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Citation: Lefkowitz E. .

Key Concept Ranking

Hepatitis C virus
Horizontal Gene Transfer
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Image of FIGURE 1

Taxonomic demarcation via sequence similarity. (A) PASC was carried out on the viral DNA-dependent DNA polymerase gene (the vaccinia virus E9L gene homolog) for every completely sequenced poxvirus genome. Each protein was aligned to every other protein, and the percent identity of each pairwise comparison was then included in a histogram plot of all possible comparisons. Peaks are identified across the top of the figure according to the taxa represented by particular pairwise sequence comparisons. (B) Phylogenetic reconstruction of the family of viruses based on their DNA polymerase protein sequences. Subfamily and genera demarcations are identified. Terminal nodes are labeled according to genus. Sequences belonging to one of the genera labeled either group A or B coincide with the A and B comparison peaks at the top of panel A. (C) Phylogenetic prediction based on the multiple nucleic acid sequence alignment of the core genomic region of each representative orthopoxvirus species or strain. BR, strain Brighton Red; GRI, strain GRI-90. Reprinted with modification from ( ) with permission of the publisher.

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Image of FIGURE 2

Virion morphology. Depiction of the shapes and sizes of viruses of families that include animal, zoonotic, and human pathogens. The virions are drawn to scale, but artistic license has been used in representing their structure. In some, the cross-sectional structure of capsid and envelope are shown, with a representation of the genome; with the very small virions, only their size and symmetry are depicted. RT, reverse transcribing; +, positive-sense genome; -, negativesense genome. Reprinted with modification from ( ) with permission of the publisher.

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ICTVdb character list

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Criteria for taxonomic classification

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Taxonomic classification of viruses infecting humans

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Summary of important characteristics used to differentiate families of viruses infecting humans

+: positive sense; −: negative sense.

Genus (unassigned family).

Not classified by the ICTV.

NA, not applicable.


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