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Abstract:

The genus is a branch of alphaproteobacteria in the order and the family. The genus represents a union with bacteria formerly in the genera and , whose members are small facultatively intracellular Gram-negative bacilli and coccobacilli. Members of the genus are zoonotic agents, for which arthropods are often reservoirs and vectors. At least 32 species are validly described, including 12 of which are definite or potential human pathogens. The most important of these are , , , and . These are the agents for a variety of human illnesses, such as Oroya fever and Carrion’s disease, trench fever, cat scratch disease, and endocarditis among immunocompetent patients and bacillary angiomatosis/peliosis among those who are immunocompromised. species infections are also common among domestic pets and wild animals. Diagnostic test methods include culture, serology, and molecularly based assays. The slow growth and fastidious nature of some species necessitates the use of molecular and/or serologic tests for most applications, but commercially available tools are lacking. While approaches to determine antimicrobial resistance are described, most antibiotics that are sensitive are bacteriostatic only, and there is often no correlation between susceptibility test results and clinical responses.

Citation: Scorpio D, Dumler J. 2015. , p 873-886. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch48
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FIGURE 1

(A and B) Electron micrographs of Marseille (A) and subsp. genotype III (B); (C) strain Houston I isolated on a blood agar plate after 10 days in culture at 36°C and 5% CO.

Citation: Scorpio D, Dumler J. 2015. , p 873-886. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch48
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Tables

Generic image for table
TABLE 1

species or subspecies presently described, their main reservoirs, confirmed or possible vector, and reported accidental hosts

Citation: Scorpio D, Dumler J. 2015. , p 873-886. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch48
Generic image for table
TABLE 2

List of sequences for PCR primers or probes used to amplify or identify spp.

Citation: Scorpio D, Dumler J. 2015. , p 873-886. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch48
Generic image for table
TABLE 2

Citation: Scorpio D, Dumler J. 2015. , p 873-886. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch48
Generic image for table
TABLE 3

MICs for species determined by the agar dilution technique with Columbia agar supplemented with 5% horse blood

Citation: Scorpio D, Dumler J. 2015. , p 873-886. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch48

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