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Chapter 3 : Laboratory Detection of Bacteremia and Fungemia

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Laboratory Detection of Bacteremia and Fungemia, Page 1 of 2

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Abstract:

The laboratory detection of bacteremia and fungemia remains one of the most important functions performed by clinical microbiology laboratories. Culture-based methods remain both the gold standard as well as the most commonly used methods. Newer diagnostic technologies do not replace cultures, but are used primarily as adjunct tests to shorten the time needed for final results.

Citation: Wilson M, Weinstein M, Reller L. 2015. Laboratory Detection of Bacteremia and Fungemia, p 15-28. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch3
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References

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1. Pien BC,, Sundaram P,, Raoof N,, Costa SF,, Mirrett S,, Woods CW,, Reller LB,, Weinstein MP. 2010. The clinical and prognostic importance of positive blood cultures in adults. Am J Med 123:819828.
2. Jin SJ,, Kim M,, Yoon JH,, Song YG. 2013. A new statistical approach to predict bacteremia using electronic medical records. Scand J Infect Dis 45:672680.
3. Weinstein MP,, Towns ML,, Quartey SM,, Mirrett S,, Reimer LG,, Parmigiani G,, Reller LB. 1997. The clinical significance of positive blood cultures in the 1990s: a prospective, comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis 24:584602.
4. McMurray BR,, Wrenn KD,, Wright SW. 1997. Usefulness of blood cultures in pyelonephritis. Am J Emerg Med 15:137140.
5. Mills AM,, Barros S. 2005. Are blood cultures necessary in adults with pyelonephritis? Ann Emerg Med 46:285287.
6. Thanassi M. 1997. Utility of urine and blood cultures in pyelonephritis. Acad Emerg Med 4:797800.
7. Velasco M,, Martínez JA,, Moreno-Martínez A,, Horcajada JP,, Ruiz J,, Barranco M,, Almela M,, Vila J,, Mensa J. 2003. Blood cultures for women with uncomplicated acute pyelonephritis: are they necessary? Clin Infect Dis 37:11271130.
8. Clinical and Laboratory Standards Institute. 2007. Principles and Practice of Blood Cultures. Document M-47. Clinical and Laboratory Standards Institute, Wayne, PA.
9. Cockerill FR,, Wilson JW,, Vetter EA,, Goodman KM,, Torgerson CA,, Harmsen WS,, Schleck CD,, Ilstrup DM,, Washington JA,, Wilson WR. 2004. Optimal testing parameters for blood cultures. Clin Infect Dis 38:17241730.
10. Mermel LA,, Maki DG. 1993. Detection of bacteremia in adults: consequences of culturing an inadequate volume of blood. Ann Intern Med 119:270272.
11. Patel R,, Vetter EA,, Harmsen WS,, Schleck CD,, Fadel HJ,, Cockerill FRIII. 2011. Optimized pathogen detection with 30-compared to 20-milliliter blood culture draws. J Clin Microbiol 49:40474051.
12. Reimer LG,, Wilson ML,, Weinstein MP. 1997. Update on the detection of bacteremia and fungemia. Clin Microbiol Rev 10:444465.
13. Washington JA. 1975. Blood cultures: principles and techniques. Mayo Clin Proc 50:9195.
14. Weinstein MP,, Reller LB,, Murphy JR,, Lichtenstein KA. 1983. The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. I. Laboratory and epidemiologic observations. Rev Infect Dis 5:3553.
15. Lee A,, Mirrett S,, Reller LB,, Weinstein MP. 2007. Detection of bloodstream infections in adults: how many cultures are needed? J Clin Microbiol 45:35463548.
16. Rosner R. 1968. Effect of various anticoagulants and no anticoagulant on ability to isolate bacteria directly from parallel clinical blood specimens. Am J Clin Pathol 68:216219.
17. Wilson ML,, Weinstein MP,, Mirrett S,, Reimer LG,, Fernando C,, Meredith FT,, Reller LB. 2000. Comparison of iodophor and alcohol pledgets with the Medi-Flex Blood Culture Prep Kit II for preventing contamination of blood cultures. J Clin Microbiol 38:46654667.
18. Everts RJ,, Vinson EN,, Adholla PO,, Reller LB. 2001. Contamination of catheter-drawn blood cultures. J Clin Microbiol 39:33933394.
19. Li J,, Plorde JJ,, Carlson LG. 1994. Effects of volume and periodicity on blood cultures. J Clin Microbiol 32:28292831.
20. Baron EJ,, Scott JD,, Tompkins LS. 2005. Prolonged incubation and extensive subculturing do not increase recovery of clinically significant microorganisms from standard automated blood cultures. Clin Infect Dis 41:16771680.
21. Fadel HJ,, Patel R,, Vetter EA,, Baddour LM. 2011. Clinical significance of a single Staphylococcus lugdunensis-positive blood culture. J Clin Microbiol 49:16971699.
22. Mirrett S,, Weinstein MP,, Reimer LG,, Wilson ML,, Reller LB. 2001. Relevance of the number of positive bottles in determining clinical significance of coagulase-negative staphylococci in blood cultures. J Clin Microbiol 39:32793281.
23. Bryan LE. 1981. Comparison of a slide blood culture system with a supplemented peptone broth culture method. J Clin Microbiol 14:389392.
24. Pfaller MA,, Sibley TK,, Westfall LM,, Hoppe-Bauer JE,, Keating MA,, Murray PR. 1982. Clinical laboratory comparison of a slide blood culture system with a conventional broth system. J Clin Microbiol 16:525530.
25. Weinstein MP,, Reller LB,, Mirrett S,, Wang WLL,, Alcid DV. 1985. Controlled evaluation of Trypticase soy broth in agar slide and conventional blood culture systems. J Clin Microbiol 21:626629.
26. Weinstein MP,, Reller LB,, Mirrett S,, Wang WLL,, Alcid DV. 1985. Clinical comparison of an agar slide blood culture system with Trypticase soy broth and a conventional blood culture bottle with supplemented peptone broth. J Clin Microbiol 21:815818.
27. Weinstein MP,, Reller LB,, Mirrett S,, Stratton CW,, Reimer LG,, Wang WLL. 1986. Controlled evaluation of the agar slide and radiometric blood culture systems for the detection of bacteremia and fungemia. J Clin Microbiol 23:221225.
28. Murray PR,, Niles AC,, Heeren RL,, Curren MM,, James LE,, Hoppe-Bauer JE. 1988. Comparative evaluation of the Oxoid Signal and Roche Septi-Chek blood culture systems. J Clin Microbiol 26:25262530.
29. Weinstein MP,, Mirrett S,, Reimer LG,, Reller LB. 1989. Effect of agitation and terminal subcultures on yield and speed of detection of the Oxoid Signal blood culture system versus the Bactec radiometric system. J Clin Microbiol 27:427430.
30. Weinstein MP,, Mirrett S,, Reimer LG,, Reller LB. 1990. Effect of altered headspace atmosphere on yield and speed of detection of the Oxoid Signal blood culture system versus the Bactec radiometric system. J Clin Microbiol 28:795797.
31. Weinstein MP,, Mirrett S,, Reller LB. 1988. Comparative evaluation of the Oxoid Signal and Bactec radiometric blood culture systems for the detection of bacteremia and fungemia. J Clin Microbiol 26:962964.
32. Cockerill FRIII,, Reed GS,, Hughes JG,, Torgenson CA,, Vetter EA,, Harmsen WS,, Dale JC,, Roberts GD,, Ilstrup DM,, Henry NK. 1997. Clinical comparison of Bactec 9240 Plus Aerobic/F resin bottles and the Isolator aerobic culture system for detection of bloodstream infections. J Clin Microbiol 35:14691472.
33. Cockerill FR,, Torgenson CAIII,, Reed GS,, Vetter EA,, Weaver AL,, Dale JC,, Roberts GD,, Henry NK,, Ilstrup DM,, Rosenblatt JE. 1996. Clinical comparison of Difco ESP, Wampole Isolator, and Becton Dickinson Septi-Chek aerobic blood culture systems. J Clin Microbiol 34:2024.
34. Hellinger WC,, Zawley JJ,, Alvarez S,, Hogan SF,, Harensen WS,, Ilstrup DM,, Cockerill FR. 1995. Clinical comparison of the Isolator and BacT/Alert aerobic blood culture systems. J Clin Microbiol 33:17871790.
35. Henry NK,, Grewell CM,, Van Grevenhof PE,, Ilstrup DM,, Washington JAII. 1984. Comparison of lysis-centrifugation with a biphasic blood culture medium for the recovery of aerobic and facultatively anaerobic bacteria. J Clin Microbiol 20:413416.
36. Henry NK,, McLimans CA,, Wright AJ,, Thompson RL,, Wilson WR,, Washington JA. 1983. Microbiological and clinical evaluation of the Isolator lysis-centrifugation blood culture tube. J Clin Microbiol 17:864869.
37. Kiehn TE,, Wong B,, Edwards FF,, Armstrong D. 1983. Comparative recovery of bacteria and yeasts from lysis-centrifugation and a conventional blood culture system. J Clin Microbiol 18:300304.
38. Thorpe TC,, Wilson ML,, Turner JE,, DiGuiseppi JL,, Willert M,, Mirrett S,, Reller LB. 1990. BacT/Alert: an automated colorimetric microbial detection system. J Clin Microbiol 28:16081612.
39. Murray PR,, Hollick GE,, Jerris RC,, Wilson ML. 1998. Multicenter comparison of Bactec 9050 and Bactec 9240 blood culture systems. J Clin Microbiol 36:16011603.
40. Waite RT,, Woods GL. 1998. Evaluation of Bactec MYCO/F Lytic medium for recovery of mycobacteria and fungi from blood. J Clin Microbiol 36:11761179.
41. Crump JA,, Tanner DC,, Mirrett S,, McKnight CM,, Reller LB. 2003. Controlled comparison of Bactec 13A, MYCO/F LYTIC, BacT/Alert MB, and ISOLATOR 10 systems for detection of mycobacteremia. J Clin Microbiol 41:19871990.
42. Crump JA,, Morrissey AB,, Ramadhani HO,, Njau BN,, Maro VP,, Reller LB. 2011. Controlled comparison of BacT/Alert MB system, manual Myco/F Lytic procedure, and Isolator 10 system for diagnosis of Mycobacterium tuberculosis bacteremia. J Clin Microbiol 49:30543057.
43. Jeng K,, Gaydos CA,, Blyn LB,, Yang S,, Won H,, Matthews H,, Toleno D,, Hsieh YH,, Carroll KC,, Hardick J,, Masek B,, Kecojevic A,, Sampath R,, Peterson S,, Rothman RE. 2012. Comparative analysis of two broad-range PCR assays for pathogen detection in positive-blood-culture bottles: PCR–high-resolution melting analysis versus PCR-mass spectrometry. J Clin Microbiol 50:32873292.
44. Westh H,, Lisby G,, Breysse F,, Böddinghaus B,, Chomarat M,, Gant V,, Goglio A,, Raglio A,, Schuster H,, Stuber F,, Wissing H,, Hoeft A. 2009. Multiplex real-time PCR and blood culture for identification of bloodstream pathogens in patients with suspected sepsis. Clin Microbiol Infect 15:544551.
45. Fernández-Cruz A,, Marín M,, Kestler M,, Alcalá L,, Rodriguez-Créixems M,, Bouza E. 2013. The value of combining blood culture and SeptiFast data for predicting complicated bloodstream infections caused by gram-positive bacteria or Candida species. J Clin Microbiol 51:11301136.
46. Feasey NA,, Banada PP,, Howson W,, Sloan DJ,, Mdolo A,, Boehme C,, Chipungu GA,, Allain TJ,, Heyderman RS,, Corbett EL,, Alland D. 2013. Evaluation of Xpert MTB/RIF for detection of tuberculosis from blood samples of HIV-infected adults confirms Mycobacterium tuberculosis bacteremia as an indicator of poor prognosis. J Clin Microbiol 51:23112316.
47. Barenfanger J,, Graham DR,, Kolluri L,, Sangwan G,, Lawhorn J,, Drake CA,, Verhulst SJ,, Peterson R,, Moja LB,, Ertmoed MM,, Moja AB,, Shevlin DW,, Vautrain R,, Dallahon CD. 2008. Decreased mortality associated with prompt Gram staining of blood cultures. Am J Clin Pathol 130:870876.
48. Bauer KA,, West JE,, Balada-Llasat JM,, Pancholi P,, Stevenson KB,, Goff DA. 2010. An antimicrobial stewardship program’s impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus/S. aureus blood culture test in patients with S. aureus bacteremia. Clin Infect Dis 51:10741080.
49. Sango A,, McCrater YS,, Johnson D,, Ferreira J,, Guzman N,, Jankowski CA. 2013. Stewardship approach for optimizing antimicrobial therapy through use of a rapid microarray assay on blood cultures positive for Enterococcus species. J Clin Microbiol 51:40084011.
50. Stone NRH,, Gorton RL,, Barker K,, Ramnarain P,, Kibbler CC. 2013. Evaluation of PNA-FISH yeast traffic light for rapid identification of yeast directly from positive blood cultures and assessment of clinical impact. J Clin Microbiol 51:13011302.
51. Samuel LP,, Tibbetts RJ,, Agotesku A,, Fey M,, Hensley R,, Meier FA. 2013. Evaluation of a microarray-based assay for rapid identification of gram-positive organisms and resistance markers in positive blood cultures. J Clin Microbiol 51:11881192.
52. Wojewoda CM,, Sercia L,, Navas M,, Tuohy M,, Wilson D,, Hall GS,, Procop GW,, Richter SS. 2013. Evaluation of the Verigene gram-positive blood culture nucleic acid test for rapid detection of bacteria and resistance determinants. J Clin Microbiol 51:20722076.
53. Beal SG,, Clurca J,, Smith G,, John J,, Lee F,, Doern CD,, Gander RM. 2013. Evaluation of the nanosphere Verigene gram-positive blood culture assay with the VersaTREK blood culture system and assessment of possible impact on selected patients. J Clin Microbiol 51:39883992.
54. Mestas J,, Polanco CM,, Felsenstein S,, Bard JD. 2014. Performance of the Verigene gram-positive blood culture assay for direct detection of gram-positive organisms and resistance markers in a pediatric hospital. J Clin Microbiol 52:283287.
55. Mancini N,, Infurnari L,, Ghidoli N,, Valzano G,, Clementi N,, Burioni R,, Clementi M. 2014. Potential impact of a microarray-based nucleic acid assay for rapid detection of gram-negative bacteria and resistance markers in positive blood cultures. J Clin Microbiol 52:12421245.
56. Altun O,, Almuhayawl M,, Ullberg M,, Ozenci V. 2013. Clinical evaluation of the FilmArray blood culture identification panel in identification of bacteria and yeasts form positive blood culture bottles. J Clin Microbiol 51:41304136.
57. Dhiman N,, Trienski TL,, DiPersio LP,, DiPersio JR. 2013. Evaluation of the BinaxNOW Staphylococcus aureus test for rapid identification of gram-positive cocci from VersaTREK blood culture bottles. J Clin Microbiol 51:29392942.
58. Qian Q,, Eichelberger K,, Kirby JE. 2014. Rapid identification of Staphylococcus aureus directly from Bactec blood culture broth by the BinaxNOW S. aureus test. J Clin Microbiol 52:319320.
59. Moussaoui W,, Jaulhac B,, Hoffmann A-M,, Ludes B,, Kostrzewa M,, Riegel P,, Prevost G. 2010. Matrix-associated laser desorption ionization time-of-flight mass spectrometry identifies 90% of bacteria directly from blood culture vials. Clin Microbiol Infect Dis 16:16311638.
60. Stevenson LG,, Drake SK,, Murray PR. 2010. Rapid identification of bacteria in positive blood culture broths by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol 48:444447.
61. Ferreira L,, Sanchez-Juanes F,, Porras-Guerra I,, Garcia-Garcia MI,, Garcia-Sanchez JE,, Gonzalez-Buitrago JM,, Munoz-Bellido JL. 2011. Microorganisms direct identification from blood culture by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Clin Microbiol Infect 17:541551.
62. Chen JHK,, Ho PL,, Kwan GSW,, She KKK,, Siu GKH,, Cheng VCC,, Yuen KY,, Yam WC. 2013. Direct bacterial identification in positive blood cultures by use of two commercial matrix-assisted laser desorption ionization–time of flight mass spectrometry systems. J Clin Microbiol 51:17331739.
63. Lagacé-Wiens PRS,, Adam HJ,, Karlowsky JA,, Nichol KA,, Pang PF,, Guenther J,, Webb AA,, Miller C,, Alfa MJ. 2012. Identification of blood culture isolates directly from positive blood cultures by use of matrix-assisted laser desorption ionization–time of flight mass spectrometry and a commercial extraction system: analysis of performance, cost, and turnaround time. J Clin Microbiol 50:33243328.
64. Vlek AL,, Bonten JM,, Boel CH. 2012. Direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry improves appropriateness of antibiotic treatment of bacteremia. PLoS One 7:e32589.
65. Flayhart D,, Borek AP,, Wakefield T,, Dick J,, Carroll KC. 2007. Comparison of Bactec PLUS blood culture media to BacT/Alert FA blood culture media for detection of bacterial pathogens in samples containing therapeutic levels of antibiotics. J Clin Microbiol 45:816821.
66. Rohner P,, Pepey B,, Auckenthaler R. 1995. Comparison of BacT/Alert with Signal blood culture system. J Clin Microbiol 33:313317.
67. Wilson ML,, Weinstein MP,, Reimer LG,, Mirrett S,, Reller LB. 1992. Controlled comparison of the BacT/Alert and Bactec 660/730 nonradiometric blood culture systems. J Clin Microbiol 30:323329.
68. Weinstein MP,, Mirrett S,, Reimer LG,, Wilson ML,, Smith-Elekes S,, Chirard CR,, Joho KL,, Reller LB. 1995. Controlled evaluation of BacT/Alert standard aerobic and FAN aerobic blood culture bottles for detection of bacteremia and fungemia. J Clin Microbiol 33:978981.
69. Wilson ML,, Weinstein MP,, Mirrett S,, Reimer LG,, Smith-Elekes S,, Chirard CR,, Reller LB. 1995. Controlled evaluation of BacT/Alert standard anaerobic and FAN anaerobic blood culture bottles for the detection of bacteremia and fungemia. J Clin Microbiol 33:22652270.
70. Kirn TJ,, Mirrett S,, Reller LB,, Weinstein MP. 2014. Controlled clinical comparison of BacT/Alert FA Plus and FN Plus blood culture media with BacT/Alert FA and FN blood culture media. J Clin Microbiol 52:839843.
71. Doern CD,, Mirrett S,, Halstead D,, Abid J,, Okada P,, Reller LB. 2014. Controlled clinical comparison of new pediatric medium with adsorbent polymeric beads (PF Plus) versus charcoal-containing PF medium in the BacT/ALERT blood culture system. J Clin Microbiol 52:1898-900.
72. Lee D-H,, Kim SC,, Bae I-G,, Koh E-H,, Kim S. 2013. Clinical evaluation of BacT/Alert FA Plus and FN Plus bottles compared with standard bottles. J Clin Microbiol 51:41504155.
73. Kirkley BA,, Easley DA,, Washington JA. 1994. Controlled clinical evaluation of Isolator and ESP aerobic blood culture systems for detection of bloodstream infections. J Clin Microbiol 32:15471549.
74. Pohlman JK,, Kirkley BA,, Easley KA,, Basille BA,, Washington JA. 1995. Controlled clinical evaluation of Bactec Plus Aerobic/F and BacT/Alert FAN bottles for detection of bloodstream infections. J Clin Microbiol 33:28562858.
75. McDonald LC,, Fune J,, Gaido LB,, Weinstein MP,, Reimer LG,, Flynn TM,, Wilson ML,, Mirrett S,, Reller LB. 1996. Clinical importance of increased sensitivity of BacT/Alert FAN aerobic and anaerobic blood culture bottles. J Clin Microbiol 34:21802184.
76. Hardy DJ,, Hulbert BB,, Migneault PC. 1992. Time to detection of positive BacT/Alert blood cultures and lack of need for routine subculture of 5- to 7-day negative cultures. J Clin Microbiol 30:27432745.
77. Wilson ML,, Mirrett S,, Reller LB,, Weinstein MP,, Reimer LG. 1993. Recovery of clinically important microorganisms from the BacT/Alert blood culture system does not require 7 day testing. Diagn Microbiol Infect Dis 16:3134.
78. Weinstein MP,, Mirrett S,, Wilson ML,, Reimer LG,, Reller LB. 1994. Controlled evaluation of 5 versus 10 milliliters of blood cultured in aerobic BacT/Alert blood culture bottles. J Clin Microbiol 32:21032106.
79. Nolte FS,, Williams JM,, Jerris RC,, Morello JA. 1993. Multicenter clinical evaluation of a continuous monitoring blood culture system using fluorescent-sensor technology (Bactec 9240). J Clin Microbiol 31:552557.
80. Smith JA,, Bryce EA,, Ngui-Yen JH,, Roberts FJ. 1995. Comparison of Bactec 9240 and BacT/Alert blood culture systems in an adult hospital. J Clin Microbiol 33:19051908.
81. Jorgensen JH,, Mirrett S,, McDonald LC,, Murray PR,, Weinstein MP,, Fune J,, Trippy CW,, Masterson M,, Reller LB. 1997. Controlled clinical laboratory comparison of Bactec Plus Aerobic/F resin medium with BacT/Alert Aerobic FAN medium for detection of bacteremia and fungemia. J Clin Microbiol 35:5358.
82. Doern GV,, Barton A,, Rao S. 1998. Controlled comparative evaluation of BacT/Alert FAN and ESP 80A aerobic media as means for detecting bacteremia and fungemia. J Clin Microbiol 36:26862689.
83. Welby-Sellenriek PL,, Keller DS,, Ferrett RJ,, Storch GA. 1997. Comparison of the BacT/Alert FAN aerobic and the Difco ESP 80A aerobic bottles for pediatric blood cultures. J Clin Microbiol 35:11661171.
84. Zwadyk P,, Pierson CLJr,, Young C. 1994. Comparison of Difco ESP and Organon Teknika BacT/Alert continuous-monitoring blood culture systems. J Clin Microbiol 32:12731279.
85. Welby PL,, Keller DS,, Storch GA. 1995. Comparison of automated Difco ESP blood culture system with biphasic BBL Septi-Chek system for detection of bloodstream infections in pediatric patients. J Clin Microbiol 33:10841088.
86. Mirrett S,, Hanson KE,, Reller LB. 2007. Controlled clinical comparison of Versa TREK and BacT/ALERT blood culture systems. J Clin Microbiol 45:299302.
87. Doern GV,, Brueggemann AB,, Dunne WM,, Jenkins SG,, Halstead DC,, McLaughlin JC. 1997. Four-day incubation period for blood culture bottles processed with the Difco ESP blood culture system. J Clin Microbiol 35:12901292.
88. Han XY,, Truant AL. 1999. The detection of positive blood cultures by the AccuMed ESP-384 system: the clinical significance of three-day testing. Diagn Microbiol Infect Dis 33:16.

Tables

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TABLE 1

Cumulative percentage of recovery of pathogenic microorganisms by number of blood cultures

Citation: Wilson M, Weinstein M, Reller L. 2015. Laboratory Detection of Bacteremia and Fungemia, p 15-28. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch3
Generic image for table
TABLE 2

Interpretive criteria for CRBSI

Citation: Wilson M, Weinstein M, Reller L. 2015. Laboratory Detection of Bacteremia and Fungemia, p 15-28. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch3
Generic image for table
TABLE 3

Summary of performance characteristics of BacT/Alert blood culture system

Citation: Wilson M, Weinstein M, Reller L. 2015. Laboratory Detection of Bacteremia and Fungemia, p 15-28. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch3
Generic image for table
TABLE 4

Summary of performance characteristics of Bactec blood culture systems

Citation: Wilson M, Weinstein M, Reller L. 2015. Laboratory Detection of Bacteremia and Fungemia, p 15-28. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch3
Generic image for table
TABLE 5

Summary of performance characteristics of VersaTREK blood culture system

Citation: Wilson M, Weinstein M, Reller L. 2015. Laboratory Detection of Bacteremia and Fungemia, p 15-28. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch3

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