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Chapter 11 : The Mating-Type Locus of : Evolution of Gene Clusters Governing Sex Determination and Sexual Reproduction from the Phylogenomic Perspective

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The Mating-Type Locus of : Evolution of Gene Clusters Governing Sex Determination and Sexual Reproduction from the Phylogenomic Perspective, Page 1 of 2

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Abstract:

The locus has emerged as an exemplary model to elucidate general principles governing the assembly and function of gene clusters. Moreover, comparative genomic studies of the evolutionary trajectory of in the pathogenic species complex mirror evolutionary steps that have been hypothesized to have given rise to the more complex sex chromosomes in mammals, insects, fish, and plants. These then represent examples of convergent evolution to specialized genomic regions governing sexual reproduction throughout the eukaryotic tree of life. Although the molecular nature of the homothallic sexual cycle of remains to be elucidated, possible models for the homothallic life cycle of are discussed. In summary, comparative genomic analysis of the structure of loci from -related species has important implications for the hypothesized evolutionary model. The genes present in these species have implications for the gene content of the ancestral homeodomain and P/R loci in the model. The P/R locus boundaries of have expanded to include not only the pheromone and pheromone receptor genes but also at least one of the pheromone response pathway genes, but not all of the and MAT locus gene homologs, which illuminates the serial expansions that created evolutionary strata in the locus genes of the pathogenic species.

Citation: Hsueh Y, Metin B, Findley K, Rodriguez-Carres M, Heitman J. 2011. The Mating-Type Locus of : Evolution of Gene Clusters Governing Sex Determination and Sexual Reproduction from the Phylogenomic Perspective, p 139-149. In Heitman J, Kozel T, Kwon-Chung K, Perfect J, Casadevall A (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555816858.ch11

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Transmission Electron Microscopy
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Multilocus Sequence Typing
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Tables

Generic image for table
TABLE 1

Gene content of locus and linked regions in and the closely related species

Citation: Hsueh Y, Metin B, Findley K, Rodriguez-Carres M, Heitman J. 2011. The Mating-Type Locus of : Evolution of Gene Clusters Governing Sex Determination and Sexual Reproduction from the Phylogenomic Perspective, p 139-149. In Heitman J, Kozel T, Kwon-Chung K, Perfect J, Casadevall A (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555816858.ch11
Generic image for table
TABLE 2

Mating systems of basidiomycete fungi

Citation: Hsueh Y, Metin B, Findley K, Rodriguez-Carres M, Heitman J. 2011. The Mating-Type Locus of : Evolution of Gene Clusters Governing Sex Determination and Sexual Reproduction from the Phylogenomic Perspective, p 139-149. In Heitman J, Kozel T, Kwon-Chung K, Perfect J, Casadevall A (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555816858.ch11

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