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1. Abdulla, S.,, R. Oberholzer,, O. Juma,, S. Kubhoja,, F. Machera,, C. Memebi,, S. Omari,, A. Urwassa,, H. Mshinda,, A. Jumanne,, N. Salim,, M. Shomari,, T. Aebi,, D. M. Schellenberg,, T. Carter,, T. Villafana,, M.-A. Demoitié,, M.-C. Dubois,, A. Leach,, M. Lievens,, J. Vekemans,, J. Cohen,, W. R. Ballou,, and M. Tanner. 2008. Safety and immunogenicity of RTS, S/AS02D malaria vaccine in infants. N. Engl. J. Med. 359:25332544.
2. Abu Bakar, N.,, N. Klonis,, N. Hanssen,, N. Chan,, and L. Tilley. 2010. Digestive vacuole genesis and endocytotic processes in the early intraerythrocytic stages of Plasmodium falciparum. J. Cell Sci. 123:441450.
3. Alkin, S. S. 2004. Monoclonal antibodies: the story of a discovery that revolutionized science and medicine. Nat. Rev. Immunol. 4:153156.
4. Altman, L. K. 1987. Who Goes First? The Story of Self-Experimentation in Medicine. Random House, New York, NY.
5. Alving, A. S. 1954. Clinical treatment of malaria. Presented 28 April 1954 in the Course on Recent Advances in Medicine and Surgery. Army Medical Service Graduate School, Walter Reed Army Medical Center, Washington, DC. http://history.amedd.army.mil/booksdocs/korea/recad2/ch5-2.htm.
6. Alving, A. S.,, D. D. Hankey,, G. R. Coatney,, R. Jones, Jr.,, W. G. Coker,, P. L. Garrison,, and W. N. Donovan. 1953. Korean vivax malaria. II. Curative treatment with pamaquine and primaquine. Am. J. Trop. Med. Hyg. 2:970976.
7. Ambruster, H. 1947. Treason’s Peace. Beechurst Press, New York, NY.
8. Anonymous. 2009, posting date. About us. TDR: for research on diseases of poverty. World Health Organization, Geneva, Switzerland. http://www.who.int/tdr/svc/about.
9. Anonymous. 1979. Antimalaria studies on qinghaosu. Chinese Med. J. 92:811816.
10. Anonymous. 2009, posting date. August W. Hofmann: coal tar chemist and teacher. http://www.colorantshistory.org/HofmannBiography.html.
11. Anonymous. 2009, posting date. Killer new malaria bug discovered. http://www.mirror.co.uk/news/top-stories/2009/05/30/killer-bug-warning-115875-21400231.
12. Anonymous. 1946. More about Paludrine. Br. Med. J. 1:919920.
13. Anonymous. 2009, posting date. Pharmakina. http://www.pharmakina.com.
14. Anonymous. 1965. Resistance of malaria parasites to drugs. WHO Tech. Rep. Ser. 296:165.
15. Anonymous. 1945. Triumph against malaria. Br. Med. J. 2:653654.
16. Aponte, J. J.,, P. Aide,, M. Renom,, I. Mandomando,, Q. Bassat,, J. Sacarlal,, M. N. Manaca,, S. Lafuente,, A. Barbosa,, A. Leach,, M. Lievens,, J. Vekemans,, B. Sigauque,, M. C. Dubois,, M. A. Demoitie,, M. Sillman,, B. Savarese,, J. G. McNeil,, E. Macete,, W. R. Ballou,, J. Cohen, and, P. L. Alonso. 2007. Safety of the RTS, S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIb trial. Lancet 370:15431551.
17. Aviado, D. M.,, and D. H. Will. 1969. Pharmacology of naphthoquinones, with special reference to the antimalarial activity of Lapinone (WR 26,041). Am. J. Trop. Med. Hyg. 18:188198.
18. Baird, J. K. 2005. Effectiveness of antimalarial drugs. N. Engl. J. Med. 352:15651577.
19. Baird, J. K.,, and S. L. Hoffman. 2004. Primaquine therapy for malaria. Clin. Infect. Dis. 39:13361345.
20. Baldwin, J.,, C. H. Michnoff,, N. A. Malmquist,, J. White,, M. G. Roth,, P. K. Rathod, and, M. A. Phillips. 2005. High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydroge-nase. J. Biol. Chem. 280:2184721853.
21. Ball, E.,, C. B. Anfinsen, and, O. Cooper. 1947. The inhibitory action of naph-thoquinones on respiratory processes. J. Biol. Chem. 168:257270.
22. Ball, E. G. 1945. Chemical and nutritional observations on malarial parasites grown in vitro. Fed. Proc. 5:397399.
23. Ballou, W. R. 2007. Obstacles to the development of a safe and effective attenuated pre-erythrocytic stage malaria vaccine. Microbes Infect. 9:761766.
24. Ballou, W. R. 2009. The development of the RTS, S malaria vaccine candidate: challenges and lessons. Parasite Immunol. 31:492500.
25. Ballou, W. R.,, and C. P. Cahill. 2007. Two decades of commitment to malaria vaccine development: GlaxoSmithKline Biologicals. Am. J. Trop. Med. Hyg. 77:289295.
26. Ballou, W. R.,, S. L. Hoffman,, J. A. Sherwood,, M. R. Hollingdale,, F. A. Neva,, W. T. Hockmeyer,, D. M. Gordon,, I. Schneider,, R. A. Wirtz,, J. F. Young, et al. 1987. Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine. Lancet i:12771281.
27. Banyal, H. S.,, and C. D. Fitch. 1982. Ferriprotoporphyrin IX binding substances and the mode of action of chloroquine against malaria. Life Sci. 31:11411144.
28. Bardes, C. L. 2008. Pale Faces: the Masks of Anemia. Bellevue, New York, NY.
29. Bass, C. C.,, and F. M. Johns. 1912. The cultivation of malarial plasmodia (Plasmodium vivax and Plasmodium falciparum) in vitro. J. Exp. Med. 16:567579.
30. Beach, D. H.,, I. W. Sherman, and, G. G. Holz, Jr. 1977. Lipids of Plasmodium lophurae, and of erythrocytes and plasma of normal and P. lophurae-infected Pekin ducklings. J. Parasitol. 63:6275.
31. Beaudoin, R. L.,, C. P. Strome,, F. Mitchell, and, T. A. Tubergen. 1977. Plasmodium berghei: immunization of mice against the ANKA strain using the unaltered sporozoite as an antigen. Exp. Parasitol. 42:15.
32. Beer, J. J. 1959. The Emergence of the German Dye Industry. University of Illinois, Urbana.
33. Biello, D. 2008. Lending a helping arm: volunteers risk malaria to test vaccine. Sci. Am. Online. http://www.scientificamerican.com/article.cfm?id=lending-a-helping-arm-to-test-malaria-vaccine
34. Bishop, A. 1942. Chemotherapy and avian malaria. Parasitology 34:154.
35. Bishop, A. 1958. Drug resistance in protozoa. Biol. Rev. 34:445500.
36. Blount, R. 1964. Malaria: an unsolved military medical problem. Am. J. Med. Sci. 247:407411.
37. Blount, R. 1967. Management of chloroquine resistant falciparum malaria. Trans. Am. Clin. Climatol. Assoc. 78:196206.
38. Boffey, P. M. August 3, 1984. Malaria vaccine is near, U.S. health officials say. New York Times.
39. Bohni, E.,, B. Fust,, J. Roieder,, K. Schaerer, and, L. Havas. 1969. Comparative toxicological, chemotherapeutic and pharmacokinetic studies with sulphor-methoxine and other sulphonamides in animals and man. Chemotherapy 14:195226.
40. Boudreau, E. F.,, H. K. Webster,, K. Pavanand, and, L. Thosingha. 1982. Type II mefloquine resistance in Thailand. Lancet ii:1335.
41. Bray, P. G.,, M. Mungthin,, I. M. Hastings,, G. A. Biagini,, D. K. Saidu,, V. Lakshmanan,, D. J. Johnson,, R. H. Hughes,, P. A. Stocks,, P. M. O’Neill,, D. A. Fidock,, D. C. Warhurst, and, S. A. Ward. 2006. PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX. Mol. Microbiol. 62:238251.
42. Bray, P. G.,, S. A. Ward, and, P. M. O’Neill. 2005. Quinolines and artemisinin: chemistry, biology and history. Curr. Top. Microbiol. Immunol. 295:338.
43. Brock, W. H. 2002. Justus von Liebig: the Chemical Gatekeeper. Cambridge University Press, Cambridge, United Kingdom.
44. Browne, M. M. August 16, 1988. The benzene ring: dream analysis. New York Times.
45. Bruce-Chwatt, L. 1988. Cinchona and its alkaloids. N. Y. State J. Med. 88:318322.
46. Bryson, H. M.,, and K. L. Goa. 1992. Halofantrine. Drugs 43:236258.
47. Canfield, C. J. 1972. Malaria in USA military personnel 1965–1971. Proc. Hel-minthol. Soc. 39:1518.
48. Canfield, C. J. 1969. Renal and hematologic complications of acute falciparum malaria in Vietnam. Ann. N. Y. Acad. Sci. 45:10431057.
49. Canfield, C. J.,, K. B. Canfield,, B. G. Schuster, and, W. K. Milhous. 1989. Presented at the 38th annual meeting of the American Society for Tropical Medicine and Hygiene, Honolulu, Hawaii.
50. Canfield, C. J.,, A. P. Hall,, B. S. MacDonald,, D. A. Neuman, and, J. A. Shaw. 1973. Treatment of falciparum malaria from Vietnam with a phenanthrene methanol (WR 33063) and a quinoline methanol (WR 30090). Antimicrob. Agents Chemother. 3:224227.
51. Canfield, C. J.,, M. Pudney, and, W. E. Gutteridge. 1995. Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro. Exp. Parasitol. 80:373381.
52. Carlton, J. M.,, S. V. Angiuoli,, B. B. Suh,, T. W. Kooij,, M. Pertea,, J. C. Silva,, M. D. Ermolaeva,, J. E. Allen,, J. D. Selengut,, H. L. Koo,, J. D. Peterson,, M. Pop,, D. S. Kosack,, M. F. Shumway,, S. L. Bidwell,, S. J. Shallom,, S. E. van Aken,, S. B. Riedmuller,, T. V. Feldblyum,, J. K. Cho,, J. Quackenbush,, M. Sedegah,, A. Shoaibi,, L. M. Cummings,, L. Florens,, J. R. Yates,, J. D. Raine,, R. E. Sinden,, M. A. Harris,, D. A. Cunningham,, P. R. Preiser,, L. W. Bergman,, A. B. Vaidya,, L. H. van Lin,, C. J. Janse,, A. P. Waters,, H. O. Smith,, O. R. White,, S. L. Salzberg,, J. C. Venter,, C. M. Fraser,, S. L. Hoffman,, M. J. Gardner, and, D. J. Ca-rucci. 2002. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature 419:512519.
53. Carroll, L. 1871. Through the Looking Glass. Macmillan, London, United Kingdom.
54. Carter, R. 2002. Spatial simulation of malaria transmission and its control by malaria transmission blocking vaccination. Int. J. Parasitol. 32:16171624.
55. Carter, R. 2001. Transmission blocking malaria vaccines. Vaccine 19:23092314.
56. Carter, R.,, and D. H. Chen. 1976. Malaria transmission blocked by immunisation with gametes of the malaria parasite. Nature 263:5760.
57. Carter, R.,, R. W. Gwadz, and, I. Green. 1979. Plasmodium gallinaceum: Transmission-blocking immunity in chickens. II. The effect of antigamete antibodies in vitro and in vivo and their elaboration during infection. Exp. Parasitol. 47:194208.
58. Carter, R.,, R. W. Gwadz, and, F. M. McAuliffe. 1979. Plasmodium gallinaceum: transmission-blocking immunity in chickens. I. Comparative immunogenicity of gametocyte- and gamete-containing preparations. Exp. Parasitol. 47:185193.
59. Chang, C.,, T. Lin-Hua, and, C. Jantanavivat. 1992. Studies on a new antima-larial compound: pyronaridine. Trans. R. Soc. Trop. Med. Hyg. 86:710.
60. Chen, C.,, and X. Zheng. 1992. Development of the new antimalarial drug py-ronaridine: a review. Biomed. Environ. Sci. 5:149160.
61. Chou, A. C.,, and C. D. Fitch. 1992. Heme polymerase: modulation by chloroquine treatment of a rodent malaria. Life Sci. 51:20732078.
62. Clyde, D. F. 1975. Immunization of man against falciparum and vivax malaria by use of attenuated sporozoites. Am. J. Trop. Med. Hyg. 24:397401.
63. Coatney, G. R. 1963. Pitfalls in a discovery: the chronicle of quinine. Am. J. Trop. Med. Hyg. 12:121128.
64. Coatney, G. R.,, and J. Greenberg. 1952. The use of antibiotics in the treatment of malaria. Ann. N. Y. Acad. Sci. 55:10751081.
65. Cochrane, A. H.,, R. Nussenzweig, and, E. Nardin. 1980. Immunization against sporozoites, p. 163–202. In J. Kreier (ed.), Malaria, vol. 3. Academic Press, San Diego, CA.
66. Cogswell, F. B. 1992. The hypnozoite and relapse in primate malaria. Clin. Microbiol. Rev. 5:2635.
67. Collins, W. E.,, and P. G. Contacos. 1972. Immunization of monkeys against Plasmodium cynomolgi by X-irradiated sporozoites. Nat. New Biol. 236:176177.
68. Cook, R. T.,, R. C. Rock,, M. Aikawa, and, M. J. J. Fournier. 1971. Ribosomes of the malarial parasite, Plasmodium knowlesi. I. Isolation, activity and sedimentation velocity. Comp. Biochem. Physiol. 39B:897911.
69. Cowman, A. F. 1998. The molecular basis of resistance to the sulfones, sulfonamides, and dihydrofolate reductase inhibitors, p. 317–330. In I. W. Sherman (ed.), Malaria: Parasite Biology, Pathogenesis, and Protection. ASM Press, Washington, DC.
70. Crockett, M.,, and K. C. Kain. 2007. Tafenoquine: a promising new antima-larial agent. Expert Opin. Investig. Drugs 16:705715.
71. Cui, L.,, and X. Z. Su. 2009. Discovery, mechanisms of action and combination therapy of artemisinin. Expert Rev Anti Infect Ther. 7:9991013.
72. Curd, F.,, D. Davey, and, F. Rose. 1945. Studies on synthetic antimalarial drugs X. Some biguanide derivatives as new types of antimalarial substances with both therapeutic and causal prophylactic activity. Ann. Trop. Med. Parasitol. 39:208216.
73. Curd, F.,, D. Davey, and, F. Rose. 1945. Studies on synthetic antimalarial drugs. I. Biological methods. Ann. Trop. Med. Parasitol. 39:139174.
74. Dahl, E. L.,, and P. J. Rosenthal. 2008. Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics. Trends Parasitol. 24:279284.
75. Dahl, E. L.,, and P. J. Rosenthal. 2007. Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. Antimicrob. Agents Chemother. 51:34853490.
76. Dahl, E. L.,, J. L. Shock,, B. R. Shenai,, J. Gut,, J. L. DeRisi, and, P. J. Rosenthal. 2006. Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrob. Agents Chemother. 50:31243131.
77. Dame, J. B.,, J. L. Williams,, T. F. McCutchan,, J. L. Weber,, R. A. Wirtz,, W. T. Hockmeyer,, W. L. Maloy,, J. D. Haynes,, I. Schneider,, D. Roberts, et al. 1984. Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum. Science 225:593599.
78. Davis, T. M.,, T. Y. Hung,, I. K. Sim,, H. A. Karunajeewa, and, K. F. Ilett. 2005. Piperaquine: a resurgent antimalarial drug. Drugs 65:7587.
79. de Castro, M. C. 2005. Was malaria present in the Amazon before the European conquest? Available evidence and future research agenda. J. Archaeol. Res. 32:337340.
80. de Kruif, P. 1926. Microbe Hunters. Harcourt Brace, San Diego, CA.
81. de Ridder, S.,, F. van der Kooy, and, R. Verpoorte. 2008. Artemisia annua as a self-reliant treatment for malaria in developing countries. J. Ethnopharmacol. 120:302314.
82. Desjardins, R. E.,, C. J. Canfield,, J. D. Haynes, and, J. D. Chulay. 1979. Quantitative assessment of antimalarial activity in vitro by a semiautomated micro-dilution technique. Antimicrob. Agents Chemother. 16:710718.
83. Desowitz, R. 1991. The Malaria Capers. More Tales of Parasites and People, Research and Reality. Norton, New York, NY.
84. Dhawan, V. K.,, and H. Thadepalli. 1982. Clindamycin. A review of fifteen years of experience. Rev. Infect. Dis. 4:11331144.
85. Dietrich, J. A.,, Y. Yoshikuni,, K. J. Fisher,, F. X. Woolard,, D. Ockey,, D. J. McPhee,, N. S. Renninger,, M. C. Chang,, D. Baker, and, J. D. Keasling. 2009. A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3). ACS Chem. Biol. 4:261267.
86. Dobson, M. J. 1998. Bitter-sweet solutions for malaria: exploring natural remedies from the past. Parassitologia 40:6981.
87. Dondorp, A. M.,, F. Nosten,, P. Yi,, D. Das,, A. P. Phyo,, J. Tarning,, K. M. Lwin,, F. Ariey,, W. Hanpithakpong,, S. J. Lee,, P. Ringwald,, K. Silamut,, M. Imwong,, K. Chotivanich,, P. Lim,, T. Herdman,, S. S. An,, S. Yeung,, P. Singhasivanon,, N. P. Day,, N. Lindegardh,, D. Socheat, and, N. J. White. 2009. Artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 361:455467.
88. Doolan, D.,, and S. L. Hoffman. 2002. Nucleic acid vaccines against malaria. Chem. Immunol. 80:308321.
89. Dugger, C. W. April 30, 2006. Mothers of Nepal vanquish a killer of children. New York Times.
90. Dugger, C. W.,, and D. G. McNeil, Jr. April 30, 2006. Rumor, fear and fatigue hinder final push to end polio. New York Times.
91. Duraisingh, M. T.,, and A. F. Cowman. 2005. Contribution of the pfmdr1 gene to antimalarial drug-resistance. Acta Trop. 94:181190.
92. Duran-Reynals, M. L. 1946. The Fever Bark Tree: the Pageant of Quinine. Double-day, New York, NY.
93. Edstein, M. D.,, D. A. Kocisko,, D. S. Walsh,, C. Eamsila,, B. G. Charles, and, K. H. Rieckmann. 2003. Plasma concentrations of tafenoquine, a new long-acting antimalarial agent, in Thai soldiers receiving monthly prophylaxis. Clin. Infect. Dis. 37:16541658.
94. Ellis, J.,, L. S. Ozaki,, R. W. Gwadz,, A. H. Cochrane,, V. Nussenzweig,, R. S. Nussenzweig, and, G. N. Godson. 1983. Cloning and expression in E. coli of the malarial sporozoite surface antigen gene from Plasmodium knowlesi. Nature 302:536538.
95. Enea, V.,, D. Arnot,, E. C. Schmidt,, A. Cochrane,, R. Gwadz, and, R. S. Nussenzweig. 1984. Circumsporozoite gene of Plasmodium cynomolgi (Gombak):cDNA cloning and expression of the repetitive circumsporozoite epitope. Proc. Natl. Acad. Sci. USA 81:75207524.
96. Epstein, J. E.,, B. Giersing,, G. Mullen,, V. Moorthy, and, T. L. Richie. 2007. Malaria vaccines: are we getting closer? Curr. Opin. Mol. Ther. 9:1224.
97. Epstein, J. E.,, S. Rao,, F. Williams,, D. Freilich,, T. Luke,, M. Sedegah,, P. de la Vega,, J. Sacci,, T. L. Richie, and, S. L. Hoffman. 2007. Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update. J. Infect. Dis. 196:145154.
98. Eyles, D. 1952. Studies on Plasmodium gallinaceum. I. Factors associated with the malaria infection in the vertebrate host which influence the degree of infection in the mosquito. Am. J. Hyg. 55:386391.
99. Eyles, D. 1952. Studies on Plasmodium gallinaceum. II. Factors in the blood of the vertebrate host influencing mosquito infection. Am. J. Hyg. 55:276290.
100. Fairley, N. H. 1957. Experiments with antimalarial drugs in man. VI. The value of chloroquine diphosphate as a suppressive drug in volunteers exposed to experimental mosquito transmitted malaria. Trans. R. Soc. Trop. Med. Hyg. 51:493501.
101. Fairley, N. H. 1946. Researches on paludrine (M4888) in malaria. Trans. R. Soc. Trop. Med. Hyg. 40:105152.
102. Fawaz, G.,, and F. S. Haddad. 1951. The effect of lapinone (M-2350) on P. vivax infection in man. Am. J. Trop. Med. Hyg. 31:569571.
103. Fernex, M.,, C. Jaquet,, M. Mittelholzer,, R. Reber, and, D. Sturchler. 1991. Neuer Medikamente für die Behandlung der Malaria Tropica. Schweiz. Rundsch. Med. Prax. 80:6771.
104. Fidock, D. A.,, T. Nomura,, A. K. Talley,, R. A. Cooper,, S. M. Dzekunov,, M. T. Ferdig,, L. M. Ursos,, A. B. Sidhu,, B. Naude,, K. W. Deitsch,, X. Z. Su,, J. C. Wootton,, P. D. Roepe, and, T. E. Wellems. 2000. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol. Cell 6:861871.
105. Fieser, L. F.,, E. Berlinger,, F. Bondhus,, F. C. Chang,, W. G. Dauben,, M. G. Ett-linger,, G. Fawaz,, M. Fields,, M. Fieser,, C. Heidelberger,, H. Heyman,, A. M. Seligman,, W. R. Vaughan,, A. G. Wilson,, E. Wilson, et al. 1948. Naphthoquinone antimalarials. J. Am. Chem. Soc. 70:31513156.
106. Fieser, L. F.,, J. P. Schirmer,, S. Archer,, R. R. Lorenz, and, P. I. Pfaffenbach. 1967. Naphthoquinone antimalarial. XXIX. 2-hydroxy-3-w-cyclohexylalkyl-1,4-naphthoquinoines. J. Med. Chem. 10:513522.
107. Fildes, P. 1940. The mechanism of the anti-bacterial action of mercury. Br. J. Exp. Pathol. 21:6773.
108. Fitch, C. D.,, R. Chevli,, H. S. Banyal,, G. Phillips,, M. A. Pfaller, and, D. J. Krogstad. 1982. Lysis of Plasmodium falciparum by ferriprotoporphyrin IX and a chloroquine-ferriprotoporphyrin IX complex. Antimicrob. Agents Chemother. 21:819822.
109. Fitch, C. D.,, and P. Kanjananggulpan. 1987. The state of ferriprotoporphyrin IX in malaria pigment. J. Biol. Chem. 262:1555215555.
110. Foote, S. J.,, J. K. Thompson,, A. F. Cowman, and, D. J. Kemp. 1989. Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum. Cell 57:921930.
111. Foster, W. D. 1965. A History of Parasitology, p. 158–186. E & S Livingstone, Edinburgh, United Kingdom.
112. Fry, M.,, and J. E. Beesley. 1991. Mitochondria of mammalian Plasmodium spp. Parasitology 102:1726.
113. Gamage-Mendis, A. C.,, J. Rajakaruna,, R. Carter, and, K. N. Mendis. 1992. Transmission blocking immunity to human Plasmodium vivax malaria in an endemic population in Kataragama, Sri Lanka. Parasite Immunol. 14:385396.
114. Gardner, M. J.,, N. Hall,, E. Fung,, O. White,, M. Berriman,, R. W. Hyman,, J. M. Carlton,, A. Pain,, K. E. Nelson,, S. Bowman,, I. T. Paulsen,, K. James,, J. A. Eisen,, K. Rutherford,, S. L. Salzberg,, A. Craig,, S. Kyes,, M. S. Chan,, V. Nene,, S. J. Shallom,, B. Suh,, J. Peterson,, S. Angiuoli,, M. Pertea,, J. Allen,, J. Selengut,, D. Haft,, M. W. Mather,, A. B. Vaidya,, D. M. Martin,, A. H. Fairlamb,, M. J. Fraunholz,, D. S. Roos,, S. A. Ralph,, G. I. McFadden,, L. M. Cum-mings,, G. M. Subramanian,, C. Mungall,, J. C. Venter,, D. J. Carucci,, S. L. Hoffman,, C. Newbold,, R. W. Davis,, C. M. Fraser, and, B. Barrell. 2002. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419:498511.
115. Garfield, M. S. 2000. Mauve. How One Man Invented a Color That Changed the World. Norton, New York, NY.
116. Garnham, P. C. 1967. Presidential address: reflections on Laveran, Marchia-fava, Golgi, Koch and Danilewsky after sixty years. Trans. R. Soc. Trop. Med. Hyg. 61:753764.
117. Garnham, P. C. C. 1947. Exo-erythrocytic schizogony in Plasmodium kochi: a preliminary note. Trans. R. Soc. Trop. Med. Hyg. 40:719722.
118. Geary, T.,, and J. Jensen. 1983. Effects of antibiotics on Plasmodium falciparum in vitro. Am. J. Trop. Med. Hyg. 32:221225.
119. German, P. I.,, and F. T. Aweeka. 2008. Clinical pharmacology of artemisinin-based combination therapies. Clin. Pharmacokinet. 47:91102.
120. Goodman, C. D.,, and G. I. McFadden. 2007. Fatty acid biosynthesis as a drug target in apicomplexan parasites. Curr. Drug Targets 8:1531.
121. Grabowsky, M. 2008. The billion dollar moment. Nature 451:10511052.
122. Graham, I. A.,, K. Besser,, S. Blumer,, C. A. Branigan,, T. Czechowski,, L. Elias,, I. Guterman,, D. Harvey,, P. G. Isaac,, A. M. Khan,, T. R. Larson,, Y. Li,, T. Paw-son,, T. Penfield,, A. M. Rae,, D. A. Rathbone,, S. Reid,, J. Ross,, M. F. Small-wood,, V. Segura,, T. Townsend,, D. Vyas,, T. Winzer, and, D. Bowles. 2010. The genetic map of Artemisia annua L. identifies loci affecting yield of the antimalarial drug artemisinin. Science 327:328331.
123. Gramiccia, G. 1988. The Life of Charles Ledger (1818–1905): Alpacas and Quinine. Macmillan, London, United Kingdom.
124. Graves, P. M. 1998. Comparison of the cost-effectiveness of vaccines and insecticide impregnation of mosquito nets for the prevention of malaria. Ann. Trop. Med. Parasitol. 92:399410.
125. Graves, P. M.,, R. Carter,, T. R. Burkot,, I. A. Quakyi, and, N. Kumar. 1988. Antibodies to Plasmodium falciparum gamete surface antigens in Papua New Guinea sera. Parasite Immunol. 10:209218.
126. Greenwood, B. 2009. Can malaria be eliminated? Trans. R. Soc. Trop. Med. Hyg. 1035:S2S5.
127. Greenwood, D. 2008. Antimicrobial Drugs: Chronicle of a Twentieth Century Triumph. Oxford University Press, New York, NY.
128. Greenwood, D. 1995. Conflicts of interest: the genesis of synthetic antimalarial agents in peace and war. J. Antimicrob. Chemother. 36:857872.
129. Greenwood, D. 1992. The quinine connection. J. Antimicrob. Chemother. 30:417427.
130. Gregson, A.,, and C. V. Plowe. 2005. Mechanisms of resistance of malaria parasites to antifolates. Pharmacol. Rev. 57:117145.
131. Gutteridge, W. E.,, D. Dave, and, W. H. Richards. 1979. Conversion of dihydroorotate to orotate in parasitic protozoa. Biochim. Biophys. Acta 582:390401.
132. Gutteridge, W. E.,, P. I. Trigg, and, D. H. Williamson. 1971. Properties of DNA from some malarial parasites. Parasitology 62:209219.
133. Gwadz, R. W. 1976. Successful immunization against the sexual stages of Plasmodium gallinaceum. Science 193:11501151.
134. Gwadz, R. W.,, and L. C. Koontz. 1984. Plasmodium knowlesi: persistence of transmission blocking immunity in monkeys immunized with gamete antigens. Infect. Immun. 44:137140.
135. Hager, T. 2006. The Demon under the Microscope. Harmony Books, New York, NY.
136. Haggis, A. W. 1941. Fundamental errors in the early history of quinine. Bull. Hist. Med. 10:417459.
137. Hale, V.,, J. D. Keasling,, N. Renninger, and, T. T. Diagana. 2007. Microbially derived artemisinin: a biotechnology solution to the global problem of access to affordable antimalarial drugs. Am. J. Trop. Med. Hyg. 77:198202.
138. Hall, S. J.,, P. F. Sims, and, J. E. Hyde. 1991. Functional expression of the dihydrofolate reductase and thymidylate synthetase activities of the human malaria parasite Plasmodium falciparum in Escherichia coli. Mol. Biochem. Parasitol. 45:317330.
139. Harrison, G. 1978. Mosquitoes, Malaria and Man: a History of Hostilities since 1880. Dutton, New York, NY.
140. Hastings, M. D.,, and C. H. Sibley. 2002. Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax. Proc. Natl. Acad. Sci. USA 99:1313713141.
141. Hawkins, V. N.,, H. Joshi,, K. Rungsihirunrat,, K. Na-Bangchang, and, C. H. Sibley. 2007. Antifolates can have a role in the treatment of Plasmodium vivax. Trends Parasitol. 23:213222.
142. Hay, S. I.,, C. A. Guerra,, A. J. Tatem,, A. M. Noor, and, R. W. Snow. 2004. The global distribution and population at risk of malaria: past, present, and future. Lancet Infect. Dis. 4:327336.
143. Hay, S. I.,, D. L. Smith, and, R. W. Snow. 2008. Measuring malaria endemicity from intense to interrupted transmission. Lancet Infect. Dis. 8:369378.
144. Haynes, R. K.,, and S. Krishna. 2004. Artemisinins: activities and actions. Microbes Infect. 6:13391346.
145. Heppner, D. G.,, D. M. Gordon,, M. Gross,, B. Wellde,, W. Leitner,, U. Krzych,, I. Schneider,, R. A. Wirtz,, R. L. Richards,, A. Trofa,, T. Hall,, J. C. Sadoff,, P. Boerger,, C. R. Alving,, D. R. Sylvester,, T. G. Porter, and, W. R. Ballou. 1996. Safety, immunogenicity, and efficacy of Plasmodium falciparum repeatless circumsporozoite protein vaccine encapsulated in liposomes. J. Infect. Dis. 174:361366.
146. Heppner, D. G., Jr.,, K. E. Kester,, C. F. Ockenhouse,, N. Tornieporth,, O. Ofori,, J. A. Lyon,, V. A. Stewart,, P. Dubois,, D. E. Lanar,, U. Krzych,, P. Moris,, E. Angov,, J. F. Cummings,, A. Leach,, B. T. Hall,, S. Dutta,, R. Schwenk,, C. Hill-ier,, A. Barbosa,, L. A. Ware,, L. Nair,, C. A. Darko,, M. R. Withers,, B. Ogutu,, M. E. Polhemus,, M. Fukuda,, S. Pichyangkul,, M. Gettyacamin,, C. Diggs,, L. Soisson,, J. Milman,, M. C. Dubois,, N. Garcon,, K. Tucker,, J. Wittes,, C. V. Plowe,, M. A. Thera,, O. K. Duombo,, M. G. Pau,, J. Goudsmit,, W. R. Ballou, and, J. Cohen. 2005. Towards an RTS, S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research. Vaccine 23:22432250.
147. Herrington, D.,, J. Davis,, E. Nardin,, M. Beier,, J. Cortese,, H. Eddy,, G. Loson-sky,, M. Hollingdale,, M. Sztein,, M. Levine, et al. 1991. Successful immunization of humans with irradiated malaria sporozoites: humoral and cellular responses of the protected individuals. Am. J. Trop. Med. Hyg. 45:539547.
148. Hien, T. T.,, and N. J. White. 1983. Qinghaosu. Lancet 341:603608.
149. Hobhouse, H. 1986. Seeds of Change: Five Plants That Changed Mankind. Harper and Row, New York, NY.
150. Hoffman, S. L.,, L. M. Goh,, T. C. Luke,, I. Schneider,, T. P. Le,, D. L. Doolan,, J. Sacci,, P. de la Vega,, M. Dowler,, C. Paul,, D. M. Gordon,, J. A. Stoute,, L. W. Church,, M. Sedegah,, D. G. Heppner,, W. R. Ballou, and, T. L. Richie. 2002. Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. J. Infect. Dis. 185:11551164.
151. Hoffman, S. L.,, M. Sedegah, and, R. C. Hedstrom. 1994. Protection against malaria by immunization with a Plasmodium yoelii circumsporozoite protein nucleic acid vaccine. Vaccine 12:15291533.
152. Holz, G. G., Jr. 1977. Lipids and the malarial parasite. Bull. W. H. O. 55:566575.
153. Homewood, C. A.,, D. C. Warhurst,, W. Peters, and, V. C. Baggaley. 1972. Ly-sosomes, pH and the anti-malarial action of chloroquine. Nature 235:5052.
154. Honigsbaum, M. 2001. The Fever Trail: in Search of a Cure for Malaria. Farrar, Straus and Giroux, New York, NY.
155. Horton, R. J. 1998. Introduction of halofantrine for malaria treatment. Parasitol. Today 4:238239.
156. Hotchkiss, R. 1990. From microbes to medicine: gramicidin, Rene Dubos and the Rockefeller, p. 1–18. In C. A. Moberg and, Z. Cohen (ed.), Launching the Antibiotic Era. Rockefeller University Press, New York, NY.
157. Hudson, A. T. 1993. Atovaquone—a novel broad-spectrum anti-infective drug. Parasitol. Today 9:6668.
158. Hudson, A. T.,, A. W. Randall,, M. Fry,, C. D. Ginger,, B. Hill,, V. S. Latter,, N. McHardy, and, R. B. Williams. 1985. Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity. Parasitology 90:4555.
159. Huff, C. G. 1968. Recent experimental research on avian malaria. Adv. Parasitol. 6:293311.
160. Hurt, D. E.,, J. Widom, and, J. Clardy. 2006. Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor. Acta Crystallogr. D 62:312323.
161. Jarcho, S. 1984. Laveran’s discovery in the retrospect of a century. Bull. Hist. Med. 58:215224.
162. Jiang, L.,, P. C. Lee,, J. White, and, P. K. Rathod. 2000. Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymi-dylate synthase inhibitor, against Plasmodium falciparum. Antimicrob. Agents Chemother. 44:10471050.
163. Kanigel, R. 1986. Apprentice to a Genius: the Making of a Scientific Dynasty. Mac-millan, New York, NY.
164. Kapuscinski, R. 2002. Shadow of the Sun. Vantage, New York, NY.
165. Kaslow, D. C. 1996. Transmission-blocking vaccines, p. 181–227. In S. L. Hoffman (ed.), Malaria Vaccine Development: a Multi-Immune Response Approach. ASM Press, Washington, DC.
166. Kean, B.,, K. E. Mott, and, A. J. Russell. 1978. Tropical Medicine and Parasitology: Classic Investigations, vol. 1, p. 2334. Cornell University Press, Ithaca, NY.
167. Kidgell, C.,, and E. A. Winzeler. 2006. Using the genome to dissect the molecular basis of drug resistance. Future Microbiol. 1:185199.
168. Kilejian, A. 1975. Circular mitochondrial DNA from the avian malarial parasite Plasmodium lophurae. Biochim. Biophys. Acta 390:276284.
169. Killick-Kendrick, R.,, and H. Richards. 2009. Len Goodwin. The Guardian, 24 February 2009.
170. Klayman, D. 1985. Qinghaosu (artemisinin): an antimalarial drug from China. Science 228:10491055.
171. Klayman, D. 1989. Weeding out malaria. Nat. Hist. 10:1824.
172. Köhler, G.,, and C. Milstein. 1975. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495497.
173. Krotoski, W. A.,, D. M. Krotoski,, P. C. Garnham,, R. S. Bray,, R. Killick-Kendrick,, C. C. Draper,, G. A. Targett, and, M. W. Guy. 1980. Relapses in primate malaria: discovery of two populations of exoerythrocytic stages. Preliminary note. Br. Med. J. 280:153154.
174. Krungkrai, J. 2004. The multiple roles of the mitochondrion of the malarial parasite. Parasitology 129:511524.
175. Lal, A. A.,, V. F. de la Cruz,, G. H. Campbell,, P. M. Procell,, W. E. Collins, and, T. F. McCutchan. 1988. Structure of the circumsporozoite gene of Plasmodium malariae. Mol. Biochem. Parasitol. 30:291294.
176. Laurence, W. H. May 4, 1944. Synthetic quinine produced ending century search. New York Times.
177. Lax, E. 2004. The Mold in Dr. Florey’s Coat. H. Holt, New York, NY.
178. Lengler, C. 2002. Insecticide treated bed nets and curtains for preventing malaria. Cochrane Database Syst. Rev. 2:138.
179. Leopold, N. F. 1958. Life Plus 99 Years. Doubleday, New York, NY.
180. Li, Q.,, W. K. Milhous, and, P. J. Weina. 2007. Artemisinin in Malaria Therapy. Nova Biomedical Books, New York, NY.
181. Li, Y.,, and W.-L. Wu. 2003. An over four millenium story behind qinghaosu (artemisinin)—a fantastic antimalarial drug from a traditional Chinese herb. Curr. Med. Chem. 10:21972230.
182. Lim, P.,, A. P. Alker,, N. Khim,, N. K. Shah,, S. Incardona,, S. Doung,, P. Yi,, D. M. Bouth,, C. Bouchier,, O. M. Puijalon,, S. R. Meshnick,, C. Wongsrichanalai,, T. Fandeur,, J. Le Bras,, P. Ringwald, and, F. Ariey. 2009. Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia. Malaria J. 8:11.
183. Lindsay, S. W.,, and M. E. Gibson. 1988. Bednets revisited—old idea, new angle. Parasitol. Today (personal ed.) 4:270272.
184. Looareesuwan, S.,, C. Viravan,, H. K. Webster,, D. E. Kyle,, D. B. Hutchinson, and, C. J. Canfield. 1996. Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand. Am. J. Trop. Med. Hyg. 54:6266.
185. Luke, T. C.,, and S. L. Hoffman. 2003. Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine. J. Exp. Biol. 206:38033808.
186. MacCallum, W. G. 1898. On the hematozoan infections of birds. J. Exp. Med. 3:117135.
187. MacDonald, G. 1973. Dynamics of Tropical Disease: a Selection of Papers with a Biographical Introduction and Bibliography. Oxford University Press, London, United Kingdom.
188. MacDonald, G. 1957. The Epidemiology and Control of Malaria. Oxford University Press, London, United Kingdom.
189. Manchester, H. 1944. Man-made quinine. Science Newsl. 45:378381.
190. Manson-Bahr, P. 1962. Patrick Manson. Thomas Nelson and Sons, London, United Kingdom.
191. Manson-Bahr, P. 1963. The story of malaria: the drama and actors. Int. Rev. Trop. Med. 2:329390.
192. Maren, T. H. 1987. Eli Kennerly Marshall Jr. Biogr. Memoirs 56:313351.
193. Marshall, E. K. 1941. Bacterial chemotherapy. Annu. Rev. Physiol. 3:643670.
194. Marshall, E. K. 1942. Chemotherapy of avian malaria. Physiol. Rev. 22:190204.
195. Martin, R. E.,, R. I. Henry,, J. L. Abbey,, J. D. Clements, and, K. Kirk. 2005. The ‘permeome’ of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparum. Genome Biol. 6:R26.
196. McCutchan, T. F.,, A. A. Lal,, V. F. de la Cruz,, L. H. Miller,, W. L. Maloy,, Y. Charoenvit,, R. L. Beaudoin,, P. Guerry,, R. Wistar, Jr.,, S. L. Hoffman, et al. 1985. Sequence of the immunodominant epitope for the surface protein on sporozoites of Plasmodium vivax. Science 230:13811383.
197. McGhee, R. B. 1988. Major animal models in malaria research: avian, p. 1545–1568. In W. Wernsdorfer and, I. McGregor (ed.), Malaria: Principles and Practices of Malariology, vol. 2. Churchill Livingstone, Edinburgh, United Kingdom.
198. McHardy, N. 1978. In vitro studies on the action of menoctone and other compounds on Theileria parva and T. annulata. Ann. Trop. Med. Parasitol. 72:501511.
199. McHardy, N.,, and D. W. Morgan. 1985. Treatment of Theileria annulata infection in calves with parvaquone. Res. Vet. Sci. 39:14.
200. McNeil, D. G. March 4, 2008. Eradicate malaria? Doubters fuel debate. New York Times.
201. McNeil, D. G. December 11, 2007. The soul of a new vaccine. New York Times.
202. Mendis, K.,, A. Rietveld,, M. Warsame,, A. Bosman,, B. Greenwood, and, W. H. Wernsdorfer. 2009. From malaria control to eradication: the WHO perspective. Trop. Med. Int. Health 14:802809.
203. Merkli, B.,, R. Richle, and, W. Peters. 1980. The inhibitory effect of a drug combination on the development of mefloquine resistance in Plasmodium berghei. Ann. Trop. Med. Parasitol. 74:19.
204. Meshnick, S. 2001. Artemisinin and its derivatives, p. 191–201. In P. Rosen-thal (ed.), Antimalarial Chemotherapy. Humana Press, Totowa, NJ.
205. Meshnick, S. 2002. Artemisinin: mechanism of action, resistance and toxicity. Int. J. Parasitol. 32:16551660.
206. Meshnick, S. 1998. From quinine to qinghaosu: historical perspectives, p. 341–354. In I. W. Sherman (ed.), Malaria: Parasite Biology, Pathogenesis, and Protection. ASM Press, Washington, DC.
207. Meshnick, S. 1997. Why does quinine still work after 350 years? Parasitol. Today 13:8990.
208. Miller, F. W.,, and J. Ilan. 1984. Evidence for major differences in ribosomal subunit proteins from Plasmodium berghei and rat liver. Mol. Biochem. Parasitol. 12:249260.
209. Miller, F. W.,, and J. Ilan. 1978. The ribosomes of Plasmodium berghei: isolation and ribosomal ribonucleic acid analysis. Parasitology 77:345365.
210. Muller, O., K., Cham, S. Jaffar, and, B. Greenwood. 1997. The Gambian National Impregnated Bednet Programme: evaluation of the 1994 cost recovery trial. Soc. Sci. Med. 44:19031909.
211. Mulligan, H. W.,, P. F. Russell, and, B. N. Mohan. 1941. Active immunization of fowls against Plasmodium gallinaceum by injections of killed homologous sporozoites. J. Mal. Inst. India 4:2534.
212. Nardin, E.,, R. Nussenzweig,, I. McGregor,, J. and Bryan. 1979. Antisporozoite antibodies. Their frequent occurrence in individuals living in an area of hyperendemic malaria. Science 206:597599.
213. Noe, D. 29 February 2004, posting date. Leopold and Loeb’s perfect crime. http://www.crimemagazine.com/04/leopoldloeb,0229.htm.
214. Noedl, H.,, D. Socheat, and, W. Satimai. 2009. Artemisinin-resistant malaria in Asia. N. Engl. J. Med. 361:540541.
215. Nosten, F.,, F. O. ter Kuile,, C. Luxemburger,, C. Woodrow,, D. E. Kyle,, T. Chongsuphajaisiddhi, and, N. J. White. 1993. Cardiac effects of antimalarial treatment with halofantrine. Lancet 341:10541056.
216. Nussenzweig, R. S.,, and D. Chen. 1974. Some characteristics of the immune response to sporozoites of simian and human malaria. Bull. Pan Am. Health Org. 8:198204.
217. Nussenzweig, R. S.,, J. Vanderberg,, H. Most, and, C. Orton. 1967. Protective immunity produced by the injection of x-irradiated sporozoites of Plasmodium berghei. Nature 216:160162.
218. Nussenzweig, R. S.,, J. Vanderberg,, G. L. Spitalny,, C. I. Rivera,, C. Orton, and, H. Most. 1972. Sporozoite-induced immunity in mammalian malaria. A review. Am. J. Trop. Med. Hyg. 21:722728.
219. Olliaro, P.,, and T. N. Wells. 2009. The global portfolio of new antimalarial medicines under development. Clin. Pharmacol. Ther. 85:584595.
220. Olliaro, P.,, and W. Taylor. 2004. Developing artemisinin-based drug combinations for the treatment of drug resistant falciparum malaria: a review. J. Postgrad. Med. 50:4044.
221. Olumse, P. 2006. Guidelines for the Treatment of Malaria. World Health Organization, Geneva, Switzerland.
222. O’Neill, P. M.,, S. A. Ward,, N. G. Berry,, J. P. Jeyadevan,, G. A. Biagini,, E. Asa-dollaly,, B. K. Park,, and P. G. Bray. 2006. A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs. Curr. Top. Med. Chem. 6:479507.
223. Orjih, A. U.,, A. H. Cochrane,, and R. S. Nussenzweig. 1982. Comparative studies on the immunogenicity of infective and attenuated sporozoites of Plasmodium berghei. Trans. R. Soc. Trop. Med. Hyg. 76:5761.
224. Pacheco, N. D.,, E. McConnell,, and R. L. Beaudoin. 1979. Duration of immunity following a single vaccination with irradiated sporozoites of Plasmodium berghei. Bull. W. H. O. 57(Suppl. 1):159163.
225. Palmer, K.,, S. M. Holliday,, and R. W. Brogden. 1973. Mefloquine. A review of its antimalarial activity, pharmacokinetic properties and therapeutic efficacy. Drugs 45:470475.
226. Park, B. S. 2003. The development of the intramural research program at the National Institutes of Health after World War II. Perspect. Biol. Med. 46:383402.
227. Partington, J. R. 1964. A History of Chemistry. Macmillan, London, United Kingdom.
228. Perkin, W. 1906. The story of the discovery of the first aniline dye. Sci. Am. 95:342343.
229. Peters, W. 1987. Chemotherapy and Drug Resistance in Malaria, vol. 2. Academic Press, London, United Kingdom.
230. Peters, W. 1987. Chemotherapy and Drug Resistance in Malaria, vol. 1. Academic Press, London, United Kingdom.
231. Peters, W. 1999. The evolution of tafenoquine—antimalarial for a new millennium? J. R. Soc. Med. 92:345352.
232. Peters, W.,, J. Portus,, and B. L. Robinson. 1977. The chemotherapy of rodent malaria, XXVIII. The development of resistance to mefloquine (WR 142,490). Ann. Trop. Med. Parasitol. 71:419427.
233. Piel, G. 1944. Quinine. Two young chemists and a century’s search by making drug synthetically from coal tar, p. 85–88. Life, June 5, 1944.
234. Potocnjak, P.,, N. Yoshida,, R. S. Nussenzweig,, and V. Nussenzweig. 1980. Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection. J. Exp. Med. 151:15041513.
235. Pradel, G. 2007. Proteins of the malaria parasite sexual stages: expression, function and potential for transmission blocking strategies. Parasitology 134:19111929.
236. Pullman, T. N.,, L. Eichelberger,, A. S. Alving,, R. Jones, Jr.,, B. Craige,, and C. M. Whoron. 1948. The use of SN-10,275 in the prophylaxis and treatment of sporozoite-induced vivax malaria (Chesson strain). J. Clin. Investig. 27:1216.
237. Rahman, A.,, M. I. Choudry,, and W. J. Thomsen. 2001. Bioassay Techniques for Drug Development. Harwood Academic Publishers, Chur, Switzerland.
238. Ralph, S. A. 2005. The apicoplast, p. 272–289. In I. W. Sherman (ed.), Molecular Approaches to Malaria. ASM Press, Washington, DC.
239. Rathod, P. K.,, N. P. Leffers,, and R. D. Young. 1992. Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum. Antimicrob. Agents Chemother. 36:704711.
240. Reiter, P. 2000. From Shakespeare to Defoe: malaria in England in the Little Ice Age. Emerg. Infect. Dis. 6:111.
241. Ridley, R. G.,, and E. R. Fletcher. 2008. Making a difference: 30 years of TDR. Nat. Rev. Microbiol. 6:401407.
242. Rieckmann, K. H. 1983. Falciparum malaria: the urgent need for safe and effective drugs. Annu. Rev. Med. 34:321335.
243. Rieckmann, K. H. 1990. Human immunization with attenuated sporozoites. Bull. W. H. O. 68(Suppl. 1):1316.
244. Ringwald, P.,, J. Bickii,, A. Same-Ekobo,, and L. K. Basco. 1997. Pyronaridine for treatment of Plasmodium ovale and Plasmodium malariae infections. Antimicrob. Agents Chemother. 41:23172319.
245. Roberts, L.,, and M. Enserink. 2007. Did they really say . . . eradication? Science 318:15441555.
246. Rocco, F. 2003. The Miraculous Fever Tree. Harper Collins, New York, NY.
247. Rogers, W. O.,, W. R. Weiss,, A. Kumar,, J. C. Aguiar,, J. A. Tine,, R. Gwadz,, J. G. Harre,, K. Gowda,, D. Rathore,, S. Kumar,, and S. L. Hoffman. 2002. Protection of rhesus macaques against lethal Plasmodium knowlesi malaria by a heterologous DNA priming and poxvirus boosting immunization regimen. Infect. Immun. 70:43294335.
248. Rollo, I. M. 1975. Antiplasmodial efficacy of 2,4-diaminopyrimidine-sulfonamide combinations, especially against chloroquine-resistant malaria. Can. Med. Assoc. J. 112:5053.
249. Roper, C.,, R. Pearce,, S. Nair,, B. Sharp,, F. Nosten,, and T. Anderson. 2004. Intercontinental spread of pyrimethamine-resistant malaria. Science 305:1124.
250. Ross, R. 1923. Memoirs: with a Full Account of the Great Malaria Problem and Its Solution. Murray, London, United Kingdom.
251. Ross, R. 1910. The Prevention of Malaria. Dutton, New York, NY.
252. Rozman, R.,, and C. J. Canfield. 1979. New experimental antimalarial drugs. Adv. Pharmacol. Chemother. 16:143.
253. Russell, P. F. 1955. Man’s Mastery of Malaria. Oxford University Press, London, United Kingdom.
254. Russell, P. F.,, H. W. Mulligan,, and B. D. Mohan. 1941. Specific agglutinogenic properties of inactivated sporozoites of P. gallinaceum. J Mal. Inst. India 4:1524.
255. Russell, P. F.,, H. W. Mulligan,, and B. N. Mohan. 1942. Active immunization of fowls against sporozoites but not trophozoites of Plasmodium gallinaceum by injections of homologous sporozoites. J. Mal. Inst. India 4:311319.
256. Saliba, K. J.,, A. M. Lehane,, and K. Kirk. 2008. A polymorphic drug pump in the malaria parasite. Mol. Microbiol. 70:775779.
257. Sato, S.,, and R. J. M. Wilson. 2005. The plastid of Plasmodium spp.: a target for inhibitors. Curr. Top. Microbiol. Immunol. 295:251273.
258. Sauerwein, R. 2007. Transmission blocking vaccines: the bonus of effective malaria control. Microbes Infect. 9:792795.
259. Saul, A. 2007. mosquito stage, transmission blocking vaccines for malaria. Curr. Opin. Infect. Dis. 20:476481.
260. Scharrer, K. 1949. Justus von Liebig and today’s agriculture. J. Chem. Edu. 26:515518.
261. Schellenberg, K. A.,, and G. R. Coatney. 1961. The influence of antimalarial drugs on nucleic acid synthesis in Plasmodium gallianceum and Plasmodium berghei. Biochem. Pharmacol. 6:143152.
262. Schlitzer, M. 2008. Antimalarial drugs—what is in use and what is in the pipeline. Arch. Pharm. 341:149163.
263. Schlitzer, M. 2007. Malaria chemotherapeutics. I. History of antimalarial drug development, currently used therapeutics and drugs in clinical development. ChemMedChem 2:944986.
264. Schmidt, L. H. 1983. Relationships between chemical structures of 8-aminoquinolines and their capacities for radical cure of infections with Plasmodium cynomolgi in rhesus monkeys. Antimicrob. Agents Chemother. 24:615652.
265. Schmidt, L. H.,, R. Crosby,, J. Rasco,, and D. Vaughan. 1978. Antimalarial activities of various 4-quinolonemethanols with special attention to WR-142,490 (mefloquine). Antimicrob. Agents Chemother. 13:10111030.
266. Sergent, E.,, and E. Sergent. 1910. Sur l’immunité dans le paludisme des oiseaux. C. R. Acad. Sci. 151:407409.
267. Shanks, G. D. 1994. The rise and fall of mefloquine as aan antimalarial drug in South East Asia. Mil. Med. 159:275281.
268. Sherman, I. W. 1998. A brief history of malaria and discovery of the parasite’s life cycle, p. 3–10. In I. W. Sherman (ed.), Malaria: Parasite Biology, Pathogenesis, and Protection. ASM Press, Washington, DC.
269. Sherman, I. W. 2008. Reflections on a century of malaria biochemistry. Adv. Parasitol., vol. 67.
270. Sherman, I. W. 2009. The Elusive Malaria Vaccine: Miracle or Mirage? ASM Press, Washington, DC.
271. Sherman, I. W. 2006. The Power of Plagues. ASM Press, Washington, DC.
272. Sherman, I. W. 2007. Twelve Diseases That Changed Our World. ASM Press, Washington, DC.
273. Sherman, I. W.,, R. A. Cox,, B. Higginson,, D. J. McLaren,, and J. Williamson. 1975. The ribosomes of the simian malaria, Plasmodium knowlesi. I. Isolation and characterization. J. Protozool. 22:568572.
274. Sherman, I. W.,, and L. A. Jones. 1976. Protein synthesis by a cell-free preparation from the bird malaria, Plasmodium lophurae. J. Protozool. 23:277281.
275. Sherman, I. W.,, and L. A. Jones. 1977. The Plasmodium lophurae (avian malaria) ribosome. J. Protozool. 24:331334.
276. Shortt, H. E.,, and P. C. C. Garnham. 1948. Pre-erythrocytic stage in mammalian malaria parasites. Nature 161:126.
277. Sidhu, A. B.,, A. C. Uhlemann,, S. G. Valderramos,, J. C. Valderramos,, S. Krishna,, and D. A. Fidock. 2006. Decreasing pfmdr1 copy number in Plasmo-dium falciparum malaria heightens susceptibility to mefloquine, lumefan-trine, halofantrine, quinine, and artemisinin. J. Infect. Dis. 194:528535.
278. Sidhu, A. B.,, S. G. Valderramos,, and D. A. Fidock. 2005. pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum. Mol. Microbiol. 57:913926.
279. Simpson, H. N. 1980. Invisible Armies. The Impact of Disease on American History. Bobbs-Merrill, Indianapolis, IN.
280. Sinnis, P.,, and V. Nussenzweig. 1996. Preventing sporozoite invasion of he-patocytes, p. 15–33. In S. Hoffman (ed.), Malaria Vaccine Development: a Multi-Immune Response Approach. ASM Press, Washington, DC.
281. Slater, L. 2005. Malarial birds: modeling infectious human disease in animals. Bull. Hist. Med. 79:261294.
282. Slater, L. B. 2009. War and Disease: Biomedical Research in the Twentieth Century. Rutgers University Press, New Brunswick, NJ.
283. Smith, D.,, and L. Sanford. 1985. Laveran’s germ. The reception and use of a medical discovery. Am. J. Trop. Med. Hyg. 34:220.
284. Smith, G. L.,, G. N. Godson,, V. Nussenzweig,, R. S. Nussenzweig,, J. Barnwell,, and B. Moss. 1984. Plasmodium knowlesi sporozoite antigen: expression by infectious recombinant vaccinia virus. Science 224:397399.
285. Smith, T. G.,, P. Lourenco,, R. Carter,, D. Walliker,, and L. C. Ranford-Cartwright. 2000. Commitment to sexual differentiation in the human malaria parasite, Plasmodium falciparum. Parasitology 121:127133.
286. Sneader, W. 1985. Drug Discovery: the Evolution of Modern Medicines. Wiley, New York, NY.
287. Sneader, W. 2005. Drug Discovery: a History. Wiley, New York, NY.
288. Spitalny, G. L.,, and R. S. Nussenzweig. 1973. Plasmodium berghei: relationship between protective immunity and anti-sporozoite (CSP) antibody in mice. Exp. Parasitol. 33:168178.
289. Stoute, J. A.,, M. Slaoui,, D. G. Heppner,, P. Momin,, K. E. Kester,, P. Desmons,, B. T. Wellde,, N. Garcon,, U. Krzych,, and M. Marchand for the RTS, S Malaria Vaccine Evaluation Group. 1997. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. N. Engl. J. Med. 336:8691.
290. Stowers, A.,, and R. Carter. 2001. Current developments in malaria transmission-blocking vaccines. Expert Opin. Biol. Ther. 1:619628.
291. Svartz, N. 1939. Presentation speech, The Nobel Prize in Physiology or Medicine 1939. http://nobelprize.org/nobel_prizes/medicine/laureates/1939/press.html.
292. Sweeney, T. 2003. Malaria Frontline: Australian Army Research during World War II. Melbourne University Press, Melbourne, Australia.
293. Sweeney, T. R. 1981. The present status of malaria chemotherapy: mefloquine a novel antimalarial. Med. Res. Rev. 1:281301.
294. Sydenham, T. 1987. Methodus Curandi Febres Propriis Observationibus Super-structura. [Original publication, 1666.] Winterdown Books, Folkestone, United Kingdom.
295. Targett, G. A.,, and B. M. Greenwood. 2008. Malaria vaccines and their potential role in the elimination of malaria. Malar. J. 7(Suppl. 1):S10.
296. Thompson, F. M.,, D. W. Porter,, S. L. Okitsu,, N. Westerfeld,, D. Vogel,, S. Todryk,, I. Poulton,, S. Correa,, C. Hutchings,, T. Berthoud,, S. Dunachie,, L. Andrews,, J. L. Williams,, R. Sinden,, S. C. Gilbert,, G. Pluschke,, R. Zurbrig-gen,, and A. V. Hill. 2008. Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial. PLoS ONE 3:e1493.
297. Tokuyasu, K.,, J. Ilan,, and J. Ilan. 1969. Biogenesis of ribosomes in Plasmodium berghei. Mil. Med. 134:10321038.
298. Trager, W. 1987. The cultivation of Plasmodium falciparum: applications in basic and applied research. Ann. Trop. Med. Parasitol. 81:511529.
299. Travis, A. S. 1993. The Rainbow Makers: the Origins of the Synthetic Dyestuffs Industry in Western Europe. Lehigh University Press, Bethlehem, PA.
300. Trenholme, G.,, R. Williams,, R. E. Desjardins,, H. Frischer,, P. E. Carson,, and C. J. Canfield. 1975. Mefloquine (WR-142,490) in the treatment of human malaria. Science 190:792794.
301. Trigg, P. I. 1989. Qinghaosu (artemisinin) as an antimalarial drug. Econ. Med. Plant Res. 3:2155.
302. Triglia, T.,, P. Wang,, P. F. Sims,, J. E. Hyde,, and A. F. Cowman. 1998. Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria. EMBO J. 17:38073815.
303. Twigg, C. A.,, and M. V. Twigg. 1973. Centenary of the death of Justus von Liebig. J. Chem. Edu. 50:273274.
304. Vaidya, A. B. 2004. Mitochondrial and plastid functions as antimalarial drug targets. Curr. Drug Targets 4:1123.
305. Vaidya, A. B. 2005. The mitochondrion, p. 234–252. In I. W. Sherman (ed.), Molecular Approaches to Malaria. ASM Press, Washington, DC.
306. Valderramos, S. G.,, and D. A. Fidock. 2006. Transport