4 : Emerging from Obscurity: Understanding Pulmonary and Extrapulmonary Syndromes, Pathogenesis, and Epidemiology of Human Infections

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Emerging from Obscurity: Understanding Pulmonary and Extrapulmonary Syndromes, Pathogenesis, and Epidemiology of Human Infections, Page 1 of 2

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This chapter explores the fascinating biology and history of human mycoplasma infections with a focus on disease caused by . It addresses the association of infections with asthma. An important question is whether mycoplasmas are a primary cause of asthma, or if mycoplasma infection is at least a cofactor in the development of asthma. The suggestion that may play a role beyond simple, acute exacerbation comes from multiple lines of evidence. First, can be recovered more often from the airways of patients with chronic, stable asthma than from matched control patients . Second, chronic reductions in lung function tests 1 year, 3 years, and up to 9 years or more after an episode of mycoplasma respiratory tract infection have been reported, establishing the ability of mycoplasmas to induce chronic to permanent lung damage long after resolution of respiratory tract symptoms. Third, is known to induce a number of inflammatory mediators implicated in the pathogenesis of asthma. A number of important research questions need renewed attention to provide a better understanding of pathogenesis. These include the role of autoimmunity induction in a variety of mycoplasma syndromes, the existence and importance of an asymptomatic carrier state, and a much better understanding of the role of direct invasion in extrapulmonary syndromes.

Citation: Talkington D, Schwartz S, Besser R, Waites K. 2001. Emerging from Obscurity: Understanding Pulmonary and Extrapulmonary Syndromes, Pathogenesis, and Epidemiology of Human Infections, p 57-84. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 5. ASM Press, Washington, DC. doi: 10.1128/9781555816988.ch4

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Lower Respiratory Tract Infections
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Scanning electron micrograph of whole cells. Arrowheads indicate terminal structures (tip organelles). Reprinted from reference with permission.

Citation: Talkington D, Schwartz S, Besser R, Waites K. 2001. Emerging from Obscurity: Understanding Pulmonary and Extrapulmonary Syndromes, Pathogenesis, and Epidemiology of Human Infections, p 57-84. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 5. ASM Press, Washington, DC. doi: 10.1128/9781555816988.ch4
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1. Abramovitz, P.,, P. Schvartzman,, D. Harel,, I. Lis,, and Y. Naot. 1987. Direct invasion of the central nervous system by Mycoplasma pneumoniae: a report of two cases. J. Infect. Dis. 155:482487.
2. Ainsworth, J. G.,, V. Katseni,, S. Hourshid,, S. Waldron,, S. Ball,, V. Cattell,, and D. Taylor-Robinson. 1991. Mycoplasma fermentans and HIV-associated nephropathy. J. Infect. 29:323326.
3. Alexander, E. R.,, H. M. Foy,, G. E. Kenny,, R. A. Kronmal,, R. McMahan,, E. R. Clarke,, W. A. MacColl,, and J. T. Grayston. 1966. Pneumonia due to Mycoplasma pneumoniae: its incidence in the membership of a co-operative medical group. N. Engl. J. Med. 275:131136.
4. Ali, N. J.,, M. Sillis,, B. E. Andrews,, P. F. Jenkins,, and B. D. Harrison. 1986. The clinical spectrum and diagnosis of Mycoplasma pneumoniae infection. Q. J. Med. 58:241251.
5. Almagor, M.,, I. Kahane,, J. M. Wiesel,, and S. Yatsiv. 1984. Role of superoxide anion in host cell injury induced by Mycoplasma pneumoniae infection. A study in normal and trisomy 21 cells. J. Clin. Investig. 73:842847.
6. Al-Mateen, M.,, M. Gibbs,, R. Dietrich,, W. G. Mitchell,, and J. H. Menkes. 1988. Encephalitis lethargica-like illness in a girl with mycoplasma infection. Neurology 38:11551158.
7. Arav-Boger, R.,, A. Assia,, Z. Spirer,, Y. Bujanover,, and S. Reif. 1995. Cholestatic hepatitis as a main manifestation of Mycoplasma pneumoniae infection. J. Pediatr. Gastroenterol. Nutr. 21:459460.
8. Balassanian, N.,, and F. C. Robbins. 1967. Mycoplasma pneumoniae infection in families. N. Engl. J. Med. 277:719725.
9. Bar-Meir, E.,, H. Amital,, Y. Levy,, A. Kneller,, Y. Bar-Dayan,, and Y. Shoenfeld. 2000. Mycoplasma pneumoniae-induced thrombotic thrombocytopenic purpura. Acta Haematol. 103:112115.
10. Barret-Conner, E. 1972. Anemia and infection. Am. J. Med. 52:242253.
11. Baseman, J. B.,, R. M. Cole,, D. C. Krause,, and D. K. Leith. 1982. Molecular basis for cytadsorption of Mycoplasma pneumoniae. J. Bacteriol. 151:15141522.
12. Baseman, J. B.,, and J. G. Tully. 1997. Mycoplasmas: sophisticated, reemerging and burdened by their notoriety. Emerg. Infect. Dis. 3:2132.
13. Baseman, J. B.,, S. P. Reddy,, and S. F. Dallo. 1996. Interplay between mycoplasma surface proteins, airway cells, and the protean manifestations of mycoplasma-mediated human infections. Am. J. Respir. Crit. Care Med. 154:S137S144.
14. Baseman, J. B.,, J. Morrison-Plummer,, D. Drouillard,, V. V. Tryon,, and S. C. Holt. 1987. Identification of a 32 kDa protein of Mycoplasma pneumoniae associated with hemadsorption. Isr. J. Med. Sci. 23:474479.
15. Baseman, J. B., 1993. The cytadhesins of Mycoplasma pneumoniae and M. genitalium, p. 243259. In S. Rottem, and I. Kahane (ed.), Subcellular Biochemistry. Plenum Press, New York, N.Y.
16. Baseman, J. B.,, M. Lange,, N. L. Criscimagna,, J. A. Girón,, and C. A. Thomas. 1995. Interplay between mycoplasmas and host target cells. Microb. Pathog. 19:105116.
17. Bauer, F. A.,, D. J. Wear,, P. Angritt,, and S.-C. Lo. 1991. Mycoplasma fermentans (incognitus strain) infection in the kidneys of patients with acquired immunodeficiency syndrome and associated nephropathy: a light microscopic, immunohistochemical, and ultrastructural study. Hum. Pathol. 22:6369.
18. Behan, P. O.,, R. G. Feldman,, J. M. Segerra,, and L. T. Draper. 1986. Neurological aspects of mycoplasma infection. Acta Neurol. Scand. 74:314322.
19. Benisch, B. M.,, A. Fayemi,, M. A. Gerber,, and J. Axelrod. 1972. Mycoplasmal pneumonia in a patient with rheumatoid heart disease. Am. J. Clin. Pathol. 8:343348.
20. Berger, R. P.,, and R. M. Wadowksy. 2000. Rhabdomyolysis associated with infection by Mycoplasma pneumoniae: a case report. Pediatrics 105:433436.
21. Biberfeld, G.,, and G. Sterner. 1969. A study of Mycoplasma pneumoniae infections in families. Scand. J. Infect. Dis. 1:3946.
22. Broome, C. V.,, M. LaVenture,, H. S. Kaye,, A. T. Davis,, H. White,, B. D. Plikaytis,, and D. W. Fraser. 1980. An explosive outbreak of Mycoplasma pneumoniae infection in a summer camp. Pediatrics 66:884888.
23. Brouard, J.,, J. Petitjean,, F. Freymuth,, and J. F. Duhamel. 1989. Mycoplasma pneumoniae respiratory infection in a child with positive HIV1 serology. Arch. Fr. Pediatr. 46:155156.
24. Campbell, T. A.,, P. S. Strong,, and G. S. Grier. 1943. Primary atypical pneumoniae: two hundred cases at Ft. Eustin, Virginia. JAMA 122:723729.
25. Carstenson, H.,, and K.-O. Nilsson. 1986. Neurologic complications associated with Mycoplasma pneumoniae infection in children. Neuropediatrics 18:5758.
26. Cassell, G. H.,, and B. Cole. 1981. Mycoplasmas as agents of human disease. N. Engl. J. Med. 304:8089.
27. Cassell, G. H.,, J. Drnec,, K. B. Waites,, M. S. Pate,, L. B. Duffy,, H. L. Watson,, and J. C. McIntosh. 1991. Efficacy of clarithromycin against Mycoplasma pneumoniae. J. Antimicrob. Chemother. 27(Suppl. A):4759.
28. Cassell, G. H.,, W. A. Clyde,, and J. K. Davis,. 1985. Mycoplasma respiratory infections, p. 65106. In S. Razin, and M. F. Barile (ed.), The Mycoplasmas, vol. 4. Academic Press, New York, N.Y.
29.Centers for Disease Control and Prevention. 1993. Outbreaks of Mycoplasma pneumoniae respiratory infection—Ohio, Texas, and New York. Morb. Mortal. Wkly. Rep. 42:931,937-939.
30. Chan, E.,, and C. H. Welsh. Fulminant Mycoplasma pneumoniae pneumonia. 1995. West. J. Med. 162:133142.
31. Chanock, R. M.,, M. K. Cook,, H. H. Fox,, R. H. Parrott,, and B. J. Huebner. 1960. Serologic evidence of infection with Eaton agent in lower respiratory illness in childhood. N. Engl. J. Med. 262:648654.
32. Chanock, R. M.,, D. M. Rifkind,, H. M. Kravetz,, V. Knight,, and K. M. Johnson. 1961. Respiratory disease in volunteers infected with Eaton agent; a preliminary report. Proc. Natl. Acad. Sci. USA 47:887890.
33. Chanock, R. M.,, L. Hayflick,, and M. P. Barile. 1962. Growth on an artificial medium of an agent associated with atypical pneumonia and its identification as a PPLO. Proc. Natl. Acad. Sci. USA 48:4149.
34. Chanock, R. M.,, L. Dienes,, M. D. Eaton,, D. G. Edward,, E. A. Freundt,, L. Hayflick,, J. F. P. Hers,, K. E. Jensen,, C. Liu,, B. P. Marmion,, H. E. Morton,, M. A. Mufson,, P. F. Smith,, N. L. Somerson,, and D. Taylor-Robinson. 1963. Mycoplasma pneumoniae: proposed nomenclature for atypical pneumonia organism (Eaton agent). Science 140:662.
35. Chanock, R. M.,, M. A. Mufson,, N. L. Somerson,, and R. B. Couch. 1963. Role of mycoplasma (PPLO) in human respiratory disease. Am. Rev. Respir. Dis. 88(3):218231, 239.
36. Cherry, J. D.,, E. S. Hurwitz,, and R. C. Welliver. 1976. Mycoplasma pneumoniae infections and exanthems. J. Pediatr. 87:369373.
37. Cherry, J. D. 1993. Anemia and mucocutaneous lesions due to Mycoplasma pneumoniae infections. Clin. Infect. Dis. 17(Suppl. 1):S47S51.
38. Chu, H. W.,, M. Kraft,, J. E. Krause,, M. D. Rex,, and R. J. Martin. 2000. Substance P and its receptor neurokinin 1 expression in asthmatic airways. J. Allergy Clin. Immunol. 106:713722.
39. Clyde, W. A., 1979. Mycoplasma pneumoniae infections of man, p. 275306. In J. G. Tully, and R. F. Whitcomb (ed.), The Mycoplasmas, vol. 2. Academic Press, New York, N.Y.
40. Collier, A. M.,, and J. Baseman. 1973. Organ culture techniques with mycoplasmas. Ann. N. Y. Acad. Sci. 225:277289.
41. Cunningham, A. F.,, S. L. Johnston,, S. A. Julious,, F. C. Lampe,, and M. E. Ward. 1998. Chronic Chlamydia pneumoniae infection and asthma exacerbations in children. Eur. Respir. J. 11:345349.
42. Daian, C. M.,, A. H. Wolff,, and L. Bielory. 2000. The role of atypical organisms in asthma. Allergy Asthma Proc. 21:107111.
43. Dallo, S. F.,, A. L Lassell,, A. Chavoya,, S. P. Reddy,, and J. B. Baseman. 1996. Biofunctional domains of the Mycoplasma pneumoniae P30 adhesin. Infect. Immun. 64:25952601.
44. Dallo, S. F.,, J. R. Horton,, C. J. Su,, and J. B. Baseman. 1990. Restriction fragment length polymorphism in the cytadhesin P1 gene of human clinical isolates of Mycoplasma pneumoniae. Infect. Immun. 58:20172020.
45. Dallo, S. F.,, C. J. Su,, J. R. Horton,, and J. B. Baseman. 1988. Identification of P1 gene domain containing epitope(s) mediating Mycoplasma pneumoniae cytadherence. J. Exp. Med. 67:718723.
46. Dallo, S. F.,, and J. B. Baseman. 2000. Intracellular DNA replication and long-term survival of pathogenic mycoplasma. Microb. Pathog. 29:301309.
47. Davis, C. P.,, S. Cochran,, J. Lisse,, G. Buck,, A. R. DiNuzzo,, T. Weber,, and J. A. Reinarz. 1988. Isolation of Mycoplasma pneumoniae from synovial fluid samples in a patient with pneumonia and polyarthritis. Arch. Intern. Med. 148:969970.
48. Decaux, G.,, M. Szyper,, M. Ectors,, A. Cornil,, and L. Franken. 1980. Central nervous system complications of Mycoplasma pneumoniae. J. Neurol. Neurosurg. Psychiatry 43:883887.
49. De Vos, M.,, L. Nimmen,, and G. Baele. 1974. Disseminated intravascular coagulation during a fatal Mycoplasma pneumoniae infection. Acta Haematol. (Basel) 2:120125.
50. Dionisio, D.,, M. Valassina,, S. Mata,, R. Rossetti,, A. Vivarelli,, F. C. Esperti,, M. Benvenuti,, C. Catalani,, and M. Uberti. 1999. Encephalitis caused directly by Mycoplasma pneumoniae. Scand. J. Infect. Dis. 31:506509.
51. Dorigo-Zetsma, J. W.,, H. B. Wilbrink,, H. van der Nat,, A. I. M. Bartelds,, M. A. Heijnen,, and J. Dankert. 2001. Results of molecular detection of Mycoplasma pneumoniae among patients with acute respiratory infection and in their household contacts reveals children as human reservoirs. J. Infect. Dis. 183:675678.
52. Eaton, M. D.,, G. Meiklejohn,, and W. VanHerick. 1944. Studies on the etiology of primary atypical pneumonia: a filterable agent transmissible to cotton rats, hamsters, and chick embryos. J. Exp. Med. 79:649667.
53. Edward, D. G.,, and E. A. Freund. 1956. The classification and nomenclature of organisms of the pleuropneumonia group. J. Gen. Microbiol. 14:197207.
54. Edwards, E. A.,, Y. E. Crawford,, W. E. Pierce,, and R. O. Peckinpaugh. 1976. A longitudinal study of Mycoplasma pneumoniae: infections in navy recruits by isolation and seroepidemiology. Am. J. Epidemiol. 104:556562.
55. el-Khatib, M.,, and A. M. Lerner. 1975. Myocarditis in Mycoplasma pneumoniae pneumonia. Occurrence with hemolytic anemia and extraordinary titers of cold isohemagglutinins. JAMA 231:493494.
56. Farraj, R. S.,, R. B. McCully,, J. K. Oh,, and T. F. Smith. 1997. Mycoplasma-associated pericarditis. Mayo Clin. Proc. 72:3336.
57. Feder, H. M., Jr.,, T. Watkin,, S. R. Cole,, and R. Quintiliani. 1981. Severe meningoencephalitis complicating Mycoplasma pneumoniae infection in a child. Arch. Pathol. Lab. Med. 105:619621.
58. Feikin, D.,, A. Schuchat,, M. Kolczak,, N. L. Barrett,, L. H. Harrison,, L. Lefkowitz,, A. McGeer,, M. M. Farley,, D. J. Vugia,, C. Lexau,, K. R. Stefonek,, J. E. Patterson,, and J. H. Jorgensen. 2000. Mortality from invasive pneumococcal pneumonia in the era of antibiotic resistance, 1995-1997. Am. J. Pub. Health 90:223229.
59. Feikin, D. R.,, J. F. Moroney,, D. F. Talkington,, W. L. Thacker,, J. E. Code,, L. A. Schwartz,, D. D. Erdman,, J. C. Butler,, and M. S. Cetron. 1999. An outbreak of acute respiratory disease caused by Mycoplasma pneumoniae and adenovirus at a federal service training academy: new implications from an old scenario. Clin. Infect. Dis. 29:15451550.
60. Feizi, T. 1993. Carbohydrates and the pathogenesis of Mycoplasma pneumoniae infection with AIDS—some observations and speculations. Clin. Infect. Dis. 17(Suppl. 1):S63S65.
61. Fernandez, C. V.,, R. Bortolussi,, K. Gordon,, S. H. Lee,, J. G. Gatien,, and M. S. Shahdrabadi. 1993. Mycoplasma pneumoniae infection associated with central nervous system complications. J. Child Neurol. 8:2731.
62. Fisher, R. S.,, A. W. Clark,, J. S. Wolinsky,, I. M. Parhad,, H. Moses,, and M. R. Mardiney. 1983. Postinfectious leukoencephalitis complicating Mycoplasma pneumoniae infection. Arch. Neurol. 40:109113.
63. Fisher, B.,, B. Yu,, D. Armstrong,, and J. Magill. 1978. Outbreak of Mycoplasma pneumonia infection among hospital personnel. Am. J. Med. Sci. 276:205209.
64. Foy, H. M. 1993. Infections caused by Mycoplasma pneumoniae and possible carrier state in different populations of patients. Clin. Infect. Dis. 17(Suppl. 1):3746.
65. Foy, H. M.,, J. T. Grayston,, G. E. Kenny,, E. R. Alexander,, and R. McMahan. 1966. Epidemiology of Mycoplasma pneumoniae infection in families. JAMA 197:859866.
66. Foy, H. M.,, G. E. Kenny,, M. K. Cooney,, and I. D. Allan. 1979. Long-term epidemiology of infections with Mycoplasma pneumoniae. J. Infect. Dis. 139:681687.
67. Foy, H. M.,, G. E. Kenny,, R. McMahan,, G. Kaiser,, and J. T. Grayston. 1971. Mycoplasma pneumoniae in the community. Am. J. Epidemiol. 93:5567.
68. Foy, H. M.,, G. E. Kenny,, R. McMahan,, A. M. Mansy,, and J. T. Grayston. 1970. Mycoplasma pneumoniae pneumonia in an urban area. Five years of surveillance. JAMA 214:16661672.
69. Foy, H. M.,, C. M. Nolan,, and I. D. Allan. 1983. Epidemiologic aspects of M. pneumoniae disease complications: a review. Yale J. Biol. Med. 56:469473.
70. Foy, H. M.,, H. Ochs,, S. D. Davis,, G. E. Kenny,, and R. R. Luce. 1973. Mycoplasma pneumonia infections in patients with immunodeficiency syndromes: report of four cases. J. Infect. Dis. 127:388393.
71. Fraser, C. M.,, J. D. Gocayne,, O. White,, M. D. Adams,, R. A. Clayton,, R. D. Fleischmann,, C. J. Bult,, A. R. Kerlavage,, G. Sutton,, and J. M. Kelley. 1995. The minimal gene complement of Mycoplasma genitalium. Science 270:397403.
72. Gabridge, M. G.,, and L. E. Hoglund. 1981. Mycoplasma pneumoniae infection of intact guinea pig tracheas cultured in a unique matrix-embed / perfusion system. In Vitro 17:847858.
73. Gil, J. C.,, R. L. Cedillo,, B. G. Mayagoitia,, and M. D. Paz. 1993. Isolation of Mycoplasma pneumoniae from asthmatic patients. Ann. Allergy 70:2325.
74. Gillberg, C. 1980. Schizophreniform psychosis in a case of Mycoplasma pneumoniae encephalitis. J. Autism Dev. Disord. 10:153158.
75. Gorski, F.,, and W. Bredt. 1977. Studies on the adherence mechanism of Mycoplasma pneumoniae. FEMS Microbiol. Lett. 1:265267.
76. Goulet, M.,, R. Dular,, J. G. Tully,, G. Billowes,, and S. Kasatiya. 1995. Isolation of Mycoplasma pneumoniae from the human genital tract. J. Clin. Microbiol. 33:28232825.
77. Gray, G. C.,, J. D. Callahan,, A. W. Hawksworth,, C. A. Fisher,, and J. C. Gaydos. 1999. Respiratory diseases among U.S. military personnel: countering emerging threats. Emerg. Infect. Dis. 5:379385.
78. Gray, G. C.,, L. B. Duffy,, R. J. Paver,, S. D. Putnam,, R. J. Reynolds,, and G. H. Cassell. 1997. Mycoplasma pneumoniae: a frequent cause of pneumonia among UG.S. Marines in southern California. Mil. Med. 162:524526.
79. Gray, G. C.,, D. C. McPhate,, M. Leinonen,, G. H. Cassell,, E. P. Deperalta,, S. D. Putnam,, J. A. Karcher,, M. H. Sawyer,, A. Laurila,, and J. D. Connor. 1998. Weekly oral azithromycin as prophylaxis for agents causing acute respiratory disease. Clin. Infect. Dis. 26:103110.
80. Gray, G. C.,, B. S. Mitchell,, J. E. Tueller,, E. R. Cross,, and D. E. Amundson. 1994. Pneumonia hospitalizations in the US Navy and Marine Corps: rates and risk factors for 6,522 admissions, 1981-1991. Am. J. Epidemiol. 139:793802.
81. Grayston, J. T.,, E. R. Alexander,, G. E. Kenney,, E. R. Clarke. J. C. Frement, and W. A. MacColl. 1965. Mycoplasma pneumoniae infections. JAMA 191:369374.
82. Grayston, J. T.,, G. E. Kenny,, H. M. Foy,, R. A. Kronmal,, and E. R. Alexander. 1967. Epidemiological studies of Mycoplasma pneumoniae infections in civilians. Ann. N. Y. Acad. Sci. 143:436446.
83. Gücüyener, K.,, F. Simsek,, O. Yilmaz,, and A. Serdaroglu. 2000. Methyl-prednisolone in neurologic complications of Mycoplasma pneumonia. Ind. J. Pediatr. 67:467469.
84. Hauksdottir, G. S.,, T. Jonsson,, V. Sigurdardottir,, and A. Love. 1998. Seroepidemiology of Mycoplasma pneumoniae infections in Iceland 1987-96. Scand. J. Infect. Dis. 30:177180.
85. Hernandez, L. A.,, G. E. Urquhart,, and W. C. Dick. 1977. Mycoplasma pneumoniae infection and arthritis in man. Br. Med. J. ii:1416.
86. Higuchi, M. L.,, N. Sambiase,, S. Palermo,, P. Gutierrez,, L. M. Demarchi,, V. D. Aiello,, and J. A. Ramires. 2000. Detection of Mycoplasma pneumoniae and Chlamydia pneumoniae in ruptured atherosclerotic plaques. Braz. J. Med. Biol. Res. 33:10231026.
87. Himmelreich, R.,, H. Hilbert,, H. Plagens,, E. Pirkl,, B. C. Li,, and R. Herrmann. 1996. Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae. Nucleic Acids Res. 24:44204449.
88. Hu, P. C.,, A. M. Collier,, and J. B. Baseman. 1977. Surface parasitism by Mycoplasma pneumonia of respiratory epithelium. J. Exp. Med. 145:13281343.
89. Huhti, E.,, T. Mokka,, J. Nikoskelainen,, and P. Halonen. 1974. Association of viral and mycoplasma infections with exacerbations of asthma. Ann. Allergy 33:145149.
90. Hyde, T. B.,, M. Gilbert,, S. B. Schwartz,, E. R. Zell,, J. P. Watt,, W. L. Thacker,, D. F. Talkington,, and R. E. Besser. 2001. Azithromycin prophylaxis during a hospital outbreak of Mycoplasma pneumoniae pneumonia. J. Infect. Dis. 183:907912.
91. Ieven, M.,, H. Demey,, D. Ursi,, G. Van Goethem,, P. Cras,, and H. Goossens. 1998. Fatal encephalitis caused by Mycoplasma pneumoniae diagnosed by the polymerase chain reaction. Clin. Infect. Dis. 27:15521553.
92. Inamine, J. M.,, K. C. Ho,, S. Loechel,, and P. C. Hu. 1990. Evidence that UGA is read as a tryptophan codon rather than as a stop codon by Mycoplasma pneumoniae, Mycoplasma genitalium, and Mycoplasma gallisepticum. J. Bacteriol. 172:504506.
93.Ito, S, Y. Abe, K. Kinomoto, T. Saitoh, T. Kato, Y. Kohli, M. Kuriyama, T. Sakai, and T. Ishizaki. 1995. Fulminant Mycoplasma pneumoniae pneumonia with marked elevation of serum soluble interleukin-2 receptor. Intern. Med. 34:430435.
94. Jacobs, E. 1991. Mycoplasma pneumoniae virulence factors and the immune response. Rev. Med. Microbiol. 2:8390.
95. Jansson, E.,, A. Backman,, K. Hakkarainen,, A. Miettinen,, and B. Seniusova. 1983. Mycoplasmas and arthritis. Z. Rheumatol. 42:315319.
96. Jensen, J. S.,, C. Heilmann,, and N. H. Valeruis. 1994. Mycoplasma pneumoniae infection in a child with AIDS. Clin. Infect. Dis. 19:207.
97. Jensen, K. J.,, L. B. Senterfit,, W. E. Scully,, T. J. Conway,, R. F. West,, and W. W. Drummy. 1967. Mycoplasma pneumoniae infections in children. An epidemiologic appraisal in families treated with oxytetracycline. Am. J. Epidemiol. 86:419432.
98. Kanayama, Y.,, K. Shiota,, K. Kotumi,, Y. Ikuno,, R. Yasumoto,, M. Ishii,, and T. Inoue. 1982. Mycoplasma pneumoniae pneumonia associated with IgA nephropathy. Scand. J. Infect. Dis. 14:231233.
99. Karjalainen, J. 1990. A loud third heart sound and asymptomatic myocarditis during Mycoplasma pneumoniae infection. Eur. Heart J. 11:960963.
100. Kashiwagi, S.,, J. Hayashi,, H. Nomura,, W. Kajiyama,, H. Ikematsu,, T. Shingu,, K. Hayashida,, and M. Kaji. 1985. An outbreak of Mycoplasma pneumoniae infections in a hospital in Japan. Kurume Med. J. 32:293296.
101. Kaufman, J. M.,, C. A. Cuvelier,, and M. Van der Staeten. 1980. Mycoplasma pneumonia with fulminant evolution into interstitial fibrosis. Thorax 35:140144.
102. Kenney, R. T.,, J. S. Li,, W. A. ClydeJr.,, T. C. Wall,, C. M. O’Connor,, P. T. Campbell,, P. Van Trigt,, and G. R. Corey. 1993. Mycoplasmal pericarditis: evidence of invasive disease. Clin. Infect. Dis. 17(Suppl. 1):S58S62.
103. Klausner, J. D.,, D. Passaro,, J. Rosenberg,, W. L. Thacker,, D. F. Talkington,, S. B. Werner,, and D. J. Vugia. 1998. Enhanced control of an outbreak of Mycoplasma pneumoniae pneumonia with azithromycin prophylaxis. J. Infect. Dis. 177:161166.
104. Kleemola, M.,, and C. Jokinen. 1992. Outbreak of Mycoplasma pneumoniae infection among hospital personnel studied by a nucleic acid hybridization test. J. Hosp. Infect. 21:213221.
105. Kleemola, M.,, and H. Kayhty. 1982. Increase in titers of antibodies to Mycoplasma pneumonia in patients with purulent meningitis. J. Infect. Dis. 146:284288.
106. Koletsky, R. J.,, and A. J. Weinstein. 1980. Fulminant Mycoplasma pneumoniae infection. Report of a fatal case, and a review of the literature. Am. Rev. Respir. Dis. 122:491496.
107. Koskiniemi, M. L. 1993. CNS manifestations associated with Mycoplasma pneumoniae infections: summary of cases at the University of Helsinki and a review. Clin. Infect. Dis. 17(Suppl.):S52S57.
108. Kraft, M.,, G. H. Cassell,, J. E. Henson,, H. Watson,, J. Williamson,, B. P. Marmion,, C. A. Gaydos,, and R. J. Martin. 1998. Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma. Am. J. Respir. Crit. Care Med. 158:9981001.
109. Krause, D. C. 1996. Mycoplasma pneumoniae cytadherence: unraveling the tie that binds. Mol. Microbiol. 20:247253.
110. Krause, D. C.,, and J. B. Baseman. 1982. Mycoplasma pneumoniae proteins which selectively bind to host cells. Infect. Immun. 37:382386.
111. Krause, D. C.,, D. K. Leith,, and J. B. Baseman. 1983. Reacquisition of specific proteins confers virulence in Mycoplasma pneumoniae. Infect. Immun. 39:830836.
112. Krause, D. C.,, and D. Taylor-Robinson,. 1992. Mycoplasmas which infect humans, p. 417444. In J. Maniloff,, R. N. McElhaney,, L. R. Finch,, and J. B. Baseman (ed.), Mycoplasmas: Molecular Biology and Pathogenesis. American Society for Microbiology, Washington, D.C.
113. Krivan, H. C.,, L. D. Olsen,, M. F. Barile,, V. Ginsburg,, and D. D. Roberts. 1989. Adhesion of Mycoplasma pneumoniae to sulfated glycolipids and inhibition by dextran sulfate. J. Biol. Chem. 264:92829288.
114. Lambert, H. P. 1969. Infections caused by Mycoplasma pneumoniae. Br. J. Dis. Chest 63:7182.
115. Lambert, H. P. 1968. Syndrome with joint manifestations in association with Mycoplasma pneumonia infection. Br. Med. J. iii:156157.
116. Launes, J.,, A. Paetau,, K. Linnavuori,, and M. Iivanainen. 1997. Direct invasion of the brain parenchyma by Mycoplasma pneumoniae. Acta Neurol. Scand. 95:374.
117. Leibowitz, Z.,, P. Schvartzman,, L. Epstein,, I. Lis,, and Y. Naot. 1988. An outbreak of Mycoplasma pneumoniae pneumonia in two kibbutzim: a clinical and epidemiologic study. Isr. J. Med. Sci. 24:8892.
118. Levine, D. P.,, and A. M. Lerner. 1978. The clinical spectrum of Mycoplasma pneumoniae infections. Med. Clin. N. Am. 62:961978.
119. Levy, M.,, and N. H. Shear. 1991. Mycoplasma pneumoniae infections and Stevens-Johnson syndrome. Report of eight cases and review of the literature. Clin. Pediatr. 30:4249.
120. Libre, J. M.,, A. Urban,, E. Gacia,, M. A. Carrasco,, and C. Murcia. 1997. Bronchiolitis obliterans organizing pneumonia associated with acute Mycoplasma pneumoniae infection. Clin. Infect. Dis. 25:13401342.
121. Lind, K.,, and M. W. Bentzon. 1976. Epidemics of Mycoplasma pneumoniae infection in Denmark from 1958 to 1974. Int. J. Epidemiol. 5:267277.
122. Lind, K.,, M. W. Benzon,, J. S. Jensen,, and W. A. Clyde, Jr. 1997. A seroepidemiological study of Mycoplasma pneumoniae infections in Denmark over the 50-year period 1946-1995. Eur. J. Epidemiol. 13:581586.
123. Linz, D.,, S. Kessler,, and J. Kane. 1983. Pulmonary caseating granulomas associated with Mycoplasma pneumoniae pneumonia. South. Med. J. 76:14291432.
124. Liu, C.,, M. D. Eaton,, and J. T. Heyl. 1957. Studies on atypical pneumonia. II. Observations concerning the development and immunological characteristics of antibody in patients. J. Exp. Med. 109:545.
125. Lucier, T. S.,, K. Heitzman,, S. K. Liu,, and P. C. Hu. 1995. Transition mutations in the 23S rRNA of erythromycin-resistant isolates of Mycoplasma pneumoniae. Antimicrob. Agents Chemother. 39:27702773.
126. Macfarlane, J. 1980. Mycoplasma pneumoniae infection, antibiotics and exanthema. Infection. 8:119120.
127. Maniloff, J., 1992. Phylogeny of mycoplasmas, p. 549559. In J. Maniloff,, R. N. McElhaney,, L. R. Finch,, and J. B. Baseman (ed.), Mycoplasmas: Molecular Biology and Pathogenesis. American Society for Microbiology, Washington, D.C.
128. Marc, E.,, M. Chaussain,, F. Moulin,, J. L. Iniguez,, G. Kalifa,, J. Raymond,, and D. Gendrel. 2000. Reduced lung diffusion capacity after Mycoplasma pneumoniae pneumonia. Pediatr. Infect. Dis. J. 19:706710.
129. Marmion, B. P.,, and G. M. Goodburn. 1961. Effect of an inorganic gold salt on Eaton’s primary atypical pneumonia agent and other observations. Nature 189:247248.
130. Marrie, T. J. 1993. Mycoplasma pneumoniae pneumonia requiring hospitalization with emphasis on infection in the elderly. Arch. Intern. Med. 153:488494.
131. Marston, B. J.,, J. F. Plouffe,, T. M. File,, B. A. Hackman,, S. J. Salstrom,, H. B. Lipman,, M. S. Kolczak,, and R. F. Breiman. 1997. Incidence of community-acquired pneumonia requiring hospitalization. Results of a population-based active surveillance study in Ohio. Arch. Intern. Med. 157:17091718.
132. Meseguer, M. A.,, J. A. Perez-Molina,, J. Fernandez-Bustamante,, R. Gomez,, I. Martos,, and M. C. Quero. 1996. Mycoplasma pneumoniae pericarditis and cardiac tamponade in a ten-year-old girl. Pediatr. Infect. Dis. J. 15:829831.
133. Micillo, E.,, A. Bianco,, D. D’Auria,, G. Mazzarella,, and G. F. Abbate. 2000. Respiratory infections and asthma. Allergy 55(Suppl. 61):4245.
134. Milla, E.,, L. Zografos,, and B. Piguet. 1998. Bilateral optic papillitis following Mycoplasma pneumoniae pneumonia. Ophthalmologica 212:344346.
135. Mogabgab, W. J. 1968. Mycoplasma pneumoniae and adenovirus respiratory illnesses in military and university personnel, 1959-1966. Am. Rev. Respir. Dis. 97:3450000.
136. Mok, J. Y.,, P. R. Waugh,, and H. Simpson. 1979. Mycoplasma pneumoniae infection. A follow-up study of 50 children with respiratory illness. Arch. Dis. Child. 54:506511.
137. Mok, J. Y. Q.,, J. M. Inglis,, and H. Simpson. 1979. Mycoplasma pneumoniae infection: a retrospective review of 103 hospitalised children. Acta Paediatr. Scand. 68:833839.
138. Monto, A. S.,, E. R. Bryan,, and L. M. Rhodes. 1974. The Tecumseh study of respiratory illness. VII. Further observations on the occurrence of respiratory syncytial virus and Mycoplasma pneumonia infections. Am. J. Epidemiol. 100:458468.
139. Monto, A. S.,, and S. K. Lim. 1971. The Tecumseh study of respiratory illness. III. Incidence and periodicity of respiratory syncytial virus and Mycoplasma pneumoniae infections. Am. J. Epidemiol. 94:290301.
140. Morrison-Plummer, J.,, D. K. Leith,, and J. B. Baseman. 1986. Biological effects of anti-lipid and anti-protein monoclonal antibodies on Mycoplasma pneumoniae. Infect. Immun. 53:398403.
141. Muldoon, R. L.,, J. Raucci,, J. Kowalski,, and K. Rajashekaraiah. 1982. An outbreak of Mycoplasma pneumoniae respiratory illness in a semi-closed religious commune. Ann. Emerg. Med. 11:613615.
142. Murray, H. W.,, H. Masur,, L. B. Setnerfit,, and R. B. Roberts. 1975. The protean manifestations of Mycoplasma pneumoniae. Am. J. Med. 58:229242.
143. Nagayama, Y.,, N. Sakurai,, and K. Yamamoto. 1990. Clinical observations of children with pleuropneumonia due to Mycoplasma pneumoniae. Pediatr. Pulmonol. 8:182187.
144. Naraqi, S.,, and S. A. Kabins. 1973. Mycoplasma pneumoniae monoarticular arthritis. J. Pediatr. 83:621623.
145. Narita, M.,, Y. Matsuzono,, T. Togashi,, and N. Kajii. 1992. DNA diagnosis of central nervous system infection by Mycoplasma pneumoniae. Pediatrics 90:250253.
146. Nelson, H. S. 1998. Allergen and irritant control: importance and implementation. Clin. Cornerstone 1:5768.
147. Nishimura, M.,, T. Saida,, S. Kuroki,, T. Kawabata,, H. Obayashi,, K. Saida,, and T. Uchiyama. 1996. Post-infectious encephalitis with anti-galactocerebroside antibody subsequent to Mycoplasma pneumoniae infection. J. Neurol. Sci. 140:9195.
148. Noah, N. D. 1976. Epidemiology of Mycoplasma pneumoniae infection in the United Kingdom: an analysis of reports to the Public Health Laboratory Service of England and Wales. Infection 4(Suppl. 1):2528.
149. Nocard, E.,, and E. R. Roux. 1898. Le microbe de la peripneumonie. Ann. Inst. Pasteur Paris 12:240262.
150. Opitz, O.,, K. Pietsch,, S. Ehlers,, and E. Jacobs. 1996/1997. Cytokine gene expression in immune mice reinfected with Mycoplasma pneumoniae: the role of T cell subsets in aggravating the inflammatory response. Immunobiology 196:575587.
151. Pasternack, A.,, H. Helin,, T. Vanttinen,, G. Jarventie,, and T. Vesikari. 1979. Acute tubulointerstitial nephritis in a patient with Mycoplasma pneumoniae infection. Scand. J. Infect. Dis. 11:8587.
152. Pellegrini, M.,, T. J. O’Brien,, J. Hoy,, and L. Sedal. 1996. Mycoplasma pneumoniae infection associated with an acute brainstem syndrome. Acta Neurol. Scand. 93:203206.
153. Poggio, T. V.,, N. Orlando,, L. Galanternik,, and S. Grinstein. 1998. Microbiology of acute arthropathies among children in Argentina: Mycoplasma pneumoniae and hominis and Ureaplasma urealyticum. Pediatr. Infect. Dis. J. 17:304308.
154. Pönkä, A. 1978. Clinical and laboratory manifestations in patients with serological evidence of Mycoplasma pneumoniae infection. Scand. J. Infect. Dis. 10:271275.
155. Pönkä, A. 1979. Carditis associated with Mycoplasma pneumoniae infection. Acta Med. Scand. 206:7786.
156. Pönkä, A. 1979. Arthritis associated with Mycoplasma pneumoniae infection. Scand. J. Rheumatol. 8:2732.
157. Pönkä, A. 1979. The occurrence and clinical picture of serologically verified Mycoplasma pneumonia infections with emphasis on central nervous system, cardiac, and joint manifestations. Ann. Clin. Res. 11(Suppl. 24):160.
158. Pönkä, A. 1980. Central nervous system manifestations associated with serologically verified Mycoplasma pneumoniae infection. Scand. J. Infect. Dis.12:175184.
159. Powell, D. A.,, and W. A. Clyde. 1975. Opsonin-reversible resistance of Mycoplasma pneumonia to in vitro phagocytosis by alveolar macrophages. Infect. Immun. 11:540550.
160. Radisic, M.,, A. Torn,, P. Gutierrez,, H. Defranchi,, and P. Pardo. 2000. Severe acute lung injury caused by Mycoplasma pneumoniae: potential role for steroid pulses in treatment. Clin. Infect. Dis. 31:15071511.
161. Rawadi, G.,, and S. Roman-Roman. 1996. Mycoplasma membrane lipoproteins induce proinflammatory cytokines by a mechanism distinct from that of lipopolysaccharide. Infect. Immun. 64:637643.
162. Razin, S., 1992. Mycoplasma taxonomy and ecology, p. 322. In J. Maniloff,, R. N. McElhaney,, L. R. Finch,, and J. B. Baseman (ed.), Mycoplasmas: Molecular Biology and Pathogenesis. American Society for Microbiology, Washington, D.C.
163. Roberts, D. D.,, L. D. Olsen,, M. F. Barile,, V. Ginsburg,, and H. C. Krivan. 1989. Sialic aciddependent adhesion of Mycoplasma pneumoniae to purified glycoproteins. J. Biol. Chem. 264:92899293.
164. Roifman, C. M.,, C. P. Rao,, H. M. Lederman,, S. Lavi,, P. Quinn,, and E. W. Gelfand. 1986. Increased susceptibility to mycoplasma infection in patients with hypogammaglobulinemia. Am. J. Med. 80:590594.
165. Root-Bernstein, R. S.,, and S. H. Hobbs. 1991. Homologies between mycoplasma adhesion peptide, CD4 and class II MHC proteins: a possible mechanism for HIV-mycoplasma synergism in AIDS. Res. Immunol. 142:519523.
166. Rossi, O. V.,, V. L. Kinnula,, H. Tuokko,, and E. Huhti. 1994. Respiratory viral and mycoplasma infections in patients hospitalized for acute asthma. Monaldi Arch. Chest Dis. 49:107111.
167. Rudd, K. E. 2000. EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res. 28:6064.
168. Sabato, A. R.,, A. J. Martin,, B. P Marmion,, T. W. Kok,, and D. M. Cooper. 1984. Mycoplasma pneumoniae: acute illness, antibiotics, and subsequent pulmonary function. Arch. Dis. Child. 59:10341037.
169. Said, M. H.,, M. P. Layani,, S. Colon,, G. Faraj,, C. Glastre,, and P. Cochat. 1999. Mycoplasma pneumoniae-associated nephritis in children. Pediatr. Nephrol. 13:3944.
170. Salzman, M. B.,, S. K. Sood,, M. L. Slavin,, and L. G. Rubin. 1992. Ocular manifestations of Mycoplasma pneumoniae infection. Clin. Infect. Dis. 14:11371139.
171. Samuelsson, T.,, and T. Borin,. 1992. Evolution of macromolecule synthesis, p. 584585. In J. Maniloff,, R. N. McElhaney,, L. R. Finch,, and J. B. Baseman (ed.), Mycoplasmas: Molecular Biology and Pathogenesis. American Society for Microbiology, Washington, D.C.
172. Sands, M. J., Jr.,, and R. Rosenthal. 1982. Progressive heart failure and death associated with Mycoplasma pneumoniae pneumonia. Chest 81:763765.
173. Schulman, P.,, T. C. Piemonte,, and B. Singh. 1980. Acute renal failure, hemolytic anemia, and Mycoplasma pneumoniae. JAMA 244:18231824.
174. Scully, R. E.,, E. J. Mark,, W. F. McNeely,, and B. U. McNeely. 1992. Case records of the Massachusetts General Hospital, case 5-1992. N. Engl. J. Med. 326:324336.
175. Seggev, J. S.,, G. V. Sedmak,, and V. P. Kurup. 1996. Isotype-specific antibody responses to acute Mycoplasma pneumoniae infection. Ann. Allergy Asthma Immunol. 77:6773.
176. Seggev, J. S.,, I. Lis,, R. Siman-Tov,, R. Gutman,, H. Abu-Samara,, G. Schey,, and Y. Naot. 1986. Mycoplasma pneumoniae is a frequent cause of exacerbation of bronchial asthma in adults. Ann. Allergy 57:263265.
177. Sequeira, W.,, E. Jones,, and D. M. Bronson. 1981. Mycoplasma pneumoniae infection with arthritis and a varicella-like eruption. JAMA 246:19361937.
178. Shimuzu, T.,, H. Mochizuki,, M. Kato,, M. Shigeta,, A. Morikawa,, and T. Hori. 1991. Immunoglobulin levels, number of eosinophils in the peripheral blood and bronchial hypersensitivity in children with Mycoplasma pneumoniae pneumonia. Jpn. J. Allergol. 40:2127.
179. Shulman, S. T.,, J. Bartlett,, W. A. Clyde, Jr.,, and E. M. Ayoub. 1972. The unusual severity of mycoplasmal pneumonia in children with sickle cell disease. N. Engl. J. Med. 287:164167.
180. Simonian, N.,, and D. Janner. 1998. Pleural effusion, hepatitis and hemolytic anemia in a twelve-year-old male child. Pediatr. Infect. Dis. J. 17:17374176177.
181. Smith, R.,, and L. Eviatar. 2000. Neurologic manifestations of Mycoplasma pneumoniae infections: diverse spectrum of diseases. A report of six cases and review of the literature. Clin. Pediatr. (Philadelphia) 39:195201.
182. Somerson, N. L.,, B. E. Walls,, and R. M. Chanock. 1965. Hemolysin of Mycoplasma pneumoniae: tentative identification as a peroxide. Science 150:226228.
183. Stallman, N. D.,, B. C. Allan,, and M. A. Wiemers. 1976. Infection with Mycoplasma pneumoniae: clinical and serological data on 286 patients. Med. J. Aust. 1:340343.
184. Stephan, J. L.,, C. Galambrun,, B. Pozzetto,, F. Grattard,, and P. Bordigoni. 1999. Aplastic anemia after Mycoplasma pneumoniae infection: a report of two cases. J. Pediatr. Hematol. Oncol. 21:299302.
185. Sterner, G.,, G. de Hevesy,, G. Tunevall,, and S. Wolontis. 1966. Acute respiratory illness with Mycoplasma pneumoniae. An outbreak in a home for children. Acta Paediatr. Scand. 55:280286.
186. Stevens, D.,, P. G. Swift,, P. G. Johnston,, P. J. Kearney,, B. D. Corner,, and D. Burman. 1978. Mycoplasma pneumoniae infections in children. Arch. Dis. Child. 53:3842.
187. Stopler, T.,, C. B. Gerichter,, and D. Branski. 1980. Antibiotic-resistant mutants of Mycoplasma pneumoniae. Isr. J. Med. Sci.16:169173.
188. Su, C. J.,, A. Chavoya,, S. F. Dallo,, and J. B. Baseman. 1990. Sequence divergency of the cytadhesin gene of Mycoplasma pneumoniae. Infect. Immun. 58:26692674.
189. Su, C. J.,, S. F. Dallo,, and J. B. Baseman. 1993. Possible origin of sequence divergence in the P1 cytadhesin gene of Mycoplasma pneumoniae. Infect. Immun. 61:816822.
190. Talkington, D. F.,, W. L. Thacker,, D. W. Keller,, and J. S. Jensen. 1998. Diagnosis of Mycoplasma pneumoniae infection in autopsy and open-lung biopsy tissues by nested PCR. J. Clin. Microbiol. 36:11511153.
191. Tanaka, H.,, S. Houma,, Y. Abe,, and H. Tamura. 1996. Effects of interleukin-2 and cyclosporine A on pathologic features in Mycoplasma pneumonia. Am. J. Respir. Crit. Care Med. 154:19081912.
192. Taylor-Robinson, D. 1981. Mycoplasmal arthritis in man. Isr. J. Med. Sci. 17:616621.
193. Taylor-Robinson, D.,, and C. Bébéar. 1997. Antibiotic susceptibilities of mycoplasmas and mycoplasmal infections. J. Antimicrob. Chemother. 40:622630.
194. Taylor-Robinson, D.,, J. M. Gumpel,, A. Hill,, and A. J. Swannell. 1978. Isolation of Mycoplasma pneumoniae from the synovial fluid of a hypogammaglobulinaemic patient in a survey of patients with inflammatory polyarthritis. Ann. Rheumatic Dis. 37:180182.
195. Thomas, N. H.,, J. E. Collins,, S. A. Robb,, and R. O. Robinson. 1993. Mycoplasma pneumonia infection and neurological disease. Arch. Dis. Child. 69:573576.
196. Tipirneni, P.,, B. S. Moore,, J. S. Hyde,, and V. Schauf. 1980. IgE antibodies to Mycoplasma pneumoniae in asthma and other atopic diseases. Ann. Allergy 45:17.
197. Tjhie, J. H.,, E. M. van de Putte,, K. Haasnoot,, A. J. van den Brule,, and C. M. Vandenbroucke-Grauls. 1997. Fatal encephalitis caused by Mycoplasma pneumoniae in a 9-year-old girl. Scand. J. Infect. Dis. 29:424425.
198. Tryon, V. V.,, and J. B. Baseman. 1987. The acquisition of human lactoferrin by Mycoplasma pneumoniae. Microb. Pathog. 3:437443.
199. Tryon, V. V.,, and J. B. Baseman,. 1992. Pathogenic determinants and mechanisms, p. 457471. In J. Maniloff,, J. McElhaney,, L. R. Finch,, and J. B. Baseman (ed.), Mycoplasmas: Molecular Biology and Pathogenesis. American Society for Microbiology, Washington, D.C.
200. Tully, J. G.,, D. L. Rose,, R. F. Whitcomb,, and R. P. Wenzel. 1979. Enhanced isolation of Mycoplasma pneumoniae from throat washings with a newly modified culture medium. J. Infect. Dis. 139:478482.
201. Turtzo, D. F.,, and P. K. Ghatak. 1976. Acute hemolytic anemia with Mycoplasma pneumonia pneumonia. JAMA 236:11401141.
202. Van Bever, H. P.,, J. W. Van Doorn,, and H. E. Demey. 1992. Adult respiratory distress syndrome associated with Mycoplasma pneumoniae infection. Eur. J. Pediatr. 151:227228.
203. Vitullo, B. B.,, S. O’Regan,, J. P. de Chadarevian,, and B. S. Kaplan. 1978. Mycoplasma pneumonia associated with acute glomerulonephritis. Nephron 21:284288.
204. Von Bonsdorff, M.,, A. Ponka,, and T. Tornroth. 1984. Mycoplasmal pneumonia associated with mesangiocapillary glomerulonephritis type II (dense deposit disease). Acta Med. Scand. 216:427429.
205. Waites, K. B.,, C. M. Bébéar,, J. A. Robertson,, D. F. Talkington,, and G. E. Kenney. 2001. Cumitech 34, Laboratory Diagnosis of Mycoplasmal Infections. Coordinating ed., F. S. Nolte. American Society for Microbiology, Washington, D.C.
206. Weinstein, M. P.,, and C. B. Hall. 1974. Mycoplasma pneumoniae infection associated with migratory polyarthritis. Am. J. Dis. Child. 127:125126.
207. Whyte, K. F.,, and G. R. Williams. 1984. Bronchiectasis after mycoplasma pneumonia. Thorax 39:390391.
208. Wongtim, S.,, and S. Mogmued. 1995. Methacholine inhalation challenge in patients with post-Mycoplasma pneumoniae pneumonia. Asian Pac. J. Allergy Immunol. 13:510.
209. Yano, T.,, Y. Ichikawa,, S. Komatu,, S. Arai,, and K. Oizumi. 1994. Association of Mycoplasma pneumoniae antigen with initial onset of bronchial asthma. Am. J. Respir. Crit. Care Med. 149:13481353.
210. Yin, D.,, and B. Yin. 1998. Influence of Mycoplasma pulmonis infection on immunologic function in patients with chronic obstructive pulmonary disease. Hunan I Ko Ta Hsueh Hsueh Pao 23:479482.


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Table 1

Members of genus known to colonize or infect humans

Citation: Talkington D, Schwartz S, Besser R, Waites K. 2001. Emerging from Obscurity: Understanding Pulmonary and Extrapulmonary Syndromes, Pathogenesis, and Epidemiology of Human Infections, p 57-84. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 5. ASM Press, Washington, DC. doi: 10.1128/9781555816988.ch4

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