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Chapter 11 : Immunopathogenesis

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Abstract:

Infection of the ocular conjunctiva with leads to trachoma, which remains the commonest infectious cause of blindness worldwide. The majority of men and women with genital infections are asymptomatic. This chapter reviews data related to host, bacterial, and environmental factors that affect the complicated multidimensional process and how they relate to tipping the balance towards chronic disease development. Recognizing the significance of early inflammatory events in chlamydial pathogenesis, the murine model of genital tract infection was adapted to characterize the early chemokine and cytokine response and correlate it with the chlamydial developmental cycle in vivo. Researchers have begun to identify the cellular receptors involved in -induced stimulation of cytokine release. Toll-like receptors (TLRs) act as pathogen recognition receptors (PRRs) that enable cells to recognize conserved bacterial, viral, and fungal structural elements. The cellular paradigm makes no distinction between damage induced by professional innate immune cells (neutrophils and monocytes) and adaptive lymphocyte populations but assumes that both cell populations contribute to pathogenesis. Since the host cell response to bacteria is the inciting inflammatory event, increased and prolonged bacterial burden correlates directly with disease development. Pathogen-specific and environmental factors that promote infection and bacterial survival lead to enhanced disease. Plasmid-encoded factors and type III secretion effectors appear to be key bacterial virulence factors.

Citation: Darville T, O'Connell C. 2012. Immunopathogenesis, p 240-264. In Tan M, Bavoil P (ed), Intracellular Pathogens I: . ASM Press, Washington, DC. doi: 10.1128/9781555817329.ch11

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Tumor Necrosis Factor alpha
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Type III Secretion System
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