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Chapter 25 : Adventures with Mutation and Selection in Beehive and Cow Country

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Adventures with Mutation and Selection in Beehive and Cow Country, Page 1 of 2

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Abstract:

This chapter presents some personal memories and reflections from Diarmaid Hughes (D.H.) and Dan Andersson (D.I.A.) based on three decades of knowing John Roth. The thesis provided some new insights into the translation process, identifying several mutant tRNAs that could suppress a −1 frameshift mutation by reading a base doublet as a codon, and mutants of EF-Tu that increased frameshifting and nonsense suppression by normal tRNAs. Coming to the John's lab, everything was the same but all the people had been turned over. At this time John had become interested in the controversial area of adaptive mutations. In an article in Nature in 1988, Cairns and coworkers suggested that some mutations are induced in response to selection rather than being formed randomly irrespective of selective conditions as proposed by the early work of Luria, Delbruck, and Lederberg. This work established a collaboration that has been and is still ongoing regarding the role of gene amplification in the Cairns system and, more important, the significance of gene amplification during adaptation and evolution of new genes. After Dan Andersson returned to Uppsala from his first postdoc stint in John’s lab, there was a period when D.H. and Dan were both looking for something new to do in bacterial genetics and met for a discussion. The simple experiments with demonstrated convincingly that carbon starvation did not cause any increase in the frequency of mutations (in contrast to what was generally assumed or claimed in that field).

Citation: Hughes D, Andersson D. 2011. Adventures with Mutation and Selection in Beehive and Cow Country, p 245-253. In Maloy S, Hughes K, Casadesús J (ed), The Lure of Bacterial Genetics. ASM Press, Washington, DC. doi: 10.1128/9781555816810.ch25

Key Concept Ranking

Microbial Genetics
0.821332
Bacterial Genetics
0.6356912
Frameshift Mutation
0.6145462
Vitamin B12
0.5361023
Salt Lakes
0.5301276
Salmonella enterica
0.5076125
0.821332
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References

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1. Abdulkarim, F., and, D. Hughes. 1996. Homologous recombination between the tuf genes of Salmonella typhimurium. J. Mol. Biol. 260:506522.
2. Abdulkarim, F.,, L. Liljas, and, D. Hughes. 1994. Mutations to kirromycin resistance occur in the interface of domains I and III of EF-Tu.GTP. FEBS Lett. 352:118122.
3. Andersson, D. 1995. Kinetics of cobalamin repression of the cob operon in Salmonella typhimurium. FEMS Microbiol. Lett. 125:8993.
4. Andersson, D. I. 1992. Involvement of the Arc system in redox regulation of the Cob operon in Salmonella typhimurium. Mol. Microbiol. 6:14911494.
5. Andersson, D. I., and, D. Hughes. 1996. Muller’s ratchet decreases fitness of a DNA-based microbe. Proc. Natl. Acad. Sci. USA 93:906907.
6. Andersson, D. I., and, D. Hughes. 2007. Effects of antibiotic resistance on bacterial fitness, virulence, and transmission, p. 307318. In F. Baquero, , C. Nombela, , G. Cassell, and , J. Gutiérrez-Fuentes (ed.), Evolutionary Biology of Bacterial and Fungal Pathogens. ASM Press, Washington, DC.
7. Andersson, D. I., and, J. R. Roth. 1989. Mutations affecting regulation of cobinamide biosynthesis in Salmonella typhimurium. J. Bacteriol. 171:67266733.
8. Andersson, D. I., and, J. R. Roth. 1989. Redox regulation of the genes for cobinamide biosynthesis in Salmonella typhimurium. J. Bacteriol. 171:6734 6739.
9. Andersson, D. I.,, E. S. Slechta, and, J. R. Roth. 1998. Evidence that gene amplification underlies adaptive mutability of the bacterial lac operon. Science 282:11331135.
10. Arwidsson, O., and, D. Hughes. 2004. Evidence against reciprocal recombination as the basis for tuf gene conversion in Salmonella enterica serovar Typhimurium.J. Mol. Biol. 338:463467.
11. Atkins, J. F., and, S. Ryce. 1974. UGA and non-triplet suppressor reading of the genetic code. Nature 249:527530.
12. Bergthorsson, U.,, D. I. Andersson, and, J. R. Roth. 2007. Ohno’s dilemma: evolution of new genes under continuous selection. Proc. Natl. Acad. Sci. USA 104:1700417009.
13. Bjedov, I.,, O. Tenaillon,, B. Gérard,, V. Souza,, E. Denamur,, M. Radman,, F. Taddei, and, I. Matic. 2003. Stress-induced mutagenesis in bacteria. Science 300:14041409.
14. Björkman, J.,, D. Hughes, and, D. I. Andersson. 1998. Virulence of antibiotic-resistant Salmonella typhimurium. Proc. Natl. Acad. Sci. USA 95:39493953.
15. Björkman, J.,, I. Nagaev,, O. G. Berg,, D. Hughes, and, D. I. Andersson. 2000. Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance. Science 287:14791482.
16. Björkman, J.,, P. Samuelsson,, D. I. Andersson, and, D. Hughes. 1999. Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium. Mol. Microbiol. 31:5358.
17. Borg, S.,, J. Björkman,, S. Eriksson,, A. Syk,, D. I. Andersson,, K. Schesser,, M. Rhen,, S. Pettersson, and, N. S. French. 1999. Novel Salmonella typhimurium properties in host-parasite interactions. Immunol. Lett. 6:247249.
18. Bossi, L.,, T. Kohno, and, J. R. Roth. 1983. Genetic characterization of the sufJ frameshift suppressor in Salmonella typhimurium. Genetics 103: 3142.
19. Bossi, L., and, J. R. Roth. 1981. Four-base codons ACCA, ACCU and ACCC are recognized by frameshift suppressor sufJ. Cell 25:489496.
20. Cairns, J.,, J. Overbaugh, and, S. Miller. 1988. The origin of mutants. Nature 335:142145.
21. Chen, P.,, D. I. Andersson, and, J. R. Roth. 1994. The control region of the pdu/cob regulon in Salmonella typhimurium. J. Bacteriol. 176:54745482.
22. Eriksson, S.,, J. Björkman,, S. Borg,, A. Syk,, S. Pettersson,, D. I. Andersson, and, M. Rhen. 2000. Salmonella typhimurium mutants that down-regulate phagocyte nitric oxide production. Cell. Microbiol. 2:239250.
23. Escalante-Semerena, J. C., and, J. R. Roth. 1987. Regulation of cobalamin biosynthetic operons in Salmonella typhimurium. J. Bacteriol. 169:22512258.
24. Hughes, D. 2000. Co-evolution of the tuf genes links gene conversion with the generation of chromosomal inversions. J. Mol. Biol. 297:3553 3564.
25. Hughes, D., and, D. I. Andersson. 1997. Carbon starvation of Salmonella typhimurium does not cause a general increase of mutation rates. J. Bacteriol. 179:66886691.
26. Hughes, D.,, J. F. Atkins, and, S. Thompson. 1987. Mutants of elongation factor Tu promote ribosomal frameshifting and nonsense readthrough. EMBO J. 6:42354239.
27. Hughes, D.,, S. Thompson,, M. O’Connor,, T. Tuohy,, B. P. Nichols, and, J. F. Atkins. 1989. Genetic characterization of frameshift suppressors with new decoding properties. J. Bacteriol. 171:10281034.
28. Hughes, K. T., and, J. R. Roth. 1985. Directed formation of deletions and duplications using Mud (Ap, lac). Genetics 109:263282.
29. Jeter, R. M.,, B. M. Olivera, and, J. R. Roth. 1984. Salmonella typhimurium synthesizes cobalamin (vitamin B12) de novo under anaerobic growth conditions. J. Bacteriol. 159:206213.
30. Jeter, R. M., and, J. R. Roth. 1987. Cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium. J. Bacteriol. 169:31893198.
31. Johanson, U.,, A. Aevarsson,, A. Liljas, and, D. Hughes. 1996. The dynamic structure of EF-G studied by fusidic acid resistance and internal revertants. J. Mol. Biol. 258:420432.
32. Johanson, U., and, D. Hughes. 1994. Fusidic acid-resistant mutants define three regions in elongation factor G of Salmonella typhimurium. Gene 143:5559.
33. Kohno, T.,, L. Bossi, and, J. R. Roth. 1983. New suppressors of frameshift mutations in Salmonella typhimurium. Genetics 103:2329.
34. Lederberg, J., and, E. M. Lederberg. 1952. Replica plating and indirect selection of bacterial mutants. J. Bacteriol. 63:399406.
35. Luria, S. E., and, M. Delbruck. 1943. Mutations of bacteria from virus sensitivity to virus resistance. Genetics 28:491511.
36. Mahan, M. J., and, J. R. Roth. 1988. Reciprocality of recombination events that rearrange the chromosome. Genetics 120:2335.
37. Mahan, M., and, J. R. Roth. 1989. Role of recBC function in formation of chromosomal rearrangements: a two-step model for recombination. Genetics 121:433443.
38. Miesel, L.,, A. Segall, and, J. R. Roth. 1994. Construction of chromosomal rearrangements in Salmonella by transduction: inversions of non-permissive segments are not lethal. Genetics 137:919932.
39. Nagaev, I.,, J. Björkman,, D. I. Andersson, and, D. Hughes. 2001. Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus. Mol. Microbiol. 40:433439.
40. Nahvi, A.,, J. E. Barrick, and, R. R. Breake. 2004. Coenzyme B12 riboswitches are widespread genetic control elements in prokaryotes. Nucleic Acids Res. 32:143150.
41. Nilsson, A. I.,, A. Zorzet,, A. Kanth,, S. Dahlström,, O. G. Berg, and, D. I. Andersson. 2006. Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes. Proc. Natl. Acad. Sci. USA 103:69766981.
42. O’Mahony, D. J.,, D. Hughes,, S. Thompson, and, J. F. Atkins. 1989. Suppression of a −1 frameshift mutation by a recessive tRNA suppressor which causes doublet decoding. J. Bacteriol. 171:38243830.
43. Paulander, W.,, S. Maisnier-Patin, and, D. I. Andersson. 2007. Multiple mechanisms to ameliorate the fitness burden of mupirocin resistance in Salmonella typhimurium. Mol. Microbiol. 64:1038 1048.
44. Ravnum, S., and, D. I. Andersson. 1997. Vitamin B12 repression of the btuB gene in Salmonella typhimurium is mediated via a translational control which requires leader and coding sequences. Mol. Microbiol. 23:3542.
45. Richter-Dahlfors, A. A., and, D. I. Andersson. 1992. Cobalamin (vitamin B12) repression of the Cob operon in Salmonella typhimurium requires sequences within the leader and the first translated open reading frame. Mol. Microbiol. 6:743749.
46. Richter-Dahlfors, A. A.,, S. Ravnum, and, D. I. Andersson. 1994. Vitamin B12 repression of the cob operon in Salmonella typhimurium: translational control of the cbiA gene. Mol. Microbiol. 13:541553.
47. Riddle, D. L., and, J. R. Roth. 1970. Suppressors of frameshift mutations in Salmonella typhimurium. J. Mol. Biol. 54:131144.
48. Riddle, D. L., and, J. R. Roth. 1972. Frameshift suppressors. 3. Effects of suppressor mutations on transfer RNA. J. Mol. Biol. 66:495506.
49. Riddle, D. L., and, J. R. Roth. 1972. Frameshift suppressors. II. Genetic mapping and dominance studies. J. Mol. Biol. 66:483493.
50. Riyasaty, S., and, J. F. Atkins. 1968. External suppression of a frameshift mutant in Salmonella. J. Mol. Biol. 34:541557.
51. Schmid, M. B., and, J. R. Roth. 1983. Genetic methods for analysis and manipulation of inversion mutations in bacteria. Genetics 105:517537.
52. Segall, A.,, M. J. Mahan, and, J. R. Roth. 1988. Rearrangement of the bacterial chromosome: forbidden inversions. Science 241:13141318.
53. Segall, A. M., and, J. R. Roth. 1989. Recombination between homologies in direct and inverse orientation in the chromosome of Salmonella: intervals which are nonpermissive for inversion formation. Genetics 122:737747.
54. Slechta, E. S.,, K. L. Bunny,, E. Kugelberg,, E. Kofoid,, D. I. Andersson, and, J. R. Roth. 2003. Adaptive mutation: general mutagenesis is not a programmed response to stress but results from rare coamplification of dinB with lac. Proc. Natl. Acad. Sci. USA 100:1284712852.
55. Sonti, R. V., and, J. R. Roth. 1989. Role of gene duplications in the adaptation of Salmonella typhimurium to growth on limiting carbon sources. Genetics 123:1928.
56. Sun, S.,, O. G. Berg,, J. R. Roth, and, D. I. Andersson. 2009. Contribution of gene amplification to evolution of increased antibiotic resistance in Salmonella typhimurium. Genetics 182:11831195.
57. Tubulekas, I.,, R. H. Buckingham, and, D. Hughes. 1991. Mutant ribosomes can generate dominant kirromycin resistance. J. Bacteriol. 173:36353643.
58. Tubulekas, I., and, D. Hughes. 1993. Suppression of rpsL phenotypes by tuf mutations reveals a unique relationship between translation elongation and growth rate. Mol. Microbiol. 7:275284.
59. Wrande, M.,, J. R. Roth, and, D. Hughes. 2008. Accumulation of mutants in aging bacterial colonies is due to growth under selection, not stress-induced mutagenesis. Proc. Natl. Acad. Sci. USA 105:1186311868.

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