, C. S. Harrington,, K. Jalava,, and S. L. On. 2000. Misidentifying helicobacters: the Helicobacter cinaedi example. J. Clin. Microbiol. 38: 2261 2266.
134. Van den Bulck, K.,, A. Decostere,, M. Baele,, A. Driessen,, J. C. Debongnie,, A. Burette,, M. Stolte,, R. Ducatelle,, and F. Haesebrouck. 2005. Identification of non- Helicobacter pylori spiral organisms in gastric samples from humans, dogs, and cats. J. Clin. Microbiol. 43: 2256 2260.
135. Veijola, L.,, A. Oksanen,, A. Linnala,, P. Sipponen,, and H. Rautelin. 2007. Persisting chronic gastritis and elevated Helicobacter pylori antibodies after successful eradication therapy. Helicobacter 12: 605 608.
136. Veijola, L.,, A. Oksanen,, P. Sipponen,, and H. Rautelin. 2008. Evaluation of a commercial immunoblot, Helicoblot 2.1, for diagnosis of Helicobacter pylori infection. Clin. Vac-cine Immunol. 15: 1705 1710.
137. Versalovic, J.,, D. Shortridge,, K. Kibler,, M. V. Griffy,, J. Beyer,, R. K. Flamm,, S. K. Tanaka,, D. Y. Graham,, and M. F. Go. 1996. Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori. Antimicrob. Agents Chemother. 40: 477 480.
138. Warren, J. R.,, and B. J. Marshall. 1983. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet i: 1273 1275.
139. Watson, C. L.,, R. J. Owen,, B. Said,, S. Lai,, J. V. Lee,, S. Surman-Lee,, and G. Nichols. 2004. Detection of Helicobacter pylori by PCR but not culture in water and biofilm samples from drinking water distribution systems in England. J. Appl. Microbiol. 97: 690 698.
140. Williams, M. P.,, J. C. Sercombe,, A. J. Lawson,, E. Slater,, R. J. Owen,, and R. E. Pounder. 1999. The effect of omeprazole dosing on the isolation of Helicobacter pylori from gastric aspirates. Aliment. Pharmacol. Ther. 13: 1161 1169.
141. Wundisch, T.,, C. Thiede,, A. Morgner,, A. Dempfle,, A. Gunther,, H. Liu,, H. Ye,, M. Q. Du,, T. D. Kim,, E. Bayerdorffer,, M. Stolte,, and A. Neubauer. 2005. Long-term follow-up of gastric MALT lymphoma after Helicobacter pylori eradication. J. Clin. Oncol. 23: 8018 8024.
142. Wueppenhorst, N.,, H. P. Stueger,, M. Kist,, and E. Glocker. 2009. Identification and molecular characterization of triple- and quadruple resistant Helicobacter pylori clinical isolates in Germany. J. Antimicrob. Chemother. 63: 648 653.
143. Yousfi, M. M.,, H. M. El-Zimaity,, R. A. Cole,, R. M. Genta,, and D. Y. Graham. 1997. Comparison of agar gel (CLOtest) or reagent strip (PyloriTek) rapid urease tests for detection of Helicobacter pylori infection. Am. J. Gastroenterol. 92: 997 999.
144. Zanoni, R. G.,, M. Rossi,, D. Giacomucci,, V. Sanguinetti,, and G. Manfreda. 2007. Occurrence and antibiotic susceptibility of Helicobacter pullorum from broiler chickens and commercial laying hens in Italy. Int. J. Food Microbiol. 116: 168 173.

Tables

Generic image for table
TABLE 1

species, hosts, and disease spectrum

Citation: Lawson A. 2011. , p 900-915. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch54
Generic image for table
TABLE 2

Key characteristics for identification of species

Test results from Baele et al. ( ) and Fox and Megraud ( ) and formal species descriptions. +, positive; –, negative; W, weakly positive; ND, not determined; Nal, nalidixic acid; Ceph, cephalexin; R, resistant; S, susceptible.

B, bipolar; M, monopolar; P, peritrichous.

Citation: Lawson A. 2011. , p 900-915. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch54

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