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Citation: SeÑa A, Pillay A, Cox D, Radolf J. .
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Image of FIGURE 1

Morphology of . (A) Scanning electron micrograph showing spiral shape. (B) Negatively stained view of the tips of two organisms. Note the insertion points (I) of periplasmic flagella (PF) near the ends. (C to E) Electron micrographs of ultrathin sections, showing the outer membrane (OM), the cytoplasmic membrane (CM), periplasmic flagella (PF), and the location of the cytoplasmic filaments (CF). Bars, 0.1 μm. Reprinted with permission of Kluwer from . doi:10.1128/9781555817381.ch60.f1

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Image of FIGURE 2

Human intestinal spirochetosis. (Top) H&E staining of a colonic biopsy sample showing a false brush border covering the luminal surface of the colon as observed by light microscopy. Reproduced with permission of Blackwell Publishing Asia Pty Ltd. from . (Bottom) Transmission electron micrograph showing attached end-on to the colonic mucosa, forming a false brush border. Magnification, ×11,000. Reproduced with permission of the American Society for Microbiology from . doi:10.1128/9781555817381.ch60.f2

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The natural course of untreated syphilis. Reprinted with permission of Appleton & Lange from . doi:10.1128/9781555817381.ch60.f3

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PCR-based molecular typing of “street strains.” (Top) Schematic representation of all gene MseI RFLP patterns identified to date. Reproduced with permission of Springer from . (Bottom) Schematic showing different repeat sizes obtained by PCR. Molecular weight markers in base pairs are shown to the left in each panel. In panel B, the size of each repeat is indicated above the amplicon. doi:10.1128/9781555817381.ch60.f4

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Characteristics and major clinical features of the treponematoses

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Clinical and laboratory criteria for diagnosis of syphilis (case definitions)

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Laboratory tests used for direct detection of in clinical samples obtained during the various stages of syphilis

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Oligonucleotide primers and probes used for real-time multiplex PCR for GUD

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Primers and thermocycling conditions for - and -specific PCR

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Nontreponemal tests for syphilis serodiagnosis

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Conventional treponemal tests for syphilis

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Treponemal IgM or IgG EIAs for syphilis

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Combined treponemal IgM/IgG EIAs for syphilis

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Rapid treponemal tests for syphilis

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Rapid combination nontreponemal and treponemal tests for syphilis

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Treponemal immunoblot assays for syphilis

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Treponemal chemiluminescence assays and multiplex flow immunoassays for syphilis


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