7 : Reemerging Infections: Recent Developments in Pertussis

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Although pertussis (whooping cough) technically qualifies as a reemerging infection by virtue of its increase in reported cases over the last 15 years, there is no doom and gloom about the future of this fascinating illness. Despite the important recent progress summarized in this chapter, there are substantial barriers to overcome in the long-term mission of controlling or eliminating the disease. A variety of primers have been used for pertussis polymerase chain reaction (PCR) assays, and this technology is available in an increasing number of centers. Serology is also being used increasingly to identify patients with pertussis, although this approach is more effective for epidemiologic purposes than in acute diagnosis. This infection is localized to the respiratory tract. Almost certainly, reaches that site via aerosol droplets produced by the cough of an actively infected individual. Immunization with whole cell pertussis vaccine has been the mainstay of public health measures against this illness since the mid-1950s. Future clinical investigation will focus on potential benefit of additional antigens for the acellular vaccines, their duration of protection, and whether they might be used for protection of the adult population which is now recognized as experiencing an increasing incidence of pertussis.

Citation: Hewlett E. 1998. Reemerging Infections: Recent Developments in Pertussis, p 145-158. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 2. ASM Press, Washington, DC. doi: 10.1128/9781555816957.ch7

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Adenylate Cyclase Toxin
T Helper Cells
Nitric Oxide Synthase
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Table 1

Virulence factors of

Citation: Hewlett E. 1998. Reemerging Infections: Recent Developments in Pertussis, p 145-158. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 2. ASM Press, Washington, DC. doi: 10.1128/9781555816957.ch7
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Table 2

Results from seven acellular pertussis vaccine trials

Citation: Hewlett E. 1998. Reemerging Infections: Recent Developments in Pertussis, p 145-158. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 2. ASM Press, Washington, DC. doi: 10.1128/9781555816957.ch7

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