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Citation: Glatzel M, Aguzzi A. .
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Image of FIGURE 1

Deposition patterns of PrP in the brain. Shown are examples of specific deposition patterns of PrP. These become apparent upon immunolabeling with antibodies directed against the prion protein. The nomenclature of deposition patterns is indicated below histology. doi:10.1128/9781555817381.ch109.f1

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Image of FIGURE 2

Western blot analysis of PrP. Depicted are PrP types according to two proposed schemes ( ), which discriminate PrP types based on the mobility of the unglycosylated band of PrP and the signal intensity of PrP di-, mono-, and unglycosylated forms and the genotype of codon 129 on (M, methionine; V, valine). One scheme ( ) differentiates 4 principal PrP types (types 1 to 4). Three principal PrP types (1, 2a, and 2b) are proposed in the second scheme ( ). doi:10.1128/9781555817381.ch109.f2

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Human prion diseases: clinical, diagnostic, and neuropathological features

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Disease-causing mutations in


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