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Abstract:

Query (Q) fever is a zoonosis caused by . The current understanding of the natural history of Q fever is that a nonimmune patient enters into contact with . The immune control of Q fever is T cell dependent, but it does not lead to eradication, and immunosuppression can induce relapse of infection in apparently cured patients or laboratory animals. Incubation of monocytes from patients with Q fever endocarditis demonstrated an increase in the secretion of interleukin 10 (IL-10), which was also increased in patients who had relapsed after treatment of Q fever endocarditis. A higher rate of complaints of various pains (headaches, myalgias, and arthralgias) in Q fever hepatitis patients were observed, including thrombocytopenia as well as elevated sedimentation rate. Q fever hepatitis patients frequently exhibit autoantibodies, including anti-smooth muscle antibodies, antinuclear antibodies, and antiphospholipid antibodies. The combination of hydroxychloroquine and doxycycline is currently the most effective therapy. The diagnosis of Q fever is easy when it is considered as part of the differential diagnosis, and the main diagnostic test for Q fever is microimmunofluorescence serology.

Citation: Raoult D, Mege J, Marrie T. 2001. Q Fever: Queries Remaining after Decades of Research, p 29-56. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 5. ASM Press, Washington, DC. doi: 10.1128/9781555816988.ch3

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Rocky Mountain Spotted Fever
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Figure 1

Number of cases of Q fever in France as diagnosed at the National Reference Center (1985 to 1999). (A) Number of submitted sera (bars) and number of positive sera (IgG titer of ≥1/200 by immunofluorescence) (diamonds). (B) Number of recorded observations of acute (squares) and chronic (triangles) Q fever.

Citation: Raoult D, Mege J, Marrie T. 2001. Q Fever: Queries Remaining after Decades of Research, p 29-56. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 5. ASM Press, Washington, DC. doi: 10.1128/9781555816988.ch3
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References

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Tables

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Table 1

Conditions that predispose to chronic infection in human beings and in laboratory animals

Citation: Raoult D, Mege J, Marrie T. 2001. Q Fever: Queries Remaining after Decades of Research, p 29-56. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 5. ASM Press, Washington, DC. doi: 10.1128/9781555816988.ch3
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Table 2

Immunological profile of patients with Q fever

Citation: Raoult D, Mege J, Marrie T. 2001. Q Fever: Queries Remaining after Decades of Research, p 29-56. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 5. ASM Press, Washington, DC. doi: 10.1128/9781555816988.ch3
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Table 3

Clinical manifestations of Q fever

Citation: Raoult D, Mege J, Marrie T. 2001. Q Fever: Queries Remaining after Decades of Research, p 29-56. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 5. ASM Press, Washington, DC. doi: 10.1128/9781555816988.ch3
Generic image for table
Table 4

Clinical spectrum of Q fever

Citation: Raoult D, Mege J, Marrie T. 2001. Q Fever: Queries Remaining after Decades of Research, p 29-56. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 5. ASM Press, Washington, DC. doi: 10.1128/9781555816988.ch3
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Table 5

Recent series of cases of Q fever endocarditis (1997 to 2000)

Citation: Raoult D, Mege J, Marrie T. 2001. Q Fever: Queries Remaining after Decades of Research, p 29-56. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 5. ASM Press, Washington, DC. doi: 10.1128/9781555816988.ch3
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Table 6

Clinical symptoms and signs and laboratory findings in Q fever endocarditis patients

Citation: Raoult D, Mege J, Marrie T. 2001. Q Fever: Queries Remaining after Decades of Research, p 29-56. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 5. ASM Press, Washington, DC. doi: 10.1128/9781555816988.ch3
Generic image for table
Table 7

Diagnostic tests for Q fever

Citation: Raoult D, Mege J, Marrie T. 2001. Q Fever: Queries Remaining after Decades of Research, p 29-56. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 5. ASM Press, Washington, DC. doi: 10.1128/9781555816988.ch3
Generic image for table
Table 8

Recently reported outbreaks of Q fever

Citation: Raoult D, Mege J, Marrie T. 2001. Q Fever: Queries Remaining after Decades of Research, p 29-56. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 5. ASM Press, Washington, DC. doi: 10.1128/9781555816988.ch3

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