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Chapter 42 : -Induced Leukocyte Transformation: an Example of Oncogene Addiction?

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Abstract:

In the case of , the initial invasion and developmental steps can be successfully completed in caprine (goat) lymphocytes in vitro after proteolytic cleavage of surface proteins. Importantly, long-term culture of -infected field isolates that leads to attenuation is associated with a significant reduction of the matrix metalloproteases (MMP) activities. A recurrent theme in research has been the search for putative parasite oncogene(s). A number of receptor-associated and cytosolic kinases, as well as transcription factors, were found to be permanently active in various -infected cell lines. The development of inside its host cell involves highly interdependent interactions between the intracellular parasite and the parasitized cell. With the determination of the genome sequences of and in 2005, combined with the availability of the genome, research on -infected bovine leukocytes has entered the postgenomic era. These resources make it possible to screen both bovine and parasite microarrays. Screening of bovine arrays will allow the identification of host cell genes that are either up or down regulated during infection and leukocyte transformation. Screening of microarrays with mRNA isolated from virulent and attenuated macrophage vaccine lines should allow the identification of parasite genes whose expression is down regulated during host cell attenuation (i.e., loss of metastatic potential).

Citation: Chaussepied M, Langsley G. 2011. -Induced Leukocyte Transformation: an Example of Oncogene Addiction?, p 537-546. In Kaufmann S, Rouse B, Sacks D (ed), The Immune Response to Infection. ASM Press, Washington, DC. doi: 10.1128/9781555816872.ch42

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Figures

Image of FIGURE 1
FIGURE 1

Time course analysis of the cell cycle distribution of buparvaquone-treated -infected cell lines. infected cell lines were kept untreated or treated with buparvaquone. After the indicated time, the cells were fixed and DNA was labeled with propidium iodide. Cell cycle distribution was analyzed by flow cytometry.

Citation: Chaussepied M, Langsley G. 2011. -Induced Leukocyte Transformation: an Example of Oncogene Addiction?, p 537-546. In Kaufmann S, Rouse B, Sacks D (ed), The Immune Response to Infection. ASM Press, Washington, DC. doi: 10.1128/9781555816872.ch42
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Image of FIGURE 2
FIGURE 2

Contrast echography following intravenous injection of microbubbles that allow blood vessels to be detected. The image was made with the help of Gilles Renault of the small animal imagery platform at the Cochin Institute. T. parva-transformed B cells were injected into thighs of Rag2/gammaC mice ( ) and tumor development followed every week for 8 weeks by contrast echography. The highly vascularized tumor shown is at 6 weeks postinjection.

Citation: Chaussepied M, Langsley G. 2011. -Induced Leukocyte Transformation: an Example of Oncogene Addiction?, p 537-546. In Kaufmann S, Rouse B, Sacks D (ed), The Immune Response to Infection. ASM Press, Washington, DC. doi: 10.1128/9781555816872.ch42
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Image of FIGURE 3
FIGURE 3

Activated signaling pathways in Theilerid-infected cells. Receptor-associated kinases including JAK, PI3-K, and Src are classically activated upon growth factor receptor engagement. In -infected cells, cytokine autocrine loops participate in -dependent proliferation and may contribute to the activation of receptor-associated, as well as cytoplasmic kinases among which are JNK, CK2, and PKA. Transcription factors like STAT, c-Myc, and AP-1 are positively regulated by phsophorylation mediated by JAK, CK2, and JNK, respectively. Phsophorylation controls their nuclear translocation, their stability, and/or their transactivating potential. Whether the intracellular macroschizont directly modulates the activation status of receptor-associated and cytosolic kinases or their target transcription factors is hypothetical. In contrast, the localization of the IKK signalosome formed by IKKa, IKKβ, and NEMO at the surface of the macroschizont suggests a direct influence of the parasite over the activity of this kinase complex that is responsible for IκBα phosphorylation and degradation and the ensuing nuclear translocation of the NF-κB p50-p65 dimer.

Citation: Chaussepied M, Langsley G. 2011. -Induced Leukocyte Transformation: an Example of Oncogene Addiction?, p 537-546. In Kaufmann S, Rouse B, Sacks D (ed), The Immune Response to Infection. ASM Press, Washington, DC. doi: 10.1128/9781555816872.ch42
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Image of FIGURE 4
FIGURE 4

-encoded polypeptides exported to the host cell. TaSE protein was shown to localize to the parasite surface but was also found associated with microtubules in discrete areas. TashAT are found in the nucleus of the infected cell. There has been some suggestion that the catalytic subunit of CK2 might be exported into the host cell.

Citation: Chaussepied M, Langsley G. 2011. -Induced Leukocyte Transformation: an Example of Oncogene Addiction?, p 537-546. In Kaufmann S, Rouse B, Sacks D (ed), The Immune Response to Infection. ASM Press, Washington, DC. doi: 10.1128/9781555816872.ch42
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References

/content/book/10.1128/9781555816872.ch42
1. Adamson, R.,, M. Logan,, J. Kinnaird,, G. Langsley, and, R. Hall. 2000. Loss of matrix metalloproteinase 9 activity in Theileria annulata-attenuated cells is at the transcriptional level and is associated with differentially expressed AP-1 species. Mol. Biochem, Parositol. 106:5161.
2. Adamson,, R., K. Lyons,, M. Sharrard,, J. Kinnaird,, D. Swan,, S. Graham,, B. Shiels, and, R. Hall. 2001. Transient transfection of Theileria annulata. Mol. Biochem. Biochem. 114:5361.
3. Baumgartner,, M., P. Angelisova,, N. Setterblad,, N. Mooney,, D. Werling,, V. Horejsi, and, G. Langsley. 2003. Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes. Blood 101:18741881.
4. Baumgartner,, M., M. Chaussepied,, M. F. Moreau,, D. Werling,, W. C Davis,, A. Garcia, and, G. Langsley. 2000. Constitutive PI3-K activity is essential for proliferation, but not survival, of Theileria parva-transformed B cells. Cell. Microbiol. 2:329339.
5. Baumgartner, M.,, I. Tardieux,, H. Ohayon,, P. Gounon, and, G. Langsley. 1999. The use of nocodazole in cell cycle analysis and parasite purification from Theileria parva-infected B cells. Microbes Infect. 1:11811188.
6. Baylis,, H. A.,, A. Megson,, C. G Brown,, G. F. Wilkie, and, R. Hall. 1992. Theileria annulata-infected cells produce abundant proteases whose activity is reduced by long-term cell culture. Parasitology 105:417423.
7. Bergers,, G., R. Brekken,, G. McMahon,, T. H Vu,, T. Itoh,, K. Tamaki,, K. Tanzawa,, P. Thorpe,, S. Itohara,, Z. Werb, and, D. Hanahan. 2000. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat. Cell. Biol. 2:737744.
8. Bonday, Z. Q.,, S. Taketani,, P. D. Gupta, and, G. Padmanaban. 1997. Heme biosynthesis by the malarial parasite. Import of delta-aminolevulinate dehydrase from the host red cell. J. Biol. Chem. 272:2183921846.
9. Botteron, C., and, D. Dobbelaere. 1998. AP-1 and ATF-2 are constitutively activated via the JNK pathway in Theileria parva-transformed T-cells. Biochem. Biophys. Res. Commun. 246:418421.
10. Brown, D. J.,, J. D. Campbell,, G. C. Russell,, J. Hopkins, and, E. J. Glass. 1995. T cell activation by Theileria annulata-infected macrophages correlates with cytokine production. Clin. Exp. Immunol. 102:507514.
11. Campbell,, J. D.,, S. E. Howie,, K. A. Odling, and, E. J. Glass. 1995. Theileria annulata induces abberrant T cell activation in vitro and in vivo. Clin. Exp. Immunol. 99:203210.
12. Chandramohanadas,, R.,, P. H. Davis,, D. P. Beiting,, M. B. Harbut,, C. Darling,, G. Velmourougane,, M. Y. Lee,, P. A. Greer,, D. S. Roos, and, D. C. Greenbaum. 2009. Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells. Science. 324:794797.
13. Chaussepied,, M., N. Janski,, M. Baumgartner,, R. Lizundia,, K. Jensen,, W. Weir,, B. R Shiels,, J. B Weitzman,, E. J. Glass,, D. Werling, and, G. Langsley. 2010. TGF-β2 induction regulates invasiveness of Theilerid-transformed leukocytes and disease susceptibility. PLoS Pathogens, in press.
14. Chaussepied,, M., D. Lallemand,, M. F. Moreau,, R. Adamson,, R. Hall, and, G. Langsley. 1998. Upregulation of Jun and Fos family members and permanent JNK activity lead to constitutive AP-1 activation in Theilerid-transformed leukocytes. Mol. Biochem. Parasitol. 94:215226.
15. Chaussepied,, M.,, A. M. Michie,, M. F. Moreau,, M. M. Harnett,, W. Harnett, and, G. Langsley. 2006. Notch is constitutively active in Theileria-transformed B cells and can be further stimulated by the filarial nematode-secreted product, ES-62. Microbes Infect. 8:11891191.
16. Collins,, R. A.,, P. Sopp,, K. I Gelder,, W. I. Morrison, and, C. J. Howard. 1996. Bovine gamma/delta TcR+ T lymphocytes are stimulated to proliferate by autologous Theileria annulata-infected cells in the presence of interleukin-2. Scand. J. Immunol. 44:444452.
17. Darghouth,, M. A.,, L. Ben Miled, A. Bouattour,, T. R. Melrose,, C. G. Brown, and, M. Kilani. 1996. A preliminary study on the attenuation of Tunisian schizont-infected cell lines of Theileria annulata. Parositol. Res. 82:647655.
18. Dessauge, F.,, S. Hilaly,, M. Baumgartner,, B. Blumen,, D. Werling, and, G. Langsley. 2005a. c-Myc activation by Theileria parasites promotes survival of infected B-lymphocytes. Oncogene 24:10751083.
19. Dessauge, F., R. Lizundia, and, G. Langsley. 2005b. Constitutively activated CK2 potentially plays a pivotal role in Theileria-induced lymphocyte transformation. Parasitology130:S37S44.
20. Dhar, S.,, D. V. Malhotra,, C. Bhushan, and, O. P. Gautam. 1986. Chemotherapy of Theileria annulata infection with buparvaquone. Vet. Rec. 119:635636.
21. Dobbelaere, D., and, V. Heussler. 1999. Transformation of leukocytes by Theileria parva and T. annulata. Annu. Rev. Microbiol. 53:142.
22. Eferl, R., and, E. F. Wagner. 2003. AP-1: a double-edged sword in tumorigenesis. Nat. Rev. Cancer 3:859868.
23. Elliott, R. L., and, G. C. Blobe. 2005. Role of transforming growth factor beta in human cancer. J. Clin. Oncol. 23:20782093.
24. Fell, A. H., P. M. Preston, and, J. D. Ansell. 1990. Establishment of Theileria-infected bovine cell lines in scid mice. Parasite Immunol. 12:335339.
25. Forsyth, L. M.,, F. C. Minns,, E. Kirvar,, R. E Adamson,, F. R. Hall,, S. McOrist,, C. G. Brown, and, P. M. Preston. 1999. Tissue damage in cattle infected with Theileria annulata accompanied by metastasis of cytokine-producing, schizont-infected mononuclear phagocytes. J. Comp. Pathol. 120:3957.
26. Galley,, Y., G. Hagens,, I. Glaser,, W. Davis,, M. Eichhorn, and, D. Dobbelaere. 1997. Jun NH2-terminal kinase is constitutively activated in T cells transformed by the intracellular parasite Theileria parva. Proc, Natl. Acad, Sci. USA 94:51195124.
27. Gardner,, M. J.,, R. Bishop,, T. Shah,, E. P. de Villiers,, J. M. Carlton,, N. Hall,, Q. Ren,, I. T. Paulsen,, A. Pain,, M. Berriman,, R. J. Wilson,, S. Sato,, S. A. Ralph,, D. J. Mann,, Z. Xiong,, S. J. Shallom,, J. Weidman,, L. Jiang,, J. Lynn,, B. Weaver,, A. Shoaibi,, A. R. Domingo,, D. Wasawo,, J. Crabtree,, J. R. Wortman,, B. Haas,, S. V. Angiuoli,, T. H. Creasy,, C. Lu,, B. Suh,, J. C. Silva,, T. R. Utterback,, T. V. Feldblyum,, M. Pertea,, J. Allen,, W. C. Nierman,, E. L. Taracha,, S. L. Salzberg,, O. R. White,, H. A. Fitzhugh,, S. Morzaria,, J. C. Venter,, C. M. Fraser, and, V. Nene. 2005. Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes. Science 309:134137.
28. Glass, E. J., and, K. Jensen. 2007. Resistance and susceptibility to a protozoan parasite of cattle—gene expression differences in macrophages from different breeds of cattle. Vet. Immunol, Immunopathol. 120:2030.
29. Glass, E. J.,, P. M. Preston,, A. Springbett,, S. Craigmile,, E. Kirvar,, G. Wilkie, and, C. G. Brown. 2005. Bos taurus and Bos indicus (Sahiwal) calves respond differently to infection with Theileria annulata and produce markedly different levels of acute phase proteins. Int. J. Parasitol. 35:337347.
30. Guergnon,, J., M. Chaussepied,, P. Sopp,, R. Lizundia,, M. F. Moreau,, B. Blumen,, D. Werling,, C. J. Howard, and, G. Langsley. 2003a. A tumour necrosis factor alpha autocrine loop contributes to proliferation and nuclear factor-kap-paB activation of Theileria parva-transformed B cells. Cell. Microbiol. 5:709716.
31. Guergnon, J.,, F. Dessauge,, G. Langsley, and, A. Garcia. 2003b. Apoptosis of Theileria-infected lymphocytes induced upon parasite death involves activation of caspases 9 and 3. Biochimie. 85:771776.
32. Guergnon,, J., F. Dessauge,, F. Traincard,, X. Cayla,, A. Rebollo,, P. E Bost,, G. Langsley, and, A. Garcia. 2006. A PKA survival pathway inhibited by DPT-PKI, a new specific cell permeable PKA inhibitor, is induced by T. annulata in parasitized B-lymphocytes. Apoptosis 11:12631273.
33. Hall,, R., T. Ilhan,, E. Kirvar,, G. Wilkie,, P. M. Preston,, M. Darghouth,, R. Somerville, and, R. Adamson. 1999. Mechanism(s) of attenuation of Theileria annulata vaccine cell lines. Trop. Med. Int. Health.4:A7884.
34. Hanahan, D., and, R. A. Weinberg. 2000. The hallmarks of cancer. Cell 100:5770.
35. Hayflick, L. 1965. The limited in vitro lifetime of human diploid cell strains. Exp. Cell. Res. 37:614636.
36. Heussler,, V. T.,, P. Kuenzi,, F. Fraga,, R. A. Schwab,, B. A. Hemmings, and, D. A. Dobbelaere. 2001. The Akt/PKB pathway is constitutively activated in Theilerid-transformed leucocytes, but does not directly control constitutive NF-kappaB activation. Cell. Microbiol. 3:537550.
37. Heussler, V. T.,, J. Machado, Jr.,, P. C. Fernandez,, C. Botteron,, C. G. Chen,, M. J. Pearse, and, D. A. Dobbelaere. 1999. The intracellular parasite Theileria parva protects infected T cells from apoptosis. Proc. Natl. Acad. Sci. USA 96:73127317.
38. Heussler, V. T.,, S. Rottenberg,, R. Schwab,, P. Kuenzi,, P. C Fernandez,, S. McKellar,, B. Shiels,, Z. J. Chen,, K. Orth,, D. Wallach, and, D. A. Dobbelaere. 2002. Hijacking of host cell IKK signalosomes by the transforming parasite Theileria. Science 298:10331036.
39. Hoffmann, A., and, D. Baltimore. 2006. Circuitry of nuclear factor kappaB signaling. Immunol. Rev. 210:171-186. Hooshmand-Rad, P. 1976. The pathogenesis of anaemia in Theileria annulata infection. Res. Vet. Sci. 20:324329.
40. Hulliger, L.,, C. G. Brown, and, J. K. Wilde. 1966. Transition of developmental stages of Theileria parva in vitro at high temperature. Nature 211:328329.
41. Hulliger, L.,, K. H. Wilde,, C. G. Brown, and, L. Turner. 1964. Mode of multiplication of Theileria in cultures of bovine lymphocytic cells. Nature 203:728730.
42. Irvin,, A. D.,, C. G. Brown,, G. K. Kanhai, and, D. A. Stagg. 1975. Comparative growth of bovine lymphosarcoma cells and lymphoid cells infected with Theileria parva in athymic (nude) mice. Nature 255:713714.
43. Ivanov,, V., B. Stein,, I. Baumann,, D. A Dobbelaere,, P. Herrlich, and, R. O. Williams. 1989. Infection with the intracellular protozoan parasite Theileria parva induces constitutively high levels of NF-kappa B in bovine T lymphocytes. Mol. Cell. Biol. 9:46774686.
44. Jensen,, K.,, G. D. Makins,, A. Kaliszewska,, M. J Hulme,, E. Paxton, and, E. J. Glass. 2009. The protozoan parasite Theileria annulata alters the differentiation state of the infected macrophage and suppresses musculoaponeurotic fibrosarcoma oncogene (MAF) transcription factors. Int. J. Parasitol. 39:10991108.
45. Jensen,, K., E. Paxton,, D. Waddington,, R. Talbot,, M. A. Darghouth, and, E. J. Glass. 2008. Differences in the transcriptional responses induced by Theileria annulata infection in bovine monocytes derived from resistant and susceptible cattle breeds. Int. J. Parasitol. 38:313325.
46. Jonkers, J., and, A. Berns. 2004. Oncogene addiction: sometimes a temporary slavery. Cancer Cell. 6:535538.
47. Kuenzi, P., P. Schneider, and, D. A. Dobbelaere. 2003. Theileria parva-transformed T cells show enhanced resistance to Fas/Fas ligand-induced apoptosis. J. Immunol. 171:12241231.
48. Lee,, S.,, S. M. Jilani,, G. V. Nikolova,, D. Carpizo, and, M. L. Iruela-Arispe. 2005. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J. Cell. Biol. 169:681691.
49. Li,, M. O.,, Y. Y. Wan,, S. Sanjabi,, A. K Robertson, and, R. A. Flavell. 2006. Transforming growth factor-beta regulation of immune responses. Annu. Rev. Immunol. 24:99146.
50. Lizundia,, R., M. Chaussepied,, M. Huerre,, D. Werling,, J. P. Di Santo, and, G. Langsley. 2006. c-Jun NH2-terminal kinase/c-Jun signaling promotes survival and metastasis of B lymphocytes transformed by Theileria. Cancer Res. 66:61056110.
51. Lizundia,, R., L. Sengmanivong,, J. Guergnon,, T. Muller,, T. Schnelle,, G. Langsley, and, S. L. Shorte. 2005. Use of micro-rotation imaging to study JNK-mediated cell survival in Theileria parva-infected B-lymphocytes. Parasitology 130:629635.
52. Machado, J., Jr.,, P. C. Fernandez,, I. Baumann, and, D. A. Dobbelaere. 2000. Characterisation of NF-kappa B complexes in Theileria parva-transformedT cells. Microbes Infect. 2:13111320.
53. McCawley, L. J., and, L. M. Matrisian. 2000. Matrix metalloproteinases: multifunctional contributors to tumor progression. Mol. Med. Today. 6:149156.
54. McGuire,, K., A. Manuja,, G. C. Russell,, A. Springbett,, S. C Craigmile,, A. K Nichani,, D. V. Malhotra, and, E. J. Glass. 2004. Quantitative analysis of pro-inflammatory cytokine mRNA expression in Theileria annulata-infected cell lines derived from resistant and susceptible cattle. Vet. Immunol. Immunopathol. 99:8798.
55. Morrison, W. I., and, D. J. McKeever. 2006. Current status of vaccine development against Theileria parasites. Parasitology 133:S169S187.
56. Narita,, M., V. Krizhanovsky,, S. Nunez,, A. Chicas,, S. A. Hearn,, M. P. Myers, and, S. W. Lowe. 2006. A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126:503514.
57. Nichani, A. K.,, B. H. Thorp,, C. G. Brown,, J. D. Campbell,, D. J. Brown,, M. Ritchie, and, R. L. Spooner. 1999. In vivo development of Theileria annulata: major changes in efferent lymph following infection with sporozoites or allogeneic schizont-infected mononuclear cells. Parasitology 118:327333.
58. ole-MoiYoi, O. K.,, W. C. Brown,, K. P. Iams,, A. Nayar,, T. Tsukamoto, and, M. D. Macklin. 1993. Evidence for the induction of casein kinase II in bovine lymphocytes transformed by the intracellular protozoan parasite Theileria parva. EMBO J. 12:16211631.
59. Oura, C. A., A. Tait, and, B. R. Shiels. 2001. Theileria annulata: identification, by differential mRNA display, of modulated host and parasite gene expression in cell lines that are competent or attenuated for differentiation to the merozoite. Exp. Parasitol. 98:1019.
60. Pahl, H. L. 1999. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18:68536866.
61. Pain, A.,, H. Renauld,, M. Berriman,, L. Murphy,, C. A. Yeats,, W. Weir,, A. Kerhornou,, M. Aslett,, R. Bishop,, C. Bouchier,, M. Cochet,, R. M. Coulson,, A. Cronin,, E. P. de Villiers,, A. Fraser,, N. Fosker,, M. Gardner,, A. Goble,, S. Griffiths-Jones,, D. E. Harris,, F. Katzer,, N. Larke,, A. Lord,, P. Maser,, S. McKellar,, P. Mooney,, F. Morton,, V. Nene,, S. O’Neil,, C. Price,, M. A. Quail,, E. Rabbinowitsch,, N. D. Rawlings,, S. Rutter,, D. Saunders,, K. Seeger,, T. Shah,, R. Squares,, S. Squares,, A. Tivey,, A. R. Walker,, J. Woodward,, D. A. Dobbelaere,, G. Langsley,, M. A. Rajandream,, D. McKeever,, B. Shiels,, A. Tait,, B. Barrell, and, N. Hall. 2005. Genome of the host-cell transforming parasite Theileria annulata compared with T. parva. Science 309:131133.
62. Palmer,, G. H.,, J. Machado, Jr., P. Fernandez,, V. Heussler,, T. Perinat, and, D. A. Dobbelaere. 1997. Parasite-mediated nuclear factor kappaB regulation in lymphoproliferation caused by Theileria parva infection. Proc. Natl. Acad. Sci. USA 94:1252712532.
63. Pepper, M. S. 1997. Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity. Cytohne Growth Factor Rev. 8:2143.
64. Reeves, R. 2001. Molecular biology of HMGA proteins: hubs of nuclear function. Gene 277:6381.
65. Reeves, R. 2009. HMG nuclear proteins: linking chromatin structure to cellular phenotype. Biochim. Biophys. Acta. 1799:314.
66. Rocchi,, M. S.,, K. T. Ballingall,, N. D. MacHugh, and, D. J. McKeever. 2006. The kinetics of Theileria parva infection and lymphocyte transformation in vitro. Int. J. Parasitol. 36:771778.
67. Sager, H.,, W. C. Davis,, D. A. Dobbelaere, and, T. W. Jungi. 1997. Macrophage-parasite relationship in theileriosis. Reversible phenotypic and functional dedifferentiation of macrophages infected with Theileria annulata. J. Leukoc. Biol. 61:459468.
68. Schmuckli-Maurer,, J., J. Kinnaird,, S. Pillai,, P. Hermann,, S. McKellar,, W. Weir,, D. Dobbelaere, and, B. Shiels. 2009. Modulation of NF-kappaB activation in Theileria annulata-infected cloned cell lines is associated with detection of parasite-dependent IKK signalosomes and disruption of the actin cytoskeleton. Cell. Microbiol. 12:158173.
69. Schmuckli-Maurer, J., B. Shiels, and, D. A. Dobbelaere. 2008. Stochastic induction of Theileria annulata merogony in vitro by chloramphenicol. Int. J. Parasitol. 38:17051715.
70. Schneider,, I., D. Haller,, B. Kullmann,, D. Beyer,, J. S. Ahmed, and, U. Seitzer. 2007. Identification, molecular characterization and subcellular localization of a Theileria annulata parasite protein secreted into the host cell cytoplasm. Parasitol. Res. 101:14711482.
71. Schnittger, L.,, C. Hollmann,, U. Diemer,, K. Boguslawski, and, J. S. Ahmed. 2000. Proliferation and cytokine profile of T. annulata-infected ovine, caprine, and bovine lympho-blastoid cells. Ann. N. Y. Acad. Sci. 916:676680.
72. Shaw, M. K. 2003. Cell invasion by Theileria sporozoites. Trends Parasitol. 19:26.
73. Shaw, M. K., L. G. Tilney, and, D. J. McKeever. 1993. Tick salivary gland extract and interleukin-2 stimulation enhance susceptibility of lymphocytes to infection by Theileria parva sporozoites. Infect. Immun. 61:14861495.
74. Shayan, P., and, J. S. Ahmed. 1997. Theilerid-mediated constitutive expression of the casein kinase II-alpha subunit in bovine lymphoblastoid cells. Parasitol. Res. 83:526532.
75. Shiels,, B., J. Kinnaird,, S. McKellar,, J. Dickson,, L. B. Miled,, R. Melrose,, D. Brown, and, A. Tait. 1992. Disruption of synchrony between parasite growth and host cell division is a determinant of differentiation to the merozoite in Theileria annulata. J. Cell. Sci. 101:99107.
76. Shiels,, B., G. Langsley,, W. Weir,, A. Pain,, S. McKellar, and, D. Dobbelaere. 2006. Alteration of host cell phenotype by Theileria annulata and Theileria parva: mining for manipulators in the parasite genomes. Int. J. Parasitol. 36:921.
77. Shiels,, B. R.,, S. McKellar,, F. Katzer,, K. Lyons,, J. Kinnaird,, C. Ward,, J. M. Wastling, and, D. Swan. 2004. A Theileria annulata DNA binding protein localized to the host cell nucleus alters the phenotype of a bovine macrophage cell line. Eukaryot. Cell. 3:495505.
78. Somerville,, R. P.,, R. E. Adamson,, C. G. Brown, and, F. R. Hall. 1998. Metastasis of Theileria annulata macroschizont-infected cells in scid mice is mediated by matrix metalloproteinases. Parasitology 116:223228.
79. Sutherland,, I. A.,, B. R. Shiels,, L. Jackson,, D. J Brown,, C. G Brown, and, P. M. Preston. 1996. Theileria annulata: altered gene expression and clonal selection during continuous in vitro culture. Exp. Parasitol. 83:125133.
80. Swan, D. G.,, K. Phillips,, A. Tait, and, B. R. Shiels. 1999. Evidence for localisation of a Theileria parasite AT hook DNA-binding protein to the nucleus of immortalised bovine host cells. Mol. Biochem. Parasitol. 101:117129.
81. Swan, D. G.,, L. Stadler,, E. Okan,, M. Hoffs,, F. Katzer,, J. Kinnaird,, S. McKellar, and, B. R. Shiels. 2003. TashHN, a Theileria annulata encoded protein transported to the host nucleus displays an association with attenuation of parasite differentiation. Cell. Microbiol. 5:947956.
82. Swan,, D. G.,, R. Stern,, S. McKellar,, K. Phillips,, C. A Oura,, T. I Karagenc,, L. Stadler, and, B. R. Shiels. 2001. Characterisation of a cluster of genes encoding Theileria annulata AT hook DNA-binding proteins and evidence for localisation to the host cell nucleus. J. Cell. Sci. 114:27472754.
83. Syfrig, J.,, C. Wells,, C. Daubenberger,, A. J Musoke, and, J. Naessens. 1998. Proteolytic cleavage of surface proteins enhances susceptibility of lymphocytes to invasion by Theileria parva sporozoites. Eur. J. Cell. Biol. 76:125132.
84. Van Antwerp,, D. J.,, S. J. Martin,, T. Kafri,, D. R Green, and, I. M. Verma. 1996. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 274:787789.
85. Wastling,, J. M.,, D. Xia,, A. Sohal,, M. Chaussepied,, A. Pain, and, G. Langsley. 2009. Proteomes and transcriptomes of the Apicomplexa—where’s the message? Int. J. Parasitol. 39:135143.
86. Weinstein, I. B. 2002. Cancer. Addiction to oncogenes—the Achilles heal of cancer. Science 297:63-64.
87. Weinstein, I. B., and, A. Joe. 2008. Oncogene addiction. Cancer Res. 68:30773080.
88. Yamada,, S., S. Konnai,, S. Imamura,, M. Simuunza,, M. Chembensofu,, A. Chota,, A. Nambota,, M. Onuma, and, K. Ohashi. 2009. Quantitative analysis of cytokine mRNA expression and protozoan DNA load in Theileria parva-infected cattle. J. Vet. Med. Sci. 71:4954.

Tables

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TABLE 1

Kinases and transcription factors activated in -infected leukocytes

Citation: Chaussepied M, Langsley G. 2011. -Induced Leukocyte Transformation: an Example of Oncogene Addiction?, p 537-546. In Kaufmann S, Rouse B, Sacks D (ed), The Immune Response to Infection. ASM Press, Washington, DC. doi: 10.1128/9781555816872.ch42

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