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Chapter 97 : Varicella-Zoster Virus

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Abstract:

Varicella-zoster virus (VZV) belongs to the family , based on morphological criteria, and is one of the eight human-pathogenic herpesviruses identified so far. The viral genome has an approximate length of 125,000 bp, making it the smallest of the human herpesviruses, and it encodes at least 70 viral genes. Prevaccination seroepidemiological studies in 11 European countries have shown that in most areas, more than 90% of 10 to 15-year-olds were already seropositive for VZV. The association between the clinical syndrome and VZV has been confirmed by detection of viral DNA by polymerase chain reaction (PCR) in fetal tissue. Real-time PCR assays based on sequence polymorphisms, especially in open reading frame (ORF) 62 or ORF 38, have also been established for detection of VZV. The enzyme-linked immunosorbent assay (ELISA) is usually used to determine VZV-specific antibodies (Abs) in blood, but it may also serve to detect Abs in cerebrospinal fluid (CSF). Screening for drug-resistant virus strains is rarely performed. Antiviral susceptibility of VZV strains can be determined. Changes in virus replication in the presence of different concentrations of various drugs are measured in most cases by plaque reduction assay. The major importance of Ab assays, of which ELISAs are currently the most commonly used, lies in their ability to identify previously infected individuals, as indicated by anti-VZV IgG Abs in the absence of immunoglobulin M (IgM). This information can be used to guide further vaccination decisions.

Citation: Puchhammer-Stöckl E, Aberle S. 2011. Varicella-Zoster Virus , p 1545-1557. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch97

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Figures

Image of FIGURE 1
FIGURE 1

Electron micrograph of VZV in skin vesicle fluid from a patient with varicella (magnification, ×100,000). Reprinted from reference 16.

Citation: Puchhammer-Stöckl E, Aberle S. 2011. Varicella-Zoster Virus , p 1545-1557. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch97
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Image of FIGURE 2
FIGURE 2

Schematic of the VZV linear double-stranded DNA genome. UL, long unique segment (100 kbp); US, short unique segment (5.4 kbp); TRS and TRL, terminal repeats; IRS and IRL, internal repeats. The arrows indicate the direction of the transcription of the viral genes indicated. RR, ribonucleotide reductase; DBP, DNA binding protein. Reprinted from reference 40

Citation: Puchhammer-Stöckl E, Aberle S. 2011. Varicella-Zoster Virus , p 1545-1557. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch97
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Image of FIGURE 3
FIGURE 3

Giemsa-stained preparation of material from the base of a vesicular lesion. Magnification, ×102. The arrow indicates a giant cell with a folded nucleus characteristic of VZV or HSV.

Citation: Puchhammer-Stöckl E, Aberle S. 2011. Varicella-Zoster Virus , p 1545-1557. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch97
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Image of FIGURE 4
FIGURE 4

Comparison of the amount of VZV DNA in CSF according to the neurological diagnosis (A), the severity of disease (B), and the presence of acute peripheral facial palsy (C). The geometric mean value is shown by a horizontal line. The value was calculated using the Mann- Whitney U test. (Modified from reference , with permission.)

Citation: Puchhammer-Stöckl E, Aberle S. 2011. Varicella-Zoster Virus , p 1545-1557. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch97
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Image of FIGURE 5
FIGURE 5

Immunofluorescence assay for the detection of VZVpositive cells from a patient with zoster. A smear of a skin vesicle was fixed and stained with MAb to VZV gE. Magnification, 3200.

Citation: Puchhammer-Stöckl E, Aberle S. 2011. Varicella-Zoster Virus , p 1545-1557. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch97
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References

/content/book/10.1128/9781555816728.chap97
1. Aberle, S. W.,, J. H. Aberle,, C. Steininger,, and E. Puchhammer- Stöckl. 2005. Quantitative real time PCR detection of Varicella-zoster virus DNA in cerebrospinal fluid in patients with neurological disease. Med. Microbiol. Immunol.194:712.
2. Aberle, S. W.,, and E. Puchhammer-Stöckl. 2002. Diagnosis of herpesvirus infections of the central nervous system. J. Clin. Virol. 25(Suppl. 1):S79S85.
3. Arvin, A. 2005. Aging, immunity, and the varicella-zoster virus. N. Engl. J. Med. 352:22662267.
4. Arvin, A. M. 2008. Humoral and cellular immunity to varicella-zoster virus: an overview. J. Infect. Dis. 197(Suppl. 2):S58S60.
5. Asano, S.,, T. Yoshikawa,, H. Kimura,, Y. Enomoto,, M. Ohashi,, H. Terasaki,, and Y. Nishiyama. 2004. Monitoring herpesvirus DNA in three cases of acute retinal necrosis by real-time PCR. J. Clin. Virol. 29:206209.
6. Beby-Defaux, A.,, S. Brabant,, D. Chatellier,, A. Bourgoin,, R. Robert,, T. Ruckes,, and G. Agius. 2009. Disseminated varicella with multiorgan failure in an immunocompetent adult. J. Med. Virol. 81:747749.
7. Bergstrom, T. 1996. Polymerase chain reaction for diagnosis of varicella zoster virus central nervous system infections without skin manifestations. Scand. J. Infect. Dis. Suppl. 100:4145.
8. Bezold, G.,, M. Lange,, H. Pillekamp,, and R. U. Peter. 2002. Varicella zoster viraemia during herpes zoster is not associated with neoplasia. J. Eur. Acad. Dermatol. Venereol. 16:357360.
9. Bezold, G. D.,, M. E. Lange,, H. Gall,, and R. U. Peter. 2001. Detection of cutaneous varicella zoster virus infections by immunofluorescence versus PCR. Eur. J. Dermatol. 11:108111.
10. Biron, K. K.,, and G. B. Elion. 1980. In vitro susceptibility of varicella-zoster virus to acyclovir. Antimicrob. Agents Chemother. 18:443447.
11. Breton, G.,, A. M. Fillet,, C. Katlama,, F. Bricaire,, and E. Caumes. 1998. Acyclovir-resistant herpes zoster in human immunodeficiency virus-infected patients: results of foscarnet therapy. Clin. Infect. Dis. 27:15251527.
12. Breuer, J.,, D. S. Schmid,, and A. A. Gershon. 2008. Use and limitations of varicella-zoster virus-specific serological testing to evaluate breakthrough disease in vaccinees and to screen for susceptibility to varicella. J. Infect. Dis. 197(Suppl. 2):S147S151.
13. Campsall, P. A.,, N. H. Au,, J. S. Prendiville,, D. P. Speert,, R. Tan,, and E. E. Thomas. 2004. Detection and genotyping of varicella-zoster virus by TaqMan allelic discrimination realtime PCR. J. Clin. Microbiol. 42:14091413.
14. Carby, M.,, A. Jones,, M. Burke,, A. Hall,, and N. Banner. 2007. Varicella infection after heart and lung transplantation: a single-center experience. J. Heart Lung Transplant. 26:399402.
15.Centers for Disease Control and Prevention. 2003. Decline in annual incidence of varicella—selected states, 1990-2001. MMWR Morb. Mortal. Wkly. Rep. 52:884885.
16. Chen, J. J.,, Z. Zhu,, A. A. Gershon,, and M. D. Gershon. 2004. Mannose 6-phosphate receptor dependence of varicella zoster virus infection in vitro and in the epidermis during varicella and zoster. Cell 119:915926.
17. Chris Maple, P. A.,, A. Gunn,, J. Sellwood,, D. W. Brown,, and J. J. Gray. 2009. Comparison of fifteen commercial assays for detecting Varicella Zoster virus IgG with reference to a time resolved fluorescence immunoassay (TRFIA) and the performance of two commercial assays for screening sera from immunocompromised individuals. J. Virol. Methods 155:143149.
18. Cinque, P.,, S. Bossolasco,, L. Vago,, C. Fornara,, S. Lipari,, S. Racca,, A. Lazzarin,, and A. Linde. 1997. Varicella-zoster virus (VZV) DNA in cerebrospinal fluid of patients infected with human immunodeficiency virus: VZV disease of the central nervous system or subclinical reactivation of VZV infection? Clin. Infect. Dis. 25:634639.
19. Coen, D. M.,, and D. D. Richman,. 2007. Antiviral agents, p. 447486. In D. M. Knipe,, P. M. Howley,, D. E. Griffin,, R. A. Lamb,, M. A. Martin,, B. Roizman,, and S. E. Straus (ed.), Fields Virology, 5th ed. Lippincott Williams and Wilkins, Philadelphia, PA.
20. Coffin, S. E.,, and R. L. Hodinka. 1995. Utility of direct immunofluorescence and virus culture for detection of varicella-zoster virus in skin lesions. J. Clin. Microbiol. 33: 27922795.
21. Cohen, J.,, S. E. Straus,, and A. M. Arvin,. 2007. Varicella zoster virus, replication, pathogenesis and management, p. 27732818. In D. M. Knipe,, P. M. Howley,, D. E. Griffin,, R. A. Lamb,, M. A. Martin,, B. Roizman,, and S. E. Straus (ed.), Fields Virology, 5th ed. Lippincott Williams and Wilkins, Philadelphia, PA.
22. Cohrs, R. J.,, J. Randall,, J. Smith,, D. H. Gilden,, C. Dabrowski,, H. van Der Keyl,, and R. Tal-Singer. 2000. Analysis of individual human trigeminal ganglia for latent herpes simplex virus type 1 and varicella-zoster virus nucleic acids using real-time PCR. J. Virol. 74:1146411471.
23. Cowl, C. T.,, U. B. S. Prakash,, P. S. Mitchell,, and M. R. Migden. 2000. Varicella-zoster virus detection by polymerase chain reaction using bronchoalveolar lavage specimens. Am. J. Respir. Crit. Care Med. 162:753754.
24. Davison, A. J.,, and J. E. Scott. 1986. The complete DNA sequence of varicella-zoster virus. J. Gen. Virol. 67(Pt. 9):17591816.
25. de Clercq, E.,, H. Degreef,, J. Wildiers,, G. de Jonge,, A. Drochmans,, J. Descamps,, and P. de Somer. 1980. Oral (E)- 5-(2-bromovinyl)-2’-deoxyuridine in severe herpes zoster. Br. Med. J. 281:1178.
26. de Jong, M. D.,, J. F. Weel,, T. Schuurman,, P. M. Wertheimvan Dillen,, and R. Boom. 2000. Quantitation of varicella-zoster virus DNA in whole blood, plasma, and serum by PCR and electrochemiluminescence. J. Clin. Microbiol. 38:25682573.
27. de Ory, F.,, J. M. Echevarria,, G. Kafatos,, C. Anastassopoulou,, N. Andrews,, J. Backhouse,, G. Berbers,, B. Bruckova,, D. I. Cohen,, H. de Melker,, I. Davidkin,, G. Gabutti,, L. M. Hesketh,, K. Johansen,, S. Jokinen,, L. Jones,, A. Linde,, E. Miller,, J. Mossong,, A. Nardone,, M. C. Rota,, A. Sauerbrei,, F. Schneider,, Z. Smetana,, A. Tischer,, A. Tsakris,, and R. Vranckx. 2006. European seroepidemiology network 2: standardisation of assays for seroepidemiology of varicella zoster virus. J. Clin. Virol. 36:111118.
28. Dobec, M.,, W. Bossart,, F. Kaeppeli,, and J. Mueller-Schoop. 2008. Serology and serum DNA detection in shingles. Swiss Med. Wkly. 138:4751.
29. Echevarria, J. M.,, I. Casas,, A. Tenorio,, F. de Ory,, and P. Martinez-Martin. 1994. Detection of varicella-zoster virus-specific DNA sequences in cerebrospinal fluid from patients with acute aseptic meningitis and no cutaneous lesions. J. Med. Virol. 43:331335.
30. Enders, G.,, E. Miller,, J. Cradock-Watson,, I. Bolley,, and M. Ridehalgh. 1994. Consequences of varicella and herpes zoster in pregnancy: prospective study of 1739 cases. Lancet 343:15481551.
31. Espy, M. J.,, R. Teo,, T. K. Ross,, K. A. Svien,, A. D. Wold,, J. R. Uhl,, and T. F. Smith. 2000. Diagnosis of varicella-zoster virus infections in the clinical laboratory by LightCycler PCR. J. Clin. Microbiol. 38:31873189.
32. Feller, L.,, N. H. Wood,, and J. Lemmer. 2007. Herpes zoster infection as an immune reconstitution inflammatory syndrome in HIV-seropositive subjects: a review. Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol. Endod. 104:455460.
33. Fillet, A. M.,, B. Dumont,, E. Caumes,, B. Visse,, H. Agut,, F. Bricaire,, and J. M. Huraux. 1998. Acyclovir-resistant varicella-zoster virus: phenotypic and genetic characterization. J. Med. Virol. 55:250254.
34. Franco-Paredes, C.,, T. Bellehemeur,, A. Merchant,, P. Sanghi,, C. DiazGranados,, and D. Rimland. 2002. Aseptic meningitis and optic neuritis preceding varicella-zoster progressive outer retinal necrosis in a patient with AIDS. AIDS 16:10451049.
35. Frey, C. R.,, M. A. Sharp,, A. S. Min,, D. S. Schmid,, V. Loparev,, and A. M. Arvin. 2003. Identification of CD8+ T cell epitopes in the immediate early 62 protein (IE62) of varicella-zoster virus, and evaluation of frequency of CD8+ T cell response to IE62, by use of IE62 peptides after varicella vaccination. J. Infect. Dis. 188:4052.
35a. Furuta, Y.,, H. Aizawa,, F. Ohtani,, H. Sawa, and S. Fukuda. 2004. Varicella-zoster virus DNA level and facial paralysis in Ramsay Hunt syndrome. Ann. Otol. Rhinol. Laryngol. 113:700705.
36. Furuta, Y.,, S. Fukuda,, S. Suzuki,, T. Takasu,, Y. Inuyama,, and K. Nagashima. 1997. Detection of varicella-zoster virus DNA in patients with acute peripheral facial palsy by the polymerase chain reaction, and its use for early diagnosis of zoster sine herpete. J. Med. Virol. 52:316319.
37. Furuta, Y.,, F. Ohtani,, H. Kawabata,, S. Fukuda,, and T. Bergstrom. 2000. High prevalence of varicella-zoster virus reactivation in herpes simplex virus-seronegative patients with acute peripheral facial palsy. Clin. Infect. Dis. 30:529533.
38. Furuta, Y.,, F. Ohtani,, H. Sawa,, S. Fukuda,, and Y. Inuyama. 2001. Quantitation of varicella-zoster virus DNA in patients with Ramsay Hunt syndrome and zoster sine herpete. J. Clin. Microbiol. 39:28562859.
39. Galil, K.,, C. Brown,, F. Lin,, and J. Seward. 2002. Hospitalizations for varicella in the United States, 1988 to 1999. Pediatr. Infect. Dis. J. 21:931935.
40. Gershon, A.,, and S. Silverstein,. 2002. Varicella-zoster virus, p. 413432. In D. Richman,, R. Whitley,, and F. Hayden (ed.), Clinical Virology, 2nd ed. ASM Press, Washington, DC.
41. Gershon, A. A.,, P. Larussa,, and S. Steinberg. 1994. Detection of antibodies to varicella-zoster virus using a latex agglutination assay. Clin. Diagn. Virol. 2:271277.
42. Gershon, A. A.,, S. P. Steinberg,, and L. Gelb. 1984. Clinical reinfection with varicella-zoster virus. J. Infect. Dis. 149:137142.
43. Gilden, D. H.,, M. Devlin,, M. Wellish,, R. Mahalingham,, C. Huff,, A. Hayward,, and A. Vafai. 1989. Persistence of varicella-zoster virus DNA in blood mononuclear cells of patients with varicella or zoster. Virus Genes 2:299305.
44. Gnann, J. W., Jr. 2002. Varicella-zoster virus: atypical presentations and unusual complications. J. Infect. Dis. 186(Suppl. 1):S91S98.
45. Gourishankar, S.,, J. C. McDermid,, G. S. Jhangri,, and J. K. Preiksaitis. 2004. Herpes zoster infection following solid organ transplantation: incidence, risk factors and outcomes in the current immunosuppressive era. Am. J. Transplant. 4:108115.
46. Grose, C.,, and P. A. Brunel. 1978. Varicella-zoster virus: isolation and propagation in human melanoma cells at 36 and 32 degrees C. Infect. Immun. 19:199203.
47. Hall, S.,, T. Maupin,, J. Seward,, A. O. Jumaan,, C. Peterson,, G. Goldman,, L. Mascola,, and M. Wharton. 2002. Second varicella infections: are they more common than previously thought? Pediatrics 109:10681073.
48. Harpaz, R.,, I. R. Ortega-Sanchez,, and J. F. Seward. 2008. Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recommend. Rep. 57:130; quiz CE2-CE4.
49. Hudnall, S. D.,, T. Chen,, P. Allison,, S. K. Tyring,, and A. Heath. 2008. Herpesvirus prevalence and viral load in healthy blood donors by quantitative real-time polymerase chain reaction. Transfusion 48:11801187.
50. Ito, Y.,, H. Kimura,, S. Hara,, S. Kido,, T. Ozaki,, Y. Nishiyama,, and T. Morishima. 2001. Investigation of varicella-zoster virus DNA in lymphocyte subpopulations by quantitative PCR assay. Microbiol. Immunol. 45:267269.
51. Kalpoe, J. S.,, A. C. Kroes,, S. Verkerk,, E. C. Claas,, R. M. Barge,, and M. F. Beersma. 2006. Clinical relevance of quantitative varicella-zoster virus (VZV) DNA detection in plasma after stem cell transplantation. Bone Marrow Transplant. 38:4146.
52. Kaneko, T.,, and Y. Ishigatsubo. 2004. Varicella pneumonia in adults. Intern. Med. 43:11051106.
53. Kennedy, P. G.,, E. Grinfeld,, and J. E. Bell. 2000. Varicellazoster virus gene expression in latently infected and explanted human ganglia. J. Virol. 74:1189311898.
54. Kido, S.,, S. Sugita,, S. Horie,, M. Miyanaga,, K. Miyata,, N. Shimizu,, T. Morio,, and M. Mochizuki. 2008. Association of varicella zoster virus load in the aqueous humor with clinical manifestations of anterior uveitis in herpes zoster ophthalmicus and zoster sine herpete. Br. J. Ophthalmol. 92:505508.
55. Kimura, H.,, S. Kido,, T. Ozaki,, N. Tanaka,, Y. Ito,, R. K. Williams,, and T. Morishima. 2000. Comparison of quantitations of viral load in varicella and zoster. J. Clin. Microbiol. 38:24472449.
56. Koskiniemi, M.,, H. Piiparinen,, T. Rantalaiho,, P. Eranko,, M. Farkkila,, K. Raiha,, E. M. Salonen,, P. Ukkonen,, and A. Vaheri. 2002. Acute central nervous system complications in varicella zoster virus infections. J. Clin. Virol. 25:293301.
57. Kronenberg, A.,, W. Bossart,, R. P. Wuthrich,, C. Cao,, S. Lautenschlager,, N. D. Wiegand,, B. Mullhaupt,, G. Noll,, N. J. Mueller,, and R. F. Speck. 2005. Retrospective analysis of varicella zoster virus (VZV) copy DNA numbers in plasma of immunocompetent patients with herpes zoster, of immunocompromised patients with disseminated VZV disease, and of asymptomatic solid organ transplant recipients. Transpl. Infect. Dis. 7:116121.
58. Kupila, L.,, T. Vuorinen,, R. Vainionpaa,, V. Hukkanen,, R. J. Marttila,, and P. Kotilainen. 2006. Etiology of aseptic meningitis and encephalitis in an adult population. Neurology 66:7580.
59. LaRussa, P.,, O. Lungu,, I. Hardy,, A. Gershon,, S. P. Steinberg,, and S. Silverstein. 1992. Restriction fragment length polymorphism of polymerase chain reaction products from vaccine and wild-type varicella-zoster virus isolates. J. Virol. 66: 10161020.
60. Larussa, P.,, S. Steinberg,, E. Waithe,, B. Hanna,, and R. Holzman. 1987. Comparison of five assays for antibody to varicella-zoster virus and the fluorescent-antibody-tomembrane- antigen test. J. Clin. Microbiol. 25:20592062.
61. Li, S.,, I. S. Chan,, H. Matthews,, J. F. Heyse,, C. Y. Chan,, B. J. Kuter,, K. M. Kaplan,, S. J. Vessey,, and J. C. Sadoff. 2002. Inverse relationship between six week postvaccination varicella antibody response to vaccine and likelihood of long term breakthrough infection. Pediatr. Infect. Dis. J. 21:337342.
62. Loparev, V. N.,, K. McCaustland,, B. P. Holloway,, P. R. Krause,, M. Takayama,, and D. S. Schmid. 2000. Rapid genotyping of varicella-zoster virus vaccine and wild-type strains with fluorophore-labeled hybridization probes. J. Clin. Microbiol. 38:43154319.
63. Loparev, V. N.,, E. N. Rubtcova,, V. Bostik,, D. Govil,, C. J. Birch,, J. D. Druce,, D. S. Schmid,, and M. C. Croxson. 2007. Identification of five major and two minor genotypes of varicella-zoster virus strains: a practical two-amplicon approach used to genotype clinical isolates in Australia and New Zealand. J. Virol. 81:1275812765.
64. Mahalingam, R.,, M. Wellish,, W. Wolf,, A. N. Dueland,, R. Cohrs,, A. Vafai,, and D. Gilden. 1990. Latent varicella-zoster viral DNA in human trigeminal and thoracic ganglia. N. Engl. J. Med. 323:627631.
65. Mainka, C.,, B. Fuss,, H. Geiger,, H. Hofelmayr,, and M. H. Wolff. 1998. Characterization of viremia at different stages of varicella-zoster virus infection. J. Med. Virol. 56:9198.
66. Malavige, G. N.,, L. Jones,, S. D. Kamaladasa,, A. Wijewickrama,, S. L. Seneviratne,, A. P. Black,, and G. S. Ogg. 2008. Viral load, clinical disease severity and cellular immune responses in primary varicella zoster virus infection in Sri Lanka. PLoS One 3:e3789.
67. Maple, P. A.,, J. Gray,, J. Breuer,, G. Kafatos,, S. Parker,, and D. Brown. 2006. Performance of a time-resolved fluorescence immunoassay for measuring varicella-zoster virus immunoglobulin G levels in adults and comparison with commercial enzyme immunoassays and Merck glycoprotein enzyme immunoassay. Clin. Vaccine Immunol. 13:214218.
68. Marin, M.,, T. L. Watson,, S. S. Chaves,, R. Civen,, B. M. Watson,, J. X. Zhang,, D. Perella,, L. Mascola,, and J. F. Seward. 2008. Varicella among adults: data from an active surveillance project, 1995-2005. J. Infect. Dis. 197(Suppl. 2):S94S100.
69. Markoulatos, P.,, A. Georgopoulou,, N. Siafakas,, E. Plakokefalos,, G. Tzanakaki,, and J. Kourea-Kremastinou. 2001. Laboratory diagnosis of common herpesvirus infections of the central nervous system by a multiplex PCR assay. J. Clin. Microbiol. 39:44264432.
70. McGeoch, D. J. 2009. Lineages of varicella-zoster virus. J. Gen. Virol. 90:963969.
71. Miller, G. G.,, and J. S. Dummer. 2007. Herpes simplex and varicella zoster viruses: forgotten but not gone. Am. J. Transplant. 7:741747.
72. Murakami, S.,, Y. Nakashiro,, M. Mizobuchi,, N. Hato,, N. Honda,, and K. Gyo. 1998. Varicella-zoster virus distribution in Ramsay Hunt syndrome revealed by polymerase chain reaction. Acta Otolaryngol. 118:145149.
73. Nardone, A.,, F. de Ory,, M. Carton,, D. Cohen,, P. van Damme,, I. Davidkin,, M. C. Rota,, H. de Melker,, J. Mossong,, M. Slacikova,, A. Tischer,, N. Andrews,, G. Berbers,, G. Gabutti,, N. Gay,, L. Jones,, S. Jokinen,, G. Kafatos,, M. V. de Aragon,, F. Schneider,, Z. Smetana,, B. Vargova,, R. Vranckx,, and E. Miller. 2007. The comparative seroepidemiology of varicella zoster virus in 11 countries in the European region. Vaccine 25:78667872.
74. Nikkels, A. F.,, K. Delbecque,, G. E. Pierard,, B. Wienkotter,, G. Schalasta,, and M. Enders. 2005. Distribution of varicellazoster virus DNA and gene products in tissues of a first-trimester varicella-infected fetus. J. Infect. Dis. 191:540545.
75. Parker, S. P.,, M. Quinlivan,, Y. Taha,, and J. Breuer. 2006. Genotyping of varicella-zoster virus and the discrimination of Oka vaccine strains by TaqMan real-time PCR. J. Clin. Microbiol. 44:39113914.
76. Persson, A.,, T. Bergstrom,, M. Lindh,, L. Namvar,, and M. Studahl. 2009. Varicella-zoster virus CNS disease—viral load, clinical manifestations and sequels. J. Clin. Virol. 46:249253.
77. Pevenstein, S. R.,, R. K. Williams,, D. McChesney,, E. K. Mont,, J. E. Smialek,, and S. E. Straus. 1999. Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia. J. Virol. 73:1051410518.
78. Preissner, C. M.,, S. P. Steinberg,, A. A. Gershon,, and T. F. Smith. 1982. Evaluation of the anticomplement immunofluorescence test for detection of antibody to varicella-zoster virus. J. Clin. Microbiol. 16:373376.
79. Puchhammer-Stöckl, E.,, C. Kunz,, G. Wagner,, and G. Enders. 1994. Detection of varicella zoster virus (VZV) DNA in fetal tissue by polymerase chain reaction. J. Perinat. Med. 22:6569.
80. Puchhammer-Stöckl, E.,, T. Popow-Kraupp,, F. X. Heinz,, C. W. Mandl,, and C. Kunz. 1991. Detection of varicella-zoster virus DNA by polymerase chain reaction in the cerebrospinal fluid of patients suffering from neurological complications associated with chicken pox or herpes zoster. J. Clin. Microbiol. 29:15131516.
81. Quinlivan, M.,, and J. Breuer. 2006. Molecular studies of Varicella zoster virus. Rev. Med. Virol. 16:225250.
82. Quinlivan, M.,, A. A. Gershon,, S. P. Steinberg,, and J. Breuer. 2005. An evaluation of single nucleotide polymorphisms used to differentiate vaccine and wild type strains of varicella-zoster virus. J. Med. Virol. 75:174180.
83. Quinlivan, M.,, K. Hawrami,, W. Barrett-Muir,, P. Aaby,, A. Arvin,, V. T. Chow,, T. J. John,, P. Matondo,, M. Peiris,, A. Poulsen,, M. Siqueira,, M. Takahashi,, Y. Talukder,, K. Yamanishi,, M. Leedham-Green,, F. T. Scott,, S. L. Thomas,, and J. Breuer. 2002. The molecular epidemiology of varicellazoster virus: evidence for geographic segregation. J. Infect. Dis. 186:888894.
84. Quinlivan, M. L.,, K. Ayres,, H. Ran,, S. McElwaine,, M. Leedham-Green,, F. T. Scott,, R. W. Johnson,, and J. Breuer. 2007. Effect of viral load on the outcome of herpes zoster. J. Clin. Microbiol. 45:39093914.
85. Rau, R.,, C. D. Fitzhugh,, K. Baird,, K. J. Cortez,, L. Li,, S. H. Fischer,, E. W. Cowen,, J. E. Balow,, T. J. Walsh,, J. I. Cohen,, and A. S. Wayne. 2008. Triad of severe abdominal pain, inappropriate antidiuretic hormone secretion, and disseminated varicella-zoster virus infection preceding cutaneous manifestations after hematopoietic stem cell transplantation: utility of PCR for early recognition and therapy. Pediatr. Infect. Dis. J. 27:265268.
86. Roque-Afonso, A. M.,, M. P. Bralet,, P. Ichai,, D. Desbois,, P. Vaghefi,, D. Castaing,, D. Samuel,, and E. Dussaix. 2008. Chickenpox-associated fulminant hepatitis that led to liver transplantation in a 63-year-old woman. Liver Transplant. 14:13091312.
87. Ruzek, D.,, N. Piskunova,, and E. Zampachova. 2007. High variability in viral load in cerebrospinal fluid from patients with herpes simplex and varicella-zoster infections of the central nervous system. Clin. Microbiol. Infect. 13:12171219.
88. Sadaoka, K.,, S. Okamoto,, Y. Gomi,, T. Tanimoto,, T. Ishikawa,, T. Yoshikawa,, Y. Asano,, K. Yamanishi,, and Y. Mori. 2008. Measurement of varicella-zoster virus (VZV)- specific cell-mediated immunity: comparison between VZV skin test and interferon-gamma enzyme-linked immunospot assay. J. Infect. Dis. 198:13271333.
89. Saiman, L.,, P. LaRussa,, S. P. Steinberg,, J. Zhou,, K. Baron,, S. Whittier,, P. Della-Latta,, and A. A. Gershon. 2001. Persistence of immunity to varicella-zoster virus after vaccination of healthcare workers. Infect. Control Hosp. Epidemiol. 22:279283.
90. Sauerbrei, A.,, U. Eichhorn,, S. Gawellek,, R. Egerer,, M. Schacke,, and P. Wutzler. 2003. Molecular characterisation of varicella-zoster virus strains in Germany and differentiation from the Oka vaccine strain. J. Med. Virol. 71:313319.
91. Sauerbrei, A.,, and P. Wutzler. 2006. Serological detection of varicella-zoster virus-specific immunoglobulin G by an enzyme-linked immunosorbent assay using glycoprotein antigen. J. Clin. Microbiol. 44:30943097.
92. Sauerbrei, A.,, R. Zell,, and P. Wutzler. 2007. Analysis of repeat units in the R2 region among different Oka varicellazoster virus vaccine strains and wild-type strains in Germany. Intervirology 50:4044.
93. Schunemann, S.,, C. Mainka,, and M. H. Wolff. 1998. Subclinical reactivation of varicella-zoster virus in immunocompromised and immunocompetent individuals. Intervirology 41:98102.
94. Sengupta, N.,, R. Booy,, H. J. Schmitt,, H. Peltola,, P. Van- Damme,, R. F. Schumacher,, M. Campins,, C. Rodrigo,, T. Heikkinen,, J. Seward,, A. Jumaan,, A. Finn,, P. Olcen,, N. Thiry,, C. Weil-Olivier,, and J. Breuer. 2008. Varicella vaccination in Europe: are we ready for a universal childhood programme? Eur. J. Pediatr. 167:4755.
95. Seward, J. F.,, B. M. Watson,, C. L. Peterson,, L. Mascola,, J. W. Pelosi,, J. X. Zhang,, T. J. Maupin,, G. S. Goldman,, L. J. Tabony,, K. G. Brodovicz,, A. O. Jumaan,, and M. Wharton. 2002. Varicella disease after introduction of varicella vaccine in the United States, 1995-2000. JAMA 287:606611.
96. Smith, C. K.,, and A. M. Arvin. 2009. Varicella in the fetus and newborn. Semin. Fetal Neonatal Med. 14:209217.
97. Snoeck, R.,, G. Andrei,, and E. De Clercq. 1994. Chemotherapy of varicella zoster virus infections. Int. J. Antimicrob. Agents 4:211226.
98. Stjernquist-Desatnik, A.,, E. Skoog,, and E. Aurelius. 2006. Detection of herpes simplex and varicella-zoster viruses in patients with Bell’s palsy by the polymerase chain reaction technique. Ann. Otol. Rhinol. Laryngol. 115:306311.
99. Stöcher, M.,, V. Leb,, M. Bozic,, H. H. Kessler,, G. Halwachs- Baumann,, O. Landt,, H. Stekel,, and J. Berg. 2003. Parallel detection of five human herpes virus DNAs by a set of realtime polymerase chain reactions in a single run. J. Clin. Virol. 26:8593.
100. Straus, S. E.,, J. Hay,, H. Smith,, and J. Owens. 1983. Genome differences among varicella-zoster virus isolates. J. Gen. Virol. 64:10311041.
101. Styczynski, J.,, P. Reusser,, H. Einsele,, R. de la Camara,, C. Cordonnier,, K. N. Ward,, P. Ljungman,, and D. Engelhard. 2009. Management of HSV, VZV and EBV infections in patients with hematological malignancies and after SCT: guidelines from the Second European Conference on Infections in Leukemia. Bone Marrow Transplant. 43:757770.
102. Suzutani, T.,, M. Saijo,, M. Nagamine,, M. Ogasawara,, and M. Azuma. 2000. Rapid phenotypic characterization method for herpes simplex virus and varicella-zoster virus thymidine kinases to screen for acyclovir-resistant viral infection. J. Clin. Microbiol. 38:18391844.
103. Takayama, M.,, and N. Takayama. 2004. New method of differentiating wild-type varicella-zoster virus (VZV) strains from Oka varicella vaccine strain by VZV ORF 6-based PCR and restriction fragment length polymorphism analysis. J. Clin. Virol. 29:113119.
104. Talarico, C. L.,, W. C. Phelps,, and K. K. Biron. 1993. Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS. J. Virol. 67:10241033.
105. Terada, K.,, T. Niizuma,, S. Kawano,, N. Kataoka,, T. Akisada,, and Y. Orita. 1998. Detection of varicella-zoster virus DNA in peripheral mononuclear cells from patients with Ramsay Hunt syndrome or zoster sine herpete. J. Med. Virol. 56:359363.
106. Tipples, G. A.,, D. Safronetz,, and M. Gray. 2003. A realtime PCR assay for the detection of varicella-zoster virus DNA and differentiation of vaccine, wild-type and control strains. J. Virol. Methods 113:113116.
107. Vafai, A.,, and M. Berger. 2001. Zoster in patients infected with HIV: a review. Am. J. Med. Sci. 321:372380.
108. van der Maas, N. A.,, P. E. Bondt,, H. de Melker,, and J. M. Kemmeren. 2009. Acute cerebellar ataxia in the Netherlands: a study on the association with vaccinations and varicella zoster infection. Vaccine 27:19701973.
109. van Doornum, G. J.,, J. Guldemeester,, A. D. Osterhaus,, and H. G. Niesters. 2003. Diagnosing herpesvirus infections by real-time amplification and rapid culture. J. Clin. Microbiol. 41:576580.
110. Vazquez, M.,, P. S. LaRussa,, A. A. Gershon,, S. P. Steinberg,, K. Freudigman,, and E. D. Shapiro. 2001. The effectiveness of the varicella vaccine in clinical practice. N. Engl. J. Med. 344:955960.
111. Vossen, M. T.,, M. R. Gent,, J. F. Weel,, M. D. de Jong,, R. A. van Lier,, and T. W. Kuijpers. 2004. Development of virus-specific CD41 T cells on reexposure to Varicella- Zoster virus. J. Infect. Dis. 190:7282.
112. Weidmann, M.,, K. Armbruster,, and F. T. Hufert. 2008. Challenges in designing a Taqman-based multiplex assay for the simultaneous detection of Herpes simplex virus types 1 and 2 and Varicella-zoster virus. J. Clin. Virol. 42:326334.
113. Williams, V.,, A. Gershon,, and P. A. Brunell. 1974. Serologic response to varicella-zoster membrane antigens measured by direct immunofluorescence. J. Infect. Dis. 130:669672.
114. Yamakawa, K.,, M. Hamada,, and T. Takeda. 2007. Different real-time PCR assays could lead to a different result of detection of varicella-zoster virus in facial palsy. J. Virol. Methods 139:227229.
115. Zaia, J.,, L. Baden,, M. J. Boeckh,, S. Chakrabarti,, H. Einsele,, P. Ljungman,, G. B. McDonald,, and H. Hirsch. 2009. Viral disease prevention after hematopoietic cell transplantation. Bone Marrow Transplant. 44:471482.

Tables

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TABLE 1

Diagnostic tests for VZV-induced disease

Citation: Puchhammer-Stöckl E, Aberle S. 2011. Varicella-Zoster Virus , p 1545-1557. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch97
Generic image for table
TABLE 2

Quantitative VZV DNA results with different clinical materials from patients with different VZV-associated diseases

Abbreviations: co, copies; GC, ganglion cells.

Citation: Puchhammer-Stöckl E, Aberle S. 2011. Varicella-Zoster Virus , p 1545-1557. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch97

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