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Chapter 111 : Mechanisms of Resistance to Antiviral Agents

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Abstract:

Understanding the mechanisms of viral drug resistance is critical for clinical management of individuals receiving antiviral therapy, for developing new antiviral drugs, and for drug resistance surveillance. This chapter reviews the mechanisms of resistance to antiviral drugs used to treat seven common viral infections: herpes simplex virus, cytomegalovirus, varicella-zoster virus, human immunodeficiency virus type 1, influenza A and B viruses, hepatitis B virus, and hepatitis C virus.

Citation: Shafer R, Chou S. 2015. Mechanisms of Resistance to Antiviral Agents, p 1894-1912. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch111
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Tables

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TABLE 1

Mechanisms and mutations associated with herpesvirus antiviral drug resistance

Citation: Shafer R, Chou S. 2015. Mechanisms of Resistance to Antiviral Agents, p 1894-1912. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch111
Generic image for table
TABLE 2

Genetic mechanisms of resistance to antiretroviral agents

Citation: Shafer R, Chou S. 2015. Mechanisms of Resistance to Antiviral Agents, p 1894-1912. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch111
Generic image for table
TABLE 3

Genetic mechanisms of resistance to inhibitors of hepatitis B virus (HBV)

Citation: Shafer R, Chou S. 2015. Mechanisms of Resistance to Antiviral Agents, p 1894-1912. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch111
Generic image for table
TABLE 4

Genetic mechanisms of resistance to hepatitis C virus inhibitors

Citation: Shafer R, Chou S. 2015. Mechanisms of Resistance to Antiviral Agents, p 1894-1912. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch111
Generic image for table
TABLE 5

Genetic mechanisms of resistance to influenza virus inhibitors

Citation: Shafer R, Chou S. 2015. Mechanisms of Resistance to Antiviral Agents, p 1894-1912. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch111

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