Chapter 6 : Human T-Lymphotropic Virus 1: Clinical Aspects of a Neglected Infection among Indigenous Populations

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This chapter discusses the clinical manifestations of human T-lymphotropic virus 1 (HTLV-1) in two neglected indigenous populations: the Aboriginal people of central Australia and the Quechua Amerindians of the southern Andes in Peru. The vast majority of the 10 million to 20 million HTLV-1-infected people worldwide, therefore, live in the developing world, and even there, infection is associated with lower socioeconomic status. Among indigenous people in Peru, prolonged breast-feeding is also probably the most important route of transmission. The remainder of the chapter focuses on HTLV-1-associated conditions that might be relevant to resource-poor areas. The major clinical manifestations of HTLV-1-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) are spastic weakness of the lower limbs, urinary and sexual dysfunction, constipation, and back pain. Although a brief report from Papua New Guinea also failed to find an association between HTLV-1 and tuberculosis, a study performed in Port Moresby, included no control group, and did not report background prevalence rates. Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy of HTLV-1-infected CD4 lymphocytes. Clinical characteristics include lymphadenopathy, hepatosplenomegaly, skin lesions, hypercalcemia, lytic bone lesions, and presentation with opportunistic infections, including pneumonia. Monoclonal integration of HTLV-1 has been found in as many as 39% of -infected HTLV-1-seropositive patients, and two patients in this study subsequently developed ATL. Conversely, case reports suggest that treating reduces the number of clones and Tax mRNA transcription and may lead to remission of chronic ATL in some patients.

Citation: Einsiedel L, Verdonck K, Gotuzzo E. 2010. Human T-Lymphotropic Virus 1: Clinical Aspects of a Neglected Infection among Indigenous Populations, p 109-127. In Scheld W, Grayson M, Hughes J (ed), Emerging Infections 9. ASM Press, Washington, DC. doi: 10.1128/9781555816803.ch6

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Hepatitis C virus
Hepatitis B virus
Adult T-cell Leukemia
Human T-lymphotropic virus
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1. Agape, P.,, M. Copin,, M. Cavrois,, G. Panelatti,, Y. Plumelle,, M. Ossondo-Landeau,, D. Quist,, N. Gros-sat,, B. Gosselin,, P. Fenaux, and, E. Wattel. 1999. Implications of HTLV-1 infection, strongyloidiasis and p53 expression in the development, response to treatment and evolution of non-Hodgkins Lymphoma in an endemic area. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 20:394402.
2. Alarcon, J. O.,, H. Friedman,, S. M. Montano,, J. R. Zunt,, K. K. Holmes, and, G. V. Quinnan. 2006. High endemicity of human T-cell lymphotropic virus type 1 among pregnant women in Peru. J. Acquir. Immune Defic. Syndr. 42:604609.
3. Araujo, A. Q. C.,, and M. Silva. 2006. The HTLV-1 neurological complex. Lancet Infect. Dis. 5:10681076.
4. Asquith, B.,, A. Mosley,, A. Heaps,, Y. Tanaka,, G. P. Taylor,, A. McLean, and, C. R. M. Bangham. 2005. Quantification of the virus-host interaction in human T-lymphotropic virus I infection. Retrovirology 2:75.
5. Australian Bureau of Statistics/Australian Institute of Health and Welfare. 2008. The Health and Welfare of Australia’s Aboriginal and Torres Strait Islander Peoples. Australian Bureau of Statistics/Australian Institute of Health and Welfare, Canberra, Australia.
6. Bailie, R. S.,, M. Stevens,, E. McDonald,, S. Halpin,, D. Brewster,, G. Robinson, and, S. Guthridge. 2005. Skin infection, housing and social circumstances in children living in remote indigenous communities: testing conceptual and methodological approaches. BMC Public Health 5:128139.
7. Bangham, C. R. M.,, K. Meekings,, F. Toulza,, M. Nejmeddine,, E. Majorovits,, B. Asquith, and, G. P. Taylor. 2009. The immune control of HTLV-1 infection: selection forces and dynamics. Front. Biosci. 14:28892903.
8. Barmak, K.,, E. Harhaj,, C. Grant,, T. Alefantis, and, B. Wigdahl. 2003. Human T-cell leukemia virus type I-induced disease: pathways to cancer and neurodegeneration. Virology 308:112.
9. Bartholomew, C.,, N. Jack, and, J. Edwards. 1998. HTLV-1 serostatus of mothers of patients with adult T-cell leukemia and HTLV-1 associated myelopathy/tropical spastic paraparesis. J. Hum. Virol. 1:302305.
10. Bastian, I. 1996. HTLV-1 Studies in the Northern Territory. Menzies School of Health Research/University of Sydney, Darwin, Australia.
11. Bastian, I.,, Y. Hinuma, and, R. R. Doherty. 1993. HTLV-1 among Northern Territory Aborigines. Med. J. Aust. 159:1216.
12. Beilke, M. A.,, S. Japa,, C. Moeller-Hadi, and, S. Martin-Schild. 2005. Tropical spastic paraparesis/human T leukemia virus type 1-associated myelopathy in HIV type 1 coinfected patients. Clin. Infect. Dis. 41:e57-e63.
13. Beilke, M. A.,, S. Japa, and, D. G. Vinson. 1998. HTLV-I and HTLV-II virus expression increase with HIV-1 coinfection. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 17:391397.
14. Beilke, M. A.,, V. Traina-Dorge,, M. Sirois,, A. Bhuiyan,, E. L. Murphy,, J. M. Walls,, R. Fagan,, E. L. Winsor, and, P. J. Kissinger. 2007. Relationship between human T lymphotropic virus (HTLV-1/2) viral burden and clinical and treatment parameters among patients infected with HIV type 1 and HTLV-1/2 coinfection. Clin. Infect. Dis. 44:12291234.
15. Beilke, M. A.,, K. Theall,, M. O’Brien,, J. L. Clayton,, S. M. Benjamin,, E. L. Winsor, and, P. J. Kissinger. 2004. Clinical outcomes and disease progression among patients coinfected with HIV and human T lymphotropic virus types 1 and 2. Clin. Infect. Dis. 39:256263.
16. Best, I.,, V. Adaui,, K. Verdonck,, E. Gonzalez,, M. Tipismana,, D. Clark,, E. Gotuzzo, and, G. Vanham. 2006. Proviral load and immune markers associated with human T-lymphotropic virus type 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Peru. Clin. Exp. Immunol. 146:226233.
17. Blas, M.,, F. Bravo,, W. Castillo,, W. J. Castillo,, R. Ballona,, P. Navarro,, J. Catacora,, R. Cairampoma, and, E. Gotuzzo. 2005. Norwegian scabies in Peru: the impact of human T cell lymphotropic virus type I infection. Am. J. Trop. Med. Hyg. 72:855857.
18. Brites, C.,, R. Alencar,, R. Gusmao,, C. Pedroso,, E. M. Netto,, D. Pedral-Sampaio, and, R. Badaro. 2001. Co-infection with HTLV-1 is associated with a shorter survival time for HIV-1 infected patients in Bahia, Brazil. AIDS 15:20532055.
19. Brites, C.,, M. Weyll,, C. Pedrosa, and, R. Badaro. 2002. Severe and Norwegian scabies are strongly associated with retroviral (HIV-1/HTLV-1) infection in Bahia, Brazil. AIDS 16:12921293.
20. Burrell, C. J.,, A. Cameron, and, G. Hart. 1983. Hepatitis B reservoirs and attack rates in an Australian community: a basis for vaccination and cross-infection. Med. J. Aust. 2:492496.
21. Cabada, M.,, E. Gonzalez,, L. Casanova,, S. Falcón,, F. Salas,, A. Kobashigawa,, B. Beltr¡n,, K. Verdonck, and, E. Gotuzzo. 2007. High prevalence of HTLV-1 infection among relatives of patients with HTLV-1 associated adult T-cell malignancies (HAATM) in Peru. 13th Int. Conf. Hum. Retrovirol. HTLV Relat. Retrovir., Hakone, Japan, 21 to 25 May 2007.
22. Casseb, J.,, M. Posada-Vergara,, P. Montanheiro,, L. M. I. Fukumori,, I. Olah,, J. Smid,, A. J. Duarte, and, A. C. Penalva de Oliveira. 2007. T CD4+ cells count among patients coinfected with human immunodeficiency virus type 1 (HIV-1) and human T-cell lymphotropic virus type 1 (HTLV-1): high prevalence of tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM). Rev. Inst. Med. Trop. Sao Paulo 49:231233.
23. Cavrois, M.,, A. Gessain,, S. Wain-Hobson, and, E. Wattel. 1996. Proliferation of HTLV-1 infected circulating cells in vivo in asymptomatic carriers and patients with HAM/TSP. Oncogene 12:24192423.
24. Chang, A. B.,, J. Masel,, N. C. Boyce,, G. Wheaton, and, P. J. Torzillo. 2003. Non-CF bronchiectasis: clinical and HRCT evaluation. Pediatr. Pulmonol. 35:477483.
25. Chieffi, P. P.,, C. Chiattone,, E. N. Feltrim,, R. C. S. Alves, and, M. A. Paschoalotti. 2000. Coinfection by Strongyloides stercoralis in blood donors infected with human T-cell leukemia/lymphoma virus type 1 in Sao Paolo City, Brazil. Mem. Inst. Oswaldo Cruz 95:711712.
26. Couderc, L. J.,, I. Cauberrere,, A. Venet,, J. Magdeleine,, A. Jouanelle,, F. Danon,, G. Buisson, and, J. C. Vernant. 1988. Bronchoalveolar lymphocytosis in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type 1. Ann. Intern. Med. 109:625628.
27. Currie, B. J.,, and J. Carapetis. 2000. Skin infections and infestations in Aboriginal communities in northern Australia. Australas. J. Dermatol. 41:139145.
28. De Castro-Costa, C. M.,, A. Arajuo,, M. M. Barreto,, O. M. Takayanagui,, M. P. Sohler,, E. L. da Silva,, S. M. de Paula,, R. Ishak,, J. G. Ribas,, L. C. Rovirosa,, H. Carton,, E. Gotuzzo,, W. W. Hall,, S. Montano,, E. L. Murphy,, J. Oger,, C. Remondegui, and, G. P. Taylor. 2006. Proposal for diagnostic criteria of tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). AIDS Res. Hum. Retrovir. 22:931935.
29. Delaporte, E.,, A. Buve,, N. Nzila,, J. Goeman,, M. Dazza,, D. Henzel,, W. Heyward,, M. St Louis,, P. Piot, and, M. Laga. 1995. HTLV-1 infection among prostitutes and pregnant women in Kinshasa, Zaire: how important is high-risk sexual behavior. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 8:511515.
30. Del Giudice, P.,, D. Saint Marie,, Y. Gerard,, P. Couppie, and, R. Pradinaud. 1997. Is crusted scabies a marker of adult T cell leukemia/lymphoma in human T lymphotropic virus type I seropositive patients? J. Infect. Dis. 176:10901092.
31. de Lourdes Bastos, M.,, B. Osterbauer,, D. L. Mesquita,, C. A. Carrera,, M. J. Albuquerque,, L. Silva,, D. N. Pereira,, L. Riley, and, E. M. Carvalho. 2009. Prevalence of human T-cell lymphotropic virus type 1 infection in hospitalized patients with tuberculosis. Int. J. Tuberc. Lung Dis. 13:15191523.
32. Desgranges, C.,, J. Bechet,, L. J. Couderc,, I. Caubarrere, and, J. C. Vernant. 1989. Detection of HTLV-1 DNA by polymerase chain reaction in alveolar lymphocytes of patients with tropical spastic paraparesis. J. Infect. Dis. 160:162163.
33. de The, G.,, and R. Bomford. 1993. An HTLV-1 vaccine: why, how for whom? AIDS Res. Hum. Retrovir. 9:381386.
34. Doherty, R. 1996. HTLV-1 in Australia and Oceania: long term resident or recent immigrant? Med. J. Aust. 164:8486.
35. Eguchi, K.,, N. Matsuoka,, H. Ida,, M. Nakashima,, M. Sakai,, S. Sakito,, A. Kawakami,, K. Terada,, H. Shimada,, Y. Kawabe,, T. Fukuda,, T. Sawada, and, S. Nagataki. 1992. Primary Sjogren’s syndrome with antibodies to HTLV-1: clinical and laboratory features. Ann. Rheum. Dis. 51:769776.
36. Einsiedel, L.,, and L. Fernandes. 2008. Strongyloides stercoralis: a cause of morbidity and mortality for indigenous people in Central Australia. Intern. Med. J. 38:697703.
37. Einsiedel, L.,, L. Fernandes,, D. Steinfort, and, R. Woodman. 2008. Bronchiectasis, the human T-cell lymphotropic virus type 1 and mortality in Central Australia, p. 52. In Proceedings of the Australasian Society of Infectious Diseases Annual Scientific Meeting. Australasian Society of Infectious Diseases, Sunshine Coast, Queensland, Australia.
38. Einsiedel, L. J.,, L. Fernandes, and, R. J. Woodman. 2008. Racial disparities in infection-related mortality at Alice Springs Hospital, Central Australia, 2000–2005. Med. J. Aust. 188:568571.
39. Einsiedel, L. J.,, and R. Woodman. 2010. Two nations: racial disparities in bloodstream infections recorded at Alice Springs Hospital, central Australia, 2001–2005. Med. J. Aust. 192:567571.
40. Fantry, L.,, E. De Jonge,, P. G. Auwaeter, and, H. M. Lederman. 1995. Immunodeficiency and elevated CD4 T lymphocyte counts in two patients coinfected with human immunodeficiency virus and human lymphotropic virus type I. Clin. Infect. Dis. 21:14661468.
41. Figueroa, J. P.,, E. Ward,, J. Morris,, A. R. Brathwaite,, A. Peruga,, W. Blattner,, S. H. Vermund, and, R. Hayes. 1997. Incidence of HIV and HTLV-1 infection among sexually transmitted disease clinic attenders in Jamaica. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 15:232237.
42. Furukawa, Y.,, M. Yamoshita,, K. Usuku,, S. Izumo,, M. Nakagawa, and, M. Osame. 2000. Phylogenetic subgroups of human T-lymphotropic virus type 1 in tax gene and their association with different risks for HTLV-1 associated myelopathy/tropical spastic paraparesis. J. Infect. Dis. 182:13431349.
43. Gabet, A.,, F. Mortreux,, A. Talarmin,, Y. Plumelle,, I. Leclercq,, A. Leroy,, A. Gessain,, E. Clity,, M. Jou-bert, and, E. Wattel. 2000. High circulating proviral load with oligoclonal expansion of HTLV-1 bearing T cells in HTLV-1 carriers with strongyloidiasis. Oncogene 19:49544960.
44. Gabet, A. S.,, M. Kazanji,, E. Clity,, J. F. Pouliquen,, D. Sainte-Marie,, C. Aznar, and, E. Wattel. 2003. Adult T-cell leukemia/lymphoma-like human T cell leukemia virus-1 replication in infective dermatitis. Br. J. Haematol. 123:406412.
45. Goon, P. K. C.,, A. Biancardi,, N. Fast,, T. Igakura,, E. Hanon,, A. J. Mosley,, B. Asquith,, K. G. Gould,, S. Marshall,, G. P. Taylor, and, C. R. M. Bangham. 2004. Human T cell lymphotropic virus (HTLV) type 1 specific CD8+ T cells: frequency and immunodominance hierarchy. J. Infect. Dis. 189:22942298.
46. Gotuzzo, E.,, J. Cabrera,, L. Deza,, K. Verdonck,, A. M. Vandamme,, R. Cairampoma,, D. Vizcarra,, M. Cabada,, G. Narvarte, and, C. De las Casas. 2004. Clinical characteristics of patients in Peru with human T-cell lymphotropic virus type 1-associated tropical spastic paraparesis. Clin. Infect. Dis. 39:939944.
47. Gotuzzo, E.,, J. Escamilla,, I. A. Phillips,, J. Sanchez,, F. S. Wignall, and, J. Antigoni. 1992. The impact of human T-lymphotropic virus type I/II infection on the prognosis of sexually acquired cases of acquired immunodeficiency syndrome. Arch. Intern. Med. 152:14291432.
48. Gotuzzo, E.,, J. Moody,, K. Verdonck,, M. Cabada,, E. Gonzalez,, S. Van Dooren,, A. M. Vandamme,, A. Terashima, and, S. H. Vermund. 2007. Frequent HTLV-1 infection in the offspring of Peruvian women with HTLV-1-associated myelopathy/tropical spastic paraparesis or strongyloidiasis. Rev. Panam. Salud Publica 22:223230.
49. Gotuzzo, E.,, A. Terashima,, H. Alvarez,, R. Tello,, R. Infante,, D. M. Watts, and, D. O. Freedman. 1999. Strongyloides stercoralis hyperinfection associated with human T cell lymphotropic virus type I in Peru. Am. J. Trop. Med. Hyg. 60:146149.
50. Gotuzzo, E.,, K. Verdonck,, E. Gonzalez,, M. Tipismana,, F. Bravo,, I. Rolando,, F. Ita,, E. Mayer,, W. Schrooten,, G. Vanham,, P. Condorhuamán,, E. Rizo Patrón, and, D. Clark. 2009. An overview of 20 years of HTLV-1 study at the Institute of Tropical Medicine Alexander von Humboldt in Lima, Peru, abstr. P-031. 14th Int. Conf. Hum. Retrovirol. HTLV Relat. Retrovir., Bahia, Brazil.
51. Gracey, M. 1998. Australian Aboriginal child health. Ann. Trop. Paediatr. 18:S53-S59.
52. Gustafson, P.,, V. Gomes,, C. S. Vieira,, P. Rabna,, R. Seng,, P. Johansson,, A. Sandstrom,, R. Norberg,, R. Lisse,, I. Lisse,, B. Samb,, P. Aaby, and, A. Naucler. 2004. Tuberculosis in Bissau: incidence and risk factors in an urban community in sub-Saharan Africa. Int. J. Epidemiol. 33:163172.
53. Hanchard, B.,, L. La Grenade,, C. Carberry,, V. Fletcher,, E. Williams,, B. Cranston,, W. A. Blattner, and, A. Manns. 1991. Childhood infective dermatitis evolving into adult T-cell leukemia after 17 years. Lancet 338:15931594.
54. Harrison, L. H.,, T. Quinn, and, M. Schrecter. 1997. Human T cell lymphotropic virus type I does not increase human immunodeficiency virus viral load in vivo. J. Infect. Dis. 175:438440.
55. Hayashi, J.,, Y. Kishihara,, E. Yoshimura,, N. Furusyo,, K. Yamaji,, Y. Kawakami,, H. Murakami, and, S. Kashiwagi. 1997. Correlation between human T cell lymphotropic virus type-1 and Strongyloides stercoralis infections and serum immunoglobulin E responses in residents of Okinawa, Japan. Am. J. Trop. Med. Hyg. 56:7175.
56. Higashiyama, Y.,, S. Katamine,, S. Kohno,, H. Mukae,, S. Hino,, T. Miyamoto, and, K. Hara. 1994. Expression of human T lymphotropic virus type 1 (HTLV-1) tax/rex gene in fresh bronchoalveolar lavage cells of HTLV-1 infected individuals. Clin. Exp. Immunol. 96:193201.
57. Hino, S.,, S. Katamine,, K. Kawase,, T. Miyamoto,, H. Doi,, Y. Tsuji, and, T. Yamabe. 1994. Intervention of maternal transmission of HTLV-1 in Nagasaki, Japan. Leukemia 8:S68-S70.
58. Hirata, T.,, N. Uchima,, K. Kishimoto,, O. Zaha,, N. Kinjo,, A. Hokama,, H. Sakugawa,, F. Kinjo, and, J. Fujita. 2006. Impairment of host immune response against Strongyloides stercoralis by human T cell lymphotropic virus type I. Am. J. Trop. Med. Hyg. 74:246249.
59. Hisada, M.,, S. Stuver,, A. Okayama,, H.-C. Li,, T. Sawada,, B. Hanchard, and, N. E. Mueller. 2004. Persistent paradox of natural history of human T lymphotropic virus type 1: analyses of Japanese and Jamaican carriers. Clin. Infect. Dis. 190:16051609.
60. Hisada, M.,, S. Stuver,, A. Okayama, and, N. E. Mueller. 1999. Gender differences in skin reactivity to purified protein derivative among carriers of HTLV-1 in Japan. J. Acquir. Immune Defic. Syndr. 22:302306.
61. Hollsberg, P. 1999. Mechanisms of T-cell activation by human T-cell lymphotropic virus type 1. Microbiol. Mol. Biol. Rev. 63:308333.
62. Igra-Siegman, Y.,, R. Kapila,, P. Sen,, Z. C. Kaminski, and, D. B. Louria. 1981. Syndrome of hyperinfection with Strongyloides stercoralis. Rev. Infect. Dis. 3:397407.
63. Ita, F.,, E. Mayor,, K. Verdonck,, E. Gonzalez, and, E. Gotuzzo. 2009. HTLV-1 might be highly endemic in rural communities of the southern Andes of Peru, abstr. P-077, p. 113. 14th Int. Conf. Hum. Retrovirol. HTLV Relat. Retrovir., Bahia, Brazil, 1 to 4 July 2009.
64. Ita, F.,, E. Mayor,, K. Verdonck,, E. Gonzalez,, Z. Juscamaita, and, E. Gotuzzo. 2009. Societal breastfeeding customs in small, rural communities: can they contribute to endemicity of HTLV-1 in the Peruvian Andes?, abstr. P-142, p. 143. 14th Int. Conf. Hum. Retrovirol. HTLV Relat. Retrovir, Bahia, Brazil, 1 to 4 July 2009.
65. Jeang, K. T.,, C. Giam,, F. Majone, and, M. Aboud. 2004. Life, death and Tax: role of HTLV-1 oncoprotein in genetic instability and cellular transformation. J. Biol. Chem. 279:3199131994.
66. Jeffrey, K. J. M.,, K. Usuku,, S. E. Hall,, W. Matsumoto,, G. P. Taylor,, J. Procter,, M. Bunce,, G. S. Ogg,, K. I. Welsh,, J. N. Weber,, A. L. Lloyd,, M. A. Nowak,, M. Naga,, D. Kodama,, S. Izumo,, M. Osame, and, C. R. M. Bangham. 1999. HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy. Proc. Natl. Acad. Sci. USA 96:38483853.
67. Kajiyama, W.,, S. Kashiwagi,, H. Ikematsu,, J. Hayashi,, H. Nomura, and, J. Okochi. 1986. Intrafamilial transmission of adult T cell leukemia virus. J. Infect. Dis. 154:851857.
68. Kanagi, M.,, T. Ohashi,, S. Hanabuchi, and, A. Hasegawa. 2004. Immunological risks of adult T-cell leukemia at primary HTLV-1 infection. Trends Microbiol. 12:346352.
69. Kaplan, J. F.,, T. Camara,, A. Hanne,, D. Green,, R. Khabbaz, and, B. Le Guenno. 1994. Low prevalence of human T lymphotropic virus type-1 infection among patients with tuberculosis in Senegal. J. Acquir. Immune Defic. Syndr. 7:418420.
70. Kashiwagi, K.,, N. Furusyo,, H. Nakashima,, N. Kubo,, N. Kinukawa,, S. Kashiwagi, and, J. Hayashi. 2004. A decrease in mother-to-child transmission of human T lymphotropic virus type I (HTLV-1) in Okinawa, Japan. Am. J. Trop. Med. Hyg. 70:158163.
71. Kendall, E. A.,, E. Gonzalez,, I. Espinoza,, M. Tipismana,, K. Verdonck,, D. Clark,, S. H. Vermund, and, E. Gotuzzo. 2009. Early neurologic abnormalities associated with human T-cell lymphotropic virus type 1 infection in a cohort of Peruvian children. J. Pediatr. 155:700706.
72. Kirkland, M. A.,, J. Frasca, and, I. Bastian. 1991. Adult T cell leukaemia lymphoma in an Aborigine. Aust. N. Z. J. Med. 21:739741.
73. Kishihara, Y.,, N. Furusyo,, K. Kashiwagi,, A. Mitsutake,, S. Kashiwagi, and, J. Hayashi. 2001. Human T-cell lymphotropic virus type 1 infection influences hepatitis C virus clearance. J. Infect. Dis. 184:11141119.
74. Kramer, M. S.,, and R. Kakuma. 2002. The Optimal Duration of Exclusive Breastfeeding. A Systematic Review. World Health Organization, Geneva, Switzerland.
75. Kwaan, N.,, A. Lee,, D. M. Chafets,, C. Nass,, B. Newman,, J. Smith,, G. Garratty, and, E. L. Murphy. 2006. Long-term variations in human T lymphotropic virus (HTLV)-I and HTLV-II proviral loads and association with clinical data. Clin. Infect. Dis. 194:15571564.
76. La Grenade, L. 1996. HTLV-1 associated infective dermatitis: past, present and future. J. Acquir. ImmuneDefic. Syndr. Hum. Retrovirol. 13:S46-S49.
77. La Grenade, L.,, B. Hanchard,, V. Fletcher,, B. Cranston, and, W. Blattner. 1990. Infective dermatitis of Jamaican children: a marker for HTLV-1 infection. Lancet 336:13451347.
78. La Grenade, L.,, A. Manns,, V. Fletcher,, C. Carberry,, B. Hanchard,, E. M. Maloney,, B. Cranston,, N. P. Williams,, R. Wilks,, E. C. Kang, and, W. Blattner. 1998. Clinical, pathologic and immunologic features of human T-lymphotropic virus type 1 associated infective dermatitis in children. Arch. Dermatol. 134:439444.
79. Larsen, O.,, S. Andersson,, Z. da Silva,, K. Hedegaard,, A. Sandstrom,, A. Naucler,, F. Dias,, M. Melbye, and, P. Aaby. 2000. Prevalences of HTLV-1 infection and associated risk determinants in an urban population in Guinea-Bissau, West Africa. J. Acquir. Immune Defic. Syndr. 25:157163.
80. Lechat, M. F.,, D. Schrager,, E. Declerq,, F. Bertrand,, W. A. Blattner, and, B. Blumberg. 1997. Decreased survival of HTLV-1 carriers in leprosy patients from the Democratic Republic of the Congo: a historical prospective study. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 15:387390.
81. Maragno, L.,, J. Casseb,, L. M. Fukumoria,, M. N. Sotto,, A. J. Duarte,, C. Festa-Neto, and, J. A. Sanches. 2009. Human T-cell lymphotropic virus type 1 infective dermatitis emerging in adulthood. Int. J. Dermatol. 48:723730.
82. March, B. J. 1996. Infectious complications of human T cell leukemia/lymphoma virus type 1. Clin. Infect. Dis. 23:138145.
83. Marinho, J.,, B. Galvao-Castro,, L. C. Rodrigues, and, M. L. Barreto. 2005. Increased risk of tuberculosis with human T-cell lymphotropic virus type 1 infection: a case control study. J. Acquir. Immune Defic. Syndr. 40:625628.
84. Maruyama, I.,, J. Tihara,, I. Sakashita,, R. Mizoguti,, S. Mori,, K. Usuku,, M. Jonosono,, M. Tara,, S. Matumoto,, S. Nina,, S. Sonoda,, S. Yasaki, and, M. Osame. 1988. HTLV-1 associated bronchopneumonopathy—a new clinical entity? Am. Rev. Respir. Dis. 137:S46.
85. Matsuyama, W.,, A. Mizoguchi,, F. Iwami,, Y. Koreeda,, J. Wakimoto,, H. Kanazawa,, S. Mori,, M. Kawa-bata,, H. Fukunaga, and, M. Osame. 2000. Clinical investigation of pulmonary Mycobacterium avium complex infection in human T lymphotropic virus type I carriers. Thorax 55:388392.
86. McDonald, M. I.,, R. Towers,, R. M. Andrews,, N. Benger,, B. J. Currie, and, J. R. Carapetis. 2006. Low rates of streptococcal pharyngitis and high rates of pyoderma in Australian Aboriginal communities where acute rheumatic fever is hyperendemic. Clin. Infect. Dis. 43:6839.
87. Meekings, K. N.,, J. Leipzig,, F. D. Bushman,, G. P. Taylor, and, C. R. Bangham. 2008. HTLV-1 integraton into transcriptionally active genome regions is associated with proviral expression and with HAM/TSP. PLoS Pathog. 4:e1000027.
88. Mita, S.,, M. Sugimoto,, M. Nakamura,, T. Murakami,, M. Tokunaga,, E. Uyama, and, S. Araki. 1993. Increased human T lymphotropic virus type 1 (HTLV-1) proviral DNA in peripheral blood mononuclear cells and bronchoalveolar lavage cells from Japanese patients with HTLV-1 associated myelopathy. Am. J. Trop. Med. Hyg. 48:170177.
89. Mochizuki, M.,, T. Watanabe, and, K. Yamaguchi. 1992. Uveitis associated with human T lymphotropic virus type I: seroepidemiologic, clinical and virological studies. J. Infect. Dis. 166:943944.
90. Mollison, L. C.,, S. Lo, and, G. Marning. 1993. HTLV-1 and scabies in Australian aborgines. Lancet 341:12811282.
91. Montes, M.,, C. Sanchez,, K. Verdonck,, J. E. Lake,, E. Gonzalez,, G. Lopez,, A. Terashima,, T. Nolan,, D. E. Lewis,, E. Gotuzzo, and, A. C. White. 2009. Regulatory T cell expansion in HTLV-1 and strongyloidiasis co-infection is associated with reduced IL-5 responses to Strongyloides stercoralis antigen. PLoS Negl. Trop. Dis. 3:e456.
92. Mori, K.,, N. Mizoguchi.,, M. Matsuo,, K. Nomata,, T. Nakamura, and, H. Kanetake. 2004. Natural course of voiding function in patients with human T-cell lymphotrophic virus type 1-associated myelopathy. J. Neurol. Sci. 217:36.
93. Mori, S.,, A. Mizoguchi,, M. Kawabata,, H. Fukunaga,, K. Usuku,, I. Maruyama, and, M. Osame. 2005. Bronchoalveolar lavage lymphocytes correlate with HTLV-1 proviral load in HTLV-1 carriers. Thorax 60:138143.
94. Mortreux, F.,, A.-S. Gabet, and, E. Wattel. 2003. Molecular and cellular aspects of HTLV-1 associated leukemogenesis in vivo. Leukemia 17:2638.
95. Murphy, E.,, R. Wilks,, O. Morgan,, B. Hanchard,, B. Granston,, J. P. Figueroa, and, W. N. Gibbs. 1996. Health effects of human T-lymphotropic virus type I (HTLV-1) in a Jamaican cohort. Int. J. Epidemiol. 25:10901097.
96. Murphy, E. L.,, B. Wang,, R. A. Sacher,, J. Fridey,, J. W. Smith,, C. C. Nass,, B. Newman,, H. E. Ownby,, G. Garratty,, S. T. Hutching, and, G. B. Schreiber. 2004. Respiratory and urinary tract infections, arthritis and asthma associated with HTLV-I and HTLV-II infection. Emerg. Infect. Dis. 10:109116.
97. Nadler, J. P.,, M. Bach, and, E. Godofsky. 1996. Management of coinfection with human immunodeficiency virus and human T-cell lymphotropic virus type I. Clin. Infect. Dis. 23:415.
98. Nagai, M.,, K. Usuku,, W. Matsumoto,, D. Kodama,, N. Takenouchi,, T. Moritoyo,, S. Hashiguchi,, M. Ichinose,, C. R. M. Bangham,, S. Izumo, and, M. Osame. 1998. Analysis of HTLV-1 proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-1 carriers: high proviral load strongly predisposes to HAM/TSP. J. Neurovirol. 4:586593.
99. Nakada, K.,, M. Kohakura,, H. Komoda, and, K. Hinuma. 1984. High incidence of HTLV-1 antibody in carriers of Strongyloides stercoralis. Lancet i:633.
100. Nakada, K.,, K. Yamaguchi,, S. Furugen,, T. Nakasone,, K. Nakasone,, Y. Oshiro,, M. Kohakura,, K. Hinuma,, M. Seiki,, M. Yoshida,, E. Matutes,, D. Catovsky,, T. Ishii, and, K. Takatsuki. 1987. Monoclonal integration of HTLV-1 proviral DNA in patients with strongyloidiasis. Int. J. Cancer 40:145148.
101. Nakagawa, M.,, S. Izumo,, H. Kubota,, K. Arimura,, M. Kawabata, and, M. Osame. 1995. HTLV-1-associated myelopathy: analysis of 213 patients based on clinical feaures and laboratory findings. J. Neurovirol. 1:5061.
102. Nascimento, M. C. F.,, J. Primo,, A. Bittencourt,, I. Siqueira,, M. Oliveira,, R. Meyer,, A. Schriefer,, S. B. Santos, and, E. M. Carvalho. 2009. Infective dermatitis has similar immunological features to human T lymphotropic virus type 1 associated myelopathy/tropical spastic paraparesis. Clin. Exp. Immunol. 156:455462.
103. Neva, F. A.,, E. Murphy,, A. Gam,, B. Hanchard,, J. P. Figueroa, and, W. A. Blattner. 1989. Antibodies to Strongyloides stercoralis in healthy Jamaican carriers of HTLV-1. N. Engl. J. Med. 320:252253.
104. Nishioka, K.,, I. Maruyama,, K. Sato,, I. Kitajima,, Y. Nakajima, and, M. Osame. 1989. Chronic inflammatory arthropathy associated with HTLV-1. Lancet i:441.
105. Norrgren, H. R.,, S. Bamba,, O. Larsen,, Z. Da Silva,, P. Aaby,, T. Koivula, and, S. Andersson. 2008. Increased prevalence of HTLV-1 in patients with pulmonary tuberculosis coinfected with HIV, but not in HIV-negative patients with tuberculosis. J. Acquir. Immune Defic. Syndr. 48:607610.
106. Okada, F.,, Y. Ando,, S. Yoshitake,, S. Yotsumoto,, S. Matsumoto,, M. Wakisaka,, T. Maeda, and, H. Mori. 2006. Pulmonary CT findings in 320 carriers of human T-lymphotropic virus type 1. Radiology 240:559564.
107. Olaleye, D. O.,, L. Bernstein,, Z. Sheng,, C. C. Ekweozor,, X.-Y. Li,, J. Sullivan-Halley, and, S. Rasheed. 1994. Type specific immune response to human T-cell lymphotropic virus type I and type II infections in Nigeria. Am. J. Trop. Med. Hyg. 50:479486.
108. Ono, A.,, M. Mochizuki,, K. Yamaguchi,, N. Miyata, and, T. Watanabe. 1995. Increased number of circulating HTLV-1 infected cells in peripheral blood mononuclear cells of HTLV-1 uveitis patients: a quantitative polymerase chain reaction study. Br. J. Ophthalmol. 79:270276.
109. Ouattara, S. A.,, M. Gody, and, G. de The. 1989. Prevalence of HTLV-1 compared to HIV-1 and HIV-2 antibodies in different groups in the Ivory Coast. J. Acquir. Immune Defic. Syndr. 2:481485.
110. Page, B. J.,, S. Lai,, D. D. Chitwood,, N. G. Klimas,, P. C. Smith, and, M. A. Fletcher. 1990. HTLV-I/II sero-positivity and death from AIDS among HIV-1 seropositive intravenous drug users. Lancet 335:14391441.
111. Pedral-Sampaio, D. B.,, E. Netto,, C. Pedroso,, C. Brites,, M. Duarte, and, W. Harrington, Jr. 1997. Co-infection of tuberculosis and HIV/HTLV retroviruses: frequency and prognosis among patients admitted to a Brazilian hospital. Braz. J. Infect. Dis. 1:3136.
112. Plumelle, Y.,, C. Gonin,, A. Edouard,, B. J. Bucher,, L. Thomas,, A. Brebion, and, G. Panelatti. 1997. Effect of Strongyloides stercoralis infection and eosinophilia on age at onset and prognosis of adult T cell leukemia. Am. J. Clin. Pathol. 107:8187.
113. Porto, A. F.,, J. Filo,, F. A. Neva,, G. Orge,, L. Alcantara,, A. Gam, and, E. M. Carvalho. 2001. Influence of human T cell lymphotropic virus type 1 infection on serologic and skin tests for strongyloidiasis. Am. J. Trop. Med. Hyg. 65:610613.
114. Porto, A. F.,, F. Neva,, H. Bittencourt,, W. Lisboa,, R. Thompson,, L. Alcantara, and, E. M. Carvalho. 2001. HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis. Parasite Immunol. 23:503507.
115. Porto, A. F.,, S. Santos,, L. Alcantara,, J. B. Guerreiro,, J. Passos,, T. Gonzalez,, F. Neva,, D. Gonzalez,, J. L. Ho, and, E. M. Carvalho. 2004. HTLV-1 modifies the clinical and immunological response to schisto-somiasis. Clin. Exp. Immunol. 137:424429.
116. Porto, A. F.,, S. Santos,, A. L. Muniz,, V. Basilio,, W. Rodrigues,, F. A. Neva,, W. O. Dutra,, K. J. Gollob,, S. Jacobson, and, E. M. Carvalho. 2005. Helminthic infection down regulates type 1 immune responses in human T cell lymphotropic virus type 1 (HTLV-1) carriers and is more prevalent in HTLV-1 carriers than in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis. J. Infect. Dis. 191:612618.
117. Primo, J. R.,, C. Brites,, M. Fatima,, S. P. Oliveira,, O. Moreno-Carvalho,, M. Machado, and, A. L. Bittencourt. 2005. Infective dermatitis and human T-cell lymphotropic virus type 1 associated myelopathy/tropical spastic paraparesis in childhood and adolescence. Clin. Infect. Dis. 41:535541.
118. Proietti, F. A.,, A. B. F. Carneiro-Proietti,, B. C. Catalan-Soares, and, E. L. Murphy. 2005. Global epidemiology of HTLV-1 infection and associated diseases. Oncogene 24:60586068.
119. Quispe, N. C.,, E. Feria,, E. Santos-Fortuna, and, A. Caterino-de-Araujo. 2009. Confirming the presence of HTLV-1 infection and the absence of HTLV-2 in blood donors from Arequipa, Peru. Rev. Inst. Med. Trop. Sao Paulo 51:2529.
120. Rajabalendaran, N.,, R. Burns,, L. C. Mollison,, W. Blessing,, M. G. Kirubakaran, and, P. Lindschau. 1993. Tropical spastic paraparesis in an Aborigine. Med. J. Aust. 159:2829.
121. Rattner, L.,, C. Grant,, B. Zimmerman,, J. Fritz,, G. Weil,, A. Denes,, R. Suresh,, N. Campbell,, S. Jacob-son, and, M. Lairmore. 2007. Effect of treatment of Strongyloides infection on HTLV-1 expression in a patient with adult T-cell leukemia. Am. J. Hematol. 82:929931.
122. Roberts, L. J.,, S. Huffam,, S. F. Walton, and, B. J. Currie. 2005. Crusted scabies: clinical and immunological findings in seventy-eight patients and a review of the literature. J. Infect. 50:375381.
123. Robinson, R. D.,, J. Lindo,, F. A. Neva,, A. A. Gamm,, P. Vogel,, S. I. Terry, and, E. S. Cooper. 1994. Im-munoepidemiologic studies of Strongyloides stercoralis and human T lymphotropic virus type I infections in Jamaica. J. Infect. Dis. 169:692696.
124. Roucoux, D. F.,, B. Wang,, D. Smith,, C. C. Nass,, J. Smith,, S. T. Hutching,, B. Newman,, T. H. Lee,, D. M. Chafets,, E. L. Murphy, et al. 2005. A prospective study of sexual transmission of human T lymphotropic virus (HTLV)-I and HTLV-II. J. Infect. Dis. 191:14901497.
125. Roudier, M.,, I. Lamaury, and, M. Strobel. 1997. Human T cell leukemia/lymphoma virus type 1 (HTLV-1) and Pneumocystis carinii associated with T cell proliferation and hemophagocytic syndrome. Leukemia 11:453454.
126. Sabouri, A. H.,, M. Saito,, K. Usuku,, S. N. Bajestan,, M. Mahmoudi,, M. Forughipour,, Z. Sabouri,, Z. Abbaspour,, M. E. Goharjoo,, E. Khayami,, A. Hasani,, S. Izumo,, K. Arimura,, R. Farid, and, M. Osame. 2005. Differences in viral and host genetic risk factors for development of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis between Iranian and Japanese HTLV-1-infected individuals. J. Gen. Virol. 86:773781.
127. Sanchez-Palacios, C.,, E. Gotuzzo,, A.-M. Van Damme, and, Y. Maldonado. 2003. Seroprevalence and risk factors for human T-cell lymphotropic virus (HTLV-1) infection among ethnically and geographically diverse Peruvian women. Int. J. Infect. Dis. 7:132137.
128. Satoh, M.,, S. Kiyuna,, Y. Shiroma,, H. Toma,, A. Kokaze, and, Y. Sato. 2003. Predictive markers for development of strongyloidiasis in patients infected with both Strongyloides stercoralis and HTLV-1. Clin. Exp. Immunol. 133:391396.
129. Satoh, M.,, H. Toma,, Y. Sato,, M. Takara,, Y. Shiroma,, S. Kiyuna, and, K. Hirayama. 2002. Reduced efficacy of treatment of strongyloidiasis in HTLV-1 carriers related to enhanced expression of IFN gamma and TGF beta. Clin. Exp. Immunol. 127:354359.
130. Satoh, M.,, H. Toma,, K. Sugahara,, K. Etoh,, Y. Shiroma,, S. Kiyuna,, M. Takahara,, M. Matsuoka,, K. Yamaguchi,, K. Nakada,, K. Fujita,, S. Kojima,, E. Hori,, Y. Tanaka,, S. Kamihara,, Y. Sato, and, T. Watanabe. 2002. Involvement of IL-2/IL-2R system activation by parasite antigen in polyclonal expansion of CD4+25+HTLV-1 infected T-cells in human carriers of both HTLV-1 and S. stercoralis. Oncogene 21:24662475.
131. Schrecter, M.,, L. Harrison,, N. A. Halsey,, G. Trade,, M. Santino,, L. H. Moulton, and, T. C. Quinn. 1994. Coinfection with human T-cell lymphotropic virus type I and HIV in Brazil: impact on markers of HIV disease progression. JAMA 271:353357.
132. Seaton, R. 1997. Tuberculosis and human T-cell lymphotropic virus type 1 infection. Clin. Infect. Dis. 24:1026.
133. Seki, M.,, Y. Higashiyama,, A. Mizokami,, J. I. Kadota,, R. Moriuchi,, S. Kohno,, Y. Suzuki,, K. Takahashi,, T. Gojobori, and, S. Katamine. 2000. Up-regulation of human T lymphotropic virus type 1 (HTLV-1) tax/rex mRNA in infected lung tissues. Clin. Exp. Immunol. 120:488498.
134. Setoguchi, Y.,, S. Takahashi,, T. Nukiwa, and, S. Kira. 1991. Detection of human T-cell lymphotropic virus type-1 related antibodies in patients with lymphocytic interstitial pneumonia. Am. Rev. Respir. Dis. 144:13611365.
135. Shimoyama, M. 1991. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukemia/lymphoma. A report from the lymphoma study group. Br. J. Haematol. 79:428437.
136. Steinfort, D.,, S. Brady,, H. S. Weisinger, and, L. Einsiedel. 2008. Bronchiectasis in Central Australia: a young face to an old disease. Respir. Med. 102:574578.
137. Strachan, H. 1888. On a form of multiple neuritis prevalent in the West Indies. Practitioner 59:477.
138. Sugimoto, M.,, H. Nakashima,, M. Matsumoto,, E. Uyama,, M. Ando, and, S. Araki. 1989. Pulmonary involvement in patients with HTLV-1-associated myelopathy: increased soluble IL-2 receptors in bronchoalveolar lavage fluid. Am. Rev. Respir. Dis. 139:13291335.
139. Sugimoto, M.,, H. Nakashima,, S. Watanabe,, E. Uyama,, F. Tanaka,, M. Ando,, S. Araki, and, S. Kawasaki. 1987. T-lymphocyte alveolitis in HTLV-1 associated myelopathy. Lancet ii:1220.
140. Sugisaki, K.,, T. Tsuda,, T, Kunamoto, and, S. Akizuki. 1998. Clinicopathologic characteristics of lungs of patients with human T-cell lymphotropic virus type 1 associated myelopathy. Am. J. Trop. Med. Hyg. 58:721725.
141. Sweet, R. 1966. A pattern of eczema in Jamaica. Br. J. Dermatol. 78:93100.
142. Takao, S.,, T. Ishida,, K. K. Bhatia,, N. Saha,, A. Soemantri, and, O. W. Kayame. 2000. Seroprevalence of human T-lymphotropic virus type 1 in Papua New Guinea and Irian Jaya measured using different Western blot criteria. J. Clin. Virol. 16:129133.
143. Talledo, M.,, G. Lopez,, J. R. Huyghe,, K. Verdonck,, E. Gonzalez,, D. Clark,, G. Vanham,, E. Gotuzzo,, G. Van Camp, and, L. Van Laer. 2009. Candidate gene analysis and susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis, p. O-25. Colloq. Negl. Trop. Dis. Lat. Am., Lima, Peru.
144. Taylor, G. P.,, and M. Matsuoka. 2005. Natural history of adult T-cell leukemia/lymphoma and approaches to therapy. Oncogene 24:60476057.
145. Taylor, G. P.,, J. Tosswill,, E. Matutes,, S. Daenke,, S. Hall,, B. J. Bain,, R. Davis,, D. Thomas,, M. Rossor,, C. R. M. Bangham, and, J. N. Weber. 1999. Prospective study of HTLV-1 infection in an initially asymptomatic cohort. J. Acquir. Immune Defic. Syndr. 22:92100.
146. Tekle-Haimanot, R.,, D. Frommel,, T. Tadesse,, M. Verdier,, M. Abebe, and, F. Denis. 1991. A survey of HTLV-1 and HIV in Ethiopian leprosy patients. AIDS 5:108110.
147. Toulza, F.,, A. Heaps,, Y. Tanaka,, G. P. Taylor, and, C. R. M. Bangham. 2008. High frequency of CD4+FoxP3+ cells in HTLV-1 infection: inverse correlation with HTLV-1 specific CTL response. Blood 111:50475053.
148. Tsukasaki, K.,, Y. Yamada,, S. Ikeda, and, M. Tomonaga. 1994. Infective dermatitis among patients with ATL in Japan. Int. J. Cancer 57:293.
149. Umeki, K.,, M. Hisada,, E. M. Maloney,, B. Hanchard, and, A. Okayama. 2009. Proviral loads and clonal expansion of HTLV-1-infected cells following vertical transmission: a 10-year follow-up of children in Jamaica. Intervirology 52:115122.
150. United Nations. 2009. State of the World’s Indigenous Peoples. The United Nations Department of Economic and Social Affairs, New York, NY.
151. Verdier, M.,, F. Denis,, A. Sangare,, G. Leonard,, F. Barin,, G. Gershy-Damet,, J. L. Rey,, B. Soro,, G. Leonard,, M. Mounier, and, J. Hugon. 1989. Prevalence of antibody to human T cell leukemia virus type 1 (HTLV-1) in populations of Ivory Coast, West Africa. J. Infect. Dis. 160:363370.
152. Verdier, M.,, F. Denis,, A. Sangare,, G. Leonard,, E. Sassou-Guesseau,, A. Gaye,, Y. Al-Qubati,, J. L. Rey,, I. N’Gaporo,, F. Doua, and, J. Hugon. 1990. Antibodies to human T lymphotropic virus type 1 in patients with leprosy in tropical areas. J. Infect. Dis. 161:13091310.
153. Verdonck, K.,, E. Gonzalez,, G. Henostroza,, P. Nabeta,, F. Llanos,, H. Cornejo,, G. Vanham,, C. Seas, and, E. Gotuzzo. 2007. HTLV-1 infection is frequent among out-patients with pulmonary tuberculosis in northern Lima, Peru. Int. J. Tuberc. Lung Dis. 11:10661072.
154. Verdonck, K.,, E. Gonzalez,, W. Schrooten, and, E. Gotuzzo. 2005. Factores asociados a la transmission sexual del virus linfotrópico humano de células T tipo I en el Perú, abstr. 188. XII Congr. Asoc. Panam. Infectol., Caracas, Venezuela.
155. Verdonck, K.,, E. Gonzalez,, W. Schrooten,, G. Vanham, and, E. Gotuzzo. 2008. HTLV-1 infection is associated with a history of active tuberculosis among family members of HTLV-1 infected patients in Peru. Epidemiol. Infect. 136:10761083.
156. Verdonck, K.,, E. Gonzalez,, S. Van Dooren,, A. Vandamme,, G. Vanham, and, E. Gotuzzo. 2007. Human T-lymphotropic virus 1: recent knowledge about an ancient infection. Lancet Infect. Dis. 7:266281.
157. Verdonck, K.,, W. Schrooten,, E. Gonzalez,, R. Cairampoma,, G. Vanham, and, E. Gotuzzo. 2005. Risk of HTLV-I sexual transmission is similar from men to women and women to men in Peru, p. P-053. 12th Int. Conf. Hum. Retrovirol. HTLV Relat. Retrovir., Montego Bay, Jamaica.
158. Welles, S. L.,, N. Tachibana,, A. Okayama,, S. Shioiri,, S. Ishihara,, K. Murai, and, N. E. Mueller. 1994. Decreased reactivity to PPD among HTLV-1 carriers in relation to virus and hematologic status. Int. J. Cancer 56:337340.
159. Yamaguchi, K.,, and T. Watanabe. 2002. Human T lymphotropic virus type 1 and adult T-cell leukemia in Japan. Int. J. Hematol. 76:240245.
160. Yasunaga, J.,, J. Sukai,, K. Nasaka,, K. Etoh,, S. Tamiya,, S. Kaga, and, S. Mita. 2001. Impaired production of naive T lymphocytes in human T cell leukaemia virus type 1 infected individuals: its implications in the immunodeficient state. Blood 97:31773183.
161. Zaha, O.,, T. Hirata,, N. Uchima,, F. Kinjo, and, A. Saito. 2004. Comparison of anthelmintic effects of two doses of ivermectin on intestinal strongyloidiasis in patients negative or positive for anti-HTLV-1 antibody. J. Infect. Chemother. 10:348351.

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