Chapter 8 : Genomics of the Enteropathogenic Yersiniae

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The study of the genome indirectly reveals enteric features of (and ). This chapter describes the salient features of postgenomic studies on and and relates this to our understanding of the diversity and evolution of virulence for these species. The enteropathogenic yersiniae are ubiquitous in the environment, and are a common cause of animal infections, and they have been isolated from cattle, sheep, pigs, domesticated animals, and avian species. Various other adhesion- and invasion-associated factors such as Ail and the Myf fimbriae have also been reported in enteropathogenic yersiniae. B12 is an essential cofactor for several reactions, including 1,2-propanediol degradation. Although the true significance of tetrathionate respiration operon in is unknown, in Salmonella, 1,2-propanediol is an important source of energy, and mutants unable to make B12 are significantly attenuated in their ability to grow in macrophages. With respect to the enteropathogenic yersiniae, the natural deselection highlights many known genes required for the enteropathogenicity by (and ), but also highlighted many previously unsuspected candidates. Perhaps the most striking aspect of the evolution of Yersinia is the extremely rapid emergence of from , and genome analysis shows how this has happened.

Citation: McNally A, Thomson N, Wren B. 2011. Genomics of the Enteropathogenic Yersiniae, p 101-111. In Fratamico P, Liu Y, Kathariou S (ed), Genomes of Foodborne and Waterborne Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555816902.ch8

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Flagellar Basal-Body Rod Protein
Type IVB Secretion System
Type III Secretion System
Yersinia pestis
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Figure 1

Line diagram to represent the whole genome differences of the A summary of the observed gene differences between representative members of the yersiniae (as defined by reciprocal FASTA analysis). Branches are not intended to infer phylogenetic distance. For text color, see key.

Citation: McNally A, Thomson N, Wren B. 2011. Genomics of the Enteropathogenic Yersiniae, p 101-111. In Fratamico P, Liu Y, Kathariou S (ed), Genomes of Foodborne and Waterborne Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555816902.ch8
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Table 1

Current and ongoing genome projects

Citation: McNally A, Thomson N, Wren B. 2011. Genomics of the Enteropathogenic Yersiniae, p 101-111. In Fratamico P, Liu Y, Kathariou S (ed), Genomes of Foodborne and Waterborne Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555816902.ch8
Generic image for table
Table 2

Properties of all the published genomes

Citation: McNally A, Thomson N, Wren B. 2011. Genomics of the Enteropathogenic Yersiniae, p 101-111. In Fratamico P, Liu Y, Kathariou S (ed), Genomes of Foodborne and Waterborne Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555816902.ch8
Generic image for table
Table 3

Selected CO92 pseudogenes that are likely to be important in the pathogenesis of the enteropathogenic yersiniae

Citation: McNally A, Thomson N, Wren B. 2011. Genomics of the Enteropathogenic Yersiniae, p 101-111. In Fratamico P, Liu Y, Kathariou S (ed), Genomes of Foodborne and Waterborne Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555816902.ch8

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