Chapter 21 : , , and Other Catalase-Positive Cocci

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This chapter discusses mainly those Gram-positive cocci that were members of the former family prior to its redefinition. The genera have now been rearranged in different families: the , the redefined , and the newly established . The two last families comprise micrococci, clinically relevant species of which now belong to the genera , , and . Staphylococci and micrococci are part of the microbiota of human and animal skin and mucous membranes and/or are found in the environment or on food. Many of these species are opportunists that may become pathogenic in a host- as well as species- and strain-dependent manner following breaks in the cutaneous barrier. Their recovery requires assessment of clinical significance to determine whether an organism is a contaminant, colonizer, or pathogen. is the clinically most important species, causing a wide range of human and animal diseases with high medical and economic burden. The coagulase-negative and cause nosocomial infections mainly in patients with predisposing factors such as immunodeficiency and/or indwelling or implanted foreign polymer bodies. The fact that staphylococci have become resistant to many available therapeutic agents has had, particularly in the case of methicillin-resistant , profound impact on patient and hygiene management. In this chapter, the taxonomy, phylogeny, biology, and mechanisms of resistance of these pathogens and their infectious diseases are covered, and the consequences for identification, differentiation, genotyping, susceptibility determination, and antibiotic therapy are discussed.

Citation: Becker K, Skov R, von Eiff C. 2015. , , and Other Catalase-Positive Cocci, p 354-382. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch21
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Image of FIGURE 1

Columbia blood agar plate with 5% sheep blood showing subsp. after 24 h of incubation. The normal phenotype is grayish colonies with a yellowish tint surrounded by a hemolysis zone (arrows), and the small-colony phenotype is characterized by tiny, nonhemolytic, and nonpigmented colonies (dashed arrows). doi:10.1128/9781555817381.ch21.f1

Citation: Becker K, Skov R, von Eiff C. 2015. , , and Other Catalase-Positive Cocci, p 354-382. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch21
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Image of FIGURE 2

Sections of Columbia blood agar plates after 48 h of incubation showing yellow colonies of (A), cream-white colonies of (B), pastel-pink colonies of (C), and orange colonies of (D). doi:10.1128/9781555817381.ch21.f2

Citation: Becker K, Skov R, von Eiff C. 2015. , , and Other Catalase-Positive Cocci, p 354-382. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch21
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1. Stackebrandt E,, Rainey FA,, Ward-Rainey NL. 1997. Proposal for a new hierarchic classification system, Actinobacteria classis nov. Int J Syst Bacteriol 47:479491.
2. Garrity GM,, Bell JA,, Lilburn TG,. 2004. Taxonomic outline of the procaryotes, p 1–399. In Garrity GM,, Brenner DJ,, Krieg NR,, Staley JT (ed), Bergey's Manual of Systematic Bacteriology, 2nd ed, release 5.0. Springer-Verlag, New York, NY.
3. Ludwig W,, Schleifer KH,, Whitman WB,. 2009. Revised road map to the phylum Firmicutes, p 1–13. In De Vos P,, Garrity G,, Jones D,, Krieg NR,, Ludwig W,, Rainey FA,, Schleifer KH,, Whitman WB (ed), Bergey’s Manual of Systematic Bacteriology, 2nd ed, vol 3 (The Firmicutes). Springer, New York, NY.
4. Stackebrandt E,, Koch C,, Gvozdiak O,, Schumann P. 1995. Taxonomic dissection of the genus Micrococcus: Kocuria gen. nov., Nesterenkonia gen. nov., Kytococcus gen. nov., Dermacoccus gen. nov., and Micrococcus Cohn 1872 gen. emend. Int J Syst Bacteriol 45:682692.
5. Stackebrandt E,, Schumann P. 2000. Description of Bogoriellaceae fam. nov.,Dermacoccaceae fam. nov., Rarobacteraceae fam. nov. and Sanguibacteraceae fam. nov. and emendation of some families of the suborder Micrococcineae. Int J Syst Evol Microbiol 50(Part 3):12791285.
6. Collins MD,, Hutson RA,, Baverud V,, Falsen E. 2000. Characterization of a Rothia-like organism from a mouse: description of Rothia nasimurium sp. nov. and reclassification of Stomatococcus mucilaginosus as Rothia mucilaginosa comb. nov. Int J Syst Evol Microbiol 50(Part 3):12471251.
7. Över U,, Tüc Y,, Söyletir G. 2000. Catalase-negative Staphylococcus aureus: a rare isolate of human infection. Clin Microbiol Infect 6:681682.
8. Boissy R,, Ahmed A,, Janto B,, Earl J,, Hall BG,, Hogg JS,, Pusch GD,, Hiller LN,, Powell E,, Hayes J,, Yu S,, Kathju S,, Stoodley P,, Post JC,, Ehrlich GD,, Hu FZ. 2011. Comparative supragenomic analyses among the pathogens Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae using a modification of the finite supragenome model. BMC Genomics 12:187.
9. von Darányi J. 1925. Qualitative Untersuchungen der Luftbakterien. Arch Hyg (Berlin) 96:182.
10. Baird-Parker AC. 1963. A classification of micrococci and staphylococci based on physiological and chemical tests. J Gen Microbiol 30:409427.
11. Mitchell RG,, Baird-Parker AC. 1967. Novobiocin resistance and the classification of staphylococci and micrococci. J Appl Bacteriol 30:251254.
12. Baba T,, Kuwahara-Arai K,, Uchiyama I,, Takeuchi F,, Ito T,, Hiramatsu K. 2009. Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, reflecting the ancestral genome of the human-pathogenic staphylococci. J Bacteriol 191:11801190.
13. Miller PH,, Facklam RR,, Miller JM. 1996. Atmospheric growth requirements for Alloiococcus species and related gram-positive cocci. J Clin Microbiol 34:10271028.
14. Schleifer KH,, Kloos WE. 1975. Isolation and characterization of staphylococci from human skin. I. Amended descriptions of Staphylococcus epidermidis and Staphylococcus saprophyticus and descriptions of three new species: Staphylococcus cohnii, Staphylococcus haemolyticus, and Staphylococcus xylosus. Int J Syst Bacteriol 25:5061.
15. Williams RE. 1963. Healthy carriage of Staphylococcus aureus: its prevalence and importance. Bacteriol Rev 27: 5671.
16. van Belkum A,, Verkaik NJ,, de Vogel CP,, Boelens HA,, Verveer J,, Nouwen JL,, Verbrugh HA,, Wertheim HF. 2009. Reclassification of Staphylococcus aureus nasal carriage types. J Infect Dis 199:18201826.
17. Tuazon CU,, Perez A,, Kishaba T,, Sheagren JN. 1975. Staphylococcus aureus among insulin-injecting diabetic patients. An increased carrier rate. JAMA 231:1272.
18. Tuazon CU,, Sheagren JN. 1974. Increased rate of carriage of Staphylococcus aureus among narcotic addicts. J Infect Dis 129:725727.
19. Chow JW,, Yu VL. 1989. Staphylococcus aureus nasal carriage in hemodialysis patients. Its role in infection and approaches to prophylaxis. Arch Intern Med 149: 12581262.
20. Cespedes C,, Miller M,, Quagliarello B,, Vavagiakis P,, Klein RS,, Lowy FD. 2002. Differences between Staphylococcus aureus isolates from medical and nonmedical hospital personnel. J Clin Microbiol 40:25942597.
21. Bassetti S,, Wolfisberg L,, Jaussi B,, Frei R,, Kuntze MF,, Battegay M,, Widmer AF. 2004. Carriage of Staphylococcus aureus among injection drug users: lower prevalence in an injection heroin maintenance program than in an oral methadone program. Infect Control Hosp Epidemiol 25: 133137.
22. Boyko EJ,, Lipsky BA,, Sandoval R,, Keane EM,, Monahan JS,, Pecoraro RE,, Hamman RF. 1989. NIDDM and prevalence of nasal Staphylococcus aureus colonization. San Luis Valley Diabetes Study. Diabetes Care 12:189192.
23. von Eiff C,, Becker K,, Machka K,, Stammer H,, Peters G. 2001. Nasal carriage as a name of Staphylococcus aureus bacteremia. N Engl J Med 344:1116.
24. Kluytmans JA,, Mouton JW,, Ijzerman EP,, Vandenbroucke-Grauls CM,, Maat AW,, Wagenvoort JH,, Verbrugh HA. 1995. Nasal carriage of Staphylococcus aureus as a major risk factor for wound infections after cardiac surgery. J Infect Dis 171:216219.
25. Wenzel RP,, Perl TM. 1995. The significance of nasal carriage of Staphylococcus aureus and the incidence of postoperative wound infection. J Hosp Infect 31:1324.
26. Bode LG,, Kluytmans JA,, Wertheim HF,, Bogaers D,, Vandenbroucke-Grauls CM,, Roosendaal R,, Troelstra A,, Box AT,, Voss A,, van der Tweel I,, van Belkum A,, Verbrugh HA,, Vos MC. 2010. Preventing surgical-site infections in nasal carriers of Staphylococcus aureus. N Engl J Med 362:917.
27. Enright MC,, Day NP,, Davies CE,, Peacock SJ,, Spratt BG. 2000. Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol 38:10081015.
28. Nübel U,, Strommenger B,, Layer F,, Witte W. 2011. From types to trees: reconstructing the spatial spread of Staphylococcus aureus based on DNA variation. Int J Med Microbiol 301:614618.
29. Monecke S,, Coombs G,, Shore AC,, Coleman DC,, Akpaka P,, Borg M,, Chow H,, Ip M,, Jatzwauk L,, Jonas D,, Kadlec K,, Kearns A,, Laurent F,, O’Brien FG,, Pearson J,, Ruppelt A,, Schwarz S,, Scicluna E,, Slickers P,, Tan HL,, Weber S,, Ehricht R. 2011. A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus. PLoS One 6:e17936.
30. Novick RP,, Projan SJ,, Kornblum J,, Ross HF,, Ji G,, Kreiswirth B,, Vandenesch F,, Moghazeh S. 1995. The agr P2 operon: an autocatalytic sensory transduction system in Staphylococcus aureus. Mol Gen Genet 248:446458.
31. Albrich WC,, Harbarth S. 2008. Health-care workers: name, vector, or victim of MRSA? Lancet Infect Dis 8:289301.
32. Morgan M. 2008. Methicillin-resistant Staphylococcus aureus and animals: zoonosis or humanosis? J Antimicrob Chemother 62:11811187.
33. de la Fuente R,, Suarez G,, Schleifer KH. 1985. Staphylococcus aureus subsp. anaerobius subsp. nov., the causal agent of abscess disease of sheep. Int J Syst Bacteriol 35:99102.
34. Sasaki T,, Kikuchi K,, Tanaka Y,, Takahashi N,, Kamata S,, Hiramatsu K. 2007. Reclassification of phenotypically identified Staphylococcus intermedius strains. J Clin Microbiol 45:27702778.
35. Devriese LA,, Vancanneyt M,, Baele M,, Vaneechoutte M,, De Graef E,, Snauwaert C,, Cleenwerck I,, Dawyndt P,, Swings J,, Decostere A,, Haesebrouck F. 2005. Staphylococcus pseudintermedius sp. nov., a coagulase-positive species from animals. Int J Syst Evol Microbiol 55:15691573.
36. Rupp ME,, Soper DE,, Archer GL. 1992. Colonization of the female genital tract with Staphylococcus saprophyticus. J Clin Microbiol 30:29752979.
37. Kloos WE,, Schleifer KH. 1983. Staphylococcus auricularis sp. nov.: an inhabitant of the human external ear. Int J Syst Bacteriol 33:914.
38. Bieber L,, Kahlmeter G. 2009. Staphylococcus lugdunensis in several niches of the normal skin flora. Clin Microbiol Infect 16:385388.
39. Pantucek R,, Svec P,, Dajcs JJ,, Machová I,, Cernohlavkova J,, Sedo O,, Gelbicova T,, Maslanova I,, Doskar J,, Zdrahal Z,, Ruzickova V,, Sedlacek I. 2013. Staphylococcus petrasii sp. nov. including S. petrasii subsp. petrasii subsp. nov. and S. petrasii subsp. croceilyticus subsp. nov., isolated from human clinical specimens and human ear infections. Syst Appl Microbiol 36:9095.
40. Zong Z. 2012. The newly-recognized species Staphylococcus massiliensis is likely to be part of the human skin microflora. Antonie Van Leeuwenhoek 101:449451.
41. Trülzsch K,, Grabein B,, Schumann P,, Mellmann A,, Antonenka U,, Heesemann J,, Becker K. 2007. Staphylococcus pettenkoferi sp. nov., a novel coagulase-negative staphylococcal species isolated from human clinical specimens. Int J Syst Evol Microbiol 57:15431548.
42. Kloos WE,, Ballard DN,, Webster JA,, Hubner RJ,, Tomasz A,, Couto I,, Sloan GL,, Dehart HP,, Fiedler F,, Schubert K,, de Lencastre H,, Sanches IS,, Heath HE,, Leblanc PA,, Ljungh A. 1997. Ribotype delineation and description of Staphylococcus sciuri subspecies and their potential as reservoirs of methicillin resistance and staphylolytic enzyme genes. Int J Syst Bacteriol 47:313323.
43. Schleifer KH,, Kilpper-Bälz R,, Devriese LA. 1984. Staphylococcus arlettae sp. nov., S. equorum sp. nov., and S. kloosii sp. nov.: three new coagulase-negative, novobiocin-resistant species from animals. Syst Appl Microbiol 5:501509.
44. Devriese LA,, Poutrel B,, Kilpper-Bälz R,, Schleifer KH. 1983. Staphylococcus gallinarum and Staphylococcus caprae, two new species from animals. Int J Syst Bacteriol 33:480486.
45. Zell C,, Resch M,, Rosenstein R,, Albrecht T,, Hertel C,, Götz F. 2008. Characterization of toxin production of coagulase-negative staphylococci isolated from food and starter cultures. Int J Food Microbiol 127:246251.
46. Kloos WE,, Ballard DN,, George CG,, Webster JA,, Hubner RJ,, Ludwig W,, Schleifer KH,, Fiedler F,, Schubert K. 1998. Delimiting the genus Staphylococcus through description of Macrococcus caseolyticus gen. nov., comb. nov. and Macrococcus equipercicus sp. nov., and Macrococcus bovicus sp. nov. and Macrococcus carouselicus sp. nov. Int J Syst Bacteriol 48(Part 3):859877.
47. Alves M,, Nogueira C,, de Magalhães-Sant’Ana A,, Chung AP,, Morais PV,, da Costa MS. 2008. Nosocomiicoccus ampullae gen. nov., sp. nov., isolated from the surface of bottles of saline solution used in wound cleansing. Int J Syst Evol Microbiol 58:29392944.
48. Kloos WE,, Musselwhite MS. 1975. Distribution and persistence of Staphylococcus and Micrococcus species and other aerobic bacteria on human skin. Appl Microbiol 30:381385.
49. Tano K,, von Essen R,, Eriksson PO,, Sjöstedt A. 2008. Alloiococcus otitidis—otitis media pathogen or normal bacterial flora? APMIS 116:785790.
50. Wisplinghoff H,, Bischoff T,, Tallent SM,, Seifert H,, Wenzel RP,, Edmond MB. 2004. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 39:309317.
51. Hidron AI,, Edwards JR,, Patel J,, Horan TC,, Sievert DM,, Pollock DA,, Fridkin SK. 2008. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007. Infect Control Hosp Epidemiol 29:9961011.
52. Proctor RA,, von Eiff C,, Kahl BC,, Becker K,, McNamara P,, Herrmann M,, Peters G. 2006. Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections. Nat Rev Microbiol 4:295305.
53. Tuchscherr L,, Heitmann V,, Hussain M,, Viemann D,, Roth J,, von Eiff C,, Peters G,, Becker K,, Löffler B. 2010. Staphylococcus aureus small-colony variants are adapted phenotypes for intracellular persistence. J Infect Dis 202:10311040.
54. Tuchscherr L,, Medina E,, Hussain M,, Völker W,, Heitmann V,, Niemann S,, Holzinger D,, Roth J,, Proctor RA,, Becker K,, Peters G,, Löffler B. 2011. Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection. EMBO Mol Med 3:129141.
55. Becker K,, Laham NA,, Fegeler W,, Proctor RA,, Peters G,, von Eiff C. 2006. Fourier-transform infrared spectroscopic analysis is a powerful tool for studying the dynamic changes in Staphylococcus aureus small-colony variants. J Clin Microbiol 44:32743278.
56. Kriegeskorte A,, König S,, Sander G,, Pirkl A,, Mahabir E,, Proctor RA,, von Eiff C,, Peters G,, Becker K. 2011. Small colony variants of Staphylococcus aureus reveal distinct protein profiles. Proteomics 11:24762490.
57. von Eiff C,, Bettin D,, Proctor RA,, Rolauffs B,, Lindner N,, Winkelmann W,, Peters G. 1997. Recovery of small colony variants of Staphylococcus aureus following gentamicin bead placement for osteomyelitis. Clin Infect Dis 25:12501251.
58. Kahl B,, Herrmann M,, Everding AS,, Koch HG,, Becker K,, Harms E,, Proctor RA,, Peters G. 1998. Persistent infection with small colony variant strains of Staphylococcus aureus in patients with cystic fibrosis. J Infect Dis 177:10231029.
59. Seifert H,, Oltmanns D,, Becker K,, Wisplinghoff H,, von Eiff C. 2005. Staphylococcus lugdunensis pacemaker-related infection. Emerg Infect Dis 11:12831286.
60. DeVries AS,, Lesher L,, Schlievert PM,, Rogers T,, Villaume LG,, Danila R,, Lynfield R. 2011. Staphylococcal toxic shock syndrome 2000–2006: epidemiology, clinical features, and molecular characteristics. PLoS One 6:e22997.
61. Stanley JR,, Amagai M. 2006. Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. N Engl J Med 355:18001810.
62. Becker K,, Keller B,, von Eiff C,, Brück M,, Lubritz G,, Etienne J,, Peters G. 2001. Enterotoxigenic potential of Staphylococcus intermedius. Appl Environ Microbiol 67:55515557.
63. Talan DA,, Staatz D,, Staatz A,, Goldstein EJ,, Singer K,, Overturf GD. 1989. Staphylococcus intermedius in canine gingiva and canine-inflicted human wound infections: laboratory characterization of a newly recognized zoonotic pathogen. J Clin Microbiol 27:7881.
64. Taponen S,, Supré K,, Piessens V,, Van Coillie E,, De Vliegher S,, Koort JM. 2012. Staphylococcus agnetis sp. nov., a coagulase-variable species from bovine subclinical and mild clinical mastitis. Int J Syst Evol Microbiol 62:6165.
65. von Eiff C,, Jansen B,, Kohnen W,, Becker K. 2005. Infections associated with medical devices: pathogenesis, management and prophylaxis. Drugs 65:179214.
66. von Eiff C,, Arciola CR,, Montanaro L,, Becker K,, Campoccia D. 2006. Emerging Staphylococcus species as new pathogens in implant infections. Int J Artif Organs 29: 360367.
67. Rogers KL,, Fey PD,, Rupp ME. 2009. Coagulase-negative staphylococcal infections. Infect Dis Clin North Am 23: 7398.
68. von Eiff C,, Peters G,, Heilmann C. 2002. Pathogenesis of infections due to coagulase-negative staphylococci. Lancet Infect Dis 2:677685.
69. Peters G,, Locci R,, Pulverer G. 1981. Microbial colonization of prosthetic devices. II. Scanning electron microscopy of naturally infected intravenous catheters. Zentralbl Bakteriol Mikrobiol Hyg B 173:293299.
70. Lalani T,, Kanafani ZA,, Chu VH,, Moore L,, Corey GR,, Pappas P,, Woods CW,, Cabell CH,, Hoen B,, Selton-Suty C,, Doco-Lecompte T,, Chirouze C,, Raoult D,, Miro JM,, Mestres CA,, Olaison L,, Eykyn S,, Abrutyn E,, Fowler VG, Jr. 2006. Prosthetic valve endocarditis due to coagulase-negative staphylococci: findings from the International Collaboration on Endocarditis Merged Database. Eur J Clin Microbiol Infect Dis 25:365368.
71. Curtis C,, Shetty N. 2008. Recent trends and prevention of infection in the neonatal intensive care unit. Curr Opin Infect Dis 21:350356.
72. Anguera I,, Del Río A,, Miró JM,, Matínez-Lacasa X,, Marco F,, Gumá JR,, Quaglio G,, Claramonte X,, Moreno A,, Mestres CA,, Mauri E,, Azqueta M,, Benito N,, García-de la Maria C,, Almela M,, Jiménez-Expósito MJ,, Sued O,, De Lazzari E,, Gatell JM. 2005. Staphylococcus lugdunensis infective endocarditis: description of 10 cases and analysis of native valve, prosthetic valve, and pacemaker lead endocarditis clinical profiles. Heart 91:e10.
73. Böcher S,, Tønning B,, Skov RL,, Prag J. 2009. Staphylococcus lugdunensis, a common cause of skin and soft tissue infections in the community. J Clin Microbiol 47:946950.
74. Becker K,, Wüllenweber J,, Odenthal HJ,, Moeller M,, Schumann P,, Peters G,, von Eiff C. 2003. Prosthetic valve endocarditis due to Kytococcus schroeteri. Emerg Infect Dis 9:14931495.
75. Altuntas F,, Yildiz O,, Eser B,, Gundogan K,, Sumerkan B,, Cetin M. 2004. Catheter-related bacteremia due to Kocuria rosea in a patient undergoing peripheral blood stem cell transplantation. BMC Infect Dis 4:62.
76. Seifert H,, Kaltheuner M,, Perdreau-Remington F. 1995. Micrococcus luteus endocarditis: case report and review of the literature. Zentralbl Bakteriol 282:431435.
77. Becker K,, Rutsch F,, Uekötter A,, Kipp F,, König J,, Marquardt T,, Peters G,, von Eiff C. 2008. Kocuria rhizophila adds to the emerging spectrum of micrococcal species involved in human infections. J Clin Microbiol 46:35373539.
78. Goldman M,, Chaudhary UB,, Greist A,, Fausel CA. 1998. Central nervous system infections due to Stomatococcus mucilaginosus in immunocompromised hosts. Clin Infect Dis 27:12411246.
79. Granlund M,, Linderholm M,, Norgren M,, Olofsson C,, Wahlin A,, Holm SE. 1996. Stomatococcus mucilaginosus septicemia in leukemic patients. Clin Microbiol Infect 2:179185.
80. Lowry TR,, Brennan JA. 2005. Stomatococcus mucilaginosis infection leading to early cervical necrotizing fasciitis. Otolaryngol Head Neck Surg 132:658660.
81. Leskinen K,, Hendolin P,, Virolainen-Julkunen A,, Ylikoski J,, Jero J. 2002. The clinical role of Alloiococcus otitidis in otitis media with effusion. Int J Pediatr Otorhinolaryngol 66:4148.
82. Harimaya A,, Fujii N,, Himi T. 2009. Preliminary study of proinflammatory cytokines and chemokines in the middle ear of acute otitis media due to Alloiococcus otitidis. Int J Pediatr Otorhinolaryngol 73:677680.
83. Becker K,, Pagnier I,, Schuhen B,, Wenzelburger F,, Friedrich AW,, Kipp F,, Peters G,, von Eiff C. 2006. Does nasal cocolonization by methicillin-resistant coagulase-negative staphylococci and methicillin-susceptible Staphylococcus aureus strains occur frequently enough to represent a risk of false-positive methicillin-resistant S. aureus determinations by molecular methods? J Clin Microbiol 44:229231.
84. Becker K,, Larsen AR,, Skov RL,, Paterson GK,, Holmes MA,, Sabat AJ,, Friedrich AW,, Köck R,, Peters G,, Kriegeskorte A. 2013. Evaluation of a modular multiplex-PCR methicillin-resistant Staphylococcus aureus (MRSA) detection assay adapted for mecC detection. J Clin Microbiol 51:19171919.
85. Huletsky A,, Giroux R,, Rossbach V,, Gagnon M,, Vaillancourt M,, Bernier M,, Gagnon F,, Truchon K,, Bastien M,, Picard FJ,, van Belkum A,, Ouellette M,, Roy PH,, Bergeron MG. 2004. New real-time PCR assay for rapid detection of methicillin-resistant Staphylococcus aureus directly from specimens containing a mixture of staphylococci. J Clin Microbiol 42:18751884.
86. Donnio PY,, Oliveira DC,, Faria NA,, Wilhelm N,, Le Coustumier A,, de Lencastre H. 2005. Partial excision of the chromosomal cassette containing the methicillin resistance determinant results in methicillin-susceptible Staphylococcus aureus. J Clin Microbiol 43:41914193.
87. Shore AC,, Rossney AS,, O’Connell B,, Herra CM,, Sullivan DJ,, Humphreys H,, Coleman DC. 2008. Detection of staphylococcal cassette chromosome mec-associated DNA segments in multiresistant methicillin-susceptible Staphylococcus aureus (MSSA) and identification of Staphylococcus epidermidis ccrAB4 in both methicillin-resistant S. aureus and MSSA. Antimicrob Agents Chemother 52:44074419.
88. Luong TT,, Ouyang S,, Bush K,, Lee CY. 2002. Type 1 capsule genes of Staphylococcus aureus are carried in a staphylococcal cassette chromosome genetic element. J Bacteriol 184:36233629.
89. Holden MT,, Feil EJ,, Lindsay JA,, Peacock SJ,, Day NP,, Enright MC,, Foster TJ,, Moore CE,, Hurst L,, Atkin R,, Barron A,, Bason N,, Bentley SD,, Chillingworth C,, Chillingworth T,, Churcher C,, Clark L,, Corton C,, Cronin A,, Doggett J,, Dowd L,, Feltwell T,, Hance Z,, Harris B,, Hauser H,, Holroyd S,, Jagels K,, James KD,, Lennard N,, Line A,, Mayes R,, Moule S,, Mungall K,, Ormond D,, Quail MA,, Rabbinowitsch E,, Rutherford K,, Sanders M,, Sharp S,, Simmonds M,, Stevens K,, Whitehead S,, Barrell BG,, Spratt BG,, Parkhill J. 2004. Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci U S A 101:97869791.
90. Cercenado E,, Marin M,, Burillo A,, Martin-Rabadan P,, Rivera M,, Bouza E. 2012. Rapid detection of Staphylococcus aureus in lower respiratory tract secretions from patients with suspected ventilator-associated pneumonia: evaluation of the Cepheid Xpert MRSA/SA SSTI assay. J Clin Microbiol 50:40954097.
91. Dubouix-Bourandy A,, de Ladoucette A,, Pietri V,, Mehdi N,, Benzaquen D,, Guinand R,, Gandois JM. 2011. Direct detection of Staphylococcus osteoarticular infections by use of Xpert MRSA/SA SSTI real-time PCR. J Clin Microbiol 49:42254230.
92. Perry JD,, Rennison C,, Butterworth LA,, Hopley AL,, Gould FK. 2003. Evaluation of S. aureus ID, a new chromogenic agar medium for detection of Staphylococcus aureus. J Clin Microbiol 41:56955698.
93. Maki DG,, Weise CE,, Sarafin HW. 1977. A semiquantitative culture method for identifying intravenouscatheter-related infection. N Engl J Med 296:13051309.
94. Raad I,, Hanna H,, Maki D. 2007. Intravascular catheter-related infections: advances in diagnosis, prevention, and management. Lancet Infect Dis 7:645657.
95. Bosley GS,, Whitney AM,, Pruckler JM,, Moss CW,, Daneshvar M,, Sih T,, and Talkington DF. 1995. Characterization of ear fluid isolates of Alloiococcus otitidis from patients with recurrent otitis media. J Clin Microbiol 33:28762880.
96. Kloos WE,, Schleifer KH. 1975. Simplified scheme for routine identification of human Staphylococcus species. J Clin Microbiol 1:8288.
97. Vaudaux P,, Kelley WL,, Lew DP. 2006. Staphylococcus aureus small colony variants: difficult to diagnose and difficult to treat. Clin Infect Dis 43:968970.
98. Eigner U,, Schmid A,, Wild U,, Bertsch D,, Fahr AM. 2005. Analysis of the comparative workflow and performance characteristics of the VITEK 2 and Phoenix systems. J Clin Microbiol 43:38293834.
99. Renneberg J,, Rieneck K,, Gutschik E. 1995. Evaluation of Staph ID 32 system and Staph-Zym system for identification of coagulase-negative staphylococci. J Clin Microbiol 33:11501153.
100. Zadoks RN,, Watts JL. 2009. Species identification of coagulase-negative staphylococci: genotyping is superior to phenotyping. Vet Microbiol 134:2028.
101. Becker K,, Harmsen D,, Mellmann A,, Meier C,, Schumann P,, Peters G,, von Eiff C. 2004. Development and evaluation of a quality-controlled ribosomal sequence database for 16S ribosomal DNA-based identification of Staphylococcus species. J Clin Microbiol 42:49884995.
102. Straub JA,, Hertel C,, Hammes WP. 1999. A 23S rDNA-targeted polymerase chain reaction-based system for detection of Staphylococcus aureus in meat starter cultures and dairy products. J Food Prot 62:11501156.
103. Edwards KJ,, Kaufmann ME,, Saunders NA. 2001. Rapid and accurate identification of coagulase-negative staphylococci by real-time PCR. J Clin Microbiol 39:30473051.
104. Skow A,, Mangold KA,, Tajuddin M,, Huntington A,, Fritz B,, Thomson RB, Jr,, Kaul KL. 2005. Species-level identification of staphylococcal isolates by real-time PCR and melt curve analysis. J Clin Microbiol 43:28762880.
105. Mendoza M,, Meugnier H,, Bes M,, Etienne J,, Freney J. 1998. Identification of Staphylococcus species by 16S-23S rDNA intergenic spacer PCR analysis. Int J Syst Bacteriol 48:10491055.
106. Jensen MA,, Webster JA,, Straus N. 1993. Rapid identification of bacteria on the basis of polymerase chain reaction-amplified ribosomal DNA spacer polymorphisms. Appl Environ Microbiol 59:945952.
107. Couto I,, Pereira S,, Miragaia M,, Sanches IS,, de Lencastre H. 2001. Identification of clinical staphylococcal isolates from humans by internal transcribed spacer PCR. J Clin Microbiol 39:30993103.
108. Krimmer V,, Merkert H,, von Eiff C,, Frosch M,, Eulert J,, Löhr JF,, Hacker J,, Ziebuhr W. 1999. Detection of Staphylococcus aureus and Staphylococcus epidermidis in clinical samples by 16S rRNA-directed in situ hybridization. J Clin Microbiol 37:26672673.
109. Goh SH,, Santucci Z,, Kloos WE,, Faltyn M,, George CG,, Driedger D,, Hemmingsen SM. 1997. Identification of Staphylococcus species and subspecies by the chaperonin 60 gene identification method and reverse checkerboard hybridization. J Clin Microbiol 35:31163121.
110. Goh SH,, Potter S,, Wood JO,, Hemmingsen SM,, Reynolds RP,, Chow AW. 1996. HSP60 gene sequences as universal targets for microbial species identification: studies with coagulase-negative staphylococci. J Clin Microbiol 34:818823.
111. Martineau F,, Picard FJ,, Ke D,, Paradis S,, Roy PH,, Ouellette M,, Bergeron MG. 2001. Development of a PCR assay for identification of staphylococci at genus and species levels. J Clin Microbiol 39:25412547.
112. Zambardi G,, Reverdy ME,, Bland S,, Bes M,, Freney J,, Fleurette J. 1994. Laboratory diagnosis of oxacillin resistance in Staphylococcus aureus by a multiplex-polymerase chain reaction assay. Diagn Microbiol Infect Dis 19:2531.
113. Poyart C,, Quesne G,, Boumaila C,, Trieu-Cuot P. 2001. Rapid and accurate species-level identification of coagulase-negative staphylococci by using the sodA gene as a target. J Clin Microbiol 39:42964301.
114. Mellmann A,, Becker K,, von Eiff C,, Keckevoet U,, Schumann P,, Harmsen D. 2006. Sequencing and staphylococci identification. Emerg Infect Dis 12:333336.
115. Wilson IG,, Cooper JE,, Gilmour A. 1991. Detection of enterotoxigenic Staphylococcus aureus in dried skimmed milk: use of the polymerase chain reaction for amplification and detection of staphylococcal enterotoxin genes entB and entC1 and the thermonuclease gene nuc. Appl Environ Microbiol 57:17931798.
116. Brakstad OG,, Aasbakk K,, Maeland JA. 1992. Detection of Staphylococcus aureus by polymerase chain reaction amplification of the nuc gene. J Clin Microbiol 30:16541660.
117. Becker K,, von Eiff C,, Keller B,, Brück M,, Etienne J,, Peters G. 2005. Thermonuclease gene as a target for specific identification of Staphylococcus intermedius isolates: use of a PCR-DNA enzyme immunoassay. Diagn Microbiol Infect Dis 51:237244.
118. Vannuffel P,, Gigi J,, Ezzedine H,, Vandercam B,, Delmee M,, Wauters G,, Gala JL. 1995. Specific detection of methicillin-resistant Staphylococcus species by multiplex PCR. J Clin Microbiol 33:28642867.
119. Kobayashi N,, Alam M,, Urasawa S. 2001. Analysis on distribution of insertion sequence IS431 in clinical isolates of staphylococci. Diagn Microbiol Infect Dis 39:6164.
120. Valderas MW,, Gatson JW,, Wreyford N,, Hart ME. 2002. The superoxide dismutase gene sodM is unique to Staphylococcus aureus: absence of sodM in coagulase-negative staphylococci. J Bacteriol 184:24652472.
121. Mason WJ,, Blevins JS,, Beenken K,, Wibowo N,, Ojha N,, Smeltzer MS. 2001. Multiplex PCR protocol for the diagnosis of staphylococcal infection. J Clin Microbiol 39:33323338.
122. Hensley DM,, Tapia R,, Encina Y. 2009. An evaluation of the AdvanDx Staphylococcus aureus/CNS PNA FISH™ assay. Clin Lab Sci 22:3033.
123. Monecke S,, Ehricht R. 2005. Rapid genotyping of methicillin-resistant Staphylococcus aureus (MRSA) isolates using miniaturised oligonucleotide arrays. Clin Microbiol Infect 11:825833.
124. Frye JG,, Jesse T,, Long F,, Rondeau G,, Porwollik S,, McClelland M,, Jackson CR,, Englen M,, Fedorka-Cray PJ. 2006. DNA microarray detection of antimicrobial resistance genes in diverse bacteria. Int J Antimicrob Agents 27:138151.
125. Rajakaruna L,, Hallas G,, Molenaar L,, Dare D,, Sutton H,, Encheva V,, Culak R,, Innes I,, Ball G,, Sefton AM,, Eydmann M,, Kearns AM,, Shah HN. 2009. High throughput identification of clinical isolates of Staphylococcus aureus using MALDI-TOF-MS of intact cells. Infect Genet Evol 9:507513.
126. Carbonnelle E,, Beretti JL,, Cottyn S,, Quesne G,, Berche P,, Nassif X,, Ferroni A. 2007. Rapid identification of staphylococci isolated in clinical microbiology laboratories by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol 45:21562161.
127. Dubois D,, Leyssene D,, Chacornac JP,, Kostrzewa M,, Schmit PO,, Talon R,, Bonnet R,, Delmas J. 2010. Identification of a variety of Staphylococcus species by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol 48:941945.
128. Moon HW,, Lee SH,, Chung HS,, Lee M,, Lee K. 2013. Performance of the Vitek MS matrix-assisted laser desorption ionization time-of-flight mass spectrometry system for identification of Gram-positive cocci routinely isolated in clinical microbiology laboratories. J Med Microbiol 62:13011306.
129. Szabados F,, Woloszyn J,, Richter C,, Kaase M,, Gatermann S. 2010. Identification of molecularly defined Staphylococcus aureus strains using matrix-assisted laser desorption/ionization time of flight mass spectrometry and the Biotyper 2.0 database. J Med Microbiol 59:787790.
130. Wolk DM,, Blyn LB,, Hall TA,, Sampath R,, Ranken R,, Ivy C,, Melton R,, Matthews H,, White N,, Li F,, Harpin V,, Ecker DJ,, Limbago B,, McDougal LK,, Wysocki VH,, Cai M,, Carroll KC. 2009. Pathogen profiling: rapid molecular characterization of Staphylococcus aureus by PCR/electrospray ionization-mass spectrometry and correlation with phenotype. J Clin Microbiol 47:31293137.
131. Amiali NM,, Mulvey MR,, Sedman J,, Louie M,, Simor AE,, Ismail AA. 2007. Rapid identification of coagulase-negative staphylococci by Fourier transform infrared spectroscopy. J Microbiol Methods 68:236242.
132. Fischer A,, von Eiff C,, Kuczius T,, Omoe K,, Peters G,, Becker K. 2007. A quantitative real-time immuno-PCR approach for detection of staphylococcal enterotoxins. J Mol Med 85:461469.
133. Joubert O,, Keller D,, Pinck A,, Monteil H,, Prevost G. 2005. Sensitive and specific detection of staphylococcal epidermolysins A and B in broth cultures by flow cytometry-assisted multiplex immunoassay. J Clin Microbiol 43:10761080.
134. Becker K,, Roth R,, Peters G. 1998. Rapid and specific detection of toxigenic Staphylococcus aureus: use of two multiplex PCR enzyme immunoassays for amplification and hybridization of staphylococcal enterotoxin genes, exfoliative toxin genes, and toxic shock syndrome toxin 1 gene. J Clin Microbiol 36:25482553.
135. Becker K,, Friedrich AW,, Lubritz G,, Weilert M,, Peters G,, von Eiff C. 2003. Prevalence of genes encoding pyrogenic toxin superantigens and exfoliative toxins among strains of Staphylococcus aureus isolated from blood and nasal specimens. J Clin Microbiol 41:14341439.
136. Monday SR,, Bohach GA. 1999. Use of multiplex PCR to detect classical and newly described pyrogenic toxin genes in staphylococcal isolates. J Clin Microbiol 37:34113414.
137. Yamaguchi T,, Nishifuji K,, Sasaki M,, Fudaba Y,, Aepfelbacher M,, Takata T,, Ohara M,, Komatsuzawa H,, Amagai M,, Sugai M. 2002. Identification of the Staphylococcus aureus etd pathogenicity island, which encodes a novel exfoliative toxin, ETD, and EDIN-B. Infect Immun 70:58355845.
138. Lina G,, Piémont Y,, Godail-Gamot F,, Bes M,, Peter M-O,, Gauduchon V,, Vandenesch F,, Etienne J. 1999. Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis 29:11281132.
139. Monecke S,, Müller E,, Buechler J,, Rejman J,, Stieber B,, Akpaka PE,, Bandt D,, Burris R,, Coombs G,, Hidalgo-Arroyo GA,, Hughes P,, Kearns A,, Abos SM,, Pichon B,, Skakni L,, Soderquist B,, Ehricht R. 2013. Rapid detection of Panton-Valentine leukocidin in Staphylococcus aureus cultures by use of a lateral flow assay based on monoclonal antibodies. J Clin Microbiol 51:487495.
140. Faller A,, Schleifer KH. 1981. Modified oxidase and benzidine tests for separation of staphylococci from micrococci. J Clin Microbiol 13:10311035.
141. Aguirre M,, Collins MD. 1992. Development of a polymerase chain reaction-probe test for identification of Alloiococcus otitis. J Clin Microbiol 30:21772180.
142. Hendolin PH,, Markkanen A,, Ylikoski J,, Wahlfors JJ. 1997. Use of multiplex PCR for simultaneous detection of four bacterial species in middle ear effusions. J Clin Microbiol 35:28542858.
143. Struelens MJ,, Hawkey PM,, French GL,, Witte W,, Tacconelli E. 2009. Laboratory tools and strategies for methicillin-resistant Staphylococcus aureus screening, surveillance and typing: state of the art and unmet needs. Clin Microbiol Infect 15:112119.
144. Tenover FC,, Arbeit RD,, Goering RV,, Mickelsen PA,, Murray BE,, Persing DH,, Swaminathan B. 1995. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 33:22332239.
145. Murchan S,, Kaufmann ME,, Deplano A,, De Ryck R,, Struelens M,, Zinn CE,, Fussing V,, Salmenlinna S,, Vuopio-Varkila J,, El Solh N,, Cuny C,, Witte W,, Tassios PT,, Legakis N,, van Leeuwen W,, van Belkum A,, Vindel A,, Laconcha I,, Garaizar J,, Haeggman S,, Olsson-Liljequist B,, Ransjo U,, Coombes G,, Cookson B. 2003. Harmonization of pulsed-field gel electrophoresis protocols for epidemiological typing of strains of methicillin-resistant Staphylococcus aureus: a single approach developed by consensus in 10 European laboratories and its application for tracing the spread of related strains. J Clin Microbiol 41:15741585.
146. Huijsdens XW,, van Dijke BJ,, Spalburg E,, van Santen-Verheuvel MG,, Heck ME,, Pluister GN,, Voss A,, Wannet WJ,, de Neeling AJ. 2006. Community-acquired MRSA and pig-farming. Ann Clin Microbiol Antimicrob 5:26.
147. Voss A,, Loeffen F,, Bakker J,, Klaassen C,, Wulf M. 2005. Methicillin-resistant Staphylococcus aureus in pig farming. Emerg Infect Dis 11:19651966.
148. Bens CC,, Voss A,, Klaassen CH. 2006. Presence of a novel DNA methylation enzyme in methicillin-resistant Staphylococcus aureus isolates associated with pig farming leads to uninterpretable results in standard pulsed-field gel electrophoresis analysis. J Clin Microbiol 44:18751876.
149. van Wamel WJ,, Hansenová Manásková S,, Fluit AC,, Verbrugh H,, de Neeling AJ,, van Duijkeren E,, van Belkum A. 2010. Short term micro-evolution and PCR-detection of methicillin-resistant and -susceptible Staphylococcus aureus sequence type 398. Eur J Clin Microbiol Infect Dis 29:119122.
150. Argudín MA,, Rodicio MR,, Guerra B. 2010. The emerging methicillin-resistant Staphylococcus aureus ST398 clone can easily be typed using the Cfr9I SmaI-neoschizomer. Lett Appl Microbiol 50:127130.
151. Robinson DA,, Enright MC. 2004. Multilocus sequence typing and the evolution of methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect 10:9297.
152. International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements (IWG-SCC). 2009. Classification of staphylococcal cassette chromosome mec (SCCmec): guidelines for reporting novel SCCmec elements. Antimicrob Agents Chemother 53:49614967.
153. Frénay HM,, Bunschoten AE,, Schouls LM,, van Leeuwen WJ,, Vandenbroucke GC,, Verhoef J,, Mooi FR. 1996. Molecular typing of methicillin-resistant Staphylococcus aureus on the basis of protein A gene polymorphism. Eur J Clin Microbiol Infect Dis 15:6064.
154. Shopsin B,, Gomez M,, Montgomery SO,, Smith DH,, Waddington M,, Dodge DE,, Bost DA,, Riehman M,, Naidich S,, Kreiswirth BN. 1999. Evaluation of protein A gene polymorphic region DNA sequencing for typing of Staphylococcus aureus strains. J Clin Microbiol 37:35563563.
155. Harmsen D,, Claus H,, Witte W,, Rothgänger J,, Claus H,, Turnwald D,, Vogel U. 2003. Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management. J Clin Microbiol 41:54425448.
156. Thomson-Carter FM,, Carter PE,, Pennington TH. 1989. Differentiation of staphylococcal species and strains by ribosomal RNA gene restriction patterns. J Gen Microbiol 135:20932097.
157. Sabat A,, Krzyszton-Russjan J,, Strzalka W,, Filipek R,, Kosowska K,, Hryniewicz W,, Travis J,, Potempa J. 2003. New method for typing Staphylococcus aureus strains: multiple-locus variable-number tandem repeat analysis of polymorphism and genetic relationships of clinical isolates. J Clin Microbiol 41:18011804.
158. Koessler T,, Francois P,, Charbonnier Y,, Huyghe A,, Bento M,, Dharan S,, Renzi G,, Lew D,, Harbarth S,, Pittet D,, Schrenzel J. 2006. Use of oligoarrays for characterization of community-onset methicillin-resistant Staphylococcus aureus. J Clin Microbiol 44:10401048.
159. Price JR,, Didelot X,, Crook DW,, Llewelyn MJ,, Paul J. 2013. Whole genome sequencing in the prevention and control of Staphylococcus aureus infection. J Hosp Infect 83:1421.
160. Amiali NM,, Mulvey MR,, Sedman J,, Simor AE,, Ismail AA. 2007. Epidemiological typing of methicillin-resistant Staphylococcus aureus strains by Fourier transform infrared spectroscopy. J Microbiol Methods 69:146153.
161. Geary C,, Jordens JZ,, Richardson JF,, Hawcroft DM,, Mitchell CJ. 1997. Epidemiological typing of coagulase-negative staphylococci from nosocomial infections. J Med Microbiol 46:195203.
162. Vandenesch F,, Lina B,, Lebeau C,, Greenland TB,, Etienne J. 1993. Epidemiological markers of coagulase-negative staphylococci. Intensive Care Med 19:311315.
163. Murayama O,, Matsuda M,, Moore JE. 2003. Studies on the genomic heterogeneity of Micrococcus luteus strains by macro-restriction analysis using pulsed-field gel electrophoresis. J Basic Microbiol 43:337340.
164. Khoramrooz SS,, Mirsalehian A,, Imaneini H,, Jabalameli F,, Sharifi A,, Aligholi M,, Razmpa E,, Saedi B,, Borghaei P,, Taherikalani M,, Emaneini M. 2012. Characterization of Alloiococcus otitidis strains isolated from children with otitis media with effusion by pulsed-field gel electrophoresis. Int J Pediatr Otorhinolaryngol 76:16581660.
165. Fraise AP. 2002. Susceptibility of antibiotic-resistant cocci to biocides. J Appl Microbiol 92(Suppl):158S162S.
166. Hope R,, Livermore DM,, Brick G,, Lillie M,, Reynolds R. 2008. Non-susceptibility trends among staphylococci from bacteraemias in the UK and Ireland, 2001–06. J Antimicrob Chemother 62(Suppl 2):ii65ii74.
167. Diekema DJ,, Pfaller MA,, Schmitz FJ,, Smayevsky J,, Bell J,, Jones RN,, Beach M. 2001. Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997–1999. Clin Infect Dis 32(Suppl 2):S114S132.
168. Diekema DJ,, BootsMiller BJ,, Vaughn TE,, Woolson RF,, Yankey JW,, Ernst EJ,, Flach SD,, Ward MM,, Franciscus CL,, Pfaller MA,, Doebbeling BN. 2004. Antimicrobial resistance trends and outbreak frequency in United States hospitals. Clin Infect Dis 38:7885.
169. Klevens RM,, Morrison MA,, Nadle J,, Petit S,, Gershman K,, Ray S,, Harrison LH,, Lynfield R,, Dumyati G,, Townes JM,, Craig AS,, Zell ER,, Fosheim GE,, McDougal LK,, Carey RB,, Fridkin SK. 2007. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 298:17631771.
170. Stefani S,, Varaldo PE. 2003. Epidemiology of methicillin-resistant staphylococci in Europe. Clin Microbiol Infect 9:11791186.
171. Zinn CS,, Westh H,, Rosdahl VT. 2004. An international multicenter study of antimicrobial resistance and typing of hospital Staphylococcus aureus isolates from 21 laboratories in 19 countries or states. Microb Drug Resist 10:160168.
172. Shittu AO,, Lin J. 2006. Antimicrobial susceptibility patterns and characterization of clinical isolates of Staphylococcus aureus in KwaZulu-Natal province, South Africa. BMC Infect Dis 6:125.
173. Rosenthal VD,, Maki DG,, Mehta A,, Álvarez-Moreno C,, Leblebicioglu H,, Higuera F,, Cuellar LE,, Madani N,, Mitrev Z,, Dueñas L,, Navoa-Ng JA,, Garcell HG,, Raka L,, Hidalgo RF,, Medeiros EA,, Kanj SS,, Abubakar S,, Nercelles P,, Pratesi RD. 2008. International Nosocomial Infection Control Consortium report, data summary for 2002–2007, issued January 2008. Am J Infect Control 36:627637.
174. Hidron AI,, Low CE,, Honig EG,, Blumberg HM. 2009. Emergence of community-acquired meticillin-resistant Staphylococcus aureus strain USA300 as a cause of necrotising community-onset pneumonia. Lancet Infect Dis 9:384392.
175. Köck R,, Harlizius J,, Bressan N,, Laerberg R,, Wieler LH,, Witte W,, Deurenberg RH,, Voss A,, Becker K,, Friedrich AW. 2009. Prevalence and molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA) among pigs on German farms and import of livestock-related MRSA into hospitals. Eur J Clin Microbiol Infect Dis 28:13751382.
176. van Loo I,, Huijsdens X,, Tiemersma E,, De Neeling A,, van de Sande-Bruinsma N,, Beaujean D,, Voss A,, Kluytmans J. 2007. Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans. Emerg Infect Dis 13:18341839.
177. Kallen AJ,, Mu Y,, Bulens S,, Reingold A,, Petit S,, Gershman K,, Ray SM,, Harrison LH,, Lynfield R,, Dumyati G,, Townes JM,, Schaffner W,, Patel PR,, Fridkin SK. 2010. Health care-associated invasive MRSA infections, 2005–2008. JAMA 304:641648.
178. European Centre for Disease Prevention Control. 2012. Antimicrobial resistance surveillance in Europe 2011. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). ECDC, Stockholm, Sweden.
179. Ito T,, Hiramatsu K,, Tomasz A,, de Lencastre H,, Perreten V,, Holden MT,, Coleman DC,, Goering R,, Giffard PM,, Skov RL,, Zhang K,, Westh H,, O’Brien F,, Tenover FC,, Oliveira DC,, Boyle-Vavra S,, Laurent F,, Kearns AM,, Kreiswirth B,, Ko KS,, Grundmann H,, Sollid JE,, John JF, Jr,, Daum R,, Soderquist B,, Buist G. 2012. Guidelines for reporting novel mecA gene homologues. Antimicrob Agents Chemother 56:49974999.
180. Kriegeskorte A,, Ballhausen B,, Idelevich EA,, Köck R,, Friedrich AW,, Karch H,, Peters G,, Becker K. 2012. Human MRSA isolates with novel genetic homolog, Germany. Emerg Infect Dis 18:10161018.
181. Shore AC,, Deasy EC,, Slickers P,, Brennan G,, O’Connell B,, Monecke S,, Ehricht R,, Coleman DC. 2011. Detection of staphylococcal cassette chromosome mec type XI encoding highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical clonal complex 130 methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 55:37653773.
182. García-Álvarez M,, Holden MT,, Lindsay H,, Webb CR,, Brown DF,, Curran MD,, Walpole E,, Brooks K,, Pickard DJ,, Teale C,, Parkhill J,, Bentley SD,, Edwards GF,, Girvan EK,, Kearns AM,, Pichon B,, Hill RL,, Larsen AR,, Skov RL,, Peacock SJ,, Maskell DJ,, Holmes MA. 2011. Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study. Lancet Infect Dis 11:595603.
183. Takano T,, Higuchi W,, Otsuka T,, Baranovich T,, Enany S,, Saito K,, Isobe H,, Dohmae S,, Ozaki K,, Takano M,, Iwao Y,, Shibuya M,, Okubo T,, Yabe S,, Shi D,, Reva I,, Teng LJ,, Yamamoto T. 2008. Novel characteristics of community-acquired methicillin-resistant Staphylococcus aureus strains belonging to multilocus sequence type 59 in Taiwan. Antimicrob Agents Chemother 52:837845.
184. Ito T,, Katayama Y,, Asada K,, Mori N,, Tsutsumimoto K,, Tiensasitorn C,, Hiramatsu K. 2001. Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 45:13231336.
185. Ito T,, Ma XX,, Takeuchi F,, Okuma K,, Yuzawa H,, Hiramatsu K. 2004. Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC. Antimicrob Agents Chemother 48:26372651.
186. Daum RS,, Ito T,, Hiramatsu K,, Hussain F,, Mongkolrattanothai K,, Jamklang M,, Boyle-Vavra S. 2002. A novel methicillin-resistance cassette in community-acquired methicillin-resistant Staphylococcus aureus isolates of diverse genetic backgrounds. J Infect Dis 186:13441347.
187. Berglund C,, Ito T,, Ikeda M,, Ma XX,, Söderquist B,, Hiramatsu K. 2008. Novel type of staphylococcal cassette chromosome mec in a methicillin-resistant Staphylococcus aureus strain isolated in Sweden. Antimicrob Agents Chemother 52:35123516.
188. Oliveira DC,, Milheiriço C,, de Lencastre H. 2006. Redefining a structural variant of staphylococcal cassette chromosome mec, SCCmec type VI. Antimicrob Agents Chemother 50:34573459.
189. Zhang K,, McClure JA,, Elsayed S,, Conly JM. 2009. Novel staphylococcal cassette chromosome mec type, tentatively designated type VIII, harboring class A mec and type 4 ccr gene complexes in a Canadian epidemic strain of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 53:531540.
190. Deurenberg RH,, Stobberingh EE. 2009. The molecular evolution of hospital- and community-associated methicillin-resistant Staphylococcus aureus. Curr Mol Med 9:100115.
191. Fluit AC,, Wielders CL,, Verhoef J,, Schmitz FJ. 2001. Epidemiology and susceptibility of 3,051 Staphylococcus aureus isolates from 25 university hospitals participating in the European SENTRY study. J Clin Microbiol 39:37273732.
192. Draghi DC,, Tench S,, Dowzicky MJ,, Sahm DF. 2008. Baseline in vitro activity of tigecycline among key bacterial pathogens exhibiting multidrug resistance. Chemotherapy 54:91100.
193. Gu B,, Kelesidis T,, Tsiodras S,, Hindler J,, Humphries RM. 2013. The emerging problem of linezolid-resistant Staphylococcus. J Antimicrob Chemother 68:411.
194. van Hal SJ,, Paterson DL,, Gosbell IB. 2011. Emergence of daptomycin resistance following vancomycin-unresponsive Staphylococcus aureus bacteraemia in a daptomycin-naïve patient—a review of the literature. Eur J Clin Microbiol Infect Dis 30:603610.
195. Long KS,, Poehlsgaard J,, Kehrenberg C,, Schwarz S,, Vester B. 2006. The Cfr rRNA methyltransferase confers resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A antibiotics. Antimicrob Agents Chemother 50:25002505.
196. Baba T,, Takeuchi F,, Kuroda M,, Yuzawa H,, Aoki K,, Oguchi A,, Nagai Y,, Iwama N,, Asano K,, Naimi T,, Kuroda H,, Cui L,, Yamamoto K,, Hiramatsu K. 2002. Genome and virulence determinants of high virulence community-acquired MRSA. Lancet 359:18191827.
197. Gillet Y,, Issartel B,, Vanhems P,, Fournet JC,, Lina G,, Bes M,, Vandenesch F,, Piemont Y,, Brousse N,, Floret D,, Etienne J. 2002. Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet 359:753759.
198. King MD,, Humphrey BJ,, Wang YF,, Kourbatova EV,, Ray SM,, Blumberg HM. 2006. Emergence of community-acquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections. Ann Intern Med 144:309317.
199. DeLeo FR,, Otto M,, Kreiswirth BN,, Chambers HF. 2010. Community-associated meticillin-resistant Staphylococcus aureus. Lancet 375:15571568.
200. David MZ,, Daum RS. 2010. Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic. Clin Microbiol Rev 23:616687.
201. Schaumburg F,, Köck R,, Mellmann A,, Richter L,, Hasenberg F,, Kriegeskorte A,, Friedrich AW,, Gatermann S,, Peters G,, von Eiff C,, Becker K. 2012. Population dynamics among methicillin resistant Staphylococcus aureus in Germany during a 6-year period. J Clin Microbiol 50:31863192.
202. Bartels MD,, Boye K,, Rhod LA,, Skov R,, Westh H. 2007. Rapid increase of genetically diverse methicillin-resistant Staphylococcus aureus, Copenhagen, Denmark. Emerg Infect Dis 13:15331540.
203. Manzur A,, Dominguez AM,, Pujol M,, González MP,, Limon E,, Hornero A,, Martin R,, Gudiol F,, Ariza J. 2008. Community-acquired methicillin-resistant Staphylococcus aureus infections: an emerging threat in Spain. Clin Microbiol Infect 14:377380.
204. Otter JA,, French GL. 2010. Molecular epidemiology of community-associated meticillin-resistant Staphylococcus aureus in Europe. Lancet Infect Dis 10:227239.
205. Williamson DA,, Roberts SA,, Ritchie SR,, Coombs GW,, Fraser JD,, Heffernan H. 2013. Clinical and molecular epidemiology of methicillin-resistant Staphylococcus aureus in New Zealand: rapid emergence of sequence type 5 (ST5)-SCCmec-IV as the dominant community-associated MRSA clone. PLoS One 8:e62020.
206. Shambat S,, Nadig S,, Prabhakara S,, Bes M,, Etienne J,, Arakere G. 2012. Clonal complexes and virulence factors of Staphylococcus aureus from several cities in India. BMC Microbiol 12:64.
207. Moremi N,, Mshana SE,, Kamugisha E,, Kataraihya J,, Tappe D,, Vogel U,, Lyamuya EF,, Claus H. 2012. Predominance of methicillin resistant Staphylococcus aureus -ST88 and new ST1797 causing wound infection and abscesses. J Infect Dev Ctries 6:620625.
208. Shittu AO,, Okon K,, Adesida S,, Oyedara O,, Witte W,, Strommenger B,, Layer F,, Nübel U. 2011. Antibiotic resistance and molecular epidemiology of Staphylococcus aureus in Nigeria. BMC Microbiol 11:92.
209. Schaumburg F,, Köck R,, Friedrich AW,, Soulanoudjingar S,, Ngoa UA,, von Eiff C,, Issifou S,, Kremsner PG,, Herrmann M,, Peters G,, Becker K. 2011. Population structure of Staphylococcus aureus from remote African Babongo Pygmies. PLoS Negl Trop Dis 5:e1150.
210. Schaumburg F,, Ngoa UA,, Kösters K,, Köck R,, Adegnika AA,, Kremsner PG,, Lell B,, Peters G,, Mellmann A,, Becker K. 2011. Virulence factors and genotypes of Staphylococcus aureus from infection and carriage in Gabon. Clin Microbiol Infect 17:15071513.
211. Pan ES,, Diep BA,, Carleton HA,, Charlebois ED,, Sensabaugh GF,, Haller BL,, Perdreau-Remington F. 2003. Increasing prevalence of methicillin-resistant Staphylococcus aureus infection in California jails. Clin Infect Dis 37:13841388.
212. Diep BA,, Chambers HF,, Graber CJ,, Szumowski JD,, Miller LG,, Han LL,, Chen JH,, Lin F,, Lin J,, Phan TH,, Carleton HA,, McDougal LK,, Tenover FC,, Cohen DE,, Mayer KH,, Sensabaugh GF,, Perdreau-Remington F. 2008. Emergence of multidrug-resistant, communityassociated, methicillin-resistant Staphylococcus aureus clone USA300 in men who have sex with men. Ann Intern Med 148:249257.
213. Kazakova SV,, Hageman JC,, Matava M,, Srinivasan A,, Phelan L,, Garfinkel B,, Boo T,, McAllister S,, Anderson J,, Jensen B,, Dodson D,, Lonsway D,, McDougal LK,, Arduino M,, Fraser VJ,, Killgore G,, Tenover FC,, Cody S,, Jernigan DB. 2005. A clone of methicillin-resistant Staphylococcus aureus among professional football players. N Engl J Med 352:468475.
214. Ho PL,, Chiu SS,, Chan MY,, Gan Y,, Chow KH,, Lai EL,, Lau YL. 2012. Molecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong. J Infect 64:500506.
215. Jensen JU,, Jensen ET,, Larsen AR,, Meyer M,, Junker L,, Rønne T,, Skov R,, Jepsen OB,, Andersen LP. 2006. Control of a methicillin-resistant Staphylococcus aureus (MRSA) outbreak in a day-care institution. J Hosp Infect 63:8492.
216. Seybold U,, Kourbatova EV,, Johnson JG,, Halvosa SJ,, Wang YF,, King MD,, Ray SM,, Blumberg HM. 2006. Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections. Clin Infect Dis 42:647656.
217. Saiman L,, O’Keefe M,, Graham PL,III,, Wu F,, Said-Salim B,, Kreiswirth B,, LaSala A,, Schlievert PM,, Della-Latta P. 2003. Hospital transmission of communityacquired methicillin-resistant Staphylococcus aureus among postpartum women. Clin Infect Dis 37:13131319.
218. Köck R,, Schaumburg F,, Mellmann A,, Köksal M,, Jurke A,, Becker K,, Friedrich AW. 2013. Livestock-associated methicillin-resistant Staphylococcus aureus (MRSA) as causes of human infection and colonization in Germany. PLoS One 8:e55040.
219. Clinical and Laboratory Standards Institute (CLSI). 2014. Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Fourth Informational Supplement (M100-S24). CLSI, Wayne, PA.
220. Centers for Disease Control and Prevention. 1997. Staphylococcus aureus with reduced susceptibility to vancomycin—United States, 1997. MMWR Morb Mortal Wkly Rep 46:765766.
221. Robert J,, Bismuth R,, Jarlier V. 2006. Decreased susceptibility to glycopeptides in methicillin-resistant Staphylococcus aureus: a 20 year study in a large French teaching hospital, 1983–2002. J Antimicrob Chemother 57:506510.
222. Hiramatsu K,, Aritaka N,, Hanaki H,, Kawasaki S,, Hosoda Y,, Hori S,, Fukuchi Y,, Kobayashi I. 1997. Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin. Lancet 350:16701673.
223. Cui L,, Ma X,, Sato K,, Okuma K,, Tenover FC,, Mamizuka EM,, Gemmell CG,, Kim MN,, Ploy MC,, El-Solh N,, Ferraz V,, Hiramatsu K. 2003. Cell wall thickening is a common feature of vancomycin resistance in Staphylococcus aureus. J Clin Microbiol 41:514.
224. Boyle-Vavra S,, Labischinski H,, Ebert CC,, Ehlert K,, Daum RS. 2001. A spectrum of changes occurs in peptidoglycan composition of glycopeptide-intermediate clinical Staphylococcus aureus isolates. Antimicrob Agents Chemother 45:280287.
225. Howden BP,, Davies JK,, Johnson PD,, Stinear TP,, Grayson ML. 2010. Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications. Clin Microbiol Rev 23:99139.
226. Howden BP,, Smith DJ,, Mansell A,, Johnson PD,, Ward PB,, Stinear TP,, Davies JK. 2008. Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia. BMC Microbiol 8:39.
227. Centers for Disease Control and Prevention. 2002. Staphylococcus aureus resistant to vancomycin—United States, 2002. MMWR Morb Mortal Wkly Rep 51:565567.
228. Clinical and Laboratory Standards Institute. 2010. Performance Standards for Antimicrobial Susceptibility Testing; Twentieth Informational Supplement. CLSI document M100-S20. Clinical and Laboratory Standards Institute, Wayne, PA.
229. el Solh N,, Davi M,, Morvan A,, Damon HA,, Marty N. 2003. Characteristics of French methicillin-resistant Staphylococcus aureus isolates with decreased susceptibility or resistance to glycopeptides. J Antimicrob Chemother 52:691694.
230. Kelley PG,, Gao W,, Ward PB,, Howden BP. 2011. Daptomycin non-susceptibility in vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous-VISA (hVISA): implications for therapy after vancomycin treatment failure. J Antimicrob Chemother 66:10571060.
231. van Duijkeren E,, Catry B,, Greko C,, Moreno MA,, Pomba MC,, Pyörälä S,, Ruzauskas M,, Sanders P,, Threlfall EJ,, Torren-Edo J,, Törneke K. 2011. Review on methicillin-resistant Staphylococcus pseudintermedius. J Antimicrob Chemother 66:27052714.
232. Martins A,, de Lourdes RS,, Cunha M. 2007. Methicillin resistance in Staphylococcus aureus and coagulase-negative staphylococci: epidemiological and molecular aspects. Microbiol Immunol 51:787795.
233. John JF,, Harvin AM. 2007. History and evolution of antibiotic resistance in coagulase-negative staphylococci: susceptibility profiles of new anti-staphylococcal agents. Ther Clin Risk Manag 3:11431152.
234. Proctor RA,, Kahl B,, von Eiff C,, Vaudaux PE,, Lew DP,, Peters G. 1998. Staphylococcal small colony variants have novel mechanisms for antibiotic resistance. Clin Infect Dis 27(Suppl 1):S68S74.
235. Skov R,, Smyth R,, Larsen AR,, Bolmstrom A,, Karlsson A,, Mills K,, Frimodt-Moller N,, Kahlmeter G. 2006. Phenotypic detection of methicillin resistance in Staphylococcus aureus by disk diffusion testing and Etest on Mueller-Hinton agar. J Clin Microbiol 44:43954399.
236. Felten A,, Grandry B,, Lagrange PH,, Casin I. 2002. Evaluation of three techniques for detection of low-level methicillin-resistant Staphylococcus aureus (MRSA): a disk diffusion method with cefoxitin and moxalactam, the Vitek 2 system, and the MRSA-screen latex agglutination test. J Clin Microbiol 40:27662771.
237. Schissler JR,, Hillier A,, Daniels JB,, Cole LK,, Gebreyes WA. 2009. Evaluation of Clinical Laboratory Standards Institute interpretive criteria for methicillin-resistant Staphylococcus pseudintermedius isolated from dogs. J Vet Diagn Invest 21:684688.
238. Roisin S,, Nonhoff C,, Denis O,, Struelens MJ. 2008. Evaluation of new Vitek 2 card and disk diffusion method for determining susceptibility of Staphylococcus aureus to oxacillin. J Clin Microbiol 46:25252528.
239. Nakatomi Y,, Sugiyama J. 1998. A rapid latex agglutination assay for the detection of penicillin-binding protein 2′. Microbiol Immunol 42:739743.
240. Kipp F,, Becker K,, Peters G,, von Eiff C. 2004. Evaluation of different methods to detect methicillin resistance in small-colony variants of Staphylococcus aureus. J Clin Microbiol 42:12771279.
241. Murakami K,, Minamide W,, Wada K,, Nakamura E,, Teraoka H,, Watanabe S. 1991. Identification of methicillin-resistant strains of staphylococci by polymerase chain reaction. J Clin Microbiol 29:22402244.
242. Monecke S,, Müller E,, Schwarz S,, Hotzel H,, Ehricht R. 2012. Rapid microarray-based identification of different mecA alleles in staphylococci. Antimicrob Agents Chemother 56:55475554.
243. Cherkaoui A,, Renzi G,, Francois P,, Schrenzel J. 2007. Comparison of four chromogenic media for culture-based screening of meticillin-resistant Staphylococcus aureus. J Med Microbiol 56:500503.
244. Diederen B,, van Duijn I,, van Belkum A,, Willemse P,, Van Keulen P,, Kluytmans J. 2005. Performance of CHROMagar MRSA medium for detection of methicillin-resistant Staphylococcus aureus. J Clin Microbiol 43:19251927.
245. Perry JD,, Davies A,, Butterworth LA,, Hopley AL,, Nicholson A,, Gould FK. 2004. Development and evaluation of a chromogenic agar medium for methicillin-resistant Staphylococcus aureus. J Clin Microbiol 42:45194523.
246. Böcher S,, Middendorf B,, Westh H,, Mellmann A,, Becker K,, Skov R,, Friedrich AW. 2010. Semi-selective broth improves screening for methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother 65:717720.
247. Appelbaum PC. 2007. Reduced glycopeptide susceptibility in methicillin-resistant Staphylococcus aureus (MRSA). Int J Antimicrob Agents 30:398408.
248. Tenover FC,, Moellering RC, Jr. 2007. The rationale for revising the Clinical and Laboratory Standards Institute vancomycin minimal inhibitory concentration interpretive criteria for Staphylococcus aureus. Clin Infect Dis 44:12081215.
249. European Committee for Antimicrobial Susceptibility Testing (EUCAST). 2010. Vancomycin—Rationale for the EUCAST Clinical Breakpoints, version 2.1. http://www.eu cast.org/fileadmin/src/media/PDFs/EUCAST_files/Rationale_documents/Vancomycin_rationale_2.1.pdf.
250. Charles PG,, Ward PB,, Johnson PD,, Howden BP,, Grayson ML. 2004. Clinical features associated with bacteremia due to heterogeneous vancomycin-intermediate Staphylococcus aureus. Clin Infect Dis 38:448451.
251. Gould IM. 2013. Treatment of bacteraemia: meticillin-resistant Staphylococcus aureus (MRSA) to vancomycin-resistant S. aureus (VRSA). Int J Antimicrob Agents 42(Suppl):S17S21.
252. Wootton M,, Howe RA,, Hillman R,, Walsh TR,, Bennett PM,, MacGowan AP. 2001. A modified population analysis profile (PAP) method to detect hetero-resistance to vancomycin in Staphylococcus aureus in a UK hospital. J Antimicrob Chemother 47:399403.
253. Walsh TR,, Bolmstrom A,, Qwarnstrom A,, Ho P,, Wootton M,, Howe RA,, MacGowan AP,, Diekema D. 2001. Evaluation of current methods for detection of staphylococci with reduced susceptibility to glycopeptides. J Clin Microbiol 39:24392444.
254. Amiali NM,, Mulvey MR,, Berger-Bächi B,, Sedman J,, Simor AE,, Ismail AA. 2008. Evaluation of Fourier transform infrared spectroscopy for the rapid identification of glycopeptide-intermediate Staphylococcus aureus. J Antimicrob Chemother 61:95102.
255. Gilbert DN,, Moellering RC, Jr,, Eliopoulos GM,, Chambers HF,, Saag MS. 2013. The Sanford Guide to Antimicrobial Therapy. Antimicrobial Therapy, Inc, Sperryville, VA.
256. Liu C,, Bayer A,, Cosgrove SE,, Daum RS,, Fridkin SK,, Gorwitz RJ,, Kaplan SL,, Karchmer AW,, Levine DP,, Murray BE,, Rybak J,, Talan DA,, Chambers HF. 2011. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillinresistant Staphylococcus aureus infections in adults and children: executive summary. Clin Infect Dis 52:285292.
257. Rayner C,, Munckhof WJ. 2005. Antibiotics currently used in the treatment of infections caused by Staphylococcus aureus. Intern Med J 35(Suppl 2):S3S16.
258. Guignard B,, Entenza JM,, Moreillon P. 2005. Beta-lactams against methicillin-resistant Staphylococcus aureus. Curr Opin Pharmacol 5:479489.
259. Itani KM,, Dryden MS,, Bhattacharyya H,, Kunkel MJ,, Baruch AM,, Weigelt JA. 2010. Efficacy and safety of linezolid versus vancomycin for the treatment of complicated skin and soft-tissue infections proven to be caused by methicillin-resistant Staphylococcus aureus. Am J Surg 199:804816.
260. Fowler VG, Jr,, Boucher HW,, Corey GR,, Abrutyn E,, Karchmer AW,, Rupp ME,, Levine DP,, Chambers HF,, Tally FP,, Vigliani GA,, Cabell CH,, Link AS,, DeMeyer I,, Filler SG,, Zervos M,, Cook P,, Parsonnet J,, Bernstein JM,, Price CS,, Forrest GN,, Fätkenheuer G,, Gareca M,, Rehm SJ,, Brodt HR,, Tice A,, Cosgrove SE. 2006. Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus. N Engl J Med 355:653665.
261. Florescu I,, Beuran M,, Dimov R,, Razbadauskas A,, Bochan M,, Fichev G,, Dukart G,, Babinchak T,, Cooper CA,, Ellis-Grosse EJ,, Dartois N,, Gandjini H. 2008. Efficacy and safety of tigecycline compared with vancomycin or linezolid for treatment of serious infections with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci: a phase 3, multicentre, double-blind, randomized study. J Antimicrob Chemother 62(Suppl 1):i17i28.
262. Nicholson SC,, Welte T,, File TM, Jr,, Strauss RS,, Michiels B,, Kaul P,, Balis D,, Arbit D,, Amsler K,, Noel GJ. 2012. A randomised, double-blind trial comparing ceftobiprole medocaril with ceftriaxone with or without linezolid for the treatment of patients with community-acquired pneumonia requiring hospitalisation. Int J Antimicrob Agents 39:240246.
263. Noel GJ,, Strauss RS,, Amsler K,, Heep M,, Pypstra R,, Solomkin JS. 2008. Results of a double-blind, randomized trial of ceftobiprole treatment of complicated skin and skin structure infections caused by gram-positive bacteria. Antimicrob Agents Chemother 52:3744.
264. Friedland HD,, O’Neal T,, Biek D,, Eckburg PB,, Rank DR,, Llorens L,, Smith A,, Witherell GW,, Laudano JB,, Thye D. 2012. CANVAS 1 and 2: analysis of clinical response at day 3 in two phase 3 trials of ceftaroline fosamil versus vancomycin plus aztreonam in treatment of acute bacterial skin and skin structure infections. Antimicrob Agents Chemother 56:22312236.
265. Farrell DJ,, Flamm RK,, Sader HS,, Jones RN. 2013. Spectrum and potency of ceftaroline tested against leading pathogens causing skin and soft-tissue infections in Europe (2010). Int J Antimicrob Agents 41:337342.
266. Wunderink RG,, Niederman MS,, Kollef MH,, Shorr AF,, Kunkel MJ,, Baruch A,, McGee WT,, Reisman A,, Chastre J. 2012. Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study. Clin Infect Dis 54:621629.
267. Proctor RA. 2008. Role of folate antagonists in the treatment of methicillin-resistant Staphylococcus aureus infection. Clin Infect Dis 46:584593.
268. Paterson DL. 2004. “Collateral damage” from cephalosporin or quinolone antibiotic therapy. Clin Infect Dis 38(Suppl 4):S341S345.
269. Gemmell CG,, Edwards DI,, Fraise AP,, Gould FK,, Ridgway GL,, Warren RE. 2006. Guidelines for the prophylaxis and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in the UK. J Antimicrob Chemother 57:589608.