Chapter 1 : Infection and Epidemiology

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The intent of this introductory chapter is to review the nature and extent of the human burden of chlamydial disease and its complications and to describe the diseases and complications that are all too familiar to everyone involved in the clinical care of patients and in the larger public health efforts to control the chlamydial infections. causes substantial and important veterinary disease, but the author has mainly considered the human pathogens and and the ability of different serovars to cause diseases as distinct as ocular trachoma and sexually transmitted infections. A primary end point in human vaccine trials directed against genital disease might well be reduction in clinically apparent pelvic inflammatory disease (PID) rather than a reduction in infection acquisition; rate of incident infection, bacterial load, and infection duration may serve as secondary outcomes. The chapter focuses on infections caused by and , since they are the common chlamydial infections in humans. Frequent treatment failures related to antibiotic resistance are not evident clinically. Several chronic diseases have been putatively linked to , including asthma and atherosclerosis. The major challenges to progress toward worldwide public health goals of reducing the burden of sequelae caused by infections relate to the common clinical themes of prolonged infection, repeated infection, scarring complications of infection, and their underlying biological mechanisms.

Citation: Batteiger B. 2012. Infection and Epidemiology, p 1-26. In Tan M, Bavoil P (ed), Intracellular Pathogens I: . ASM Press, Washington, DC. doi: 10.1128/9781555817329.ch1

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Lower Respiratory Tract Infections
Tumor Necrosis Factor alpha
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The WHO simplified system for the assessment of trachoma

Citation: Batteiger B. 2012. Infection and Epidemiology, p 1-26. In Tan M, Bavoil P (ed), Intracellular Pathogens I: . ASM Press, Washington, DC. doi: 10.1128/9781555817329.ch1

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