Chapter 20 : DNA Polymorphisms and Their Relevance for Infections with Human Cytomegalovirus and

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The fungal pathogen and the human cytomegalovirus (HCMV) represent a great challenge for immuno suppressed patients. This chapter summarizes our current knowledge about the increasing number of genetic markers influencing the pathobiology of and susceptibility to and HCMV. Further complications that arise after exposure to include allergic bronchopulmonary aspergillosis (ABPA) with hypersensitivity reactions that often occur in immunocompetent hosts with asthma or cystic fibrosis. The promoter of IL-10 contains several polymorphisms from which SNPs at positions -1082, -819, and -592 have been intensively investigated. HCMV is one of the most demanding complications after allo-SCT. The highest risk for patients after transplantation exists when stem cells from an HCMV-negative donor are transferred into an HCMV-positive recipient. Researchers found no significant association between 71 of 80 markers and the occurrence of HCMV reactivation or disease in patients after allo-SCT. Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) is an important negative regulator of T-cell activation. The hope for early identification of patients at risk for and/or HCMV infection is legitimate and might have an impact on individualization of antifungal and antiviral prophylaxis and treatment in the near future.

Citation: Mezger M, Einsele H, Loeffler J. 2012. DNA Polymorphisms and Their Relevance for Infections with Human Cytomegalovirus and , p 345-357. In Hacker J, Dobrindt U, Kurth R (ed), Genome Plasticity and Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817213.ch20

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Generic image for table

Association between defined genetic polymorphisms and an increased risk to suffer from diseases with

Citation: Mezger M, Einsele H, Loeffler J. 2012. DNA Polymorphisms and Their Relevance for Infections with Human Cytomegalovirus and , p 345-357. In Hacker J, Dobrindt U, Kurth R (ed), Genome Plasticity and Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817213.ch20
Generic image for table

Association between defined genetic polymorphisms and an increased risk to suffer from diseases with HCMV

Citation: Mezger M, Einsele H, Loeffler J. 2012. DNA Polymorphisms and Their Relevance for Infections with Human Cytomegalovirus and , p 345-357. In Hacker J, Dobrindt U, Kurth R (ed), Genome Plasticity and Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817213.ch20

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