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Intracellular Pathogens I:

Editors: Ming Tan1, Patrik Bavoil2
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Affiliations: 1: Departments of Microbiology & Molecular Genetics, and Medicine, University of California, Irvine, CA; 2: Departments of Microbial Pathogenesis, and Microbiology & Immunology, University of Maryland, Baltimore, MD
Content Type: Monograph
Format: Hardcover, Electronic
Publication Year: 2012

Category: Bacterial Pathogenesis

is a current review of basic research on biology and pathogenesis in one comprehensive volume. The book details the scientific knowledge about how these obligate intracellular bacteria invade, survive and replicate inside eukaryotic cells and also describes the spectrum of disease caused by an infection including protective and pathologic immune responses.

describes the latest developments, including genomics and biomathematical modeling, and progress towards genetic tools and a vaccine. The book serves as a significant research book for scientists, physicians, medical students, public health professionals, epidemiologists, biocomputational scientists and government policy makers.

There are no separately available contributors for this publication.

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image of Intracellular Pathogens I: <span class="jp-italic">Chlamydiales</span>

Quarterly Review of Biology

29 May 2014

The Chlamydiae are a major group of intracellular bacterial pathogens that cause significant disease in humans as well as animals. The main human species of Chlamydia, C. trachomatis, is responsible for sexually transmitted infections and the blinding eye disease trachoma. Despite modern molecular diagnostic techniques, effective antibiotics, and ever-increasing education programs, sexually transmitted infections due to C. trachomatis continue to increase at an alarming rate. Just as important are the millions of people who suffer from trachoma, primarily in the developing world. A major reason for this “lack of control” of chlamydial infections is the fact that we still understand relatively little about the basic biology of this common human and animal pathogen. This book is therefore very timely in that it provides a comprehensive analysis of many of the recent key discoveries in chlamydiology and how our understanding of the basic biology of this organism is rapidly expanding. The volume will be of interest to a broad audience, including scientists, basic researchers, physicians, medical students, public health professionals, epidemiologists, and biocomputing scientists. A strength of this book is the depth that it provides in covering many of the basic aspects of chlamydiology and how our understanding of the cell and molecular biology of this complex pathogen is rapidly expanding.

This volume consists of 16 chapters, each written by a world authority on the topic. Because the Chlamydiae are very difficult to grow in vitro and, until very recently, no genetic transformation system was available, the ability to sequence whole genomes has become a powerful tool for their analysis. The chapter Deep and Wide: Comparative Genomics of Chlamydia is therefore a highlight as it summarizes the approaches of “wide sequencing” (sequencing strains from a phylogenetically wide variety of strains) as well as “deep sequencing” (use of powerful sequencing technologies to sequence the complexity of chlamydial metapopulations). A series of in-depth chapters cover our rapidly expanding understanding of chlamydial cell biology, including aspects such as the chlamydial cell envelope, chlamydial adhesion, the initial interaction with the host cell, and the developing inclusion. The information is complex but is well presented by the experts, including the use of many excellent figures and tables.

Effective control of chlamydial infection still alludes and the development of an effective chlamydial vaccine has been slow. Several chapters address what is known of the host immune response to Chlamydia, in both animal models and humans, and the progress toward vaccine development. An exciting addition in this book is the chapter on biomathematical modeling of chlamydial infection and disease. Although mathematical modeling is often foreign for many, the authors of this chapter have made it easy to understand and highlight just how powerful it can be for expanding our understanding of chlamydial mechanisms. The book also includes a summary of the recent progress toward the development of a transformation system for Chlamydia.

In summary, this volume provides a series of expert and detailed updates on the complexity of Chlamydia, how they function, how they interact with their host cells and, importantly, why they are still such successful human and animal pathogens. The chlamydial inclusion (front cover image) could be visualized as a hatching egg, emerging from the cell that it has just hijacked for its own purposes, and ready to now spread its hundreds of progeny to infect the next unsuspecting host. This book equally showcases the many parts of Chlamydia that make it such a successful pathogen.

Quarterly Review of Biology

Volume 89, Number 2, Pages 184-185

Reviewer: Peter Timms, Microbiology, University of the Sunshine Coast, Maroochydore, Australia

Review Date: June 2014

Microbiology Today

02 June 2013

This excellent book offers an in depth look at the world of the Chlamydiales from a basic science perspective. It will be of particular interest to those that have a fascination with these highly successful obligate intracellular pathogens, which cause infections spanning the respiratory tract, eyes and genital tract. Molecular diagnostic techniques revolutionised the detection of C. trachomatis in the latter part of the 20th century and this book illustrates how evolving technologies continue to enable a greater understanding of the biology and pathogenesis of these organisms, often challenging our previous concepts.

Chapters from many well known scientists are clearly written, fully referenced and cover topics including bacterial cell biology, infection and invasion processes from the initial interactions with host cells to gene regulation, protein secretion and the host immune response to the infection. Bacterial persistence is also explored where the authors draw on comparisons with infectious organisms known to persist and cause chronic disease to attempt to explain this as yet unconfirmed (in humans) anomaly. Progress towards a vaccine and ground breaking developments in the genetic manipulation of this notoriously difficult genus are also discussed and open up exciting new prospects for future research.

This reference book would be extremely useful to any researcher wishing to have a well rounded understanding of the Chlamydiales.

Society for General Microbiology: Microbiology Today

Reviewer: Professor Catherine Ison &amp; Rachel Pitt, Health Protection Agency

Review Date: May 2013

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