Chapter 41 : and Other Uncommon Members of the Complex

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The species along with other organisms together form the so- called complex, with important differences among these organisms in epidemiology, microbiology, and even therapy. Human disease caused by is indistinguishable clinically or pathologically from the disease caused by . In the last decades, DNA probes became the most common molecular-based tool for identification of pathogenic mycobacterial isolates. The current recommended regimen for the treatment of tuberculosis includes the use of isoniazid, rifampin, and pyrazinamide for 2 months, followed by isoniazid and rifampin for 4 months. The bacille Calmette-Guérin (BCG) strain of is a laboratory-obtained attenuated strain described by Albert Calmette and Camille Guérin in 1922. is a species from the complex that includes strains which share phenotypic characteristics with and . Strains of this species have been isolated in sub- Saharan African countries, where it is the cause of human tuberculosis with variable percentages. However, in developed countries, isolation is uncommon and is associated with immigrant patients from Africa; such patients can infect immigrants from other countries and even autochthonous patients. Disease caused by is identical to that caused by . There are reports which evaluate both diseases: one of them showed no differences between the two species, except for less clustering of cases than cases, and the appearance of lower lobe lung disease less frequently in cases.

Citation: Esteban J, Alonso-Rodríguez N. 2011. and Other Uncommon Members of the Complex, p 607-617. In Schlossberg D (ed), Tuberculosis and Nontuberculous Mycobacterial Infections, Sixth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817138.ch41

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Restriction Fragment Length Polymorphism
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Image of Figure 1.
Figure 1.

Spoligotyping pattern of . Spacers in the DR locus are indicated by the numbers 1 to 43.

Citation: Esteban J, Alonso-Rodríguez N. 2011. and Other Uncommon Members of the Complex, p 607-617. In Schlossberg D (ed), Tuberculosis and Nontuberculous Mycobacterial Infections, Sixth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817138.ch41
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Image of Figure 2.
Figure 2.

Nuclear magnetic resonance of vertebral tuberculosis due to .

Citation: Esteban J, Alonso-Rodríguez N. 2011. and Other Uncommon Members of the Complex, p 607-617. In Schlossberg D (ed), Tuberculosis and Nontuberculous Mycobacterial Infections, Sixth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817138.ch41
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Image of Figure 3.
Figure 3.

Microcolonies of in Middlebrook 7H11 after 1 week of incubation at 37°C. Magnification, ×10.

Citation: Esteban J, Alonso-Rodríguez N. 2011. and Other Uncommon Members of the Complex, p 607-617. In Schlossberg D (ed), Tuberculosis and Nontuberculous Mycobacterial Infections, Sixth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817138.ch41
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Table 1.

Members of the complex

Citation: Esteban J, Alonso-Rodríguez N. 2011. and Other Uncommon Members of the Complex, p 607-617. In Schlossberg D (ed), Tuberculosis and Nontuberculous Mycobacterial Infections, Sixth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817138.ch41

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