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Bacterial Stress Responses, Second Edition

Editors: Gisela Storz1, Regine Hengge2
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Affiliations: 1: Eunice Kennedy Shriver Institute of Child Health and Human Development, Bethesda, Maryland; 2: Freie Universität Berlin, Berlin, Germany
Content Type: Monograph
Format: Electronic, Hardcover
Publication Year: 2011

Category: Microbial Genetics and Molecular Biology

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The second edition of the highly acclaimed incorporates and reviews the vast number of new findings that have greatly advanced the understanding of bacterial stress responses in the decade since the publication of the first edition. Readers will discover how this improved understanding not only enhances our knowledge of all cellular regulation at the molecular level, but also provides new ammunition in the fight against pathogens and helps optimize the use of bacteria in biotechnology.

The first section explores general regulatory principles, including the latest findings from genomics studies. In the second and third sections readers will learn how much more researchers have discovered about both specific and general stress responses. Next, the fourth section reviews how stress responses affect the interactions between bacteria and host cells. The fifth section describes bacterial stress responses in different niches and communities, with an emphasis on extreme environments. The final section examines how our growing understanding of bacterial stress responses can be used to better combat bacterial infection with antibiotics and improve biofuel production and bioremediation.

All chapters have been contributed by leaders and pioneers in their respective fields and then carefully edited to ensure conciseness and clarity. With its coverage of a broad range of model organisms as well as biotechnologically, medically, and environmentally relevant bacteria, this new edition fully encapsulates our understanding of bacterial stress responses. Moreover, it serves as a springboard for new investigations and new applications.

There are no separately available contributors for this publication.

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02 January 2013

At A Glance

The second edition of the highly acclaimed Bacterial Stress Responses incorporates and reviews the vast number of new findings that have greatly advanced the understanding of bacterial stress responses in the decade since the publication of the first edition. Readers will discover how this improved understanding not only enhances our knowledge of all cellular regulation at the molecular level, but also provides new ammunition in the fight against pathogens and helps optimize the use of bacteria in biotechnology. The first section explores general regulatory principles, including the latest findings from genomics studies. In the second and third sections readers will learn how much more researchers have discovered about both specific and general stress responses. Next, the fourth section reviews how stress responses affect the interactions between bacteria and host cells. The fifth section describes bacterial stress responses in different niches and communities, with an emphasis on extreme environments. The final section examines how our growing understanding of bacterial stress responses can be used to better combat bacterial infection with antibiotics and improve biofuel production and bioremediation. All chapters have been contributed by leaders and pioneers in their respective fields and then carefully edited to ensure conciseness and clarity. With its coverage of a broad range of model organisms as well as biotechnologically, medically, and environmentally relevant bacteria, this new edition fully encapsulates our understanding of bacterial stress responses. Moreover, it serves as a springboard for new investigations and new applications.

New in the Second Edition

- Incorporates new fields such as network analysis, metagenomics, and regulatory RNAs

- Examines new findings from genomics studies that have changed ourunderstanding of regulation

- Explains how new findings from bacterial stress response studies facilitate the development of antibiotics

- Discusses the latest efforts to exploit bacterial stress responses for biofuel production and bioremediation

- Presents significant insights into how bacteria survive stress conditions by undergoing changes of state, morphology, or cell surface

More Key Features

- Features contributors who are leaders in the investigation of bacterial stress responses and the development of new applications based on new findings

- Serves as a gateway to the literature in the field

- Highlights important directions for future research

Description

Bacteria have a remarkable ability to respond quickly to their environment, especially in adverse conditions. This book explores and investigates how bacterial cells respond to this stress.

Purpose

This is an update of a book was first published 10 years ago. Since that time, there has been a tremendous increase in both technology and information on how bacteria survive. This type of information can be useful in the development of new antimicrobial agents, in agriculture, and in the production of biofuel and food products.

Audience

This book is directed at scientists working in this diverse field as well as students interested in basic mechanisms of gene regulation and response. The authors have contributed their experience, advice, and enthusiasm throughout the book which is evident in each chapter.

Features

The first three sections focus on general background information on stress responses in bacteria while the last three sections show specific examples in pathogens, effect of environment on bacterial response, and applications where these responses can be useful in making products. In all cases, it appears that transcription factors are central to the control of protein production. This response to stress by bacteria must occur rapidly in order to survive, therefore on a molecular level these changes need to occur immediately. Thus, bacteria have developed mechanisms to sense critical changes in the environment such as levels of oxygen, presence of metals, and change in temperature, energy source, or presence of damaging toxins. Additionally, bacterial colonies have the capability of signaling between bacteria in order to control population levels or product a biofilm for protection. There is discussion of quorum sensing by which bacterial cooperate in order to protect the entire bacterial colony. For bacteria,living in colonies requires cooperation with neighbors and, in exchange, the protection of individual cells. In this way, bacteria can survive both the extremes of the environment, the presence of antibiotics, or immune reactions in hosts, as well as invasion by phages.

Assessment

There is still much that remains to be known about how bacteria survive environmental stress. This book shows many good examples of experimental models that investigate gene regulation, protein production, and bacterial communication that leads to survival of the bacterial species.

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Reviewer: Rebecca Horvat, PhD, D, ABMM, University of Kansas Medical Center

Review Date: 2011

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