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Chapter 10 : Mucosal Immunity to

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Abstract:

Prior to the human immunodeficiency virus (HIV) epidemic, host defense against at mucosal sites was largely considered one-dimensional. This chapter is divided into in-depth reviews of host defense mechanisms against oral, vaginal, and Gastrointestinal (GI) candidiasis, with emphasis on the uniqueness of the responses at each site. Then it has a short discussion of the emerging role of mucosal biofilms in pathogenesis and host defense. The chapter concludes with suggested future directions for the field of mucosal immunity and candidiasis. Oropharyngeal candidiasis (OPC) encompasses infections of the hard and soft palate, tongue, buccal mucosa, and floor of the mouth and can present as reddened patches (erythematous) or white curdlike lesions (pseudomembranous). Interestingly, highly active antiretroviral therapy (HAART) has reduced the incidence of OPC. Polymorphonuclear cells (PMNs) are considered to play a role in innate defenses against OPC because neutropenic cancer patients are susceptible to disease. Another form of oral candidiasis is -associated denture stomatitis (DS). is the most common cause of DS and can readily form biofilms on denture material. The most recent data on host defense against GI candidiasis involve understanding the role of dendritic cells (DCs) in directing both local and systemic adaptive immunity. Vulvovaginal candidiasis (VVC) affects a significant number of women, predominantly in their reproductive years.

Citation: Fidel, Jr. P, Noverr M. 2012. Mucosal Immunity to , p 137-154. In Calderone R, Clancy C (ed), and Candidiasis, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817176.ch10

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