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Chapter 92 : Hendra and Nipah Viruses

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Abstract:

Hendra and Nipah viruses are classified as biosafety level 4 (BSL-4) agents in the United States and Australia, as there is a risk of infection of laboratory personnel and appropriate precautions must be taken. Widespread presence of Nipah virus antigens could be seen by immunohistochemistry (IHC) in endothelial and smooth muscle cells of blood vessels and in various parenchymal cells, particularly in neurons. Primer sequences can be designed to detect both Hendra and Nipah viruses or to detect each virus separately. Real-time reverse transcriptase polymerase chain reaction (RT-PCR) assays can facilitate research into the pathogenesis of Hendra and Nipah viruses. African green monkey kidney (Vero) cells inoculated with high-titer samples contain antigen within a few days of inoculation. Cytopathic effect (CPE) is usually seen within 3 to 5 days. The CPE is noticeable by the formation of syncytia containing several nuclei. To confirm the presence and identity of the virus, fixed cells are tested by immunofluorescence assay, or supernatant fluids can be tested for evidence of viral replication by RT-PCR techniques. Hendra and Nipah viruses can be reliably distinguished from each other only by neutralization tests. Other cells, such as rabbit kidney cells (RK-13), are susceptible to Hendra and Nipah viruses. Hyperimmune mouse ascites fluid, which recognizes all of the structural proteins of Nipah or Hendra viruses, is used as the positive control. The enzyme-linked immunosorbent assay (ELISA) immunoglobulin M (IgM) test has been the most important technique for serological confirmation in acute patients.

Citation: Rollin P, Rota P, Zaki S, Ksiazek T. 2011. Hendra and Nipah Viruses, p 1479-1487. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch92

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Figures

Image of FIGURE 1
FIGURE 1

Ultrastructural characteristics of Nipah virus isolate in cell culture as seen by negative-stain (A) and thin-section (B) EM (courtesy of C. S. Goldsmith). (A) A single nucleocapsid shows the typical herringbone appearance characteristic of the family . (B) Nipah virus nucleocapsids become tightly aligned along the plasma membrane as particle prepares to bud. Scale bar, 100 nm.

Citation: Rollin P, Rota P, Zaki S, Ksiazek T. 2011. Hendra and Nipah Viruses, p 1479-1487. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch92
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Image of FIGURE 2
FIGURE 2

Typical eosinophilic viral inclusions (black arrowheads) in the cytoplasm of neurons (hematoxylin and eosin stain; original magnification, ×250).

Citation: Rollin P, Rota P, Zaki S, Ksiazek T. 2011. Hendra and Nipah Viruses, p 1479-1487. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch92
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Image of FIGURE 3
FIGURE 3

Nipah virus encephalitis: viral antigen present among numerous neurons. Note the abundance of extracellular antigen (immunoalkaline phosphatase with naphthol fast red substrate and light hematoxylin counterstain; magnification, ×120).

Citation: Rollin P, Rota P, Zaki S, Ksiazek T. 2011. Hendra and Nipah Viruses, p 1479-1487. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch92
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References

/content/book/10.1128/9781555816728.chap92
1.Anonymous. 2003. Outbreaks of encephalitis due to Nipah/ Hendra-like viruses, Western Bangladesh. Health Sci. Bull. (English) 1:16.
2. Asiah, N. M.,, J. N. Mills,, B. L. Ong,, and T. G. Ksiazek. 2001. Epidemiological investigation of Nipah virus infection in peridomestic animals in peninsular Malaysia and future plans, p. 4750. In Office International des Epizooties and Department of Veterinary Services, Malaysia, Report of the Regional Seminar on Nipah Virus Infection; Kuala Lumpur, Malaysia. OIE Representation for Asia and the Pacific, Tokyo, Japan.
3. Bossart, K. N.,, Z. Zhu,, D. Middleton,, J. Klippel,, G. Crameri,, J. Bingham,, J. A. McEachern,, D. Green,, T. J. Hancock,, E. P. Chan,, A. C. Hickey,, D. S. Dimitrov,, L. F. Wang,, and C. C. Broder. 2009. A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute Nipah virus infection. PLoS Path. 5:e1000642.
4.Centers for Disease Control and Prevention and the National Institutes of Health. 2009. Biosafety in Microbiological and Biomedical Laboratories, 5th ed. U.S. Department of Health and Human Services, Washington, DC. http://www .cdc.gov/od/ohs/biosfty/bmbl5/BMBL_5th_Edition.pdf.
5. Chadha, M. S.,, A. C. Mishra,, N. K. Ganguly,, T. G. Ksiazek,, P. E. Rollin,, J. A. Comer,, P. A. Rota,, W. J. Bellini,, and L. Lowe. 2006. Nipah virus associated with an encephalitis outbreak, Siliguri, India, 2001. Emerg. Infect. Dis. 12:235240.
6. Chong, F. C.,, W. S. Tan,, D. R. Biak,, T. C. Ling,, and B. T. Tey. 2009. Purification of histidine-tagged nucleocapsid protein of Nipah virus using immobilized metal affinity chromatography. J. Chromatogr. B 877:15611567.
7. Chong, H. T.,, S. R. Kunjapan,, T. Thayaparan,, J. M. G. Tong,, V. Patharunam,, M. R. Jusoh,, and C. T. Tan. 2000. Nipah encephalitis outbreak in Malaysia, clinical features in patients from Seremban. Neurol. J. Southeast Asia 5:6167.
8. Chong, H. T.,, A. Kamarulzaman,, C. T. Tan,, K. J. Goh,, T. Thayaparan,, S. R. Kunjapan,, N. K. Chew,, K. B. Chua,, and S. K. Lam. 2001. Treatment of acute Nipah encephalitis with ribavirin. Ann. Neurol. 49:810813.
9. Chua, K. B.,, W. J. Bellini,, P. A. Rota,, B. H. Harcourt,, A. Tamin,, S. K. Lam,, T. G. Ksiazek,, P. E. Rollin,, S. R. Zaki,, W. Shieh,, C. S. Goldsmith,, D. J. Gubler,, J. T. Roehrig,, B. Eaton,, A. R. Gould,, J. Olson,, H. Field,, P. Daniels,, A. E. Ling,, C. J. Peters,, L. J. Anderson,, and B. W. Mahy. 2000. Nipah virus: a recently emergent deadly paramyxovirus. Science 288:14321435.
10. Chua, K. B.,, S. K. Lam,, K. J. Goh,, P. S. Hooi,, T. G. Ksiazek,, A. Kamarulzaman,, J. Olson,, and C. T. Tan. 2001. The presence of Nipah virus in respiratory secretions and urine of patients during an outbreak of Nipah virus encephalitis in Malaysia. J. Infect. 42:4043.
11. Crameri, G.,, L. F. Wang,, C. Morrissy,, J. White,, and B. T. Eaton. 2002. A rapid immune plaque assay for the detection of Hendra and Nipah viruses and anti-virus antibodies. J. Virol. Methods 99:4151.
12. Daniels, P.,, T. Ksiazek,, and B. T. Eaton. 2001. Laboratory diagnosis of Nipah and Hendra virus infections. Microbes Infect. 3:289295.
13. Drexler, J. F.,, V. M. Corman,, F. Gloza-Rausch,, A. Seebens,, A. Annan,, A. Ipsen,, T. Kruppa,, M. A. Muller,, E. K. Kalko,, Y. Adu-Sarkodie,, S. Oppong,, and C. Drosten. 2009. Henipavirus RNA in African bats. PLoS One 4:e6367.
14. Epstein, J. H.,, V. Prakash,, C. S. Smith,, P. Daszak,, A. B. McLaughlin,, G. Meehan,, H. E. Field,, and A. A. Cunningham. 2008. Henipavirus infection in fruit bats (Pteropus giganteus), India. Emerg. Infect. Dis. 14:13091311.
15. Eshaghi, M.,, W. S. Tan,, T. B. Mohidin,, and K. Yusoff. 2004. Nipah virus glycoprotein: production in baculovirus and application in diagnosis. Virus Res. 106:7176.
16. Eshaghi, M.,, W. S. Tan,, W. K. Chin,, and K. Yusoff. 2005. Purification of the extra-cellular domain of Nipah virus glycoprotein produced in Escherichia coli and possible application in diagnosis. J. Biotechnol. 116:221226.
17. Eshaghi, M.,, W. S. Tan,, S. T. Ong,, and K. Yusoff. 2005. Purification and characterization of Nipah virus nucleocapsid protein produced in insect cells. J. Clin. Microbiol. 43:31723177.
18. Field, H.,, P. Young,, J. M. Yob,, J. N. Mill,, L. Hall,, and J. Mackenzie. 2001. The natural history of Hendra and Nipah viruses. Microbes Infect. 3:307314.
19. Field, H. 2009. Hendra virus infection risks. Neurol. Asia 14:7778.
20.Food and Agriculture Organization. 2002. Manual on the Diagnosis of Nipah Virus Infection in Animals. RAP publication no. 2002/01. FAO, Regional Office for Asia and the Pacific, Bangkok, Thailand.
21. Freiberg, A. N.,, M. N. Worthy,, B. Lee,, and M. R. Holbrook. 2010. Combinatorial chloroquine and ribavirin treatment does not prevent death in a hamster model of Nipah and Hendra virus infection. J. Gen. Virol. 91:765772.
22. Georges-Courbot, M. C.,, H. Contamin,, C. Faure,, P. Loth,, S. Baize,, P. Leyssen,, J. Neyts,, and V. Deubel. 2006. Poly(I)- poly(C12U) but not ribavirin prevents death in a hamster model of Nipah virus infection. Antimicrob. Agents Chemother. 50:17681772.
23. Goh, K. J.,, C. T. Tan,, N. K. Chew,, P. S. Tan,, A. Kamarulzaman,, S. A. Sarji,, K. T. Wong,, B. J. J. Abdullah,, K. B. Chua,, and S. K. Lam. 2000. Clinical features of Nipah virus encephalitis among pig farmers in Malaysia. N. Engl. J. Med. 342:12291235.
24. Goldsmith, C. S.,, T. Whistler,, P. E. Rollin,, T. G. Ksiazek,, P. Rota,, W. J. Bellini,, P. Daszak,, K. T. Wong,, W.-J. Shieh,, T. G. Ksiazek,, and S. R. Zaki. 2003. Elucidation of Nipah virus morphogenesis and replication using ultrastructural and molecular approaches. Virus Res. 92:8998.
25. Guillaume, V.,, H. Contamin,, P. Loth,, M.-C. Georges- Courbot,, A. Lefeuvre,, P. Marianneau,, K. B. Chua,, S. K. Lam,, R. Buckland,, V. Deubel,, and T. F. Wild. 2004. Nipah virus: vaccination and passive protection studies in a hamster model. J. Virol. 78:834840.
26. Guillaume, V.,, A. Lefeuvre,, C. Faure,, P. Marianneau,, R. Buckland,, S. K. Lam,, T. F. Wild,, and V. Deubel. 2004. Specific detection of Nipah virus using real-time RT-PCR (TaqMan). J. Virol. Methods 120:229237.
27. Gurley, E. S.,, J. M. Montgomery,, M. J. Hossain,, M. Jahangir,, M. R. Islam,, M. A. R. Molla,, S. M. Shamsuzzaman,, K. Akram,, K. Zaman,, N. Asgari,, J. A. Comer,, A. K. Azad,, P. E. Rollin,, T. G. Ksiazek,, and R. F. Breiman. 2007. Risk of nosocomial transmission of Nipah virus in a Bangladesh hospital. Infect. Control Hosp. Epidemiol. 28:740742.
28. Halpin, K.,, P. L. Young,, H. E. Field,, and J. S. Mackenzie. 2000. Isolation of Hendra virus from pteropid bats: a natural reservoir of Hendra virus. J. Gen. Virol. 81:19271932.
29. Harcourt, B. H.,, L. Lowe,, A. Tamin,, X. Liu,, B. Bankamp,, N. Bowden,, P. E. Rollin,, J. A. Comer,, T. G. Ksiazek,, J. H. Mohammed,, E. S. Gurley,, R. Breiman,, W. J. Bellini,, and P. A. Rota. 2005. Genetic characterization of Nipah virus, Bangladesh, 2004. Emerg. Infect. Dis. 11:15941597.
30. Harit, A. K.,, R. L. Ichhpujani,, S. Gupta,, K. S. Gill,, S. Lal,, N. K. Ganguly,, and S. P. Agarwal. 2006. Nipah/Hendra virus outbreak in Siliguri, West Bengal, India in 2001. Indian J. Med. Res. 23:553560.
31. Hayman, D. T.,, R. Suu-Ire,, A. C. Breed,, J. A. McEachern,, L. Wang,, J. L. Wood,, and A. A. Cunningham. 2008. Evidence of henipavirus infection in West African fruit bats. PLoS One 3:e2739.
32. Hooper, P.,, S. Zaki,, P. Daniels,, and D. Middleton. 2001. Comparative pathology of the diseases caused by Hendra and Nipah viruses. Microbes Infect. 3:315322.
33. Hyatt, A. D.,, S. R. Zaki,, C. S. Goldsmith,, T. G. Wise,, and S. G. Hengstberger. 2001. Ultrastructure of Hendra virus and Nipah virus within cultured cells and host animals. Microbes Infect. 3:297306.
34. Johara, M. Y.,, H. Field,, R. A. Mohd,, C. Morrissy,, B. van der Heide,, P. Rota,, A. bin Adzhar,, J. White,, P. Daniels,, A. Jamaluddin,, and T. G. Ksiazek. 2001. Nipah virus infection in bats (order Chiroptera) in peninsular Malaysia. Emerg. Infect. Dis. 7:439441.
35. Johnson, K. M.,, L. H. Elliott,, and D. L. Heymann. 1981. Preparation of polyvalent viral immunofluorescent intracellular antigens and use in human serosurveys. J. Clin. Microbiol. 14:527529.
36. Kaku, Y.,, A. Noguchi,, G. A. Marsh,, J. A. McEachern,, A. Okutani,, K. Hotta,, B. Bazartseren,, S. Fukushi,, C. C. Broder,, A. Yamada,, S. Inoue,, and L. F. Wang. 2009. A neutralization test for specific detection of Nipah virus antibodies using pseudotyped vesicular stomatitis virus expressing green fluorescent protein. J. Virol. Methods 160:713.
37. Krishanan, S.,, and K. Biswas. 2007. Nipah outbreak in India and Bangladesh. Commun. Dis. Dep. Newsl. 4:3.
38. Lam, S. K.,, and K. B. Chua. 2002. Nipah virus encephalitis outbreak in Malaysia. Clin. Infect. Dis. 34:S48S51.
39. Lamb, R. A.,, and D. Kolakofsky,. 2001. Paramyxoviridae: the viruses and their replication, p. 13051340. In D. M. Knipe,, P. M. Howley,, D. E. Griffin,, R. A. Lamb,, M. A. Martin,, B. Roizman,, and S. E. Straus (ed.), Fields Virology, 4th ed., vol. 1. Lippincott Williams & Wilkins, Philadelphia, PA.
40. Luby, S. P.,, E. S. Gurley,, and M. J. Hossain. 2009. Transmission of human infection with Nipah virus. Clin. Infect. Dis. 49:17431748.
41. Luby, S. P.,, M. J. Hossain,, E. Gurley,, B. N. Ahmed,, S. Banu,, S. U. Khan,, N. Homaira,, P. Rota,, P. E. Rollin,, J. A. Comer,, K. Eben,, T. G. Ksiazek,, and M. Rahman. 2009. Recurrent zoonotic transmission of Nipah virus into humans, Bangladesh, 2001-2007. Emerg. Infect. Dis. 15:12291235.
42. McEachern, J. A.,, J. Bingham,, G. Crameri,, D. J. Green,, T. J. Hancock,, D. Middleton,, Y. R. Feng,, C. C. Broder,, L. F. Wang,, and K. N. Bossart. 2008. A recombinant subunit vaccine formulation protects against lethal Nipah virus challenge in cats. Vaccine 26:38423952.
43. Middleton, D. J.,, H. A. Westbury,, C. J. Morrissy,, B. M. van der Heide,, G. M. Russell,, M. A. Braun,, and A. D. Hyatt. 2002. Experimental Nipah virus infection in pigs and cats. J. Comp. Pathol. 126:124136.
44. Mungall, B. A.,, D. Middleton,, G. Crameri,, J. Bingham,, K. Halpin,, G. Russell,, D. Green,, J. McEachern,, L. I. Pritchard,, B. T. Eaton,, L. F. Wang,, K. N. Bossart,, and C. C. Broder. 2006. Feline model of acute Nipah virus infection and protection with a soluble glycoprotein-based subunit vaccine. J. Virol. 80:1229312302.
45. Murray, K.,, R. Rogers,, L. Selvey,, P. Selleck,, A. Hyatt,, A. Gould,, L. Gleeson,, P. Hooper,, and H. Westbury. 1995. A novel morbillivirus pneumonia of horses and its transmission to humans. Emerg. Infect. Dis. 1:3133.
46. Murray, K.,, P. Selleck,, P. Hooper,, A. Hyatt,, A. Gould,, L. Gleeson,, H. Westbury,, L. Hiley,, L. Selvey,, and B. Rodwell. 1995. A morbillivirus that caused fatal disease in horses and humans. Science 268:9497.
47. Olson, J. G.,, C. Rupprecht,, P. E. Rollin,, U. S. An,, M. Niezgoda,, T. Clemins,, J. Walston,, and T. G. Ksiazek. 2002. Antibodies to Nipah-like virus in bats (Pteropus lylei), Cambodia. Emerg. Infect. Dis. 8:987988.
48. O’Sullivan, J. D.,, A. M. Allworth,, D. L. Paterson,, T. M. Snow,, R. Boots,, L. J. Gleeson,, A. R. Gould,, A. D. Hyatt,, and J. Bradfield. 1997. Fatal encephalitis due to novel paramyxovirus transmitted from horses. Lancet 349:9395.
49. Paterson, D. L.,, P. K. Murray,, and J. G. McCormack. 1998. Zoonotic disease in Australia caused by a novel member of the paramyxoviridae. Clin. Infect. Dis. 27:112118.
50. Playford, E. G.,, B. McCall,, G. Smith,, V. Slinko,, G. Allen,, I. Smith,, F. Moore,, C. Taylor,, Y. H. Kung,, and H. Field. 2010. Human Hendra virus encephalitis associated with equine outbreak, Australia, 2008. Emerg. Infect. Dis. 16:219223.
51. Ramasundrum, V.,, C. T. Tan,, K. B. Chua,, H. T. Chong,, K. J. Goh,, N. K. Chew,, K. S. Tan,, T. Thayaparan,, S. R. Kunjapan,, V. Petharunam,, Y. L. Loh,, T. G. Ksiazek,, and S. K. Lam. 2000. Kinetics of IgM and IgG seroconversion in Nipah virus infection. Neurol. J. Southeast Asia 5:2328.
52. Reynes, J.-M.,, D. Counor,, S. Ong,, C. Faure,, V. Seng,, S. Molia,, J. Walston,, M. C. Georges-Courbot,, V. Deubel,, and J.-L. Sarthou. 2005. Nipah virus in Lyle’s flying foxes, Cambodia. Emerg. Infect. Dis. 11:10421047.
53. Selvey, L. A.,, R. M. Wells,, J. G. McCormack,, A. J. Ansford,, K. Murray,, R. J. Rogers,, P. S. Lavercombe,, P. Selleck,, and J. W. Sheridan. 1995. Infection of humans and horses by a newly described morbillivirus. Med. J. Aust. 162:642645.
54. Sendow, I.,, H. E. Field,, J. Curran,, Darminto,, C. Morrissy,, G. Meehan,, T. Buick,, and P. Daniels. 2006. Henipavirus in Pteropus vampyrus bats, Indonesia. Emerg. Infect. Dis. 12:711712.
55. Sharifah, S. H.,, A. R. Sohayati,, M. Maizan,, L. Y. Chang,, M. Sharina,, K. Latiffah,, S. S. Arshad,, C. M. Zaini,, F. Humes,, P. Daszak,, and J. Epstein. 2009. Genetic characterization of a Nipah virus isolated from a Pteropus vampyrus in Malaysia. Neurol. Asia 14:6769.
56. Sim, B. F.,, R. Jusoh,, C. C. Chang,, and R. Khalid. 2002. Nipah encephalitis: a report of 18 patients from Kuala Lumpur Hospital. Neurol. J. Southeast Asia 7:1318.
57. Smith, I. L.,, K. Halpin,, D. Warrilow,, and G. A. Smith. 2001. Development of a fluorogenic RT-PCR assay (Taq- Man) for the detection of Hendra virus. J. Virol. Methods 98:3340.
58. Tamin, A.,, B. H. Harcourt,, T. G. Ksiazek,, P. E. Rollin,, W. J. Bellini,, and P. A. Rota. 2002. Functional properties of the fusion and attachment glycoproteins of Nipah virus. Virology 296:190200.
59. Tamin, A.,, B. H. Harcourt,, M. K. Lo,, J. A. Roth,, M. C. Wolf,, B. Lee,, H. Weingartl,, J. C. Audonnet,, W. J. Bellini,, and P. A. Rota. 2009. Development of a neutralization assay for Nipah virus using pseudotype particles. J. Virol. Methods 160:16.
60. Tan, W. S.,, S. T. Ong,, M. Eshaghi,, S. S. Foo,, and K. Yusoff. 2004. Solubility, immunogenicity and physical properties of the nucleocapsid protein of Nipah virus produced in Escherichia coli. J. Med. Virol. 73:105112.
61. Torres-Velez, F. J.,, W. J. Shieh,, P. E. Rollin,, T. Morken,, C. Brown,, T. G. Ksiazek,, and S. R. Zaki. 2008. Histopathologic and immunohistochemical characterization of Nipah virus infection in the guinea pig. Vet. Pathol. 45:576585.
62. Wacharapluesadee, S.,, B. Lumlertdacha,, K. Boongird,, S. Wanghongsa,, L. Chanhome,, P. E. Rollin,, P. Stockton,, C. E. Rupprecht,, T. G. Ksiazek,, and T. Hemachudha. 2005. Bat Nipah virus, Thailand. Emerg. Infect. Dis. 11:19491951.
63. Weingartl, H. M.,, Y. Berhane,, J. L. Caswell,, S. Loosmore,, J. C. Audonnet,, J. A. Roth,, and M. Czub. 2006. Recombinant Nipah virus vaccines protect pigs against challenge. J. Virol. 80:79297938.
64. Westbury, H. A.,, P. T. Hooper,, P. W. Selleck,, and P. K. Murray. 1995. Equine morbillivirus pneumonia: susceptibility of laboratory animals to the virus. Aust. Vet. J. 72:278279.
65. Westbury, H. A. 2000. Hendra virus disease in horses. Rev. Sci. Tech. Off. Int. Epizoot. 19:151159.
66. Williamson, M. M.,, P. T. Hooper,, P. W. Selleck,, L. J. Gleeson,, P. W. Daniels,, H. A. Westbury,, and P. K. Murray. 1998. Transmission studies of Hendra virus (equine morbillivirus) in fruit bats, horses and cats. Aust. Vet. J. 76:813818.
67. Williamson, M. M.,, P. T. Hooper,, P. W. Selleck,, H. A. Westbury,, and R. F. Slocombe. 1999. Experimental Hendra virus infection in pregnant guinea-pigs and fruit bats (Pteropus poliocephalus). J. Comp. Pathol. 122:201207.
68. Wong, K. T.,, I. Grosjean,, C. Brisson,, B. Blanquier,, M. Fevre-Montange,, A. Bernard,, P. Loth,, M. C. Georges- Courbot,, M. Chevallier,, H. Akaoka,, P. Marianneau,, S. K. Lam,, T. F. Wild,, and V. Deubel. 2003. A golden hamster model for human acute Nipah virus infection. Am. J. Pathol. 163:21272137.
69. Wong, K. T.,, W. J. Shieh,, S. Kumar,, K. Norain,, W. Abdullah,, J. Guarner,, C. S. Goldsmith,, K. B. Chua,, S. K. Lam,, C. T. Tan,, K. J. Goh,, H. T. Chong,, R. Jusoh,, P. E. Rollin,, T. G. Ksiazek,, S. R. Zaki, and the Nipah Virus Pathology Working Group. 2002. Nipah virus infection. Pathology and pathogenesis of an emerging paramyxoviral zoonosis. Am. J. Pathol. 161:21532167.
70. Yu, F.,, N. S. Khairullah,, S. Inoue,, V. Balasubramaniam,, S. J. Berendam,, L. K. Teh,, N. S. W. Ibrahim,, S. Abdul Rahman,, S. S. Hassan,, F. Hasebe,, M. Sinniah,, and K. Morita. 2006. Serodiagnosis using recombinant Nipah virus nucleocapsid protein expressed in Escherichia coli. J. Clin. Microbiol. 44:31343138.
71. Zaki, S.,, P. W. Greer,, L. M. Coffield,, C. S. Goldsmith,, K. B. Nolte,, K. Foucar,, R. M. Feddersen,, R. Zumwalt,, G. L. Miller,, A. S. Khan,, P. E. Rollin,, T. G. Ksiazek,, S. T. Nichol,, B. W. J. Mahy,, and C. J. Peters. 1995. Hantavirus pulmonary syndrome: pathogenesis of an emerging infectious disease. Am. J. Pathol. 146:552579.

Tables

Generic image for table
TABLE 1

Hendra and Nipah virus outbreaks in Australia, Bangladesh, and India, 1994 to January 2010

Citation: Rollin P, Rota P, Zaki S, Ksiazek T. 2011. Hendra and Nipah Viruses, p 1479-1487. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch92
Generic image for table
TABLE 2

Signs and symptoms of patients with confirmed Nipah or Hendra virus infection

Citation: Rollin P, Rota P, Zaki S, Ksiazek T. 2011. Hendra and Nipah Viruses, p 1479-1487. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch92

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