Chapter 68 : Antibacterial Agents*

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Antibacterial Agents*, Page 1 of 2

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Antimicrobial chemotherapy has played a vital role in the treatment of human infectious diseases since the discovery of penicillin in the 1920s. Hundreds of antimicrobial agents have been developed, and multiple agents in a variety of classes are currently available for clinical use. However, the sheer numbers and continuing development of agents make it difficult for clinicians to keep up with progress in the field. Similarly, this variety presents significant challenges for clinical microbiologists, who must decide which agents are appropriate for inclusion in routine and specialized susceptibility testing. This chapter provides an overview of the antibacterial agents currently marketed in the United States, with major emphasis on their mechanisms of action, spectra of activity, important pharmacologic parameters, and toxicities. Antibiotics that have fallen into disuse or remained investigational are mentioned only briefly.

Citation: Lewis, J, Bush K. 2015. Antibacterial Agents*, p 1171-1211. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch68
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Chemical structures of β-lactam antibiotics. doi:10.1128/9781555817381.ch68.f1

Citation: Lewis, J, Bush K. 2015. Antibacterial Agents*, p 1171-1211. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch68
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